PH31443A - Imidazodiazepine. - Google Patents

Imidazodiazepine.

Info

Publication number: PH31443A
Authority: PH; Philippines
Prior art keywords: formula; lower alkyl; atom; imidazodiazepine; imidazodiazepines
Prior art date: 1994-03-16

Application number

PH50110A

Other languages

English (en)

Inventor

Godel Thierry

Hunkeler Walter

Widmer Ulrich

Stadler Heinz

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-16

Filing date

1995-03-10

Publication date

1998-11-03

1995-03-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1998-11-03 Publication of PH31443A publication Critical patent/PH31443A/en

Links

BMGXAZCDDYTVFV-UHFFFAOYSA-N imidazo[4,5-c]diazepine Chemical compound C1=CN=NC2=NC=NC2=C1 BMGXAZCDDYTVFV-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
MBDPOXAMXCPREM-UHFFFAOYSA-N 4-imidazo[4,5-c]diazepin-3-yloxadiazole Chemical class N1=NC2=NC=NC2=CC=C1C1=CON=N1 MBDPOXAMXCPREM-UHFFFAOYSA-N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Plant Substances (AREA)

PH50110A 1994-03-16 1995-03-10 Imidazodiazepine. PH31443A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH78394		1994-03-16
CH1095		1995-01-03

Publications (1)

Publication Number	Publication Date
PH31443A true PH31443A (en)	1998-11-03

Family

ID=25683249

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH50110A PH31443A (en)	1994-03-16	1995-03-10	Imidazodiazepine.

Country Status (27)

Country	Link
US (1)	US5665718A (is)
EP (1)	EP0672666B1 (is)
JP (1)	JP2690282B2 (is)
KR (1)	KR100214800B1 (is)
CN (1)	CN1036995C (is)
AT (1)	ATE203536T1 (is)
AU (1)	AU679608B2 (is)
BG (1)	BG62210B1 (is)
CA (1)	CA2143246C (is)
CZ (1)	CZ288594B6 (is)
DE (1)	DE59509432D1 (is)
DK (1)	DK0672666T3 (is)
ES (1)	ES2160646T3 (is)
FI (1)	FI112487B (is)
GR (1)	GR3037019T3 (is)
HU (1)	HU219987B (is)
IL (1)	IL112955A (is)
IS (1)	IS4273A (is)
LV (1)	LV11327B (is)
MA (1)	MA23479A1 (is)
NO (1)	NO303731B1 (is)
NZ (1)	NZ270685A (is)
PH (1)	PH31443A (is)
PT (1)	PT672666E (is)
RO (1)	RO117698B1 (is)
RU (1)	RU2139873C1 (is)
SK (1)	SK33995A3 (is)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW349100B (en) *	1994-11-11	1999-01-01	Hoffmann La Roche	Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5905176A (en) *	1998-08-28	1999-05-18	Eastman Chemical Company	Process for the production of cyclobutyl halides
TR200103237T2 (tr) *	1999-05-12	2002-04-22	F. Hoffmann-La Roche Ag	İmidazodiazepin türevi
US7160880B1 (en) *	1999-05-14	2007-01-09	Cenes Limited	Short-acting benzodiazepines
RU2199309C1 (ru) *	2001-12-29	2003-02-27	Закрытое акционерное общество "Брынцалов-А"	Лекарственное средство нобрассит седативного и анксиолитического действия
US20060065608A1 (en) *	2004-09-29	2006-03-30	Choate Chris E	Process and apparatus for generating useful biomass from organic waste streams
DE602006021535D1 (de) *	2005-01-19	2011-06-09	Merck Sharp & Dohme	Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer-krankheit
CN101106994A (zh) *	2005-01-19	2008-01-16	默克公司	用于治疗阿尔茨海默氏病的氨基甲基β-分泌酶抑制剂
EP1888594A2 (en) *	2005-05-16	2008-02-20	Wisys Technology Foundation, Inc.	Gabaergic agents to treat memory deficits
DE602007009128D1 (de) *	2006-07-10	2010-10-21	Paion Uk Ltd	Benzodiazepinsalze mit kurzzeitwirkung und polymorphe formen davon
GB0613693D0 (en) *	2006-07-10	2006-08-16	Cenes Ltd	Benzodiazepine salts (3)
CA2696703C (en)	2007-08-20	2016-07-26	Evotec Neurosciences Gmbh	Treatment of sleep disorders
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
WO2009024324A2 (en) *	2007-08-20	2009-02-26	Evotec Neurosciences Gmbh	Treatment of sleep disorders
RU2503681C2 (ru) *	2008-09-30	2014-01-10	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Новое конденсированное производное аминодигидротиазина
EP2450039A1 (en)	2010-11-08	2012-05-09	PAION UK Ltd.	Dosing regimen for sedation with CNS 7056 (Remimazolam)
GEAP201813666A (en)	2012-05-22	2018-01-25	Paion Uk Ltd	Compositions comprising short-acting benzodiazepines
AR094963A1 (es)	2013-03-04	2015-09-09	Ono Pharmaceutical Co	Reacción de oxidación excelente en el índice de conversión
CU24362B1 (es)	2013-09-06	2018-10-04	Aurigene Discovery Tech Ltd	Derivados de 1,2,4-oxadiazol como inmunomoduladores
MX384444B (es) *	2015-03-10	2025-03-14	Aurigene Discovery Tech Ltd	Compuestos de 1,2,4-oxadiazol y tiadiazol como inmunomoduladores
WO2016142886A2 (en) *	2015-03-10	2016-09-15	Aurigene Discovery Technologies Limited	3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
MX2018012498A (es)	2016-04-14	2019-07-01	Paion Uk Ltd	Benzodiazepinas inhaladas y nasales oralmente.
WO2019061324A1 (en)	2017-09-29	2019-04-04	Curis Inc.	CRYSTALLINE FORMS OF IMMUNOMODULATORS
BR112020006669A2 (pt)	2017-10-11	2020-09-24	Aurigene Discovery Technologies Limited	formas cristalinas de 1,2,4-oxadiazol 3-substituído
KR20200083503A (ko)	2017-11-03	2020-07-08	오리진 디스커버리 테크놀로지스 리미티드	Tim-3 경로와 pd-1 경로의 이중 저해제
EA202090749A1 (ru)	2017-11-06	2020-08-19	Ориджен Дискавери Текнолоджис Лимитед	Способы совместной терапии для иммуномодуляции

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA755418B (en) *	1974-09-11	1977-06-29	Hoffmann La Roche	Diazepine derivatives
IL49161A (en) *	1975-08-07	1982-04-30	Sparamedica Ag	Imidazo(1,5-a)(1,4)-diazepine derivatives,their manufacture and pharmaceutical compositions containing them
SE422580B (sv) *	1975-08-07	1982-03-15	Hoffmann La Roche	Analogiforfarande for framstellning av imidazo (1,5-a)(1,4)diazepin-foreningar
FI63033C (fi) *	1977-07-21	1983-04-11	Boehringer Sohn Ingelheim	Foerfarande foer framstaellning av anxiolytiska tranquilliserande sedativa och/eller neuroleptiska substituerade 1-piperazinyl-4h-s-triazolo(3,4-c)tieno(2,3-e)-1,4-diazepiner
DK151808C (da) *	1982-11-16	1988-06-20	Ferrosan As	Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
DE3587913D1 (de) *	1984-01-19	1994-10-06	Hoffmann La Roche	Imidazodiazepin-Derivate.
AU587802B2 (en) *	1985-03-08	1989-08-31	Ferrosan A/S	Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
US4622320A (en) *	1985-05-17	1986-11-11	As Ferrosan	Oxadiazolylimidazobenzodiazepine, compositions, and method
DK174086D0 (da) *	1986-04-16	1986-04-16	Ferrosan As	Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4904654A (en) *	1989-07-26	1990-02-27	Merck & Co., Inc.	7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
US4939139A (en) *	1989-07-26	1990-07-03	Merck & Co., Inc.	7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine

1995
- 1995-02-23 CA CA002143246A patent/CA2143246C/en not_active Expired - Lifetime
- 1995-03-03 AT AT95103028T patent/ATE203536T1/de active
- 1995-03-03 ES ES95103028T patent/ES2160646T3/es not_active Expired - Lifetime
- 1995-03-03 DK DK95103028T patent/DK0672666T3/da active
- 1995-03-03 EP EP95103028A patent/EP0672666B1/de not_active Expired - Lifetime
- 1995-03-03 DE DE59509432T patent/DE59509432D1/de not_active Expired - Lifetime
- 1995-03-03 PT PT95103028T patent/PT672666E/pt unknown
- 1995-03-10 PH PH50110A patent/PH31443A/en unknown
- 1995-03-10 NZ NZ270685A patent/NZ270685A/en not_active IP Right Cessation
- 1995-03-10 IL IL112955A patent/IL112955A/en not_active IP Right Cessation
- 1995-03-10 AU AU14760/95A patent/AU679608B2/en not_active Expired
- 1995-03-13 HU HU9500743A patent/HU219987B/hu not_active IP Right Cessation
- 1995-03-14 RU RU95103921A patent/RU2139873C1/ru active
- 1995-03-15 IS IS4273A patent/IS4273A/is unknown
- 1995-03-15 NO NO950999A patent/NO303731B1/no not_active IP Right Cessation
- 1995-03-15 CN CN95102481A patent/CN1036995C/zh not_active Expired - Lifetime
- 1995-03-15 CZ CZ1995663A patent/CZ288594B6/cs not_active IP Right Cessation
- 1995-03-15 MA MA23807A patent/MA23479A1/fr unknown
- 1995-03-15 RO RO95-00534A patent/RO117698B1/ro unknown
- 1995-03-15 LV LVP-95-59A patent/LV11327B/lv unknown
- 1995-03-15 SK SK339-95A patent/SK33995A3/sk unknown
- 1995-03-16 BG BG99505A patent/BG62210B1/bg unknown
- 1995-03-16 JP JP7057227A patent/JP2690282B2/ja not_active Expired - Lifetime
- 1995-03-16 FI FI951251A patent/FI112487B/fi not_active IP Right Cessation
- 1995-03-16 KR KR1019950005414A patent/KR100214800B1/ko not_active Expired - Lifetime
1996
- 1996-01-16 US US08/586,439 patent/US5665718A/en not_active Expired - Lifetime
2001
- 2001-10-25 GR GR20010401890T patent/GR3037019T3/el unknown

Also Published As

Publication number	Publication date
ES2160646T3 (es)	2001-11-16
RU2139873C1 (ru)	1999-10-20
NO950999D0 (no)	1995-03-15
CZ66395A3 (en)	1995-10-18
DE59509432D1 (de)	2001-08-30
FI112487B (fi)	2003-12-15
KR950032199A (ko)	1995-12-20
CN1036995C (zh)	1998-01-14
JP2690282B2 (ja)	1997-12-10
DK0672666T3 (da)	2001-11-12
RO117698B1 (ro)	2002-06-28
FI951251A0 (fi)	1995-03-16
FI951251A7 (fi)	1995-09-17
SK33995A3 (en)	1995-10-11
RU95103921A (ru)	1996-12-10
IS4273A (is)	1995-09-17
US5665718A (en)	1997-09-09
BG99505A (en)	1996-01-31
CN1111632A (zh)	1995-11-15
KR100214800B1 (ko)	1999-08-02
AU1476095A (en)	1995-09-28
LV11327A (lv)	1996-06-20
CA2143246A1 (en)	1995-09-17
EP0672666A3 (de)	1995-11-08
CA2143246C (en)	2000-08-22
EP0672666A2 (de)	1995-09-20
NO950999L (no)	1995-09-18
HUT71817A (en)	1996-02-28
LV11327B (en)	1996-10-20
CZ288594B6 (cs)	2001-07-11
NO303731B1 (no)	1998-08-24
GR3037019T3 (en)	2002-01-31
EP0672666B1 (de)	2001-07-25
MA23479A1 (fr)	1995-10-01
IL112955A0 (en)	1995-06-29
PT672666E (pt)	2002-01-30
JPH07258260A (ja)	1995-10-09
HU9500743D0 (en)	1995-04-28
BG62210B1 (bg)	1999-05-31
AU679608B2 (en)	1997-07-03
ATE203536T1 (de)	2001-08-15
HU219987B (hu)	2001-10-28
IL112955A (en)	1998-02-08
NZ270685A (en)	1996-05-28

Publication	Publication Date	Title
PH31443A (en)	1998-11-03	Imidazodiazepine.
DE3468878D1 (en)	1988-02-25	7-amino-azoloû1,5-a¨pyrimidines and fungicides containing them
EP0256503A3 (en)	1989-07-19	Pyridinecarboxamide derivatives and their use as fungicide
HUT38309A (en)	1986-05-28	Process for preparing new prostaglandin derivatives and pharmaceutical compositions containing such active substance
IL93061A0 (en)	1990-11-05	Benzo(1,8)naphthyridine derivatives,their preparation and compositions containing them
ES2068413T3 (es)	1995-04-16	Derivados de 4-fenilftalazina.
EP0288969A3 (en)	1990-05-23	Antiulcer composition
GR3020420T3 (en)	1996-10-31	Alkyl derivatives of trazodone with cns activity.
GR3007846T3 (is)	1993-08-31
AU631209B2 (en)	1992-11-19	Carboxamide derivatives
IE812975L (en)	1982-06-18	Use of azolylglycols as plant growth regulants
IL93062A0 (en)	1990-11-05	Benzo(1,8)naphthyridine derivatives,their preparation and compositions containing them
AU3626189A (en)	1989-12-14	New derivatives of phenothiazine, their preparation and the compositions which contain them
ES479378A1 (es)	1980-01-16	Un procedimiento para la preparacion de compuestos de cefa- losporina.
DE3362723D1 (en)	1986-04-30	Pyrido-triazoloquinazolines, their preparation and use
EP0443474A3 (en)	1992-04-22	1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents
CA2011668A1 (en)	1990-09-30	Germicidal composition