PH26905A - Tetrazole excitatory amino acid receptor antagonists - Google Patents

Tetrazole excitatory amino acid receptor antagonists Download PDF

Info

Publication number: PH26905A
Authority: PH; Philippines
Prior art keywords: compound; mixture; acid; mammals; treating
Prior art date: 1989-06-26

Application number

PH40711A

Other languages

English (en)

Inventor

Paul Leslie Ornstein

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-26

Filing date

1990-06-21

Publication date

1992-12-03

1990-06-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1992-12-03 Publication of PH26905A publication Critical patent/PH26905A/en

Links

150000003536 tetrazoles Chemical class 0.000 title description 12
229940123511 Excitatory amino acid receptor antagonist Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 87
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238000000034 method Methods 0.000 claims description 27
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 23
150000003839 salts Chemical class 0.000 claims description 23
241000124008 Mammalia Species 0.000 claims description 21
239000002253 acid Substances 0.000 claims description 16
125000000217 alkyl group Chemical group 0.000 claims description 13
238000011282 treatment Methods 0.000 claims description 12
230000000903 blocking effect Effects 0.000 claims description 9
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239000001257 hydrogen Substances 0.000 claims description 9
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
150000002148 esters Chemical class 0.000 claims description 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
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208000024827 Alzheimer disease Diseases 0.000 claims description 4
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238000012453 sprague-dawley rat model Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000012058 sterile packaged powder Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
TYFQFVWCELRYAO-UHFFFAOYSA-L suberate(2-) Chemical compound [O-]C(=O)CCCCCCC([O-])=O TYFQFVWCELRYAO-UHFFFAOYSA-L 0.000 description 1
239000000126 substance Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
208000028325 tonic-clonic seizure Diseases 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
PIILXFBHQILWPS-UHFFFAOYSA-N tributyltin Chemical compound CCCC[Sn](CCCC)CCCC PIILXFBHQILWPS-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
LEIMLDGFXIOXMT-UHFFFAOYSA-N trimethylsilyl cyanide Chemical compound C[Si](C)(C)C#N LEIMLDGFXIOXMT-UHFFFAOYSA-N 0.000 description 1
FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
238000010792 warming Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

PH40711A 1989-06-26 1990-06-21 Tetrazole excitatory amino acid receptor antagonists PH26905A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/371,568 US4968678A (en)	1988-02-19	1989-06-26	Tetrazole excitatory amino acid receptor antagonists

Publications (1)

Publication Number	Publication Date
PH26905A true PH26905A (en)	1992-12-03

Family

ID=23464503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH40711A PH26905A (en)	1989-06-26	1990-06-21	Tetrazole excitatory amino acid receptor antagonists

Country Status (17)

Country	Link
US (1)	US4968678A (zh)
EP (1)	EP0405834A3 (zh)
JP (1)	JPH0348679A (zh)
KR (1)	KR910000703A (zh)
CN (1)	CN1028024C (zh)
AU (1)	AU621498B2 (zh)
CA (1)	CA2019167A1 (zh)
FI (1)	FI903183A7 (zh)
HU (1)	HU206339B (zh)
IE (1)	IE902288A1 (zh)
IL (1)	IL94777A (zh)
MX (1)	MX21219A (zh)
NZ (1)	NZ234109A (zh)
PH (1)	PH26905A (zh)
PT (1)	PT94447B (zh)
RU (2)	RU1833385C (zh)
ZA (1)	ZA904717B (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA891113B (en) *	1988-02-19	1990-10-31	Lilly Co Eli	Tetrazole excitatory amino acid receptor antagonists
US5594007A (en) *	1991-04-18	1997-01-14	Pfizer Inc.	Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
US5196421A (en) *	1991-06-05	1993-03-23	Eli Lilly And Company	Excitatory amino acid receptor antagonists in methods for the use thereof
US5153196A (en) *	1991-06-05	1992-10-06	Eli Lilly And Company	Excitatory amino acid receptor antagonists and methods for the use thereof
AU675786B2 (en) *	1992-04-15	1997-02-20	Merck Sharp & Dohme Limited	Azacyclic compounds
US5192751A (en) *	1992-07-24	1993-03-09	Eli Lilly And Company	Use of competitive NMDA receptor antagonists in the treatment of urinary incontinence
EP0691844A1 (en) *	1993-03-29	1996-01-17	Queen's University At Kingston	Method for treating amyloidosis
US20040208875A1 (en)	1995-03-15	2004-10-21	Queen's University At Kingston	Method for treating amyloidosis
BR9408506A (pt) *	1994-01-31	1997-08-05	Pfizer	Compostos neuroprotetores
RU2139857C1 (ru) *	1994-08-18	1999-10-20	Пфайзер Инк.	Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора
US5880138A (en) *	1996-10-01	1999-03-09	Eli Lilly And Company	NMDA receptor selective antagonists
AU2003275462A1 (en) *	2002-10-04	2004-05-04	Cook Urological, Incorporated	Rigid extractor with wire basket
US8043303B2 (en) *	2002-10-04	2011-10-25	Cook Medical Technologies Llc	Handle for interchangeable medical device
CN100480248C (zh) *	2003-02-04	2009-04-22	弗·哈夫曼-拉罗切有限公司	用作γ-分泌酶抑制剂的丙二酰胺衍生物
US7244764B2 (en)	2003-06-23	2007-07-17	Neurochem (International) Limited	Methods and compositions for treating amyloid-related diseases
US7414076B2 (en)	2003-06-23	2008-08-19	Neurochem (International) Limited	Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en)	2003-06-23	2007-01-11	Xianqi Kong	Methods and compositions for treating amyloid-related diseases
US20050192592A1 (en) *	2004-02-27	2005-09-01	Cook Urological Incorporated	Self-tensioning handle for endoscopic device
EP1836161B1 (en)	2004-12-22	2016-07-20	BHI Limited Partnership	Methods and compositions for treating amyloid-related diseases
TW200716088A (en)	2005-04-15	2007-05-01	Neurochem Int Ltd	Formulations and methods for treating amyloidosis
WO2007056003A1 (en)	2005-11-03	2007-05-18	Vance Products Incorporated, D/B/A Cook Urological Incorporated	Articulating basket with simultaneous basket extension or basket retraction
ATE481094T1 (de)	2005-12-22	2010-10-15	Kiacta Sarl	Behandlung von diabetischer nephropathie
SI2089417T1 (sl)	2006-10-12	2015-04-30	Bhi Limited Partnership	Metode, spojine, sestavki in vektorji za dostavo 3-amino-1-propansulfonske kisline
EP3427729A1 (en)	2017-07-13	2019-01-16	Paris Sciences et Lettres - Quartier Latin	Probenecid for use in treating epileptic diseases, disorders or conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3536715A (en) *	1967-03-24	1970-10-27	Miles Lab	2-lower alkyl-5-(omega-(4-phenyl-1-piperazinyl) lower alkyl)-2h-tetrazoles
CA1248531A (en) *	1984-04-17	1989-01-10	Jeffrey C. Watkins	4-substituted piperazine-2-carboxylic acids
PH23848A (en) *	1985-05-24	1989-11-23	Ciba Geigy Ag	Certain phosphonic acids and derivatives
US4746653A (en) *	1986-02-28	1988-05-24	Ciba-Geigy Corporation	Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
IL84492A0 (en) *	1986-11-21	1988-04-29	Ciba Geigy Ag	Unsaturated phosphonic acids and derivatives
ZA891113B (en) *	1988-02-19	1990-10-31	Lilly Co Eli	Tetrazole excitatory amino acid receptor antagonists

1989
- 1989-06-26 US US07/371,568 patent/US4968678A/en not_active Expired - Fee Related
1990
- 1990-06-18 IL IL9477790A patent/IL94777A/en not_active IP Right Cessation
- 1990-06-18 ZA ZA904717A patent/ZA904717B/xx unknown
- 1990-06-18 NZ NZ234109A patent/NZ234109A/en unknown
- 1990-06-18 CA CA002019167A patent/CA2019167A1/en not_active Abandoned
- 1990-06-18 KR KR1019900008930A patent/KR910000703A/ko not_active Ceased
- 1990-06-19 MX MX2121990A patent/MX21219A/es unknown
- 1990-06-20 EP EP19900306753 patent/EP0405834A3/en not_active Ceased
- 1990-06-21 PH PH40711A patent/PH26905A/en unknown
- 1990-06-21 PT PT94447A patent/PT94447B/pt not_active IP Right Cessation
- 1990-06-22 AU AU57808/90A patent/AU621498B2/en not_active Ceased
- 1990-06-25 RU SU904830299A patent/RU1833385C/ru active
- 1990-06-25 HU HU903976A patent/HU206339B/hu not_active IP Right Cessation
- 1990-06-25 IE IE228890A patent/IE902288A1/en unknown
- 1990-06-25 JP JP2166530A patent/JPH0348679A/ja active Pending
- 1990-06-25 FI FI903183A patent/FI903183A7/fi not_active Application Discontinuation
- 1990-06-25 CN CN90103125A patent/CN1028024C/zh not_active Expired - Fee Related
1991
- 1991-12-10 RU SU915010214A patent/RU2089546C1/ru active

Also Published As

Publication number	Publication date
HU903976D0 (en)	1990-11-28
PT94447A (pt)	1991-02-08
MX21219A (es)	1993-11-01
IL94777A0 (en)	1991-04-15
HUT54364A (en)	1991-02-28
IE902288L (en)	1990-12-26
IE902288A1 (en)	1991-01-16
HU206339B (en)	1992-10-28
EP0405834A2 (en)	1991-01-02
EP0405834A3 (en)	1991-12-27
ZA904717B (en)	1992-02-26
FI903183A0 (fi)	1990-06-25
CN1028024C (zh)	1995-03-29
CN1048385A (zh)	1991-01-09
JPH0348679A (ja)	1991-03-01
FI903183A7 (fi)	1990-12-27
KR910000703A (ko)	1991-01-30
PT94447B (pt)	1997-02-28
AU5780890A (en)	1991-01-03
NZ234109A (en)	1992-04-28
AU621498B2 (en)	1992-03-12
IL94777A (en)	1994-05-30
US4968678A (en)	1990-11-06
RU2089546C1 (ru)	1997-09-10
CA2019167A1 (en)	1990-12-26
RU1833385C (ru)	1993-08-07

Publication	Publication Date	Title
US4968678A (en)	1990-11-06	Tetrazole excitatory amino acid receptor antagonists
US4902695A (en)	1990-02-20	Excitatory amino acid receptor antagonists
US4207324A (en)	1980-06-10	1,2-Di-Substituted-4-haloimidazole-5-acetic acid derivatives and their use
CN100519528C (zh)	2009-07-29	具有镇痛作用的化合物
KR0163355B1 (ko)	1998-12-01	신경보호성 인돌론 및 관련 유도체
JP2000344746A (ja)	2000-12-12	かゆみ症治療用の新規４−アリールピペリジン誘導体
IL91952A (en)	1994-06-24	Piperidinyl benzimidazoles, their preparation and pharmaceutical compositions containing them
EP0330353B1 (en)	1993-04-07	Tetrazole excitatory amino acid receptor antagonists
US5494934A (en)	1996-02-27	Guanidine compounds
EP1208087B1 (en)	2003-05-14	Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid
JPS626545B2 (zh)	1987-02-12
US4902687A (en)	1990-02-20	Excitatory amino acid receptor antagonists
HU193916B (en)	1987-12-28	Process for preparing substituted imidazole derivatives and pharmaceutics comprising these compounds
US5173502A (en)	1992-12-22	Substituted trifluoropropan-1-yl-imidazole alpha 2-receptor anagonists
US5059688A (en)	1991-10-22	1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation
US4752645A (en)	1988-06-21	Benzazepine derivatives
JPH05320135A (ja)	1993-12-03	テトラヒドロベンズアゼピン誘導体
US4978660A (en)	1990-12-18	α-adrenergic receptor antagonists
US4794181A (en)	1988-12-27	1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines
JPS6257620B2 (zh)	1987-12-02
JPS6154798B2 (zh)	1986-11-25
JPH055828B2 (zh)	1993-01-25
HU197726B (en)	1989-05-29	Process for production of derivatives of bensoic acid and medical compositions containing them