PH23038A - Benzoylurea derivatives having anti-tumor activity - Google Patents

Benzoylurea derivatives having anti-tumor activity

Info

Publication number: PH23038A
Authority: PH; Philippines
Prior art keywords: compounds; tumor activity; found; formula; benzoylurea derivatives
Prior art date: 1983-09-01

Application number

PH31171A

Other languages

English (en)

Inventor

Marius Sander Brouwer

Roelof Van Hes

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-01

Filing date

1984-08-31

Publication date

1989-03-10

1984-08-31 Application filed by Duphar Int Res filed Critical Duphar Int Res

1989-03-10 Publication of PH23038A publication Critical patent/PH23038A/en

Links

HRYILSDLIGTCOP-UHFFFAOYSA-N N-benzoylurea Chemical class NC(=O)NC(=O)C1=CC=CC=C1 HRYILSDLIGTCOP-UHFFFAOYSA-N 0.000 title abstract 2
230000000259 anti-tumor effect Effects 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 4
230000015572 biosynthetic process Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
- C07C335/26—Y being a hydrogen or a carbon atom, e.g. benzoylthioureas

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PH31171A 1983-09-01 1984-08-31 Benzoylurea derivatives having anti-tumor activity PH23038A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL8303043		1983-09-01

Publications (1)

Publication Number	Publication Date
PH23038A true PH23038A (en)	1989-03-10

Family

ID=19842331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH31171A PH23038A (en)	1983-09-01	1984-08-31	Benzoylurea derivatives having anti-tumor activity

Country Status (13)

Country	Link
EP (1)	EP0136745B1 (de)
JP (1)	JPS60120847A (de)
AT (1)	ATE43788T1 (de)
AU (1)	AU572549B2 (de)
CA (1)	CA1252791A (de)
DE (1)	DE3478573D1 (de)
DK (1)	DK412084A (de)
ES (1)	ES535491A0 (de)
GR (1)	GR80221B (de)
IL (1)	IL72818A0 (de)
NZ (1)	NZ209365A (de)
PH (1)	PH23038A (de)
ZA (1)	ZA846767B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE40111T1 (de) *	1984-07-05	1989-02-15	Duphar Int Res	Benzoylharnstoffverbindungen sowie solche enthaltende insektizide und akarizide zusammensetzungen.
EP0173244B1 (de) *	1984-08-24	1990-02-07	Ciba-Geigy Ag	Benzoylphenylharnstoffe
TR23048A (tr) *	1984-08-31	1989-02-14	Ciba Geigy Ag	Fenilbenzoiluereler,bunlarin im aline mahsus usul ve bunlarin zararhlarla muecadelede kullanimi
EP0179022B1 (de) *	1984-10-18	1990-11-07	Ciba-Geigy Ag	Benzoylphenylharnstoffe
US5153224A (en) *	1984-10-18	1992-10-06	Ciba-Geigy Corporation	Benzoylphenylureas
EP0179021A3 (de) *	1984-10-18	1987-05-13	Ciba-Geigy Ag	Benzoylphenylharnstoffe
US5135953A (en) *	1984-12-28	1992-08-04	Ciba-Geigy	Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals
ZA861446B (en) *	1985-03-01	1986-10-29	Duphar Int Res	Benzoyl urea derivatives having anti-tumor activity
AU602305B2 (en) *	1985-03-14	1990-10-11	Istituto Guido Donegani S.P.A.	N-(halobenzoyl)-N-(polyhaloalkoxyphenyl) urea derivatives
JPH0742267B2 (ja) *	1985-06-04	1995-05-10	日本曹達株式会社	ベンゾイルウレア誘導体、その製造方法及び殺虫剤
DE3741062A1 (de) *	1987-12-04	1989-08-31	Hoechst Ag	(thio)benzoylharnstoffe und deren funktionelle derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als schaedlingsbekaempfungsmittel
AU642524B2 (en) *	1990-09-10	1993-10-21	Duphar International Research B.V.	Pharmaceutical formulation containing a benzoyl urea derivative
GB9313285D0 (en) *	1993-06-28	1993-08-11	Zeneca Ltd	Acid derivatives
US5463011A (en) *	1993-06-28	1995-10-31	Zeneca Limited	Acid derivatives
GB9313268D0 (en) *	1993-06-28	1993-08-11	Zeneca Ltd	Chemical compounds
EP1294682B1 (de) *	2000-06-09	2004-04-28	Aventis Pharma Deutschland GmbH	Acylphenylharnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
PE20021091A1 (es)	2001-05-25	2003-02-04	Aventis Pharma Gmbh	Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion
US7223796B2 (en)	2002-04-11	2007-05-29	Sanofi-Aventis Deutschland Gmbh	Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use
DE10215907A1 (de) *	2002-04-11	2003-11-06	Aventis Pharma Gmbh	Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
US7297709B2 (en)	2003-05-22	2007-11-20	Abbott Laboratories	Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
DE10335092B3 (de) *	2003-08-01	2005-02-03	Aventis Pharma Deutschland Gmbh	Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung
DE602007010664D1 (de)	2006-09-04	2010-12-30	Univ Dundee	P53 aktivierende benzoylharnstoff- und benzoylthioharnstoff-verbindungen
CN101880246B (zh) *	2009-05-05	2012-10-03	中国科学院上海药物研究所	取代苯甲酰脲类化合物及其制备方法和用途
GB0909912D0 (en)	2009-06-09	2009-07-22	Univ Dundee	Compounds
SG11201503620RA (en) *	2012-11-08	2015-06-29	Univ Rutgers	Antimicrobial agents
US9458150B2 (en)	2013-11-08	2016-10-04	Rutgers, The State University Of New Jersey	Antimicrobial agents
CN109195957A (zh)	2016-02-25	2019-01-11	塔克西斯医药股份有限公司	合成方法和中间体
CA3058183A1 (en)	2017-03-30	2018-10-04	Taxis Pharmaceuticals, Inc.	Synthetic processes and synthetic intermediates towardthe production of txa709
CN113004183B (zh) *	2021-02-08	2023-03-14	中山大学附属第三医院（中山大学肝脏病医院）	一种索拉非尼抗肿瘤抑制助剂化合物及其组合物和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5640667A (en) *	1979-09-11	1981-04-16	Ishihara Sangyo Kaisha Ltd	Urea derivative
AU1862083A (en) *	1982-09-02	1984-03-08	Duphar International Research B.V.	Tumor growth inhibitors
ATE28862T1 (de) *	1983-01-24	1987-08-15	Duphar Int Res	Aktive kompositionen gegen motten, weisse fliegen und holzwuermer, pharmazeutische kompositionen und benzoylharnstoffderivaten.
DK147084A (da) *	1983-03-19	1984-09-20	Bayer Ag	1-phenyl-3-benzoyl-(thio)-urinstoffer, deres fremstilling og anvendelse som skadedyrsbekaempelsesmidler
IT1161228B (it) *	1983-04-22	1987-03-18	Montedison Spa	Benzoil-uree ad attivita' insetticida

1984
- 1984-08-27 AT AT84201221T patent/ATE43788T1/de active
- 1984-08-27 DE DE8484201221T patent/DE3478573D1/de not_active Expired
- 1984-08-27 EP EP84201221A patent/EP0136745B1/de not_active Expired
- 1984-08-28 GR GR80221A patent/GR80221B/el unknown
- 1984-08-29 AU AU32504/84A patent/AU572549B2/en not_active Ceased
- 1984-08-29 ES ES535491A patent/ES535491A0/es active Granted
- 1984-08-29 NZ NZ209365A patent/NZ209365A/xx unknown
- 1984-08-29 ZA ZA846767A patent/ZA846767B/xx unknown
- 1984-08-29 CA CA000461993A patent/CA1252791A/en not_active Expired
- 1984-08-29 DK DK412084A patent/DK412084A/da not_active Application Discontinuation
- 1984-08-30 IL IL72818A patent/IL72818A0/xx unknown
- 1984-08-31 PH PH31171A patent/PH23038A/en unknown
- 1984-08-31 JP JP59182516A patent/JPS60120847A/ja active Pending

Also Published As

Publication number	Publication date
NZ209365A (en)	1989-07-27
AU572549B2 (en)	1988-05-12
EP0136745A2 (de)	1985-04-10
CA1252791A (en)	1989-04-18
GR80221B (en)	1984-12-14
DK412084D0 (da)	1984-08-29
ES8505338A1 (es)	1985-05-16
ES535491A0 (es)	1985-05-16
IL72818A0 (en)	1984-11-30
ZA846767B (en)	1985-04-24
EP0136745A3 (en)	1986-01-22
ATE43788T1 (de)	1989-06-15
EP0136745B1 (de)	1989-06-07
DK412084A (da)	1985-03-02
AU3250484A (en)	1985-03-07
DE3478573D1 (en)	1989-07-13
JPS60120847A (ja)	1985-06-28

Publication	Publication Date	Title
DE3478573D1 (en)	1989-07-13	Benzoyl urea derivatives having anti-tumor activity
CA1268780C (fr)	1990-05-08	Groupes protecteurs n-hydroxyles et methode de preparation de 3-acylamino-1-hydroxy-2-azetidinones
FR2564101B1 (fr)	1987-08-07	Procede perfectionne d'esterification de la colophane par le pentaerythritol
CA2100655A1 (en)	1992-08-09	Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
DE3476392D1 (en)	1989-03-02	Purine derivatives
HUT51295A (en)	1990-04-28	Process for producing peptidalcohol derivatives of anticoagulant activity
ES8606374A1 (es)	1986-04-16	Un procedimiento para preparar derivados de acido neuramini-co
PT73841A (en)	1981-11-01	Process for preparing novel guanidine derivatives
IT1160199B (it)	1987-03-04	Procedimento per la produzione di dialchilbenzeni ortosoppressi
DE3483735D1 (en)	1991-01-24	Hexahydropyrrolo(2,1-a)isochinolinderivate.
IT8049291A0 (it)	1980-07-21	Procedimento per la depurazione di pentaeritritolo
IT8322692A0 (it)	1983-08-30	Composizioni per il trattamento della ruggine.
ES8504799A1 (es)	1985-04-16	Procedimiento de obtencion de piridopirimidinonas
DE3461189D1 (en)	1986-12-11	New 3-alkylthio-2-o-carbamoyl-propane-1.2-diol-1-o-phosphocholines, and processes for their preparation
DE3560948D1 (en)	1987-12-17	A n-(6-substituted pyridine-2-carbonyl)-3-substituted histidine derivative, a method of preparing the same and its use as an anti-tumor agent
IT8249499A0 (it)	1982-11-16	Procedimento per la produzione di coke metallurgico