PH15252A - 3-(-2-hydroxy-4-(substituted)phenyl cycloalkanone and cycloalkanol anagesic agents,compositions containing them,and method of use thereof - Google Patents

3-(-2-hydroxy-4-(substituted)phenyl cycloalkanone and cycloalkanol anagesic agents,compositions containing them,and method of use thereof

Info

Publication number
PH15252A
PH15252A PH21596A PH21596A PH15252A PH 15252 A PH15252 A PH 15252A PH 21596 A PH21596 A PH 21596A PH 21596 A PH21596 A PH 21596A PH 15252 A PH15252 A PH 15252A
Authority
PH
Philippines
Prior art keywords
anagesic
cycloalkanone
cycloalkanol
hydroxy
phenyl
Prior art date
Application number
PH21596A
Other languages
English (en)
Inventor
Charles Armon Harbert
Michael Ross Johnson
Lawrence Sherman Melvin Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PH15252A publication Critical patent/PH15252A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/42—Halogenated derivatives containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C07C41/56—Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/95—Esters of quinone carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PH21596A 1977-09-13 1978-09-13 3-(-2-hydroxy-4-(substituted)phenyl cycloalkanone and cycloalkanol anagesic agents,compositions containing them,and method of use thereof PH15252A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83310277A 1977-09-13 1977-09-13
US92668778A 1978-07-25 1978-07-25

Publications (1)

Publication Number Publication Date
PH15252A true PH15252A (en) 1982-11-02

Family

ID=27125579

Family Applications (2)

Application Number Title Priority Date Filing Date
PH21596A PH15252A (en) 1977-09-13 1978-09-13 3-(-2-hydroxy-4-(substituted)phenyl cycloalkanone and cycloalkanol anagesic agents,compositions containing them,and method of use thereof
PH23144A PH16597A (en) 1977-09-13 1979-10-09 Process for the selective alkylation of 3-(2,4-dihydroxyphenyl)cycloalkanones

Family Applications After (1)

Application Number Title Priority Date Filing Date
PH23144A PH16597A (en) 1977-09-13 1979-10-09 Process for the selective alkylation of 3-(2,4-dihydroxyphenyl)cycloalkanones

Country Status (27)

Country Link
JP (1) JPS5448741A (de)
AR (1) AR224618A1 (de)
AT (1) AT361455B (de)
AU (1) AU513523B2 (de)
CA (1) CA1110261A (de)
CH (1) CH635812A5 (de)
DE (1) DE2839836C2 (de)
DK (1) DK400878A (de)
ES (3) ES473288A1 (de)
FI (1) FI66584C (de)
FR (1) FR2402639A1 (de)
GB (1) GB2004870B (de)
GR (1) GR74134B (de)
HK (1) HK13284A (de)
IE (1) IE47187B1 (de)
IL (1) IL55556A (de)
IN (1) IN150334B (de)
IT (1) IT1099054B (de)
KE (1) KE3352A (de)
LU (1) LU80220A1 (de)
MX (1) MX5306E (de)
MY (1) MY8500094A (de)
NL (2) NL7809274A (de)
NO (2) NO149426C (de)
NZ (1) NZ188391A (de)
PH (2) PH15252A (de)
SE (1) SE431085B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285867A (en) * 1980-09-19 1981-08-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
IN162851B (de) * 1980-09-19 1988-07-16 Pfizer
US5650270A (en) * 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
JPS58201737A (ja) * 1982-05-18 1983-11-24 Mitsui Toatsu Chem Inc 新規芳香族アルカン誘導体、その製造法およびそれを有効成分とする殺虫、殺ダニ剤
GB8330099D0 (en) * 1983-11-11 1983-12-21 Ici Plc Cycloalkane derivatives
IL75480A0 (en) * 1985-06-11 1985-10-31 Yissum Res Dev Co Alkoxyphenol derivatives and pharmaceutical compositions containing them
US4623657A (en) * 1985-09-05 1986-11-18 Hoechst-Roussel Pharmaceuticals Inc. Spiro [benzofuran-2(3H),1'-cycloheptane]s and their therapeutic use
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
WO2000056702A1 (en) * 1999-03-22 2000-09-28 Pfizer Inc. Resorcinol derivatives
US6828460B2 (en) 1999-03-22 2004-12-07 Pfizer Inc. Resorcinol derivatives
CA2823724A1 (en) * 2006-04-24 2007-11-08 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
US7618966B2 (en) 2006-04-24 2009-11-17 Allergan, Inc. Abnormal Cannabidiols as agents for lowering intraocular pressure
US7612101B2 (en) 2006-04-24 2009-11-03 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
US7718830B2 (en) 2006-04-24 2010-05-18 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
CN109369514B (zh) * 2018-12-10 2021-10-26 天津科技大学 一种六元碳环衍生物的合成方法
EP3997098A4 (de) 2019-07-12 2023-10-11 Canopy Growth Corporation Cannabinoidderivate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU487907A1 (ru) * 1973-09-21 1975-10-15 Полоцкий Химический Комбинат Им. 50-Летия Белор.Сср Полимерна композици

Also Published As

Publication number Publication date
IN150334B (de) 1982-09-11
AU513523B2 (en) 1980-12-04
AT361455B (de) 1981-03-10
AR224618A1 (es) 1981-12-30
ES8100795A1 (es) 1980-11-01
JPS5758329B2 (de) 1982-12-09
NZ188391A (en) 1984-05-31
ES480150A1 (es) 1980-09-01
GB2004870B (en) 1982-01-20
FI66584B (fi) 1984-07-31
DE2839836C2 (de) 1983-01-27
IT7827558A0 (it) 1978-09-12
HK13284A (en) 1984-02-24
IL55556A0 (en) 1978-12-17
ATA658778A (de) 1980-08-15
IE781841L (en) 1979-03-13
ES473288A1 (es) 1980-03-01
SE7809060L (sv) 1979-03-14
FI782794A7 (fi) 1979-03-14
NL7809274A (nl) 1979-03-15
IE47187B1 (en) 1984-01-11
FI66584C (fi) 1984-11-12
AU3981878A (en) 1980-03-20
JPS5448741A (en) 1979-04-17
PH16597A (en) 1983-11-22
DK400878A (da) 1979-03-14
NO792840L (no) 1979-03-14
CH635812A5 (fr) 1983-04-29
KE3352A (en) 1983-12-16
MX5306E (es) 1983-06-14
SE431085B (sv) 1984-01-16
NL8303358A (nl) 1984-02-01
GB2004870A (en) 1979-04-11
GR74134B (de) 1984-06-06
NO149426C (no) 1984-04-18
MY8500094A (en) 1985-12-31
DE2839836A1 (de) 1979-03-15
NO149426B (no) 1984-01-09
IL55556A (en) 1982-11-30
LU80220A1 (fr) 1980-04-21
NO783087L (no) 1979-03-14
ES480149A0 (es) 1980-11-01
FR2402639A1 (fr) 1979-04-06
CA1110261A (en) 1981-10-06
IT1099054B (it) 1985-09-18

Similar Documents

Publication Publication Date Title
EG12043A (en) Herbicide,composition containing the compound and method of use
PH12473A (en) Herbicidal compound,herbicidal composition containing the same,and method of use thereof
PH13828A (en) Dextrorotatory isomers of asymmetric spirohydantoins compositions containing them and method of use thereof
PH16326A (en) New chemical compounds,pharmaceutical compositions containing the same and method of use
GB2028803B (en) Insecticidal compositions containing new urea and thioureacompounds
PH18091A (en) Novel spiro-oxazolidindiones,pharmaceutical compositions containing same and method of use thereof
PH14401A (en) Hydroxyaminohydrocarbonphosphonic acid derivatives,compositions containing same and method of use
KE3352A (en) 3-(2-hydroxy-4-(substituted)phenyl)cycloalkanone and cycloalkanol analgesic agents
PL203784A1 (pl) Srodek owadobojczy i sposob wytwarzania podstawionych fenylokarbamoilo-2-pirazolin
EP0000771A3 (en) 2,5,7-trimethyloctane-3-ol and 2,4-dimethylnonane-8-ol; processes for their preparation; their use as olfactory agents; olfactory compositions containing them, as well as the preparation of such olfactory compositions; starting products for their preparation.
PT68543A (en) Process for the preparation of 3-2-hydroxi-4-substituted -phenyl cycloalkanone and cycloalkanol analgesic agents andintermediates therefor
JPS5340783A (en) Novel alkoxy substituted pyrimidinylthionophosphonic acid and use of same as pesticide and mitecide
PH14398A (en) Pharmaceutical compounds,compositions containing same and method of use
PH14818A (en) Synergistic fungicidal composition and method of use
DE2860495D1 (en) Cyclohexanes, method for their preparation, their use and compositions containing them
JPS52136120A (en) New propanee1*22dioxydioxime and its method of manufacturing and insecticide containing said compound
JPS5386023A (en) Pesticide composition of piresloid series
IL53216A0 (en) Novel cyclohexene nitriles and perfume compositions containing them
IT7821450A0 (it) Composti pesticidi, composizioni che li contengono, e relativi processi di preparazione e metodi di impiego.
ZA756350B (en) Herbicidal compound, herbicidal composition containing the same, and method of use thereof
ZA754613B (en) Herbicidal compound, herbicidal composition containing the same, and method of use thereof
PH14512A (en) Anti-bacterial compositions and method of use thereof
JPS5487732A (en) Phenyl azopyridone compound* method of making same and use thereof as dye
PH12053A (en) Pesticidal dihydrotetrazolo(1,5-a)quinazolin-5-ones,compositions and methods of using the same
ZA775930B (en) Insecticidal and ovicidal compositions and method for using same