PH26728A - The use of certain lactam derivatives in the treatment of depression - Google Patents

The use of certain lactam derivatives in the treatment of depression Download PDF

Info

Publication number: PH26728A
Authority: PH; Philippines
Prior art keywords: compound; formula; group; hydrogen atom; methyl
Prior art date: 1988-09-01

Application number

PH39185A

Other languages

English (en)

Inventor

Ian Harold Coates

Alexander William Oxford

Peter Charles North

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-01

Filing date

1989-08-31

Publication date

1992-09-28

1989-08-31 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1992-09-28 Publication of PH26728A publication Critical patent/PH26728A/en

Links

238000011282 treatment Methods 0.000 title claims description 13
208000020401 Depressive disease Diseases 0.000 title claims description 7
150000003951 lactams Chemical class 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 43
239000004480 active ingredient Substances 0.000 claims description 20
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 19
-1 phenyl- methoxymethyl Chemical group 0.000 claims description 17
150000003839 salts Chemical class 0.000 claims description 16
238000000034 method Methods 0.000 claims description 14
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
125000000217 alkyl group Chemical group 0.000 claims description 13
239000012453 solvate Substances 0.000 claims description 13
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
241000282414 Homo sapiens Species 0.000 claims description 7
125000000753 cycloalkyl group Chemical group 0.000 claims description 6
239000003814 drug Substances 0.000 claims description 5
241001465754 Metazoa Species 0.000 claims description 4
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims description 2
125000005843 halogen group Chemical group 0.000 claims description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
125000002883 imidazolyl group Chemical group 0.000 claims description 2
HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims description 2
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
239000003826 tablet Substances 0.000 description 23
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
239000000203 mixture Substances 0.000 description 18
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YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
239000012458 free base Substances 0.000 description 6
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UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 6
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235000019759 Maize starch Nutrition 0.000 description 5
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238000002347 injection Methods 0.000 description 5
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FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
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229920002472 Starch Polymers 0.000 description 3
239000000872 buffer Substances 0.000 description 3
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 3
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229920002785 Croscarmellose sodium Polymers 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
125000003342 alkenyl group Chemical group 0.000 description 2
125000000304 alkynyl group Chemical group 0.000 description 2
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IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
AHHFSTCSFJWTEF-UHFFFAOYSA-N 4-(chloromethyl)-5-methyl-1-tritylimidazole Chemical compound CC1=C(CCl)N=CN1C(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 AHHFSTCSFJWTEF-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PH39185A 1988-09-01 1989-08-31 The use of certain lactam derivatives in the treatment of depression PH26728A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888820653A GB8820653D0 (en)	1988-09-01	1988-09-01	Medicaments

Publications (1)

Publication Number	Publication Date
PH26728A true PH26728A (en)	1992-09-28

Family

ID=10643005

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PH39185A PH26728A (en)	1988-09-01	1989-08-31	The use of certain lactam derivatives in the treatment of depression
PH39186A PH26985A (en)	1988-09-01	1989-08-31	Medicaments

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PH39186A PH26985A (en)	1988-09-01	1989-08-31	Medicaments

Country Status (10)

Country	Link
EP (1)	EP0357414A3 (da)
JP (1)	JPH02180822A (da)
KR (1)	KR900004341A (da)
AU (1)	AU627770B2 (da)
CA (1)	CA1330535C (da)
DK (1)	DK432889A (da)
GB (1)	GB8820653D0 (da)
IL (1)	IL91481A0 (da)
PH (2)	PH26728A (da)
ZA (1)	ZA896674B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5276050A (en) *	1989-08-01	1994-01-04	Glaxo Group Limited	Medicaments
GB0305553D0 (en) *	2003-03-11	2003-04-16	Glaxo Group Ltd	Compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR871809B (en) *	1986-11-28	1988-03-07	Glaxo Group Ltd	Process for the preparation of tricyclic ketones
GB8630071D0 (en) *	1986-12-17	1987-01-28	Glaxo Group Ltd	Medicaments
DE3788057T2 (de) *	1986-12-17	1994-03-03	Glaxo Group Ltd	Verwendung von heterocyclischen Verbindungen zur Behandlung von Depressionen.
NZ226032A (en) *	1987-09-03	1991-12-23	Glaxo Group Ltd	2-(imidazolylmethyl)-pyrido or-azepino(4,3-b)indole-1(2h)-one derivatives; preparatory processes and pharmaceutical compositions

1988
- 1988-09-01 GB GB888820653A patent/GB8820653D0/en active Pending
1989
- 1989-08-31 DK DK432889A patent/DK432889A/da unknown
- 1989-08-31 PH PH39185A patent/PH26728A/en unknown
- 1989-08-31 ZA ZA896674A patent/ZA896674B/xx unknown
- 1989-08-31 AU AU40968/89A patent/AU627770B2/en not_active Ceased
- 1989-08-31 KR KR1019890012467A patent/KR900004341A/ko not_active Withdrawn
- 1989-08-31 PH PH39186A patent/PH26985A/en unknown
- 1989-08-31 JP JP1226379A patent/JPH02180822A/ja active Pending
- 1989-08-31 CA CA000609995A patent/CA1330535C/en not_active Expired - Fee Related
- 1989-08-31 EP EP89308804A patent/EP0357414A3/en not_active Withdrawn
- 1989-08-31 IL IL91481A patent/IL91481A0/xx unknown

Also Published As

Publication number	Publication date
IL91481A0 (en)	1990-04-29
KR900004341A (ko)	1990-04-12
EP0357414A2 (en)	1990-03-07
AU627770B2 (en)	1992-09-03
PH26985A (en)	1992-12-28
CA1330535C (en)	1994-07-05
GB8820653D0 (en)	1988-10-05
ZA896674B (en)	1990-06-27
EP0357414A3 (en)	1990-06-13
AU4096889A (en)	1990-03-08
DK432889A (da)	1990-03-02
DK432889D0 (da)	1989-08-31
JPH02180822A (ja)	1990-07-13

Publication	Publication Date	Title
AU613662B2 (en)	1991-08-08	Lactam derivatives
EP0276559B1 (en)	1992-08-05	Use of ketone derivatives in the treatment of depression
IE873230L (en)	1988-05-28	5ht3-antagonists plus ranitidine compositions
EP0275668B1 (en)	1992-09-30	Use of ketone derivatives in the treatment of cognitive disorders
JPH02104585A (ja)	1990-04-17	インドール誘導体
AU627769B2 (en)	1992-09-03	The use of lactam derivatives in the treatment of cognitive disorders
CA1330535C (en)	1994-07-05	Medicament for treating depression
US5221687A (en)	1993-06-22	Medicaments
AU627768B2 (en)	1992-09-03	The use of lactam derivatives in the treatment of addiction
US5229407A (en)	1993-07-20	Medicaments
EP0411900A2 (en)	1991-02-06	Medicaments for the treatment of bulimia
EP0269452A2 (en)	1988-06-01	Use of ketone derivatives for the manufacture of medicaments
US5635513A (en)	1997-06-03	6-fluoro-2,3,4,5-tetrahydro-5-methyl-2[(5-methyl-1H-imidazol-4yl)methyl]-1H-pyrido[4,3-b]in
US5276050A (en)	1994-01-04	Medicaments
AU633254B2 (en)	1993-01-28	Tricyclic ketones Patent to Lapse
CA2022380A1 (en)	1991-02-02	Medicaments
IE902768A1 (en)	1991-02-27	Medicaments
CA1339022C (en)	1997-03-25	Lactam derivatives
JP2000273042A (ja)	2000-10-03	医薬