PE44199A1 - Benzo[e]isoindoles y benzo[h]isoquinolinas triciclicos - Google Patents

Benzo[e]isoindoles y benzo[h]isoquinolinas triciclicos

Info

Publication number
PE44199A1
PE44199A1 PE1998000005A PE00000598A PE44199A1 PE 44199 A1 PE44199 A1 PE 44199A1 PE 1998000005 A PE1998000005 A PE 1998000005A PE 00000598 A PE00000598 A PE 00000598A PE 44199 A1 PE44199 A1 PE 44199A1
Authority
PE
Peru
Prior art keywords
benzo
lower alkyl
triciclicos
isoindoles
isoquinolines
Prior art date
Application number
PE1998000005A
Other languages
English (en)
Inventor
Heinz Stadler
Michael Bos
Jurgen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE44199A1 publication Critical patent/PE44199A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: R1, R2, R3 Y R4 SON H, HALOGENO, OH, ALQUILO INFERIOR, ALCOXILO INFERIOR o FENILO; o R2 Y R3 JUNTOS SON -O-CH2-O-; R5 ES H, ALQUILO INFERIOR o BENCILO; n ES 0 o 1; CON LA CONDICION DE QUE EL COMPUESTO (I) NO ES 2-METIL-1,3,4,4a,5,10b-HEXAHIDRO-2H-BENZO[H]ISOQUINOLIN-6-ONA RACEMICA. TAMBIEN SE REFIERE A SU PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DE FORMULA (I) ACTUAN UNIENDOSE A LOS RECEPTORES (5HT2) DE SEROTONINA, SIENDO UTILES EN EL TRATAMIENTO O PREVENCION DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL TALES COMO DEPRESION, ANSIEDAD, INSOMNIO, PSICOSIS, ENTRE OTROS
PE1998000005A 1997-01-08 1998-01-05 Benzo[e]isoindoles y benzo[h]isoquinolinas triciclicos PE44199A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97100172 1997-01-08

Publications (1)

Publication Number Publication Date
PE44199A1 true PE44199A1 (es) 1999-05-06

Family

ID=8226353

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000005A PE44199A1 (es) 1997-01-08 1998-01-05 Benzo[e]isoindoles y benzo[h]isoquinolinas triciclicos

Country Status (12)

Country Link
US (1) US6310208B1 (es)
KR (1) KR100433609B1 (es)
CN (1) CN1113872C (es)
AR (1) AR011358A1 (es)
CO (1) CO4930268A1 (es)
ES (1) ES2212264T3 (es)
HR (1) HRP980003A2 (es)
MA (1) MA26461A1 (es)
PE (1) PE44199A1 (es)
PT (1) PT958285E (es)
TR (1) TR199901586T2 (es)
ZA (1) ZA9817B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2248524A3 (en) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
EP2742936A1 (en) 2006-05-16 2014-06-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
CN101648865B (zh) * 2008-08-16 2013-03-20 重庆市科学技术研究院 多酚丙烯酸衍生物及其在药物中的应用
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
WO2011097797A1 (zh) * 2010-02-10 2011-08-18 Peng Jinlian 多酚丙烯酸衍生物，其制备方法以及在制备药物中的应用
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC AGENT FOR URINARY INCONTINENCE OF STRESS AND FECAL INCONTINENCE
CN112028878A (zh) * 2020-09-11 2020-12-04 江阴迈康升华医药科技有限公司 一种多氢异喹啉衍生物及其制备方法和医疗用途
WO2022221774A1 (en) * 2021-04-16 2022-10-20 Eleusis Therapeutics Us, Inc. Aryl-ring-substituted 3-phenylazetidines and their use in methods for treating 5-ht2 responsive conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH504438A (de) 1968-05-27 1971-03-15 Sandoz Ag Verfahren zur Herstellung von 1,2,3,4,4a,5,6,10b-Octahydrobenz(h)isochinolin-6-on
US4678791A (en) 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression
JPH03101658A (ja) * 1989-09-13 1991-04-26 Nippon Chemiphar Co Ltd ピロリジン酢酸誘導体
US5180733A (en) 1990-03-30 1993-01-19 Abbott Laboratories Biogenic amine uptake inhibitors

Also Published As

Publication number Publication date
PT958285E (pt) 2004-05-31
TR199901586T2 (xx) 1999-10-21
CN1113872C (zh) 2003-07-09
KR100433609B1 (ko) 2004-05-31
US6310208B1 (en) 2001-10-30
AR011358A1 (es) 2000-08-16
ZA9817B (en) 1998-07-08
HRP980003A2 (en) 1998-10-31
MA26461A1 (fr) 2004-12-20
ES2212264T3 (es) 2004-07-16
CO4930268A1 (es) 2000-06-27
KR20000069962A (ko) 2000-11-25
CN1243510A (zh) 2000-02-02

Similar Documents

Publication Publication Date Title
ES2164657T3 (es) Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
ES2127946T3 (es) Antagonistas de neurocinina diazabiciclica.
EA199700156A1 (ru) Производные индола как антагонисты рецептора 5-нт
AR245700A1 (es) Nuevos derivados de la 2-anilino-pirimidina como agentes antiparasitarios.
DK0640592T3 (da) N-acylerede tricycliske azaheteroringe anvendelige som vasopressin-antagonister
ES2064771T3 (es) Antagonistas de los receptores muscarinicos.
ES2174836T3 (es) Heterrociclos nitrogenados triciclicos condesados como antagonistas de receptor de la sustancia p.
PE20020366A1 (es) Derivados de piperazina como ligandos del receptor 5ht2
ES2164072T3 (es) Heterociclos no aromaticos que contienen nitrogeno sustituidos con bencilamino.
PE20010575A1 (es) Derivados de indol y su uso como ligandos del receptor 5ht2
ECSP941156A (es) 3 bencilaminometil piperidinas substituidas con heteroarilamino y heteroarilsulfonamido y compuestos afines
ECSP066520A (es) Derivados de dihidrobenzofuranilo alcanamina y métodos para su uso
MX9102582A (es) Derivados de indol 3,7-disubstituidos, procedimiento para su preparacion y composicion farmaceutica que los contiene.
ATE247639T1 (de) Arylsubstituierte cyclische amine als selektive dopamin-d3-liganden
ES2038707T3 (es) Procedimiento para la obtencion de enantiomeros (+) y (-) de derivados de la 3,4-dihidro-2h-(1)-benzopiran-3-amina.
PE20000467A1 (es) Derivado de indol util como inhibidor de serotonina
PE44199A1 (es) Benzo[e]isoindoles y benzo[h]isoquinolinas triciclicos
ES2084339T3 (es) Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central.
GB8518658D0 (en) Medicaments
ES2132401T3 (es) Tetrahidro-1h-benzazepinonas y hexahidroazepinonas como antagonistas selectivos del receptor colecistoquinina-b.
ATE109136T1 (de) Substituierte cyclohexene mit zentraler nervensystem-wirkung.
EA200001184A1 (ru) Фенилсульфонамидфенилэтиламины, полезные в качестве допаминовых рецепторов
AR013844A1 (es) Compuestos derivados de 3-oxo-pirido[1,2-a] bencimidazol-4-carboxamida sustituidos en posicion 5 con alquilo que contiene heteroatomo,- y composiciones farmaceuticas que los comprenden.
ES2187783T3 (es) Derivados de indolina utiles como antagonistas del receptor 5-ht-2c.
DE69918046D1 (de) Neue basische Derivate von Benz(e)isoindol-1-onen und Pyrrolo(3,4-c)chinolin-1-onen mit 5-HT3-antagonistischer Aktivität, ihre Herstellung und ihre therapeutische Verwendung

Legal Events

Date Code Title Description
FA Abandonment or withdrawal