PE62399A1 - Aplicacion oral de (+)-o-demetiltramadol como analgesico - Google Patents

Aplicacion oral de (+)-o-demetiltramadol como analgesico

Info

Publication number
PE62399A1
PE62399A1 PE1998000210A PE00021098A PE62399A1 PE 62399 A1 PE62399 A1 PE 62399A1 PE 1998000210 A PE1998000210 A PE 1998000210A PE 00021098 A PE00021098 A PE 00021098A PE 62399 A1 PE62399 A1 PE 62399A1
Authority
PE
Peru
Prior art keywords
demetiltramadol
analgesic
oral application
refers
acids
Prior art date
Application number
PE1998000210A
Other languages
English (en)
Inventor
Elmar Josef Friderichs
Werner Winter
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE62399A1 publication Critical patent/PE62399A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A (+)-O-DEMETILTRAMADOL COMO BASE LIBRE Y/O SU SAL. SUS SALES SE FORMAN CON ACIDOS ORGANICOS PARTICULARMENTE ACIDOS GRASOS C8-C22 Y ACIDOS CARBOXILICOS AROMATICOS. TAMBIEN SE REFIERE A SU UTILIZACION EN FORMA DE TABLETAS DE MATRIZ CON LIBERACION RETARDADA DE LA SUSTANCIA ACTIVA; EL FORMADOR DE DICHA MATRIZ ESTA CONSTITUIDO POR AL MENOS UN ETER O ESTER DE CELULOSA DE PREFERENCIA METILHIDROXIPROPILCELULOSA, HIDROXIMETILCELULOSA, ENTRE OTROS. EL (+)-O-DEMETILTRAMADOL PUEDE SER UTIL EN EL TRATAMIENTO DE ALGIAS INTENSAS, AGUDAS Y/O CRONICAS
PE1998000210A 1997-03-25 1998-03-24 Aplicacion oral de (+)-o-demetiltramadol como analgesico PE62399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712398A DE19712398A1 (de) 1997-03-25 1997-03-25 Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel

Publications (1)

Publication Number Publication Date
PE62399A1 true PE62399A1 (es) 1999-07-10

Family

ID=7824498

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000210A PE62399A1 (es) 1997-03-25 1998-03-24 Aplicacion oral de (+)-o-demetiltramadol como analgesico

Country Status (14)

Country Link
EP (1) EP0870499A1 (es)
JP (1) JPH1112166A (es)
KR (1) KR19980080580A (es)
CN (1) CN1196932A (es)
AU (1) AU5951798A (es)
BR (1) BR9801839A (es)
CA (1) CA2232930A1 (es)
DE (1) DE19712398A1 (es)
HU (1) HUP9800623A3 (es)
IL (1) IL123788A0 (es)
NO (1) NO981320L (es)
PE (1) PE62399A1 (es)
PL (1) PL325509A1 (es)
UY (1) UY24934A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
DE10108123A1 (de) * 2001-02-21 2002-10-02 Gruenenthal Gmbh Wirkstoffkombination
WO2011110595A1 (de) 2010-03-10 2011-09-15 Grünenthal GmbH Kristalline salze und/oder cokristalle von o-desmethyltramadol
US10702485B2 (en) * 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2077637C (en) * 1991-09-06 2007-01-09 Robert B. Raffa Compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone and their use
AU661723B2 (en) * 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
DE4315525B4 (de) * 1993-05-10 2010-04-15 Euro-Celtique S.A. Pharmazeutische Zusammensetzung
DE4329794C2 (de) * 1993-09-03 1997-09-18 Gruenenthal Gmbh Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19601744C2 (de) * 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol

Also Published As

Publication number Publication date
BR9801839A (pt) 2000-01-18
HUP9800623A3 (en) 1999-03-29
AU5951798A (en) 1998-10-01
CA2232930A1 (en) 1998-09-25
IL123788A0 (en) 1998-10-30
EP0870499A1 (de) 1998-10-14
KR19980080580A (ko) 1998-11-25
NO981320D0 (no) 1998-03-24
JPH1112166A (ja) 1999-01-19
PL325509A1 (en) 1998-09-28
CN1196932A (zh) 1998-10-28
DE19712398A1 (de) 1998-10-01
HUP9800623A2 (hu) 1999-01-28
NO981320L (no) 1998-09-28
UY24934A1 (es) 1998-04-21
HU9800623D0 (en) 1998-05-28

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Legal Events

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FA Abandonment or withdrawal