PE9999A1 - Derivados de cefalosporin piridino - Google Patents

Derivados de cefalosporin piridino

Info

Publication number
PE9999A1
PE9999A1 PE1997000922A PE00092297A PE9999A1 PE 9999 A1 PE9999 A1 PE 9999A1 PE 1997000922 A PE1997000922 A PE 1997000922A PE 00092297 A PE00092297 A PE 00092297A PE 9999 A1 PE9999 A1 PE 9999A1
Authority
PE
Peru
Prior art keywords
rent
alcx
formula
heterociclo
piridine
Prior art date
Application number
PE1997000922A
Other languages
English (en)
Inventor
Urs Weiss
Ingrid Heinze-Krauss
Malcolm Page
Peter Angehrn
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE9999A1 publication Critical patent/PE9999A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/187-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "X" ES CH o N; R1 ES H, ALQUILO INFERIOR, CICLOALQUILO o ACETILO; R2 ES H, ALQUILO INFERIOR, OMEGA-HIDROXI ALQUILO, BENCILO o ALQUILO INFERIOR-HETEROCICLO, EN DONDE EL BENCILO o HETEROCICLO ESTAN OPCIONALMENTE SUSTITUIDOS POR NH2, CN, CARBOXILO, OH, ALQUILO INFERIOR, ALCOXILO INFERIOR, CON(R)2 o CH2CONR4R5; R ES H o ALQUILO INFERIOR; R4 Y R5 SON H, OMEGA-HIDROXI ALQUILO, FENILO, NAFTILO o HETEROCICLO, EN DONDE EL FENILO, NAFTILO O HETEROCICLO ESTAN OPCIONALMENTE SUSTITUIDOS POR OH (OPCIONALMENTE PROTEGIDO), HALOGENO, ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, ALCOXILO INFERIOR OPCIONALMENTE SUSTITUIDO, OMEGA-HIDROXI ALQUILO Y/O CIANO; o R4 Y R5 FORMAN CONJUNTAMENTE UN GRUPO DE FORMULA (i); m ES 0 o 1; n ES 0; 1 o 2; CON LA CONDICION DE QUE m ES 1 CUANDO EL ANILLO DE PIRIDINA "A" ES PIRIDINA-4-ILO. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DE FORMULA (I) PRESENTAN POTENTE Y AMPLIA ACTIVIDAD ANTIBACTERIANA, ESPECIALMENTE FRENTE A ESTAFILOCOCOS AUREUS RESISTENTES A METICICLINA (MRSA), ENTEROCOCOS Y NEUMOCOCOS RESISTENTES A METICILINA
PE1997000922A 1996-10-22 1997-10-17 Derivados de cefalosporin piridino PE9999A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96116927 1996-10-22

Publications (1)

Publication Number Publication Date
PE9999A1 true PE9999A1 (es) 1999-02-10

Family

ID=8223321

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000922A PE9999A1 (es) 1996-10-22 1997-10-17 Derivados de cefalosporin piridino

Country Status (23)

Country Link
US (1) US5935950A (es)
JP (1) JP3004954B2 (es)
KR (1) KR100253783B1 (es)
CN (1) CN1184815A (es)
AR (1) AR009122A1 (es)
AU (1) AU727502B2 (es)
BR (1) BR9705113A (es)
CA (1) CA2214677A1 (es)
CO (1) CO4910143A1 (es)
CZ (1) CZ333297A3 (es)
HR (1) HRP970559A2 (es)
HU (1) HUP9701661A3 (es)
IL (1) IL121987A0 (es)
MA (1) MA24383A1 (es)
NO (1) NO974759L (es)
NZ (1) NZ328594A (es)
PE (1) PE9999A1 (es)
PL (1) PL322713A1 (es)
SG (1) SG55392A1 (es)
TR (1) TR199701185A2 (es)
TW (1) TW446707B (es)
YU (1) YU40097A (es)
ZA (1) ZA979244B (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY106991A (en) * 1989-09-04 1995-08-30 Pfizer Novel cephalosporin derivatives or compounds
DE69016719T2 (de) * 1989-09-04 1995-06-01 Beecham Group Plc Cephalosporinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate und Zwischenverbindungen.
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
PT620225E (pt) * 1993-04-16 2003-03-31 Basilea Pharmaceutica Ag Derivados de cefalosporina

Also Published As

Publication number Publication date
AU727502B2 (en) 2000-12-14
YU40097A (sh) 1999-12-27
MX9707716A (es) 1998-06-28
HUP9701661A2 (hu) 1998-11-30
HRP970559A2 (en) 1998-10-31
TR199701185A3 (tr) 1998-05-21
ZA979244B (en) 1998-04-22
CA2214677A1 (en) 1998-04-22
NO974759L (no) 1998-04-23
BR9705113A (pt) 1998-10-27
AR009122A1 (es) 2000-03-08
US5935950A (en) 1999-08-10
PL322713A1 (en) 1998-04-27
HUP9701661A3 (en) 2001-04-28
TR199701185A2 (xx) 1998-05-21
IL121987A0 (en) 1998-03-10
CN1184815A (zh) 1998-06-17
CO4910143A1 (es) 2000-04-24
TW446707B (en) 2001-07-21
JP3004954B2 (ja) 2000-01-31
KR100253783B1 (ko) 2000-07-01
NZ328594A (en) 1998-06-26
AU4277597A (en) 1998-04-30
CZ333297A3 (cs) 1998-05-13
JPH10120687A (ja) 1998-05-12
HU9701661D0 (en) 1997-12-29
NO974759D0 (no) 1997-10-15
KR19980033013A (ko) 1998-07-25
SG55392A1 (en) 1998-12-21
MA24383A1 (fr) 1998-07-01

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed