PH23425A - Sulfonamide derivatives as antiarrhythmic agents - Google Patents

Sulfonamide derivatives as antiarrhythmic agents

Info

Publication number: PH23425A
Authority: PH; Philippines
Prior art keywords: alkyl; group; formula; compounds; antiarrhythmic agents
Prior art date: 1986-05-01

Application number

PH35179A

Other languages

English (en)

Inventor

John Edmund Arrowsmith

Peter Edward Cross

Geoffrey Noel Thomas

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-01

Filing date

1987-04-24

Publication date

1989-08-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26290703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH23425(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1986-05-01 Priority claimed from GB868610668A external-priority patent/GB8610668D0/en

1986-12-17 Priority claimed from GB868630059A external-priority patent/GB8630059D0/en

1987-04-24 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

1989-08-07 Publication of PH23425A publication Critical patent/PH23425A/en

Links

239000003416 antiarrhythmic agent Substances 0.000 title abstract 2
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
-1 piperidino, morpholino Chemical group 0.000 abstract 2
125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)
Pyrrole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Manufacturing Of Micro-Capsules (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)
Polyamides (AREA)
Lubricants (AREA)
Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
Fats And Perfumes (AREA)
Medicines Containing Plant Substances (AREA)

PH35179A 1986-05-01 1987-04-24 Sulfonamide derivatives as antiarrhythmic agents PH23425A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868610668A GB8610668D0 (en)	1986-05-01	1986-05-01	Anti-arrhythmia agents
GB868630059A GB8630059D0 (en)	1986-12-17	1986-12-17	Antiarrhythmic agents

Publications (1)

Publication Number	Publication Date
PH23425A true PH23425A (en)	1989-08-07

Family

ID=26290703

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH35179A PH23425A (en)	1986-05-01	1987-04-24	Sulfonamide derivatives as antiarrhythmic agents

Country Status (27)

Country	Link
US (2)	US4959366A (bs)
EP (1)	EP0245997B1 (bs)
KR (2)	KR870011084A (bs)
CN (1)	CN1019801B (bs)
AT (1)	ATE74906T1 (bs)
AU (1)	AU578557B2 (bs)
BA (2)	BA98301A (bs)
CA (1)	CA1289140C (bs)
DE (2)	DE3778201D1 (bs)
DK (1)	DK175096B1 (bs)
EG (1)	EG18188A (bs)
ES (1)	ES2033840T3 (bs)
FI (1)	FI88291C (bs)
GR (1)	GR3004457T3 (bs)
HU (1)	HU196743B (bs)
IE (1)	IE59366B1 (bs)
IL (1)	IL82373A (bs)
LU (1)	LU90519I2 (bs)
LV (1)	LV5715B4 (bs)
MY (1)	MY111142A (bs)
NL (1)	NL300002I2 (bs)
NO (2)	NO168527C (bs)
NZ (1)	NZ220151A (bs)
PH (1)	PH23425A (bs)
PL (1)	PL149924B1 (bs)
PT (1)	PT84782B (bs)
YU (2)	YU46195B (bs)

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US5602174A (en) *	1986-02-15	1997-02-11	Beecham Wuefling Gmbh & Co.	Treatment
NL8700842A (bs) *	1987-04-10	1988-11-01	Duphar Int Res
SE8705150D0 (sv) *	1987-12-23	1987-12-23	Haessle Ab	Novel antiarrhythmic agents
US4906634A (en) *	1988-03-08	1990-03-06	Schering A.G.	Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
GB8809314D0 (en) *	1988-04-20	1988-05-25	Wellcome Found	Anti-hypertensive sulfonanilides
GB8819307D0 (en) *	1988-08-13	1988-09-14	Pfizer Ltd	Antiarrhythmic agents
US5166209A (en) *	1989-04-21	1992-11-24	Burroughs Wellcome Co.	Pharmacologically active compounds
HUT58270A (en) *	1989-06-02	1992-02-28	Wyeth John & Brother Ltd	Process for producing amine derivatives and pharmaceutical compositions containing them
US5084463A (en) *	1989-12-11	1992-01-28	American Home Products Corporation	N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity
AU4787593A (en) *	1992-07-31	1994-03-03	Syntex (U.S.A.) Inc.	Heterocyclic derivatives useful in the treatment of cardiovascular diseases
US5451677A (en) *	1993-02-09	1995-09-19	Merck & Co., Inc.	Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
GB9404485D0 (en) *	1994-03-09	1994-04-20	Cancer Res Campaign Tech	Benzamide analogues
DE4422517A1 (de) *	1994-06-28	1996-01-04	Dresden Arzneimittel	Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO1996004231A1 (en) *	1994-08-04	1996-02-15	C & C Research Labs.	Novel amine derivative, process for producing the same, and use thereof as antiarrhythmic
DE69500377T2 (de)	1994-08-19	1997-10-09	Mitsui Toatsu Chemicals	Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen
US5679706A (en) *	1994-09-30	1997-10-21	Bristol-Myers Squibb Company	Combination of a potassium channel activator and an antiarrhythmic agent
FR2726267B1 (fr) *	1994-10-26	1998-01-02	Smithkline Beecham Lab	Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer
CN1055682C (zh) *	1995-12-06	2000-08-23	中国药科大学	甲磺酰胺基苯乙胺衍生物的新制备方法
CN1055679C (zh) *	1995-12-06	2000-08-23	中国药科大学	具有心血管活性的苯乙胺衍生物
GB9722662D0 (en) *	1997-10-27	1997-12-24	Pfizer Ltd	Polymorphs
HUP9702411A2 (hu) *	1997-12-11	2000-03-28	Gyógyszerkutató Intézet Kft.	Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények
JP2005506292A (ja) *	2001-03-08	2005-03-03	エモリー　ユニバーシティ	ｐＨに依存するＮＭＤＡレセプターアンタゴニスト
CN100358865C (zh) *	2001-07-30	2008-01-02	中国科学院上海药物研究所	一类磺酰胺苯烷胺类化合物及其制备方法和用途
DE10201550A1 (de) *	2002-01-17	2003-07-31	Merck Patent Gmbh	Phenoxy-Piperidine
WO2003091205A1 (fr) *	2002-04-26	2003-11-06	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Sulfamidophenylalkylamines, production et utilisation de ces dernieres
US8367657B2 (en) *	2003-06-17	2013-02-05	Arena Pharmaceuticals, Inc.	Processes for preparing 3-benzazepines
CN1805938B (zh) *	2003-06-17	2010-06-16	艾尼纳制药公司	用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
DE102004025726B4 (de) *	2004-05-26	2006-07-06	Roder, Hanno, Dr.	Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit
EP2124554B1 (en) *	2006-12-14	2012-02-08	Tautatis, Inc.	Compositions and methods for the treatment of cancer
KR20100045983A (ko)	2007-06-29	2010-05-04	에모리 유니버시티	신경보호를 위한 ｎｍｄａ 수용체 길항물질
CN101372467B (zh) *	2007-08-23	2011-09-14	明德国际仓储贸易(上海)有限公司	具有n,n-二烷氨基的桥基化合物及所应用的染料化合物
US8822727B2 (en)	2008-03-04	2014-09-02	Arena Pharmaceuticals, Inc.	Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
WO2010148207A2 (en)	2009-06-18	2010-12-23	Arena Pharmaceuticals, Inc.	Processes for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en)	2010-06-02	2011-12-08	Arena Pharmaceuticals, Inc.	Processes for the preparation of 5-ht2c receptor agonists
JP2013539470A (ja)	2010-09-01	2013-10-24	アリーナファーマシューティカルズ，インコーポレイテッド	ロルカセリンと光学活性な酸との塩
EA201390335A1 (ru)	2010-09-01	2013-09-30	Арена Фармасьютикалз, Инк.	Введение лоркасерина индивидуумам с почечной недостаточностью
KR20130101524A (ko)	2010-09-01	2013-09-13	아레나 파마슈티칼스, 인크.	5-ｈｔ2ｃ 아고니스트의 비-흡습성 염
CN102531946A (zh) *	2012-01-05	2012-07-04	山东大学	3-甲氧基苯甲酰胺衍生物及其制备方法与应用
RU2674670C1 (ru)	2012-10-09	2018-12-12	Арена Фармасьютикалз, Инк.	Способ коррекции массы тела
FR3029113A1 (fr)	2014-12-02	2016-06-03	Univ Paris-Sud	Composes pour le traitement des maladies mitochondriales
CZ307826B6 (cs) *	2017-12-01	2019-05-29	Farmak, A.S.	Způsob přípravy N-[4-(2-{[2-(4-methansulfonamidofenoxy)ethyl](methyl)amino}ethyl)fenyl]methansulfonamidu (Dofetilidu)
US10888524B2 (en)	2018-02-05	2021-01-12	Enaltec Pharma Research Pvt. Ltd.	Immediate release tablet of dofetilide

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FR977261A (fr) *	1948-11-04	1951-03-29		équilibrage des masses dans les moteurs à combustion interne
FR148F (bs) *	1962-01-24
US3478149A (en) *	1962-01-24	1969-11-11	Mead Johnson & Co	Therapeutic compositions and methods employing sulfonamidophenethanolamines
US3852468A (en) *	1967-02-27	1974-12-03	Ici Ltd	Alkanolamine derivatives as {62 -adrenergic blocking agents
US3758692A (en) *	1969-04-14	1973-09-11	Mead Johnson & Co	Ylamines sympathomimetic process and compositions employing sulfonamidophenalk
US3574741A (en) *	1969-04-14	1971-04-13	Mead Johnson & Co	Sulfonamidophenalkylamines
GB1263987A (en) *	1969-05-30	1972-02-16	Allen & Hanburys Ltd	Phenethylamine derivatives
BE757005A (fr) *	1969-10-02	1971-04-02	Bristol Myers Co	Phenethanolamines substituees et procede pour leur preparation
GB1301134A (en) *	1970-07-18	1972-12-29	Pfizer Ltd	SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
DE2965655D1 (en) *	1978-06-28	1983-07-21	Beecham Group Plc	Secondary amines, their preparation, pharmaceutical compositions containing them and their use
CA1120058A (en) *	1978-07-03	1982-03-16	Jack Mills	Phenethanolamines, formulations and potentiation of oncolytic drugs
ATE1899T1 (de) *	1979-06-16	1982-12-15	Beecham Group Plc	Sekundaere amine, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen.
DD202692A5 (de) *	1979-12-04	1983-09-28	Ciba Geigy	Verfahren zur herstellung neuer derivate des 2-amino-aethanols
FR2541999B1 (fr) *	1983-03-04	1986-09-19	Bristol Myers Co	Phenethanolamines et leurs utilisations
EP0164865B1 (en) *	1984-05-04	1988-12-21	The Upjohn Company	N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
US4569801A (en) *	1984-10-15	1986-02-11	Eli Lilly And Company	Alkylsulfonamidophenylalkylamines

1987
- 1987-04-19 EG EG230/87A patent/EG18188A/xx active
- 1987-04-24 PH PH35179A patent/PH23425A/en unknown
- 1987-04-27 MY MYPI87000548A patent/MY111142A/en unknown
- 1987-04-29 CA CA000535897A patent/CA1289140C/en not_active Expired - Lifetime
- 1987-04-29 EP EP87303782A patent/EP0245997B1/en not_active Expired - Lifetime
- 1987-04-29 FI FI871898A patent/FI88291C/fi not_active IP Right Cessation
- 1987-04-29 ES ES198787303782T patent/ES2033840T3/es not_active Expired - Lifetime
- 1987-04-29 PL PL1987265418A patent/PL149924B1/pl unknown
- 1987-04-29 DE DE8787303782T patent/DE3778201D1/de not_active Expired - Lifetime
- 1987-04-29 US US07/044,086 patent/US4959366A/en not_active Expired - Lifetime
- 1987-04-29 DE DE2000175004 patent/DE10075004I2/de active Active
- 1987-04-29 IL IL82373A patent/IL82373A/xx not_active IP Right Cessation
- 1987-04-29 PT PT84782A patent/PT84782B/pt unknown
- 1987-04-29 AT AT87303782T patent/ATE74906T1/de active
- 1987-04-30 YU YU78387A patent/YU46195B/sh unknown
- 1987-04-30 DK DK198702202A patent/DK175096B1/da active Protection Beyond IP Right Term
- 1987-04-30 NZ NZ220151A patent/NZ220151A/xx unknown
- 1987-04-30 KR KR870004213A patent/KR870011084A/ko not_active Ceased
- 1987-04-30 HU HU871971A patent/HU196743B/hu unknown
- 1987-04-30 NO NO871820A patent/NO168527C/no not_active IP Right Cessation
- 1987-04-30 AU AU72260/87A patent/AU578557B2/en not_active Expired
- 1987-05-01 CN CN87103300A patent/CN1019801B/zh not_active Expired
- 1987-05-11 IE IE116587A patent/IE59366B1/en not_active IP Right Cessation
1988
- 1988-04-12 YU YU73588A patent/YU46541B/sh unknown
1990
- 1990-06-20 US US07/541,232 patent/US5079248A/en not_active Expired - Lifetime
- 1990-12-07 KR KR1019900020068A patent/KR930001339B1/ko not_active Expired - Lifetime
1992
- 1992-04-29 GR GR920400823T patent/GR3004457T3/el unknown
1995
- 1995-03-15 LV LV950058A patent/LV5715B4/xx unknown
1998
- 1998-03-30 BA BA980301A patent/BA98301A/bs unknown
- 1998-03-30 BA BA980211A patent/BA98211B1/bs active
2000
- 2000-02-01 NL NL300002C patent/NL300002I2/nl unknown
- 2000-02-09 LU LU90519C patent/LU90519I2/fr unknown
2001
- 2001-06-26 NO NO2001011C patent/NO2001011I1/no unknown

Also Published As

Publication number	Publication date
AU7226087A (en)	1987-11-19
MY111142A (en)	1999-09-30
LV5715A4 (lv)	1995-10-20
PL265418A1 (en)	1988-07-21
GR3004457T3 (bs)	1993-03-31
FI88291B (fi)	1993-01-15
EG18188A (en)	1992-09-30
IL82373A0 (en)	1987-10-30
KR870011084A (ko)	1987-12-19
IE59366B1 (en)	1994-02-09
ES2033840T3 (es)	1993-04-01
AU578557B2 (en)	1988-10-27
YU46195B (sh)	1993-05-28
DE10075004I1 (de)	2000-04-13
EP0245997A3 (en)	1989-12-20
ATE74906T1 (de)	1992-05-15
HUT43558A (en)	1987-11-30
FI88291C (fi)	1993-04-26
DE3778201D1 (de)	1992-05-21
IL82373A (en)	1992-01-15
HU196743B (en)	1989-01-30
LU90519I2 (fr)	2000-04-10
DK175096B1 (da)	2004-06-01
YU78387A (en)	1988-08-31
NO168527C (no)	1992-03-04
US5079248A (en)	1992-01-07
CN1019801B (zh)	1992-12-30
NZ220151A (en)	1989-02-24
IE871165L (en)	1987-11-01
CN87103300A (zh)	1987-11-11
LV5715B4 (lv)	1996-02-20
NO871820L (no)	1987-11-02
KR920014397A (ko)	1992-07-30
US4959366A (en)	1990-09-25
PL149924B1 (en)	1990-04-30
PT84782A (en)	1987-05-01
PT84782B (pt)	1989-12-29
YU73588A (en)	1990-04-30
DK220287A (da)	1987-11-02
DK220287D0 (da)	1987-04-30
NL300002I2 (nl)	2000-05-01
KR930001339B1 (ko)	1993-02-26
NO168527B (no)	1991-11-25
NL300002I1 (nl)	2000-04-03
FI871898A0 (fi)	1987-04-29
CA1289140C (en)	1991-09-17
YU46541B (sh)	1993-11-16
DE10075004I2 (de)	2006-02-02
NO2001011I1 (no)	2001-07-16
EP0245997A2 (en)	1987-11-19
EP0245997B1 (en)	1992-04-15
NO871820D0 (no)	1987-04-30
BA98211B1 (bs)	1999-08-02
FI871898A7 (fi)	1987-11-02
BA98301A (bs)	2001-09-14

Publication	Publication Date	Title
AU578557B2 (en)	1988-10-27	Sulfonamide antiarrhythmic agents and intermediates therefor
ES2017611A4 (es)	1991-03-01	Diazolas sustituidas y su uso como fungicidas
AU593739B2 (en)	1990-02-15	Antiarrhythmic agents
MA20697A1 (fr)	1986-12-31	Amides derives de la quinoleine et procede pour leur preparation
PT87050A (pt)	1988-04-01	Process for preparing indane sulfonamides antiarrhythmic agents
ATE32885T1 (de)	1988-03-15	Pentahydroperfluoralkylamin-n-oxide.
ATE126504T1 (de)	1995-09-15	1-phenoxycarbonyl-2-pyrrolidon-derivate und nootrope wirkstoffe.