PH22136A - Dihydropyridazinone derivatives and use thereof - Google Patents

Dihydropyridazinone derivatives and use thereof

Info

Publication number: PH22136A
Authority: PH; Philippines
Prior art keywords: compounds; formula; dihydropyridazinone derivatives; dihydropyridazinone; derivatives
Prior art date: 1984-01-13

Application number

PH31697A

Other languages

English (en)

Inventor

Robert A Slater

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-01-13

Filing date

1985-01-09

Publication date

1988-06-01

1985-01-09 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1988-06-01 Publication of PH22136A publication Critical patent/PH22136A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Hydrogenated Pyridines (AREA)

PH31697A 1984-01-13 1985-01-09 Dihydropyridazinone derivatives and use thereof PH22136A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB848400863A GB8400863D0 (en)	1984-01-13	1984-01-13	Chemical compounds

Publications (1)

Publication Number	Publication Date
PH22136A true PH22136A (en)	1988-06-01

Family

ID=10554924

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH31697A PH22136A (en)	1984-01-13	1985-01-09	Dihydropyridazinone derivatives and use thereof

Country Status (31)

Country	Link
US (1)	US4654342A (fr)
EP (1)	EP0150937B1 (fr)
JP (3)	JPS60158181A (fr)
KR (1)	KR920006781B1 (fr)
CN (1)	CN85101722A (fr)
AT (1)	ATE37179T1 (fr)
AU (1)	AU572252B2 (fr)
CA (2)	CA1251209A (fr)
CS (1)	CS248731B2 (fr)
DD (1)	DD231350A5 (fr)
DE (1)	DE3564941D1 (fr)
DK (1)	DK162519C (fr)
ES (3)	ES8607949A1 (fr)
FI (1)	FI850140L (fr)
GB (1)	GB8400863D0 (fr)
GR (1)	GR850068B (fr)
HU (1)	HU193591B (fr)
IE (1)	IE57969B1 (fr)
IL (1)	IL74031A (fr)
JO (1)	JO1351B1 (fr)
MY (1)	MY100124A (fr)
NO (1)	NO850129L (fr)
NZ (1)	NZ210816A (fr)
PH (1)	PH22136A (fr)
PL (1)	PL147123B1 (fr)
PT (1)	PT79819B (fr)
RO (1)	RO92607A (fr)
SU (1)	SU1396963A3 (fr)
WO (1)	WO1985003076A1 (fr)
ZA (1)	ZA85251B (fr)
ZW (1)	ZW385A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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CA1251448A (fr) *	1985-03-27	1989-03-21	William J. Coates	Derives de pyridazinone
AU581324B2 (en) *	1985-07-05	1989-02-16	Smith Kline & French Laboratories Limited	Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones
GB8603780D0 (en) *	1986-02-15	1986-03-19	Smith Kline French Lab	Chemical compounds
GB8722776D0 (en) *	1987-09-28	1987-11-04	Smith Kline French Lab	Chemical compounds
US5011837A (en) *	1988-08-09	1991-04-30	E. R. Squibb & Sons, Inc.	Aryl cyanoguanidines: potassium channel activators and method of making same
NZ229828A (en) *	1988-08-09	1992-03-26	Squibb & Sons Inc	Aryl cyanoguanidine derivatives and pharmaceutical compositions
AU2002254124A1 (en)	2001-02-27	2002-09-12	Mitokor	Aryl-n-cyanoguanidines and methods related thereto
DE60213841T2 (de) *	2001-11-05	2007-02-15	Merck Patent Gmbh	Hydrazono-malonitrile
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
DE102004011512B4 (de)	2004-03-08	2022-01-13	Boehringer Ingelheim Vetmedica Gmbh	Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en) *	2004-03-25	2015-03-17	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (fr)	2004-03-25	2005-09-28	Boehringer Ingelheim Vetmedica Gmbh	Utilisation des inhibiteurs de PDE III pour la réduction de la taille du coeur chez des mammifères souffrant d'insufficances cardiaques
AU2006311577B2 (en)	2005-11-09	2013-02-07	Zalicus Inc.	Methods, compositions, and kits for the treatment of medical conditions
PL1951227T3 (pl) *	2005-11-14	2017-09-29	Boehringer Ingelheim Vetmedica Gmbh	Zastosowania pimobendanu do leczenia bezobjawowej(utajonej) niewydolności serca
EP1920785A1 (fr) *	2006-11-07	2008-05-14	Boehringer Ingelheim Vetmedica Gmbh	Préparation liquide contenant un complexe du pimobendane et de la cyclodextrine
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
CA2726917C (fr)	2008-06-04	2018-06-26	Synergy Pharmaceuticals Inc.	Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
EP2321341B1 (fr)	2008-07-16	2017-02-22	Synergy Pharmaceuticals Inc.	Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
US8664252B2 (en)	2008-11-25	2014-03-04	Boehringer Ingelheim Vetmedica Gmbh	Phosphodiesterase type III (PDE III) inhibitors or CA2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
EA201391254A1 (ru)	2011-03-01	2014-02-28	Синерджи Фармасьютикалз Инк.	Способ получения агонистов гуанилатциклазы c
WO2013106547A1 (fr)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation
ES2924478T3 (es)	2012-03-15	2022-10-07	Boehringer Ingelheim Vetmedica Gmbh	Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
JP6499591B2 (ja)	2013-02-25	2019-04-10	シナジーファーマシューティカルズインコーポレイテッド	結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
WO2014151200A2 (fr)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions utiles pour le traitement de troubles gastro-intestinaux
CN105764916B (zh)	2013-06-05	2021-05-18	博士医疗爱尔兰有限公司	鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
PL3021832T3 (pl)	2013-07-19	2021-08-23	Boehringer Ingelheim Vetmedica Gmbh	Konserwowana ciekła wodna kompozycja farmaceutyczna zawierająca eteryfikowane pochodne cyklodekstryny
EP3492106B1 (fr)	2013-08-09	2021-02-17	Ardelyx, Inc.	Composés et procédés d'inhibition du transport de phosphate
BR122019024673B1 (pt)	2013-12-04	2023-04-11	Boehringer Ingelheim Vetmedica Gmbh	Composições farmacêuticas aprimoradas de pimobendan
CN104987310A (zh) *	2015-06-03	2015-10-21	青岛农业大学	左西孟旦的合成工艺
US10537570B2 (en)	2016-04-06	2020-01-21	Boehringer Ingelheim Vetmedica Gmbh	Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN110117257B (zh) *	2018-02-05	2022-12-06	安徽省新星药物开发有限责任公司	一种含胍基的p2y12受体拮抗剂、制备方法及其用途
EP3972599B1 (fr)	2019-05-21	2025-10-22	Ardelyx, Inc.	Combinaison pour baisser le phosphate sérique chez un patient

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3822260A (en) *	1970-10-09	1974-07-02	American Cyanamid Co	6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones
BE791539A (fr) *	1971-11-19	1973-05-17	Basf Ag	Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
EP0030835B1 (fr) *	1979-12-05	1983-05-11	Morishita Pharmaceutical Co. Ltd.	Dérivés de 6-phényl-3(2H)-pyridazinones substituées en position 2, leur production et compositions pharmaceutiques les contenant
EP0059688B1 (fr) *	1981-03-04	1985-05-15	Ciba-Geigy Ag	Pyridazinones, leur procédé de préparation, compositions pharmaceutiques contenant ces composés et leur utilisation
JPS58113180A (ja) *	1981-12-28	1983-07-05	Mitsui Toatsu Chem Inc	ピリダジノン誘導体
JPS58140076A (ja) *	1982-02-09	1983-08-19	Mitsubishi Chem Ind Ltd	ピリダジノン誘導体又はその塩類
DE3204375C2 (de) *	1982-02-09	1983-12-01	J. Rettenmaier & Söhne GmbH + Co, 7091 Holzmühle	Verfahren zur Herabsetzung der Saugfähigkeit von Holz
DE3302021A1 (de) *	1983-01-22	1984-07-26	Basf Ag, 6700 Ludwigshafen	6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
AU581324B2 (en) *	1985-07-05	1989-02-16	Smith Kline & French Laboratories Limited	Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones

1984
- 1984-01-13 GB GB848400863A patent/GB8400863D0/en active Pending
1985
- 1985-01-02 JO JO19851351A patent/JO1351B1/en active
- 1985-01-07 CA CA000471594A patent/CA1251209A/fr not_active Expired
- 1985-01-07 ZW ZW3/85A patent/ZW385A1/xx unknown
- 1985-01-08 DK DK009185A patent/DK162519C/da not_active IP Right Cessation
- 1985-01-09 PH PH31697A patent/PH22136A/en unknown
- 1985-01-10 CS CS85202A patent/CS248731B2/cs unknown
- 1985-01-10 DD DD85272500A patent/DD231350A5/de not_active IP Right Cessation
- 1985-01-10 GR GR850068A patent/GR850068B/el unknown
- 1985-01-10 PT PT79819A patent/PT79819B/pt not_active IP Right Cessation
- 1985-01-10 ES ES539446A patent/ES8607949A1/es not_active Expired
- 1985-01-10 IL IL74031A patent/IL74031A/xx unknown
- 1985-01-11 EP EP85300196A patent/EP0150937B1/fr not_active Expired
- 1985-01-11 AT AT85300196T patent/ATE37179T1/de active
- 1985-01-11 DE DE8585300196T patent/DE3564941D1/de not_active Expired
- 1985-01-11 ZA ZA85251A patent/ZA85251B/xx unknown
- 1985-01-11 HU HU85109A patent/HU193591B/hu not_active IP Right Cessation
- 1985-01-11 IE IE69/85A patent/IE57969B1/en not_active IP Right Cessation
- 1985-01-11 NO NO850129A patent/NO850129L/no unknown
- 1985-01-11 NZ NZ210816A patent/NZ210816A/en unknown
- 1985-01-11 AU AU37611/85A patent/AU572252B2/en not_active Ceased
- 1985-01-11 JP JP60003912A patent/JPS60158181A/ja active Pending
- 1985-01-11 FI FI850140A patent/FI850140L/fi not_active Application Discontinuation
- 1985-01-11 PL PL1985251516A patent/PL147123B1/pl unknown
- 1985-01-11 WO PCT/GB1985/000014 patent/WO1985003076A1/fr not_active Ceased
- 1985-01-12 KR KR1019850000179A patent/KR920006781B1/ko not_active Expired
- 1985-01-14 US US06/690,911 patent/US4654342A/en not_active Expired - Fee Related
- 1985-04-01 CN CN198585101722A patent/CN85101722A/zh active Pending
- 1985-09-12 RO RO85120090A patent/RO92607A/fr unknown
- 1985-09-12 SU SU853958649A patent/SU1396963A3/ru active
- 1985-12-05 ES ES549629A patent/ES8703846A1/es not_active Expired
1986
- 1986-05-14 ES ES554965A patent/ES8706645A1/es not_active Expired
1987
- 1987-06-02 MY MYPI87000758A patent/MY100124A/en unknown
1988
- 1988-05-09 JP JP63113411A patent/JPS63313776A/ja active Pending
- 1988-05-09 JP JP63113410A patent/JPS63313775A/ja active Pending
- 1988-10-21 CA CA000581012A patent/CA1260471A/fr not_active Expired

Also Published As

Publication number	Publication date
US4654342A (en)	1987-03-31
NZ210816A (en)	1987-06-30
KR850005417A (ko)	1985-08-26
DD231350A5 (de)	1985-12-24
JO1351B1 (en)	1986-11-30
WO1985003076A1 (fr)	1985-07-18
KR920006781B1 (ko)	1992-08-17
JPS63313776A (ja)	1988-12-21
FI850140A0 (fi)	1985-01-11
JPS60158181A (ja)	1985-08-19
CA1260471C (fr)	1989-09-26
CS248731B2 (en)	1987-02-12
ES8706645A1 (es)	1987-07-01
GR850068B (fr)	1985-05-03
ES554965A0 (es)	1987-07-01
ES8607949A1 (es)	1986-06-01
SU1396963A3 (ru)	1988-05-15
DK162519B (da)	1991-11-11
DK9185A (da)	1985-07-14
FI850140A7 (fi)	1985-07-14
IE57969B1 (en)	1993-06-02
IL74031A (en)	1988-07-31
ZA85251B (en)	1986-08-27
DK162519C (da)	1992-03-30
ES539446A0 (es)	1986-06-01
CA1260471A (fr)	1989-09-26
PL251516A1 (en)	1985-12-17
RO92607A (fr)	1987-11-30
IE850069L (en)	1985-07-13
PL147123B1 (en)	1989-04-29
DE3564941D1 (en)	1988-10-20
ZW385A1 (en)	1985-08-07
ATE37179T1 (de)	1988-09-15
AU3761185A (en)	1985-07-18
GB8400863D0 (en)	1984-02-15
JPS63313775A (ja)	1988-12-21
EP0150937A3 (en)	1985-08-21
AU572252B2 (en)	1988-05-05
CN85101722A (zh)	1987-01-31
CA1251209A (fr)	1989-03-14
IL74031A0 (en)	1985-04-30
FI850140L (fi)	1985-07-14
HUT37128A (en)	1985-11-28
EP0150937A2 (fr)	1985-08-07
NO850129L (no)	1985-07-15
MY100124A (en)	1989-12-18
ES8703846A1 (es)	1987-03-01
HU193591B (en)	1987-11-30
EP0150937B1 (fr)	1988-09-14
PT79819A (en)	1985-02-01
ES549629A0 (es)	1987-03-01
PT79819B (en)	1987-01-07
DK9185D0 (da)	1985-01-08

Publication	Publication Date	Title
PH22136A (en)	1988-06-01	Dihydropyridazinone derivatives and use thereof
AU1507888A (en)	1988-11-03	New bicyclic compounds, processes for preparation thereof and pharmaceutical composition comprising the same
ZA872925B (en)	1987-11-25	Heterocyclic compounds
DE3465594D1 (en)	1987-10-01	Tropone derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
NZ216741A (en)	1988-10-28	6-oxo-1,6-dihydropyridazines and pharmaceutical compositions
ES8302719A1 (es)	1982-12-01	Un procedimiento para preparar compuestos de cefem