PH26280A - Treatment of thrombocytosis with 5-(4-chlorophenyl)-2,4-dimethyl-3N-1,2,4-triazole-3-thione - Google Patents

Treatment of thrombocytosis with 5-(4-chlorophenyl)-2,4-dimethyl-3N-1,2,4-triazole-3-thione Download PDF

Info

Publication number: PH26280A
Authority: PH; Philippines
Prior art keywords: triazole; thione; chlorophenyl; dimethyl; administered
Prior art date: 1988-09-06

Application number

PH39201A

Other languages

English (en)

Inventor

John T Yarrington

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-06

Filing date

1989-09-06

Publication date

1992-04-10

1989-09-06 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1992-04-10 Publication of PH26280A publication Critical patent/PH26280A/en

Links

208000005485 Thrombocytosis Diseases 0.000 title claims description 12
238000000034 method Methods 0.000 claims description 19
208000014767 Myeloproliferative disease Diseases 0.000 claims description 7
208000032027 Essential Thrombocythemia Diseases 0.000 claims description 6
208000007536 Thrombosis Diseases 0.000 claims description 6
208000032843 Hemorrhage Diseases 0.000 claims description 5
241001061127 Thione Species 0.000 claims description 4
208000017733 acquired polycythemia vera Diseases 0.000 claims description 4
208000037244 polycythemia vera Diseases 0.000 claims description 4
208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 2
208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 2
208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 2
201000010099 disease Diseases 0.000 claims description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
230000002265 prevention Effects 0.000 claims description 2
PYRFHJUXDGQZPM-UHFFFAOYSA-N 1,2,4-triazole-3-thione Chemical compound S=C1N=CN=N1 PYRFHJUXDGQZPM-UHFFFAOYSA-N 0.000 claims 1
230000001684 chronic effect Effects 0.000 claims 1
208000032839 leukemia Diseases 0.000 claims 1
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208000014754 thrombocytosis disease Diseases 0.000 claims 1
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BQGRNCIJMQGMBY-UHFFFAOYSA-N 5-(4-chlorophenyl)-2,4-dimethyl-1,2,4-triazole-3-thione Chemical compound CN1C(=S)N(C)N=C1C1=CC=C(Cl)C=C1 BQGRNCIJMQGMBY-UHFFFAOYSA-N 0.000 description 1
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WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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239000002168 alkylating agent Substances 0.000 description 1
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HDZGCSFEDULWCS-UHFFFAOYSA-N monomethylhydrazine Chemical compound CNN HDZGCSFEDULWCS-UHFFFAOYSA-N 0.000 description 1
230000008693 nausea Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PH39201A 1988-09-06 1989-09-06 Treatment of thrombocytosis with 5-(4-chlorophenyl)-2,4-dimethyl-3N-1,2,4-triazole-3-thione PH26280A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/241,160 US4847276A (en)	1988-09-06	1988-09-06	Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione

Publications (1)

Publication Number	Publication Date
PH26280A true PH26280A (en)	1992-04-10

Family

ID=22909496

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH39201A PH26280A (en)	1988-09-06	1989-09-06	Treatment of thrombocytosis with 5-(4-chlorophenyl)-2,4-dimethyl-3N-1,2,4-triazole-3-thione

Country Status (8)

Country	Link
US (1)	US4847276A (da)
EP (1)	EP0358150A3 (da)
JP (1)	JPH02115123A (da)
KR (1)	KR900004338A (da)
AU (1)	AU615791B2 (da)
DK (1)	DK439189A (da)
PH (1)	PH26280A (da)
ZA (1)	ZA896739B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5236942A (en) *	1990-04-19	1993-08-17	Merrell Dow Pharmaceuticals Inc.	5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful in the treatment of Altzheimer's dementia
US5331002A (en) *	1990-04-19	1994-07-19	Merrell Dow Pharmaceuticals Inc.	5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers
US5100906A (en) *	1990-04-19	1992-03-31	Merrell Dow Pharmaceuticals Inc.	5-aryl-4-alkyl-3h-1,2,4-triazole-3-thiones useful as memory enhancers
IL98405A0 (en) *	1990-06-11	1992-07-15	Fmc Corp	Pharmaceutical compositions containing enzyme inhibiting agents
US5489598A (en) *	1994-06-08	1996-02-06	Warner-Lambert Company	Cytoprotection utilizing aryltriazol-3-thiones
WO1996033177A1 (en) *	1995-04-20	1996-10-24	Hoechst Marion Roussel, Inc.	3-phenyl-1,4-dialkyl-1,2,4-triazolium salts and their use as antidepressants
US6103740A (en) *	1997-08-21	2000-08-15	Eli Lilly And Company	Methods for lowering platelet counts
FR2777784B1 (fr) *	1998-04-27	2004-03-19	Arepa	Composition pharmaceutique a base d'estrogene et de progesterone
AU7604400A (en)	1999-09-21	2001-04-24	Emory University	Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
US8034831B2 (en)	2002-11-06	2011-10-11	Celgene Corporation	Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en)	2002-11-06	2009-07-21	Celgene Corporation	Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
AU2004206783B2 (en) *	2003-01-23	2009-03-26	Shire Holdings Ag	Formulation and methods for the treatment of thrombocythemia
BRPI0418798A (pt) *	2004-05-05	2007-10-16	Celgene Corp	métodos de tratamento ou prevenção, e de controle, de uma doença mieloproliferativa, de redução ou prevenção de um efeito adverso, de aumento da eficácia terapêutica de um tratamento de doença mieloproliferativa, composição farmacêutica, e, kit
US7700608B2 (en) *	2004-08-04	2010-04-20	Shire Holdings Ag	Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) *	2004-08-04	2006-02-09	Shire Holdings Ag	Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US8304420B2 (en)	2006-11-28	2012-11-06	Shire Llc	Substituted quinazolines for reducing platelet count
US7910597B2 (en) *	2006-11-28	2011-03-22	Shire Llc	Substituted quinazolines
US20090092693A1 (en) *	2007-10-05	2009-04-09	Mady Attila	Platelet manipulation to prevent and treat endovascular disease and its sequelae, to prevent and treat arrhythmias and to prevent malignancy
US8021854B2 (en) *	2007-10-05	2011-09-20	Attila Mady	Method of treating vascular disease
US7588784B2 (en) *	2007-10-05	2009-09-15	Attila Mady	Use of onion extracts to prevent and treat acute and chronic cardiac and vascular complications and their sequelae, as well as to resolve hematomas
GB2462022B (en)	2008-06-16	2011-05-25	Biovascular Inc	Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR243171A1 (es) *	1985-10-29	1993-07-30	Merrell Pharma Inc	Procedimiento para preparar 5-aril-2,4-dialquil-3h-1,2,4-triazol-3-tionas.
AR243179A1 (es) *	1985-10-29	1993-07-30	Merrell Dow Pharma	Procedimiento para preparar nuevas 5-(het)-2,4-dialquil-3h-1,2,4-triazolo-3-tionas
US4775688A (en) *	1985-12-11	1988-10-04	Merrell Dow Pharmaceuticals Inc.	5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants

1988
- 1988-09-06 US US07/241,160 patent/US4847276A/en not_active Expired - Fee Related
1989
- 1989-09-01 ZA ZA896739A patent/ZA896739B/xx unknown
- 1989-09-01 AU AU41022/89A patent/AU615791B2/en not_active Ceased
- 1989-09-04 JP JP1227647A patent/JPH02115123A/ja active Pending
- 1989-09-04 EP EP19890116299 patent/EP0358150A3/en not_active Withdrawn
- 1989-09-05 DK DK439189A patent/DK439189A/da not_active Application Discontinuation
- 1989-09-05 KR KR1019890012788A patent/KR900004338A/ko not_active Withdrawn
- 1989-09-06 PH PH39201A patent/PH26280A/en unknown

Also Published As

Publication number	Publication date
KR900004338A (ko)	1990-04-12
AU4102289A (en)	1990-03-15
JPH02115123A (ja)	1990-04-27
EP0358150A3 (en)	1991-01-09
AU615791B2 (en)	1991-10-10
DK439189D0 (da)	1989-09-05
ZA896739B (en)	1990-06-27
EP0358150A2 (en)	1990-03-14
DK439189A (da)	1990-03-07
US4847276A (en)	1989-07-11

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