ZA896739B - Treatment of thrombocytosis with 5-(4-chlorophenyl)-2,4-dimethyl-3h-1,2,4-triazole-3-thione - Google Patents

Treatment of thrombocytosis with 5-(4-chlorophenyl)-2,4-dimethyl-3h-1,2,4-triazole-3-thione

Info

Publication number
ZA896739B
ZA896739B ZA896739A ZA896739A ZA896739B ZA 896739 B ZA896739 B ZA 896739B ZA 896739 A ZA896739 A ZA 896739A ZA 896739 A ZA896739 A ZA 896739A ZA 896739 B ZA896739 B ZA 896739B
Authority
ZA
South Africa
Prior art keywords
thrombocytosis
thione
triazole
chlorophenyl
dimethyl
Prior art date
Application number
ZA896739A
Other languages
English (en)
Inventor
John T Yarrington
T Yarrington John
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA896739B publication Critical patent/ZA896739B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA896739A 1988-09-06 1989-09-01 Treatment of thrombocytosis with 5-(4-chlorophenyl)-2,4-dimethyl-3h-1,2,4-triazole-3-thione ZA896739B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/241,160 US4847276A (en) 1988-09-06 1988-09-06 Treatment of thromobocytosis with 5-(4-chlorophenyl)-2,4-diemthyl-3H-1,2,4-triazole-3-thione

Publications (1)

Publication Number Publication Date
ZA896739B true ZA896739B (en) 1990-06-27

Family

ID=22909496

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA896739A ZA896739B (en) 1988-09-06 1989-09-01 Treatment of thrombocytosis with 5-(4-chlorophenyl)-2,4-dimethyl-3h-1,2,4-triazole-3-thione

Country Status (8)

Country Link
US (1) US4847276A (da)
EP (1) EP0358150A3 (da)
JP (1) JPH02115123A (da)
KR (1) KR900004338A (da)
AU (1) AU615791B2 (da)
DK (1) DK439189A (da)
PH (1) PH26280A (da)
ZA (1) ZA896739B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100906A (en) * 1990-04-19 1992-03-31 Merrell Dow Pharmaceuticals Inc. 5-aryl-4-alkyl-3h-1,2,4-triazole-3-thiones useful as memory enhancers
US5236942A (en) * 1990-04-19 1993-08-17 Merrell Dow Pharmaceuticals Inc. 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful in the treatment of Altzheimer's dementia
US5331002A (en) * 1990-04-19 1994-07-19 Merrell Dow Pharmaceuticals Inc. 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers
IL98405A0 (en) * 1990-06-11 1992-07-15 Fmc Corp Pharmaceutical compositions containing enzyme inhibiting agents
US5489598A (en) * 1994-06-08 1996-02-06 Warner-Lambert Company Cytoprotection utilizing aryltriazol-3-thiones
AU704798B2 (en) * 1995-04-20 1999-05-06 Hoechst Marion Roussel, Inc. 3-phenyl-1,4-dialkyl-1,2,4-triazolium salts and their use as antidepressants
US6103740A (en) * 1997-08-21 2000-08-15 Eli Lilly And Company Methods for lowering platelet counts
FR2777784B1 (fr) * 1998-04-27 2004-03-19 Arepa Composition pharmaceutique a base d'estrogene et de progesterone
EP1216037A2 (en) 1999-09-21 2002-06-26 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US20040209907A1 (en) * 2003-01-23 2004-10-21 Richard Franklin Formulation and methods for the treatment of thrombocythemia
CA2565447A1 (en) * 2004-05-05 2005-12-01 Celgene Corporation Method of using and compositions comprising immunomodulatory compounds for the treatment and management of myeloproliferative diseases
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US20090092693A1 (en) * 2007-10-05 2009-04-09 Mady Attila Platelet manipulation to prevent and treat endovascular disease and its sequelae, to prevent and treat arrhythmias and to prevent malignancy
US8021854B2 (en) * 2007-10-05 2011-09-20 Attila Mady Method of treating vascular disease
US7588784B2 (en) * 2007-10-05 2009-09-15 Attila Mady Use of onion extracts to prevent and treat acute and chronic cardiac and vascular complications and their sequelae, as well as to resolve hematomas
GB2460915B (en) * 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR243179A1 (es) * 1985-10-29 1993-07-30 Merrell Dow Pharma Procedimiento para preparar nuevas 5-(het)-2,4-dialquil-3h-1,2,4-triazolo-3-tionas
AR243171A1 (es) * 1985-10-29 1993-07-30 Merrell Pharma Inc Procedimiento para preparar 5-aril-2,4-dialquil-3h-1,2,4-triazol-3-tionas.
US4775688A (en) * 1985-12-11 1988-10-04 Merrell Dow Pharmaceuticals Inc. 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants

Also Published As

Publication number Publication date
US4847276A (en) 1989-07-11
PH26280A (en) 1992-04-10
DK439189A (da) 1990-03-07
KR900004338A (ko) 1990-04-12
EP0358150A2 (en) 1990-03-14
JPH02115123A (ja) 1990-04-27
DK439189D0 (da) 1989-09-05
AU4102289A (en) 1990-03-15
EP0358150A3 (en) 1991-01-09
AU615791B2 (en) 1991-10-10

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