ATE129498T1 - Kondensierte heterozyklische verbindungen, ihre herstellung und verwendung. - Google Patents

Kondensierte heterozyklische verbindungen, ihre herstellung und verwendung.

Info

Publication number
ATE129498T1
ATE129498T1 AT90111903T AT90111903T ATE129498T1 AT E129498 T1 ATE129498 T1 AT E129498T1 AT 90111903 T AT90111903 T AT 90111903T AT 90111903 T AT90111903 T AT 90111903T AT E129498 T1 ATE129498 T1 AT E129498T1
Authority
AT
Austria
Prior art keywords
condensed heterocyclic
production
heterocyclic compounds
group
bridgehead
Prior art date
Application number
AT90111903T
Other languages
English (en)
Inventor
Hiroyuki Mitsudera
Masato Konobe
Yasuo Ishida
Kazuho Matsuura
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE129498T1 publication Critical patent/ATE129498T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT90111903T 1989-06-23 1990-06-22 Kondensierte heterozyklische verbindungen, ihre herstellung und verwendung. ATE129498T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP16150789 1989-06-23
JP28035889 1989-10-27
JP11431890 1990-04-27

Publications (1)

Publication Number Publication Date
ATE129498T1 true ATE129498T1 (de) 1995-11-15

Family

ID=27312700

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90111903T ATE129498T1 (de) 1989-06-23 1990-06-22 Kondensierte heterozyklische verbindungen, ihre herstellung und verwendung.

Country Status (11)

Country Link
US (1) US5498774A (de)
EP (1) EP0404190B1 (de)
KR (1) KR910000724A (de)
AT (1) ATE129498T1 (de)
AU (1) AU622330B2 (de)
BR (1) BR9002976A (de)
CA (1) CA2019651A1 (de)
DE (1) DE69023171T2 (de)
HU (1) HUT54685A (de)
PL (2) PL165356B1 (de)
YU (1) YU123390A (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910011852A (ko) * 1989-12-04 1991-08-07 폴 디. 매튜카이티스 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
FR2687675B1 (fr) * 1992-01-31 1997-04-18 Roussel Uclaf Nouveaux derives bicycliques de la pyridine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
CA2131797C (en) * 1992-03-12 2010-05-18 Laramie Mary Gaster Condensed indole derivatives as 5ht4-receptor antagonists
CA2303152A1 (en) 1997-09-05 1999-03-18 Glaxo Group Limited 2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (cox-2) inhibitors
CN1263755C (zh) 1998-11-03 2006-07-12 葛兰素集团有限公司 作为选择性cox－2抑制剂的吡唑并吡啶衍生物
DE69915519T2 (de) 1999-02-27 2005-02-03 Glaxo Group Ltd., Greenford Pyrazolopyridine
GB9919588D0 (en) 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
GB9930358D0 (en) 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
PE20020506A1 (es) 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
US7163940B2 (en) 2000-12-15 2007-01-16 Smithkline Beecham Corporation Pyrazolopyridinyl pyrimidine therapeutic compounds
DE60112609T2 (de) 2000-12-15 2006-01-19 Glaxo Group Ltd., Greenford Pyrazolopyridine
ES2227451T3 (es) * 2001-03-08 2005-04-01 Smithkline Beecham Corporation Derivados de pirazolopiridina.
JP4237497B2 (ja) 2001-03-30 2009-03-11 スミスクライン ビーチャム コーポレーション ピラゾロピリジン類、その調製方法及びその治療用化合物としての使用
JP2004525150A (ja) * 2001-03-30 2004-08-19 スミスクライン ビーチャム コーポレーション 治療用化合物としてのピラゾロピリジン類の使用
WO2002083672A1 (en) 2001-04-10 2002-10-24 Smithkline Beecham Corporation Antiviral pyrazolopyridine compounds
US6756498B2 (en) 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
EP1385847B1 (de) 2001-04-27 2005-06-01 SmithKline Beecham Corporation Pyrazolo[1,5]pyridinderivate
EP1399442B1 (de) * 2001-06-06 2006-08-09 Vertex Pharmaceuticals Incorporated Cak inhibitoren und deren verwendungen
IL158667A0 (en) 2001-06-21 2004-05-12 Smithkline Beecham Corp Imidazo [1,2-a] pyridine derivatives for the prophylaxis and treatment of herpes viral infections
EP1423389B1 (de) * 2001-09-07 2007-06-06 SmithKline Beecham Corporation Pyrazolo-pyridine für die behandlung von herpes-ansteckungen
ES2262893T3 (es) * 2001-10-05 2006-12-01 Smithkline Beecham Corporation Derivados de imidazo-piridina para su uso en el tratamiento de infeccion virica por herpes.
PE20030739A1 (es) 2001-11-30 2003-08-28 Schering Corp Antagonistas del receptor de adenosina a2a
US7199120B2 (en) 2001-12-11 2007-04-03 Smithkline Beecham Corporation Pyrazolo-pyridine derivatives as antiherpes agents
DE60210819T2 (de) 2001-12-17 2007-04-19 Smithkline Beecham Corp. Pyrazolopyridazinderivate
TW200306822A (en) * 2002-01-31 2003-12-01 Daiichi Seiyaku Co Imidazo[1, 2-a]pyridine derivative
US20040021778A1 (en) * 2002-08-05 2004-02-05 Oldani Jerome L. Security system with remote access and control
US7153863B2 (en) * 2002-10-03 2006-12-26 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridline derivatives
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
US7709468B2 (en) 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
WO2007034282A2 (en) * 2005-09-19 2007-03-29 Pfizer Products Inc. Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists
PT1966214T (pt) 2005-12-21 2017-02-03 Janssen Pharmaceutica Nv Triazolpiridazinas como moduladores de tirosina quinase
WO2007086080A2 (en) * 2006-01-30 2007-08-02 Glenmark Pharmaceuticals Limited NOVEL IMIDAZO[1,2-a]PYRIDINE CANNABINOID RECEPTOR LIGANDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
US20080249305A1 (en) * 2007-03-27 2008-10-09 Calderwood David J Novel imidazole based heterocycles
SI2203439T1 (sl) 2007-09-14 2011-05-31 Ortho Mcneil Janssen Pharm 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni
BRPI0817101A2 (pt) 2007-09-14 2017-05-09 Addex Pharmaceuticals Sa 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
ES2409215T3 (es) * 2007-09-14 2013-06-25 Janssen Pharmaceuticals, Inc. 4-fenil-1H-piridin-2-onas 1-3-disustituidas
ES2637794T3 (es) * 2007-11-14 2017-10-17 Janssen Pharmaceuticals, Inc. Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
US8324241B2 (en) 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
WO2009126861A2 (en) 2008-04-11 2009-10-15 Bristol-Myers Squibb Company Triazolopyridine compounds useful as dgat1 inhibitors
ES2439291T3 (es) 2008-09-02 2014-01-22 Janssen Pharmaceuticals, Inc. Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos
CA2738849C (en) 2008-10-16 2016-06-28 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
ES2401691T3 (es) 2008-11-28 2013-04-23 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Derivados de indol y de benzoxacina como moduladores de los receptores metabotrópicos de glutamato
ES2440001T3 (es) 2009-05-12 2014-01-27 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
SG176018A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
JP5641664B2 (ja) 2009-10-30 2014-12-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ イミダゾ［１，２−ｂ］ピリダジン誘導体およびＰＤＥ１０阻害剤としてのそれらの使用
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
CN103298809B (zh) 2010-11-08 2016-08-31 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
CA2814998C (en) 2010-11-08 2019-10-29 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN103298468A (zh) 2011-02-01 2013-09-11 协和发酵麒麟株式会社 稠环杂环衍生物
BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
AU2013283426B2 (en) 2012-06-26 2018-02-22 Janssen Pharmaceutica Nv Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological or metabolic disorders
WO2014009305A1 (en) 2012-07-09 2014-01-16 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
US9540366B2 (en) 2012-07-31 2017-01-10 Kyowa Hakko Kirin Co., Ltd. Ring-fused heterocyclic compound
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
US10537573B2 (en) 2014-01-21 2020-01-21 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
IL279202B2 (en) 2014-01-21 2023-09-01 Janssen Pharmaceutica Nv Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
PE20161573A1 (es) 2014-02-13 2017-01-19 Incyte Corp Ciclopropilamina como inhibidor de la lsd1
EP3392244A1 (de) 2014-02-13 2018-10-24 Incyte Corporation Cyclopropylamine als lsd1-inhibitoren
US9493450B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
PE20180455A1 (es) 2015-04-03 2018-03-05 Incyte Corp Compuestos heterociclicos como inhibidores de lsd1
SG10202001219UA (en) 2015-08-12 2020-03-30 Incyte Corp Salts of an lsd1 inhibitor
CN109414410B (zh) 2016-04-22 2022-08-12 因赛特公司 Lsd1抑制剂的制剂
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791025A (fr) * 1971-11-19 1973-05-07 Allen & Hanburys Ltd Composes heterocycliques
US4159375A (en) * 1978-08-24 1979-06-26 American Cyanamid Company 6- AND 7-Aryl-1,2,4-triazolo[4,3-b]-1,2,4-triazines
DE3276110D1 (en) * 1981-03-04 1987-05-27 Ici Plc Amide derivatives, processes for preparing them, their use as fungicides and pesticidal compositions containing them
EP0061836B1 (de) * 1981-03-19 1986-12-30 Imperial Chemical Industries Plc Amidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Fungizide und Pestizide, die sie enthalten
OA07174A (fr) * 1981-08-24 1984-04-30 May & Baker Ltd Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent.
US4405619A (en) * 1981-09-02 1983-09-20 Diamond Shamrock Corporation Antiinflammatory substituted-1,2,4-triazolo[4,3-b]-1,2,4-triazines
GB2107308B (en) * 1981-09-30 1986-01-15 Ici Plc Herbicidal and fungicidal
US4478845A (en) * 1983-01-19 1984-10-23 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic imidazoimidazoles
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
US4507481A (en) * 1983-07-29 1985-03-26 Pennwalt Corporation Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines
JPS60139672A (ja) * 1983-12-27 1985-07-24 Mitsui Toatsu Chem Inc アミド誘導体の製造法
PH25866A (en) * 1986-03-20 1991-12-02 Takeda Chemical Industries Ltd Sulfonylurea compounds and their herbicides
US4792565A (en) * 1986-04-24 1988-12-20 Mitsui Toatsu Chemicals, Inc. Pyrazolecarbonylamine derivatives and agricultural and horticultural fungicides containing said compounds
FR2607813B1 (fr) * 1986-12-05 1989-03-31 Montpellier I Universite Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
US4743586A (en) * 1986-10-29 1988-05-10 American Cyanamid Company Method of treating hypertension using substituted imidazo[1,5-d]1,2,4-triazin-1(2H)-ones
AU2261488A (en) * 1987-08-07 1989-03-09 Australian National University, The Imidazo(1,2-b)pyridazines
AU2261688A (en) * 1987-08-07 1989-03-09 Australasian Drug Development Limited Aryloxy-and aralkylthio-imidazo(1,2-b)pyridazines
IL88619A0 (en) * 1987-12-15 1989-07-31 Pfizer Non-peptidic renin inhibitors
JPH0662625B2 (ja) * 1988-03-15 1994-08-17 富士写真フイルム株式会社 １Ｈ−ピラゾロ〔５，１−ｃ〕−１，２，４−トリアゾール系化合物の製造方法
JPH02145588A (ja) * 1988-11-29 1990-06-05 Konica Corp ６位ヘテロ原子置換１，２，４−トリアゾロ［３，４−ｂ］−１，３，４−チアジアジン系化合物の製造方法

Also Published As

Publication number Publication date
PL285756A1 (en) 1991-08-26
PL165356B1 (pl) 1994-12-30
AU622330B2 (en) 1992-04-02
KR910000724A (ko) 1991-01-30
CA2019651A1 (en) 1990-12-23
PL164890B1 (pl) 1994-10-31
EP0404190B1 (de) 1995-10-25
PL289850A1 (en) 1991-10-07
DE69023171D1 (de) 1995-11-30
AU5777490A (en) 1991-01-17
EP0404190A1 (de) 1990-12-27
YU123390A (sh) 1992-09-07
US5498774A (en) 1996-03-12
HU903963D0 (en) 1990-11-28
HUT54685A (en) 1991-03-28
DE69023171T2 (de) 1996-03-28
BR9002976A (pt) 1991-08-20

Similar Documents

Publication Publication Date Title
ATE129498T1 (de) Kondensierte heterozyklische verbindungen, ihre herstellung und verwendung.
ATE172201T1 (de) Morphinan-derivate und medizinische verwendung
DE69628368D1 (de) Heterocyclische Verbindungen, ihre Herstellung und Verwendung
ATE338754T1 (de) Heterocyclische verbindungen, ihre herstellung und verwendung
DE69111029D1 (de) Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung.
ATE119774T1 (de) Imidazopyridinderivate und ihre verwendung.
ID25649A (id) Turunan-turunan sikloalkena, produksi serta penggunaannya
ES2145743T3 (es) Compuesto de anillo condensado benzoxa, su produccion y composicion farmaceutica que lo contiene.
FI935830A0 (fi) Bicykliska aminderivat
DE69208408D1 (de) Phenylthioharnstoffderivate und ihre pharmazeutische Verwendung
ES2043807T3 (es) Compuestos anticancer.
DE69024397D1 (de) Diaminoethylen-Verbindungen
AU628521B2 (en) Improvements in or relating to organic compounds
DE69121259D1 (de) Beta-Lactam-Verbindungen und ihre Herstellung
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
DE3586591D1 (de) Antibiotisch wirkende isoxazolderivate, ihre herstellung und verwendung.
DE69607890D1 (de) Aromatische Hydroxamsäure-Verbindungen, ihre Herstellung und Verwendung
ATE111097T1 (de) Fungizide.
DE3362523D1 (en) Optically active imidazolylpropanol compounds, and their production and use
TH12632A (th) สารประกอบเฮเทอโรไซคลิค
TH42384A (th) อนุพันธ์ d-โปรไลน์