PH26947A - DNA encoding rabbit TNF vector having said DNA inserted thereinto host transformed with said vector rabbit TNF polypeptide and process for production thereof - Google Patents

DNA encoding rabbit TNF vector having said DNA inserted thereinto host transformed with said vector rabbit TNF polypeptide and process for production thereof Download PDF

Info

Publication number: PH26947A
Authority: PH; Philippines
Prior art keywords: leu; ser; ctc; gly; glu
Prior art date: 1983-12-02

Application number

PH31507A

Other languages

English (en)

Inventor

Masaaki Yamada

Yasuji Furutani

Mitsue Notake

Original Assignee

Dainippon Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-02

Filing date

1984-11-29

Publication date

1992-12-03

1984-11-29 Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co

1992-12-03 Publication of PH26947A publication Critical patent/PH26947A/en

Links

241000283973 Oryctolagus cuniculus Species 0.000 title claims description 117
238000000034 method Methods 0.000 title claims description 71
230000008569 process Effects 0.000 title claims description 27
239000013598 vector Substances 0.000 title claims description 19
238000004519 manufacturing process Methods 0.000 title claims description 14
108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 131
102000003390 tumor necrosis factor Human genes 0.000 claims description 131
108020004999 messenger RNA Proteins 0.000 claims description 61
239000002299 complementary DNA Substances 0.000 claims description 60
108090000765 processed proteins & peptides Proteins 0.000 claims description 40
102000004196 processed proteins & peptides Human genes 0.000 claims description 40
239000013612 plasmid Substances 0.000 claims description 39
229920001184 polypeptide Polymers 0.000 claims description 39
150000001413 amino acids Chemical group 0.000 claims description 26
108020004705 Codon Proteins 0.000 claims description 22
230000000694 effects Effects 0.000 claims description 16
241000588724 Escherichia coli Species 0.000 claims description 12
239000002253 acid Substances 0.000 claims description 9
230000004071 biological effect Effects 0.000 claims description 6
239000000411 inducer Substances 0.000 claims description 6
108010070643 prolylglutamic acid Proteins 0.000 claims description 6
CQQGCWPXDHTTNF-GUBZILKMSA-N Leu-Ala-Glu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCC(O)=O CQQGCWPXDHTTNF-GUBZILKMSA-N 0.000 claims description 5
108010026333 seryl-proline Proteins 0.000 claims description 5
108010092799 RNA-directed DNA polymerase Proteins 0.000 claims description 4
KKKVOZNCLALMPV-XKBZYTNZSA-N Ser-Thr-Glu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(O)=O KKKVOZNCLALMPV-XKBZYTNZSA-N 0.000 claims description 4
CRCHQCUINSOGFD-JBACZVJFSA-N Trp-Tyr-Glu Chemical compound C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N CRCHQCUINSOGFD-JBACZVJFSA-N 0.000 claims description 4
238000012986 modification Methods 0.000 claims description 4
230000004048 modification Effects 0.000 claims description 4
YAXNATKKPOWVCP-ZLUOBGJFSA-N Ala-Asn-Ala Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(O)=O YAXNATKKPOWVCP-ZLUOBGJFSA-N 0.000 claims description 3
IXIWEFWRKIUMQX-DCAQKATOSA-N Asp-Arg-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O IXIWEFWRKIUMQX-DCAQKATOSA-N 0.000 claims description 3
CGOHAEBMDSEKFB-FXQIFTODSA-N Glu-Glu-Ala Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(O)=O CGOHAEBMDSEKFB-FXQIFTODSA-N 0.000 claims description 3
UMZHHILWZBFPGL-LOKLDPHHSA-N Glu-Thr-Pro Chemical compound C[C@H]([C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCC(=O)O)N)O UMZHHILWZBFPGL-LOKLDPHHSA-N 0.000 claims description 3
UUTGYDAKPISJAO-JYJNAYRXSA-N Glu-Tyr-Leu Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 UUTGYDAKPISJAO-JYJNAYRXSA-N 0.000 claims description 3
PBCHMHROGNUXMK-DLOVCJGASA-N Leu-Ala-His Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 PBCHMHROGNUXMK-DLOVCJGASA-N 0.000 claims description 3
YSKSXVKQLLBVEX-SZMVWBNQSA-N Leu-Gln-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)C(O)=O)=CNC2=C1 YSKSXVKQLLBVEX-SZMVWBNQSA-N 0.000 claims description 3
VWHGTYCRDRBSFI-ZETCQYMHSA-N Leu-Gly-Gly Chemical compound CC(C)C[C@H](N)C(=O)NCC(=O)NCC(O)=O VWHGTYCRDRBSFI-ZETCQYMHSA-N 0.000 claims description 3
IRMLZWSRWSGTOP-CIUDSAMLSA-N Leu-Ser-Ala Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O IRMLZWSRWSGTOP-CIUDSAMLSA-N 0.000 claims description 3
FGZVGOAAROXFAB-IXOXFDKPSA-N Leu-Thr-His Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](CC(C)C)N)O FGZVGOAAROXFAB-IXOXFDKPSA-N 0.000 claims description 3
KAGCQPSEVAETCA-JYJNAYRXSA-N Phe-Gln-Leu Chemical compound CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC1=CC=CC=C1)N KAGCQPSEVAETCA-JYJNAYRXSA-N 0.000 claims description 3
YQHZVYJAGWMHES-ZLUOBGJFSA-N Ser-Ala-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(O)=O YQHZVYJAGWMHES-ZLUOBGJFSA-N 0.000 claims description 3
SNVIOQXAHVORQM-WDSKDSINSA-N Ser-Gly-Gln Chemical compound [H]N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O SNVIOQXAHVORQM-WDSKDSINSA-N 0.000 claims description 3
JUTGONBTALQWMK-NAKRPEOUSA-N Ser-Met-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)N JUTGONBTALQWMK-NAKRPEOUSA-N 0.000 claims description 3
MNYNCKZAEIAONY-XGEHTFHBSA-N Thr-Val-Ser Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(O)=O MNYNCKZAEIAONY-XGEHTFHBSA-N 0.000 claims description 3
IWADHXDXSQONEL-GUBZILKMSA-N Val-Val-Ala Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(O)=O IWADHXDXSQONEL-GUBZILKMSA-N 0.000 claims description 3
108010092854 aspartyllysine Proteins 0.000 claims description 3
108010044311 leucyl-glycyl-glycine Proteins 0.000 claims description 3
108010080629 tryptophan-leucine Proteins 0.000 claims description 3
206010028851 Necrosis Diseases 0.000 claims description 2
KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims description 2
108010057821 leucylproline Proteins 0.000 claims description 2
230000017074 necrotic cell death Effects 0.000 claims description 2
AFWYPMDMDYCKMD-KBPBESRZSA-N Gly-Leu-Tyr Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 AFWYPMDMDYCKMD-KBPBESRZSA-N 0.000 claims 3
HVKMTOIAYDOJPL-NRPADANISA-N Ser-Gln-Val Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O HVKMTOIAYDOJPL-NRPADANISA-N 0.000 claims 3
108010050475 glycyl-leucyl-tyrosine Proteins 0.000 claims 3
CCUAQNUWXLYFRA-IMJSIDKUSA-N Ala-Asn Chemical compound C[C@H]([NH3+])C(=O)N[C@H](C([O-])=O)CC(N)=O CCUAQNUWXLYFRA-IMJSIDKUSA-N 0.000 claims 2
101100273639 Carassius auratus ccna1 gene Proteins 0.000 claims 2
LKDIBBOKUAASNP-FXQIFTODSA-N Glu-Ala-Glu Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O LKDIBBOKUAASNP-FXQIFTODSA-N 0.000 claims 2
JSIQVRIXMINMTA-ZDLURKLDSA-N Glu-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O JSIQVRIXMINMTA-ZDLURKLDSA-N 0.000 claims 2
YZACQYVWLCQWBT-BQBZGAKWSA-N Gly-Cys-Arg Chemical compound [H]NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O YZACQYVWLCQWBT-BQBZGAKWSA-N 0.000 claims 2
AAHSHTLISQUZJL-QSFUFRPTSA-N Gly-Ile-Ile Chemical compound [H]NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O AAHSHTLISQUZJL-QSFUFRPTSA-N 0.000 claims 2
PFMUCCYYAAFKTH-YFKPBYRVSA-N Gly-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)CN PFMUCCYYAAFKTH-YFKPBYRVSA-N 0.000 claims 2
RCFDOSNHHZGBOY-UHFFFAOYSA-N L-isoleucyl-L-alanine Natural products CCC(C)C(N)C(=O)NC(C)C(O)=O RCFDOSNHHZGBOY-UHFFFAOYSA-N 0.000 claims 2
IEWBEPKLKUXQBU-VOAKCMCISA-N Leu-Leu-Thr Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O IEWBEPKLKUXQBU-VOAKCMCISA-N 0.000 claims 2
XGDCYUQSFDQISZ-BQBZGAKWSA-N Leu-Ser Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CO)C(O)=O XGDCYUQSFDQISZ-BQBZGAKWSA-N 0.000 claims 2
SITLTJHOQZFJGG-UHFFFAOYSA-N N-L-alpha-glutamyl-L-valine Natural products CC(C)C(C(O)=O)NC(=O)C(N)CCC(O)=O SITLTJHOQZFJGG-UHFFFAOYSA-N 0.000 claims 2
WBAXJMCUFIXCNI-WDSKDSINSA-N Ser-Pro Chemical compound OC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O WBAXJMCUFIXCNI-WDSKDSINSA-N 0.000 claims 2
STTYIMSDIYISRG-UHFFFAOYSA-N Valyl-Serine Chemical compound CC(C)C(N)C(=O)NC(CO)C(O)=O STTYIMSDIYISRG-UHFFFAOYSA-N 0.000 claims 2
108010005233 alanylglutamic acid Proteins 0.000 claims 2
230000007850 degeneration Effects 0.000 claims 2
108010050848 glycylleucine Proteins 0.000 claims 2
108010064235 lysylglycine Proteins 0.000 claims 2
241001502050 Acis Species 0.000 claims 1
CVGNCMIULZNYES-WHFBIAKZSA-N Ala-Asn-Gly Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(O)=O CVGNCMIULZNYES-WHFBIAKZSA-N 0.000 claims 1
XCVRVWZTXPCYJT-BIIVOSGPSA-N Ala-Asn-Pro Chemical compound C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@@H]1C(=O)O)N XCVRVWZTXPCYJT-BIIVOSGPSA-N 0.000 claims 1
KUFVXLQLDHJVOG-SHGPDSBTSA-N Ala-Thr-Thr Chemical compound C[C@H]([C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@H](C)N)O KUFVXLQLDHJVOG-SHGPDSBTSA-N 0.000 claims 1
COXMUHNBYCVVRG-DCAQKATOSA-N Arg-Leu-Ser Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O COXMUHNBYCVVRG-DCAQKATOSA-N 0.000 claims 1
OWUCNXMFJRFOFI-BQBZGAKWSA-N Asn-Gly-Met Chemical compound [H]N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(O)=O OWUCNXMFJRFOFI-BQBZGAKWSA-N 0.000 claims 1
HXWUJJADFMXNKA-BQBZGAKWSA-N Asn-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC(N)=O HXWUJJADFMXNKA-BQBZGAKWSA-N 0.000 claims 1
VHQSGALUSWIYOD-QXEWZRGKSA-N Asn-Pro-Val Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(O)=O VHQSGALUSWIYOD-QXEWZRGKSA-N 0.000 claims 1
101001026137 Cavia porcellus Glutathione S-transferase A Proteins 0.000 claims 1
ANPADMNVVOOYKW-DCAQKATOSA-N Cys-His-Arg Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O ANPADMNVVOOYKW-DCAQKATOSA-N 0.000 claims 1
SRIRHERUAMYIOQ-CIUDSAMLSA-N Cys-Leu-Ser Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O SRIRHERUAMYIOQ-CIUDSAMLSA-N 0.000 claims 1
241000588722 Escherichia Species 0.000 claims 1
SNLOOPZHAQDMJG-CIUDSAMLSA-N Gln-Glu-Glu Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O SNLOOPZHAQDMJG-CIUDSAMLSA-N 0.000 claims 1
JEFZIKRIDLHOIF-BYPYZUCNSA-N Gln-Gly Chemical compound NC(=O)CC[C@H](N)C(=O)NCC(O)=O JEFZIKRIDLHOIF-BYPYZUCNSA-N 0.000 claims 1
QKCZZAZNMMVICF-DCAQKATOSA-N Gln-Leu-Glu Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O QKCZZAZNMMVICF-DCAQKATOSA-N 0.000 claims 1
IOFDDSNZJDIGPB-GVXVVHGQSA-N Gln-Leu-Val Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=O IOFDDSNZJDIGPB-GVXVVHGQSA-N 0.000 claims 1
RWCBJYUPAUTWJD-NHCYSSNCSA-N Gln-Met-Val Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(O)=O RWCBJYUPAUTWJD-NHCYSSNCSA-N 0.000 claims 1
UKKNTTCNGZLJEX-WHFBIAKZSA-N Gln-Ser Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](CO)C(O)=O UKKNTTCNGZLJEX-WHFBIAKZSA-N 0.000 claims 1
IIMZHVKZBGSEKZ-SZMVWBNQSA-N Gln-Trp-Leu Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(O)=O IIMZHVKZBGSEKZ-SZMVWBNQSA-N 0.000 claims 1
BBFCMGBMYIAGRS-AUTRQRHGSA-N Gln-Val-Glu Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O BBFCMGBMYIAGRS-AUTRQRHGSA-N 0.000 claims 1
LSPKYLAFTPBWIL-BYPYZUCNSA-N Glu-Gly Chemical compound OC(=O)CC[C@H](N)C(=O)NCC(O)=O LSPKYLAFTPBWIL-BYPYZUCNSA-N 0.000 claims 1
RFTVTKBHDXCEEX-WDSKDSINSA-N Glu-Ser-Gly Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(O)=O RFTVTKBHDXCEEX-WDSKDSINSA-N 0.000 claims 1
SITLTJHOQZFJGG-XPUUQOCRSA-N Glu-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O SITLTJHOQZFJGG-XPUUQOCRSA-N 0.000 claims 1
UZWUBBRJWFTHTD-LAEOZQHASA-N Glu-Val-Asn Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)CCC(O)=O UZWUBBRJWFTHTD-LAEOZQHASA-N 0.000 claims 1
QPDUVFSVVAOUHE-XVKPBYJWSA-N Gly-Gln-Val Chemical compound CC(C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CN)C(O)=O QPDUVFSVVAOUHE-XVKPBYJWSA-N 0.000 claims 1
DKEXFJVMVGETOO-LURJTMIESA-N Gly-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)CN DKEXFJVMVGETOO-LURJTMIESA-N 0.000 claims 1
POJJAZJHBGXEGM-YUMQZZPRSA-N Gly-Ser-Lys Chemical compound C(CCN)C[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)CN POJJAZJHBGXEGM-YUMQZZPRSA-N 0.000 claims 1
NIKBMHGRNAPJFW-IUCAKERBSA-N His-Arg Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CN=CN1 NIKBMHGRNAPJFW-IUCAKERBSA-N 0.000 claims 1
MMFKFJORZBJVNF-UWVGGRQHSA-N His-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CN=CN1 MMFKFJORZBJVNF-UWVGGRQHSA-N 0.000 claims 1
DRKZDEFADVYTLU-AVGNSLFASA-N His-Val-Val Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(O)=O DRKZDEFADVYTLU-AVGNSLFASA-N 0.000 claims 1
GQKSJYINYYWPMR-NGZCFLSTSA-N Ile-Gly-Pro Chemical compound CC[C@H](C)[C@@H](C(=O)NCC(=O)N1CCC[C@@H]1C(=O)O)N GQKSJYINYYWPMR-NGZCFLSTSA-N 0.000 claims 1
BCVIOZZGJNOEQS-XKNYDFJKSA-N Ile-Ile Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@H](C(O)=O)[C@@H](C)CC BCVIOZZGJNOEQS-XKNYDFJKSA-N 0.000 claims 1
GVEODXUBBFDBPW-MGHWNKPDSA-N Ile-Tyr-Leu Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 GVEODXUBBFDBPW-MGHWNKPDSA-N 0.000 claims 1
102100034343 Integrase Human genes 0.000 claims 1
QLROSWPKSBORFJ-BQBZGAKWSA-N L-Prolyl-L-glutamic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 QLROSWPKSBORFJ-BQBZGAKWSA-N 0.000 claims 1
HQUXQAMSWFIRET-AVGNSLFASA-N Leu-Glu-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(O)=O)CCCCN HQUXQAMSWFIRET-AVGNSLFASA-N 0.000 claims 1
LESXFEZIFXFIQR-LURJTMIESA-N Leu-Gly Chemical compound CC(C)C[C@H](N)C(=O)NCC(O)=O LESXFEZIFXFIQR-LURJTMIESA-N 0.000 claims 1
VTJUNIYRYIAIHF-IUCAKERBSA-N Leu-Pro Chemical compound CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(O)=O VTJUNIYRYIAIHF-IUCAKERBSA-N 0.000 claims 1
IZPVWNSAVUQBGP-CIUDSAMLSA-N Leu-Ser-Asp Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(O)=O IZPVWNSAVUQBGP-CIUDSAMLSA-N 0.000 claims 1
LRKCBIUDWAXNEG-CSMHCCOUSA-N Leu-Thr Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O LRKCBIUDWAXNEG-CSMHCCOUSA-N 0.000 claims 1
SEPNOAFMZLLCEW-UBHSHLNASA-N Phe-Ala-Val Chemical compound N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O SEPNOAFMZLLCEW-UBHSHLNASA-N 0.000 claims 1
GLUBLISJVJFHQS-VIFPVBQESA-N Phe-Gly Chemical compound OC(=O)CNC(=O)[C@@H](N)CC1=CC=CC=C1 GLUBLISJVJFHQS-VIFPVBQESA-N 0.000 claims 1
ROHDXJUFQVRDAV-UWVGGRQHSA-N Phe-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 ROHDXJUFQVRDAV-UWVGGRQHSA-N 0.000 claims 1
FELJDCNGZFDUNR-WDSKDSINSA-N Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1 FELJDCNGZFDUNR-WDSKDSINSA-N 0.000 claims 1
MTHRMUXESFIAMS-DCAQKATOSA-N Pro-Asn-Lys Chemical compound C1C[C@H](NC1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)O MTHRMUXESFIAMS-DCAQKATOSA-N 0.000 claims 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)

PH31507A 1983-12-02 1984-11-29 DNA encoding rabbit TNF vector having said DNA inserted thereinto host transformed with said vector rabbit TNF polypeptide and process for production thereof PH26947A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP58228790A JPH0695939B2 (ja)	1983-12-02	1983-12-02	ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ

Publications (1)

Publication Number	Publication Date
PH26947A true PH26947A (en)	1992-12-03

Family

ID=16881888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH31507A PH26947A (en)	1983-12-02	1984-11-29	DNA encoding rabbit TNF vector having said DNA inserted thereinto host transformed with said vector rabbit TNF polypeptide and process for production thereof

Country Status (10)

Country	Link
US (1)	US5043271A (fr)
EP (1)	EP0146026B1 (fr)
JP (1)	JPH0695939B2 (fr)
KR (1)	KR920009523B1 (fr)
AT (1)	ATE60933T1 (fr)
AU (1)	AU577810B2 (fr)
DE (1)	DE3484125D1 (fr)
DK (1)	DK572284A (fr)
ES (2)	ES8604309A1 (fr)
PH (1)	PH26947A (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1265444A (fr) *	1983-06-27	1990-02-06	Lloyd J. Old	Effet du facteur humain de necrose des tumeurs et de l'interferon humain sur des cellules cancereuses humaines et methodes utilisees
JPS60112718A (ja) *	1983-11-21	1985-06-19	Kyorin Pharmaceut Co Ltd	抗腫瘍作用を示す蛋白性物質及びその製造方法
JPS60139624A (ja) *	1983-12-27	1985-07-24	Dainippon Pharmaceut Co Ltd	抗腫瘍作用を有する蛋白質
US4879226A (en) *	1984-04-06	1989-11-07	Asahi Kasei Kogyo Kabushiki Kaisha	Novel human physiologically active polypeptide
GR851626B (fr) *	1984-07-05	1985-11-26	Genentech Inc
US6686455B1 (en)	1984-07-05	2004-02-03	Genentech, Inc.	Tumor necrosis factor
US5672347A (en) *	1984-07-05	1997-09-30	Genentech, Inc.	Tumor necrosis factor antagonists and their use
WO1986003751A2 (fr) *	1984-12-21	1986-07-03	Biogen N.V.	Purification, production et utilisation de facteurs necrotiques tumoraux
US5425940A (en) *	1986-04-09	1995-06-20	Cetus Oncology Corporation	Combination therapy using interleukin-2 and tumor necrosis factor
US5998378A (en) *	1989-08-16	1999-12-07	Chiron Corporation	Compositions for the inhibition of TNF hormone formation and uses thereof
US6586222B1 (en)	1989-08-16	2003-07-01	Chiron Corporation	Recombinant PR-3 and compositions thereof
ATE148992T1 (de)	1989-08-16	1997-03-15	Chiron Corp	Zusammensetzungen zur hemmung der bildung von proteinhormon und deren verwendungen
US5843693A (en) *	1989-08-16	1998-12-01	Chiron Corporation	Assay method for screening for inhibitors of proTNF conversion
WO1991017180A1 (fr) *	1990-04-27	1991-11-14	Peptide Technology Ltd	Peptides derives du facteur de necrose tumorale humain alpha utiles contre les parasites paludeens intracellulaires
US5653974A (en) *	1990-10-18	1997-08-05	Board Of Regents,The University Of Texas System	Preparation and characterization of liposomal formulations of tumor necrosis factor
WO1995024501A1 (fr)	1994-03-07	1995-09-14	Cetus Oncology Corporation	Compositions pour l'inhibition de la formation des facteurs de necrose tumorale (tnf) et leur utilisation
JP4754219B2 (ja)	2002-12-02	2011-08-24	アムジエン・フレモント・インコーポレイテツド	腫瘍壊死因子を対象とする抗体、およびそれらの使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57140725A (en) *	1981-12-28	1982-08-31	Dainippon Pharmaceut Co Ltd	Physiologically active substance having carcinostatic action
JPS6019719A (ja) *	1983-07-15	1985-01-31	Asahi Chem Ind Co Ltd	抗腫瘍活性を有する蛋白質
DE3472793D1 (en) *	1983-12-26	1988-08-25	Asahi Chemical Ind	A novel physiologically active polypeptide
DE19975063I2 (de) *	1984-03-06	2005-08-18	Dainippon Pharmaceutical Co	DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d.
US4879226A (en) *	1984-04-06	1989-11-07	Asahi Kasei Kogyo Kabushiki Kaisha	Novel human physiologically active polypeptide

1983
- 1983-12-02 JP JP58228790A patent/JPH0695939B2/ja not_active Expired - Lifetime
1984
- 1984-11-27 ES ES538000A patent/ES8604309A1/es not_active Expired
- 1984-11-27 AT AT84114325T patent/ATE60933T1/de not_active IP Right Cessation
- 1984-11-27 DE DE8484114325T patent/DE3484125D1/de not_active Expired - Lifetime
- 1984-11-27 KR KR1019840007423A patent/KR920009523B1/ko not_active Expired
- 1984-11-27 EP EP84114325A patent/EP0146026B1/fr not_active Expired - Lifetime
- 1984-11-29 PH PH31507A patent/PH26947A/en unknown
- 1984-11-29 AU AU36014/84A patent/AU577810B2/en not_active Ceased
- 1984-11-30 US US06/677,680 patent/US5043271A/en not_active Expired - Fee Related
- 1984-11-30 DK DK572284A patent/DK572284A/da not_active Application Discontinuation
1985
- 1985-09-30 ES ES547436A patent/ES8605578A1/es not_active Expired

Also Published As

Publication number	Publication date
DK572284A (da)	1985-06-03
ES538000A0 (es)	1986-01-16
KR850004272A (ko)	1985-07-11
US5043271A (en)	1991-08-27
ES8604309A1 (es)	1986-01-16
KR920009523B1 (ko)	1992-10-17
ATE60933T1 (de)	1991-03-15
JPS60120990A (ja)	1985-06-28
ES8605578A1 (es)	1986-03-16
AU3601484A (en)	1985-06-06
EP0146026B1 (fr)	1991-02-20
AU577810B2 (en)	1988-10-06
EP0146026A3 (en)	1987-05-20
JPH0695939B2 (ja)	1994-11-30
ES547436A0 (es)	1986-03-16
DK572284D0 (da)	1984-11-30
EP0146026A2 (fr)	1985-06-26
DE3484125D1 (de)	1991-03-28

Publication	Publication Date	Title
US5288852A (en)	1994-02-22	Human tumor necrosis factor polypeptides
EP0155549B1 (fr)	1991-03-20	ADN codant pour le facteur humain de nécrose de tumeur et le polypeptide du facteur humain de nécrose de tumeur
US5100784A (en)	1992-03-31	Process for the preparation of mature human serum albumin
EP0251037B1 (fr)	1994-06-15	Mutants du polypeptide du TNF humain et ADN codant pour ces mutants
US5043271A (en)	1991-08-27	DNA encoding rabbit TNE, vector having said DNA inserted thereinto, host transformed with said vector, rabbit TNF polypeptide, and process for production thereof
US5376639A (en)	1994-12-27	Treatment of sarcoma with interleukin 1α polypeptides
EP0285448A2 (fr)	1988-10-05	Facteur d'inhibition de la leucémie
CA2004261A1 (fr)	1990-06-01	Interleukine-6 synthetique
CA1335360C (fr)	1995-04-25	Activateur des lymphocytes tueurs naturels recombinant
KR940000542B1 (ko)	1994-01-24	재조합 dna 기술에 의해 제조된 생리적 활성물질의 정제방법
EP0479071A2 (fr)	1992-04-08	Polypeptide
CA2111327A1 (fr)	1993-01-21	Muteines il-6 exemptes de cysteine
EP0452391B1 (fr)	1997-07-16	Polypeptide possedant une activite de facteur chimiotactique monocyte humain et adn codant ce polypeptide
CA2005600A1 (fr)	1990-06-20	Facteur de croissance des cellules endotheliales
JP3497504B2 (ja)	2004-02-16	細胞増殖阻害剤
EP0300459A2 (fr)	1989-01-25	Inhibitor de trypsine sécrété par le pancréas humain
SU1614765A3 (ru)	1990-12-15	Способ получени рекомбинантной плазмидной ДНК pHTN 713, кодирующей фактор некроза опухоли человека
EP0757994B1 (fr)	2003-09-03	Mutant de tcf
JPH07501947A (ja)	1995-03-02	野生インターロイキン６より改良された生物学的活性を有する突然変異インターロイキン６
US5739008A (en)	1998-04-14	DNA encoding a protein comprising calmodulin-and actin-binding human caldesmon peptide fragment
JP2514631B2 (ja)	1996-07-10	Ｂ細胞分化因子をコ―ドする遺伝子
JP3068026B2 (ja)	2000-07-24	Ｂ細胞分化因子の製造方法
EP0668291A2 (fr)	1995-08-23	Amplificateur de la régénération du foie de mammifères, et variantes dudit
JP3022950B2 (ja)	2000-03-21	Ｂ細胞分化因子
JP2721854B2 (ja)	1998-03-04	抗腫瘍活性物質