PE62796A1 - Dispositivo de liberacion de droga intravaginal conteniendo un precursor de 17b-estradiol - Google Patents
Dispositivo de liberacion de droga intravaginal conteniendo un precursor de 17b-estradiolInfo
- Publication number
- PE62796A1 PE62796A1 PE1995287516A PE28751695A PE62796A1 PE 62796 A1 PE62796 A1 PE 62796A1 PE 1995287516 A PE1995287516 A PE 1995287516A PE 28751695 A PE28751695 A PE 28751695A PE 62796 A1 PE62796 A1 PE 62796A1
- Authority
- PE
- Peru
- Prior art keywords
- estradiol
- precursor
- drug release
- release device
- device containing
- Prior art date
Links
- 239000002243 precursor Substances 0.000 title abstract 5
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229960005309 estradiol Drugs 0.000 abstract 3
- -1 HYDROXYL GROUP Chemical group 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE AL DISPOSITIVO QUE COMPRENDE UN PRECURSOR DE 17�-ESTRADIOL TAL COMO 17�-ESTRADIOL-3-ACETATO, EN UNA MATRIZ DE POLIMEROS; ESTANDO ADAPTADO PARA LIBERAR EL PRECURSOR EN UN MODELO DE ORDEN CERO, DURANTE POR LO MENOS TRES SEMANAS; SIENDO EL PRECURSOR UNA MITAD DE 17�-ESTRADIOL, EN DONDE EL O CADA GRUPO HIDROXILO DE LA MITAD 17�-ESTRADIOL ES BLOQUEADA POR UN GRUPO BLOQUEANTE TAL COMO ACILO DE CADENA CORTA ALIFATICA O PROPIONILO, EL CUAL ES FACILMENTE ELIMINADO; TENIENDO EL PRECURSOR LIPOFILICIDAD O SOLUBILIDAD EN SILICONA LIQUIDA DE NO MENOS DE 0,1 mg/100ml; UN VALOR K ESTANDAR DE NO MENOS DE 0,1 �g/d/mm; HIDROFILICIDAD, SEGUN SE DETERMINA POR LA SOLUBILIDAD EN AGUA DESTILADA DE NO MENOS DE 1 �g/100ml
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES940976 | 1994-12-19 | ||
| IES950247 | 1995-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE62796A1 true PE62796A1 (es) | 1996-12-28 |
Family
ID=26319777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1995287516A PE62796A1 (es) | 1994-12-19 | 1995-12-19 | Dispositivo de liberacion de droga intravaginal conteniendo un precursor de 17b-estradiol |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5855906A (es) |
| EP (1) | EP0799025B1 (es) |
| JP (1) | JPH10510825A (es) |
| CN (1) | CN1138526C (es) |
| AR (1) | AR002010A1 (es) |
| AT (1) | ATE178204T1 (es) |
| AU (1) | AU692659B2 (es) |
| CA (1) | CA2207622C (es) |
| DE (1) | DE69508791T2 (es) |
| DK (1) | DK0799025T3 (es) |
| ES (1) | ES2133841T3 (es) |
| FI (1) | FI119414B (es) |
| GR (1) | GR3030614T3 (es) |
| IL (1) | IL116433A (es) |
| NO (1) | NO316707B1 (es) |
| NZ (1) | NZ298490A (es) |
| PE (1) | PE62796A1 (es) |
| TR (1) | TR199501599A2 (es) |
| WO (1) | WO1996019196A1 (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6407082B1 (en) * | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
| US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
| US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
| DE69809222T2 (de) | 1997-05-07 | 2003-08-14 | Galen (Chemicals) Ltd., Dublin | Vorrichtungen zur intravaginalen verabreichung von testosteron und testosteron-vorläuferverbindungen |
| US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
| US20040176336A1 (en) * | 2000-03-21 | 2004-09-09 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US20050113351A1 (en) * | 2000-03-21 | 2005-05-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| US6811549B2 (en) * | 2001-02-16 | 2004-11-02 | William H. Fleming | Administration of therapeutic or diagnostic agents using interlabial pad |
| US6962908B2 (en) | 2001-12-21 | 2005-11-08 | Warner Chilcott Company Inc. | Oral pharmaceutical products containing 17 β-estradiol-3-lower alkanoate, method of administering the same and process of preparation |
| WO2003080019A1 (en) * | 2002-03-27 | 2003-10-02 | Galen (Chemicals) Limited | Intravaginal reservoir drug delivery devices |
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| US7833545B2 (en) * | 2003-04-29 | 2010-11-16 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
| GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| US20060183724A1 (en) * | 2005-02-03 | 2006-08-17 | Diliberti Charles E | Compositions of unconjugated estrogens and methods for their use |
| WO2006084083A2 (en) * | 2005-02-03 | 2006-08-10 | Duramed Pharmaceuticals, Inc. | Devices for delivering agents to a vaginal tract |
| EP1933810B1 (en) | 2005-08-11 | 2012-10-10 | Massachusetts Institute of Technology | Intravesical drug delivery device and method |
| US20070077269A1 (en) * | 2005-10-04 | 2007-04-05 | Woodward John R | Method of birth control and hormone regulation |
| US8900620B2 (en) | 2005-10-13 | 2014-12-02 | DePuy Synthes Products, LLC | Drug-impregnated encasement |
| GB0613333D0 (en) * | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| GB0613638D0 (en) * | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| WO2008007098A2 (en) * | 2006-07-12 | 2008-01-17 | Controlled Therapeutics (Scotland) Ltd. | Drug delivery polymer with hydrochloride salt of clindamycin |
| GB0620685D0 (en) * | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| SG195525A1 (en) * | 2007-06-26 | 2013-12-30 | Warner Chilcott Co Llc | Intravaginal drug delivery devices for the delivery of macromolecules and water-soluble drugs |
| EA201070703A1 (ru) | 2007-12-11 | 2010-12-30 | Массачусетс Инститьют Оф Текнолоджи | Имплантируемое устройство для доставки лекарства и способы лечения мочевого пузыря и других полостей тела или трубчатых органов |
| EA201170297A1 (ru) | 2008-08-09 | 2011-08-30 | Массачусетс Инститьют Оф Текнолоджи | Имплантируемое устройство для доставки лекарственных средств и способ лечения мужской мочеполовой системы и окружающих тканей |
| AU2010256558B2 (en) | 2009-06-03 | 2013-10-03 | Forsight Labs, Llc | Anterior segment drug delivery |
| CA2765630C (en) | 2009-06-26 | 2016-07-05 | Taris Biomedical, Inc. | Solid drug tablets for implantable drug delivery devices |
| US9017312B2 (en) | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| JP2014503554A (ja) | 2011-01-10 | 2014-02-13 | タリス バイオメディカル，インコーポレイテッド | 膀胱痛及び刺激性排尿の持続的治療の使用のためのリドカインレジメン |
| ES2637388T3 (es) | 2011-02-04 | 2017-10-13 | Taris Biomedical, Inc. | Dispositivo implantable para la liberación controlada de un fármaco de baja solubilidad |
| RU2740680C2 (ru) | 2011-09-14 | 2021-01-19 | Форсайт Вижн5, Инк. | Глазное вкладочное устройство и способы |
| TWI590843B (zh) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | 膜及其製造方法 |
| EP2911623B1 (en) | 2012-10-26 | 2019-08-14 | Forsight Vision5, Inc. | Ophthalmic system for sustained release of drug to eye |
| PL2968880T3 (pl) | 2013-03-15 | 2025-06-23 | Taris Biomedical Llc | Urządzenia do dostarczania leku ze składnikiem przepuszczalnym dla leku |
| AU2014281010B2 (en) | 2013-06-21 | 2018-05-10 | DePuy Synthes Products, Inc. | Films and methods of manufacture |
| IL299897B2 (en) | 2013-08-19 | 2024-02-01 | Taris Biomedical Llc | Devices and methods for administering multiple units of drug |
| CN104546668B (zh) * | 2013-10-23 | 2019-03-05 | 国家卫生计生委科学技术研究所 | 液体硅橡胶为载体的药物缓控释系统的制备及应用 |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| JP6667450B2 (ja) * | 2014-04-01 | 2020-03-18 | ポリ−メッド インコーポレイテッド | 避妊具及び関連した器具 |
| US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
| EP4744688A2 (en) | 2015-04-23 | 2026-05-20 | Janssen Biotech Inc | DRUG DELIVERY DEVICES WITH A DRUG-PERMEABLE COMPONENT AND METHODS |
| CN114573654B (zh) * | 2020-12-01 | 2025-09-12 | 北京奇明达企业管理有限公司 | 17-O-乙酰-17-β雌二醇的自组装的三聚体、其制备、活性和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| US4291014A (en) * | 1979-01-11 | 1981-09-22 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estradiol diacetate |
| US4438139A (en) * | 1979-08-14 | 1984-03-20 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estrogens |
| SE8602666D0 (sv) * | 1986-06-16 | 1986-06-16 | Leo Ab | Intravaginal devices |
-
1995
- 1995-12-18 IL IL11643395A patent/IL116433A/en not_active IP Right Cessation
- 1995-12-19 DE DE69508791T patent/DE69508791T2/de not_active Expired - Lifetime
- 1995-12-19 JP JP8519650A patent/JPH10510825A/ja not_active Ceased
- 1995-12-19 AR ARP950100619A patent/AR002010A1/es unknown
- 1995-12-19 US US08/849,329 patent/US5855906A/en not_active Expired - Lifetime
- 1995-12-19 DK DK95942772T patent/DK0799025T3/da active
- 1995-12-19 AU AU43991/96A patent/AU692659B2/en not_active Ceased
- 1995-12-19 WO PCT/IE1995/000063 patent/WO1996019196A1/en not_active Ceased
- 1995-12-19 PE PE1995287516A patent/PE62796A1/es not_active Application Discontinuation
- 1995-12-19 NZ NZ298490A patent/NZ298490A/xx unknown
- 1995-12-19 CA CA002207622A patent/CA2207622C/en not_active Expired - Lifetime
- 1995-12-19 ES ES95942772T patent/ES2133841T3/es not_active Expired - Lifetime
- 1995-12-19 TR TR95/01599A patent/TR199501599A2/xx unknown
- 1995-12-19 CN CNB951968947A patent/CN1138526C/zh not_active Expired - Lifetime
- 1995-12-19 AT AT95942772T patent/ATE178204T1/de not_active IP Right Cessation
- 1995-12-19 EP EP95942772A patent/EP0799025B1/en not_active Expired - Lifetime
-
1997
- 1997-06-17 FI FI972579A patent/FI119414B/fi not_active IP Right Cessation
- 1997-06-17 NO NO19972798A patent/NO316707B1/no unknown
-
1999
- 1999-06-29 GR GR990401699T patent/GR3030614T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO972798D0 (no) | 1997-06-17 |
| JPH10510825A (ja) | 1998-10-20 |
| CA2207622C (en) | 2006-10-17 |
| FI972579L (fi) | 1997-06-17 |
| DE69508791D1 (de) | 1999-05-06 |
| IL116433A0 (en) | 1996-03-31 |
| FI119414B (fi) | 2008-11-14 |
| FI972579A0 (fi) | 1997-06-17 |
| ES2133841T3 (es) | 1999-09-16 |
| AR002010A1 (es) | 1998-01-07 |
| CN1170353A (zh) | 1998-01-14 |
| DE69508791T2 (de) | 1999-12-02 |
| GR3030614T3 (en) | 1999-10-29 |
| NO972798L (no) | 1997-08-19 |
| CN1138526C (zh) | 2004-02-18 |
| WO1996019196A1 (en) | 1996-06-27 |
| ATE178204T1 (de) | 1999-04-15 |
| IL116433A (en) | 2002-02-10 |
| EP0799025B1 (en) | 1999-03-31 |
| TR199501599A2 (tr) | 1996-07-21 |
| US5855906A (en) | 1999-01-05 |
| DK0799025T3 (da) | 1999-10-18 |
| NO316707B1 (no) | 2004-04-13 |
| EP0799025A1 (en) | 1997-10-08 |
| NZ298490A (en) | 1999-11-29 |
| AU4399196A (en) | 1996-07-10 |
| CA2207622A1 (en) | 1996-06-27 |
| AU692659B2 (en) | 1998-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |