PH25884A - 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1-biosynthesis - Google Patents

3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1-biosynthesis

Info

Publication number: PH25884A
Authority: PH; Philippines
Prior art keywords: interleukin; biosynthesis; oxindole; carboxamides; substituted
Prior art date: 1988-04-13

Application number

PH38414A

Other languages

English (en)

Inventor

Ivan George Otterness

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-13

Filing date

1989-03-31

Publication date

1991-12-02

1989-03-31 Application filed by Pfizer filed Critical Pfizer

1991-12-02 Publication of PH25884A publication Critical patent/PH25884A/en

Links

-1 3-substituted-2-oxindole-1-carboxamides Chemical class 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
102000000589 Interleukin-1 Human genes 0.000 abstract 3
108010002352 Interleukin-1 Proteins 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 3
230000015572 biosynthetic process Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
210000000988 bone and bone Anatomy 0.000 abstract 1
210000002808 connective tissue Anatomy 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004064 dysfunction Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Indole Compounds (AREA)

PH38414A 1988-04-13 1989-03-31 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1-biosynthesis PH25884A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/181,131 US4861794A (en)	1988-04-13	1988-04-13	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis

Publications (1)

Publication Number	Publication Date
PH25884A true PH25884A (en)	1991-12-02

Family

ID=22663029

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH38414A PH25884A (en)	1988-04-13	1989-03-31	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1-biosynthesis

Country Status (17)

Country	Link
US (1)	US4861794A (de)
EP (1)	EP0337627B1 (de)
JP (1)	JPH01305028A (de)
KR (1)	KR920002327B1 (de)
AT (1)	ATE89724T1 (de)
AU (1)	AU601325B2 (de)
CA (1)	CA1324761C (de)
DE (1)	DE68906706T2 (de)
DK (1)	DK174389A (de)
HU (1)	HU203970B (de)
IE (1)	IE63458B1 (de)
IL (1)	IL89871A (de)
MY (1)	MY103871A (de)
NZ (1)	NZ228711A (de)
PH (1)	PH25884A (de)
PT (1)	PT90248B (de)
ZA (1)	ZA892623B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5300655A (en) *	1989-04-18	1994-04-05	Pfizer Inc.	2-carboxy-thiophene derivatives
US5047554A (en)	1989-04-18	1991-09-10	Pfizer Inc.	3-substituted-2-oxindole derivatives
IL95880A (en) *	1989-10-13	1995-12-31	Pfizer	Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
US5008283A (en) *	1990-03-19	1991-04-16	Pfizer Inc.	Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5006547A (en) *	1990-03-19	1991-04-09	Pfizer Inc.	Tenidap as an inhibitor of the release of elastase by neutrophils
US5064851A (en) *	1990-07-24	1991-11-12	Pfizer Inc.	3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
EP0525197B1 (de) *	1991-01-21	1997-08-27	Shionogi Seiyaku Kabushiki Kaisha	3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
US5122534A (en) *	1991-02-08	1992-06-16	Pfizer Inc.	Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
WO1992016226A1 (en) *	1991-03-19	1992-10-01	Smithkline Beecham Corporation	Il-1 inhibitors
DE4111305C2 (de) *	1991-04-08	1994-12-01	Mack Chem Pharm	Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5298522A (en) *	1993-01-22	1994-03-29	Pfizer Inc.	6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) *	1984-05-04	1986-02-11	Pfizer Inc.	N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4678802A (en) *	1985-07-09	1987-07-07	Pfizer Inc.	1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8517958D0 (en) *	1985-07-16	1985-08-21	Cellena Cell Eng Ag	Compositions containing melatonin/homologues
JPH01501705A (ja) *	1986-01-30	1989-06-15	ユニバ−シテイ・オブ・ユタ	骨損失の治療
US4677132A (en) *	1986-03-12	1987-06-30	American Home Products Corporation	Inhibition of bone resorption by etodolac
US5036099A (en) *	1987-02-02	1991-07-30	Pfizer Inc.	Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide

1988
- 1988-04-13 US US07/181,131 patent/US4861794A/en not_active Expired - Lifetime
1989
- 1989-03-28 DE DE8989303049T patent/DE68906706T2/de not_active Expired - Fee Related
- 1989-03-28 AT AT89303049T patent/ATE89724T1/de not_active IP Right Cessation
- 1989-03-28 EP EP89303049A patent/EP0337627B1/de not_active Expired - Lifetime
- 1989-03-31 PH PH38414A patent/PH25884A/en unknown
- 1989-04-06 IL IL8987189A patent/IL89871A/en not_active IP Right Cessation
- 1989-04-08 MY MYPI89000447A patent/MY103871A/en unknown
- 1989-04-11 JP JP1091706A patent/JPH01305028A/ja active Pending
- 1989-04-11 CA CA000596295A patent/CA1324761C/en not_active Expired - Fee Related
- 1989-04-11 PT PT90248A patent/PT90248B/pt not_active IP Right Cessation
- 1989-04-11 ZA ZA892623A patent/ZA892623B/xx unknown
- 1989-04-12 HU HU891755A patent/HU203970B/hu not_active IP Right Cessation
- 1989-04-12 IE IE117289A patent/IE63458B1/en not_active IP Right Cessation
- 1989-04-12 DK DK174389A patent/DK174389A/da not_active Application Discontinuation
- 1989-04-12 KR KR1019890004821A patent/KR920002327B1/ko not_active Expired
- 1989-04-12 AU AU32711/89A patent/AU601325B2/en not_active Ceased
- 1989-04-12 NZ NZ228711A patent/NZ228711A/en unknown

Also Published As

Publication number	Publication date
IE891172L (en)	1989-10-13
AU601325B2 (en)	1990-09-06
DK174389A (da)	1989-10-16
HUT52377A (en)	1990-07-28
KR920002327B1 (ko)	1992-03-21
IL89871A (en)	1994-11-11
NZ228711A (en)	1997-02-24
PT90248B (pt)	1994-11-30
IE63458B1 (en)	1995-04-19
DE68906706T2 (de)	1993-09-16
AU3271189A (en)	1989-10-19
US4861794A (en)	1989-08-29
EP0337627A3 (de)	1991-01-02
IL89871A0 (en)	1989-12-15
DE68906706D1 (de)	1993-07-01
PT90248A (pt)	1989-11-10
ATE89724T1 (de)	1993-06-15
CA1324761C (en)	1993-11-30
EP0337627B1 (de)	1993-05-26
HU203970B (en)	1991-11-28
ZA892623B (en)	1990-11-28
MY103871A (en)	1993-09-30
EP0337627A2 (de)	1989-10-18
JPH01305028A (ja)	1989-12-08
DK174389D0 (da)	1989-04-12
KR890015739A (ko)	1989-11-25

Publication	Publication Date	Title
PH31263A (en)	1998-06-18	Methods of inhibiting vascular smooth muscle cell proliferation and restinosis.
PH25884A (en)	1991-12-02	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1-biosynthesis
IL81887A0 (en)	1987-10-20	Dihydroisoxazole derivatives,their preparation and pharmaceutical compositions containing them
AU2246292A (en)	1992-12-21	Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
IL78661A (en)	1992-08-18	Bone targeted inhibitors of carbonic anhydrase and methods for the preparation thereof
IL89872A0 (en)	1989-12-15	3-substituted-2-oxindole-1-carboxamides for suppressing t-cell function
EP1418910A4 (de)	2005-01-05	Verfahren zur unterdrückung oder umkehrung der tau-filament-bildungspolymerisation
HUT70757A (en)	1995-10-30	Pharmaceutical compositions for treating skin disorders
MY106834A (en)	1995-07-31	3-substitited-2-oxiindole derivatives as inhibitors of interleukin-1 biosynthesis.
ZA899508B (en)	1991-07-31	Derivatives of 5-hydroxy and 5-methoxy 2-aminopyrimidines as inhibitors of interleukin-1 production