PH31443A - Imidazodiazepine. - Google Patents

Imidazodiazepine.

Info

Publication number: PH31443A
Authority: PH; Philippines
Prior art keywords: formula; lower alkyl; atom; imidazodiazepine; imidazodiazepines
Prior art date: 1994-03-16

Application number

PH50110A

Other languages

English (en)

Inventor

Godel Thierry

Hunkeler Walter

Widmer Ulrich

Stadler Heinz

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-16

Filing date

1995-03-10

Publication date

1998-11-03

1995-03-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1998-11-03 Publication of PH31443A publication Critical patent/PH31443A/en

Links

BMGXAZCDDYTVFV-UHFFFAOYSA-N imidazo[4,5-c]diazepine Chemical compound C1=CN=NC2=NC=NC2=C1 BMGXAZCDDYTVFV-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
MBDPOXAMXCPREM-UHFFFAOYSA-N 4-imidazo[4,5-c]diazepin-3-yloxadiazole Chemical class N1=NC2=NC=NC2=CC=C1C1=CON=N1 MBDPOXAMXCPREM-UHFFFAOYSA-N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Plant Substances (AREA)

PH50110A 1994-03-16 1995-03-10 Imidazodiazepine. PH31443A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH78394		1994-03-16
CH1095		1995-01-03

Publications (1)

Publication Number	Publication Date
PH31443A true PH31443A (en)	1998-11-03

Family

ID=25683249

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH50110A PH31443A (en)	1994-03-16	1995-03-10	Imidazodiazepine.

Country Status (27)

Country	Link
US (1)	US5665718A (is)
EP (1)	EP0672666B1 (is)
JP (1)	JP2690282B2 (is)
KR (1)	KR100214800B1 (is)
CN (1)	CN1036995C (is)
AT (1)	ATE203536T1 (is)
AU (1)	AU679608B2 (is)
BG (1)	BG62210B1 (is)
CA (1)	CA2143246C (is)
CZ (1)	CZ288594B6 (is)
DE (1)	DE59509432D1 (is)
DK (1)	DK0672666T3 (is)
ES (1)	ES2160646T3 (is)
FI (1)	FI112487B (is)
GR (1)	GR3037019T3 (is)
HU (1)	HU219987B (is)
IL (1)	IL112955A (is)
IS (1)	IS4273A (is)
LV (1)	LV11327B (is)
MA (1)	MA23479A1 (is)
NO (1)	NO303731B1 (is)
NZ (1)	NZ270685A (is)
PH (1)	PH31443A (is)
PT (1)	PT672666E (is)
RO (1)	RO117698B1 (is)
RU (1)	RU2139873C1 (is)
SK (1)	SK33995A3 (is)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW349100B (en) *	1994-11-11	1999-01-01	Hoffmann La Roche	Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5905176A (en) *	1998-08-28	1999-05-18	Eastman Chemical Company	Process for the production of cyclobutyl halides
WO2000069858A1 (en)	1999-05-12	2000-11-23	F. Hoffmann-La Roche Ag	Imidazodiazepine derivative
US7160880B1 (en) *	1999-05-14	2007-01-09	Cenes Limited	Short-acting benzodiazepines
RU2199309C1 (ru) *	2001-12-29	2003-02-27	Закрытое акционерное общество "Брынцалов-А"	Лекарственное средство нобрассит седативного и анксиолитического действия
US20060065608A1 (en) *	2004-09-29	2006-03-30	Choate Chris E	Process and apparatus for generating useful biomass from organic waste streams
EP1855679B1 (en) *	2005-01-19	2016-06-29	Merck Sharp & Dohme Corp.	Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease
CA2594946A1 (en) *	2005-01-19	2006-07-27	Merck & Co., Inc	Tertiary carbinamines having substituted heterocycles, which are active as inhibitors of beta-secretase, for the treatment of alzheimer's disease
US7595395B2 (en) *	2005-05-16	2009-09-29	Wisys Technology Foundation	Gabaergic agents to treat memory deficits
GB0613693D0 (en) *	2006-07-10	2006-08-16	Cenes Ltd	Benzodiazepine salts (3)
BRPI0714886B8 (pt)	2006-07-10	2021-05-25	Paion Uk Ltd	sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica
WO2009024324A2 (en) *	2007-08-20	2009-02-26	Evotec Neurosciences Gmbh	Treatment of sleep disorders
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
KR101589314B1 (ko)	2007-08-20	2016-01-28	에보텍 인터내셔널 게엠베하	수면 장애의 치료
RU2503681C2 (ru) *	2008-09-30	2014-01-10	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Новое конденсированное производное аминодигидротиазина
EP2450039A1 (en)	2010-11-08	2012-05-09	PAION UK Ltd.	Dosing regimen for sedation with CNS 7056 (Remimazolam)
PE20150683A1 (es)	2012-05-22	2015-06-03	Paion Uk Ltd	Composiciones que comprenden benzodiazepinas de accion corta
AR094963A1 (es)	2013-03-04	2015-09-09	Ono Pharmaceutical Co	Reacción de oxidación excelente en el índice de conversión
HUE038169T2 (hu)	2013-09-06	2018-09-28	Aurigene Discovery Tech Ltd	1,2,4-Oxadiazol származékok mint immunomodulátorok
KR102894264B1 (ko) *	2015-03-10	2025-12-02	오리진 온콜로지 리미티드	면역조절제로서의 1,2,4-옥사다이아졸 및 티아다이아졸 화합물
BR112017019304A2 (pt) *	2015-03-10	2018-05-08	Aurigene Discovery Technologies Limited	compostos de 1,2,4-oxadiazol 3-substituído e tiadiazol como imunomoduladores
US20190175613A1 (en)	2016-04-14	2019-06-13	Paion Uk Limited	Orally inhaled and nasal benzodiazepines
WO2019061324A1 (en)	2017-09-29	2019-04-04	Curis Inc.	CRYSTALLINE FORMS OF IMMUNOMODULATORS
EP3694841A1 (en)	2017-10-11	2020-08-19	Aurigene Discovery Technologies Limited	Crystalline forms of 3-substituted 1,2,4-oxadiazole
MY206121A (en)	2017-11-03	2024-11-29	Aurigene Discovery Tech Ltd	Dual inhibitors of tim-3 and pd-1 pathways
AU2018360389B2 (en)	2017-11-06	2024-09-19	Aurigene Oncology Limited	Conjoint therapies for immunomodulation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA755418B (en) *	1974-09-11	1977-06-29	Hoffmann La Roche	Diazepine derivatives
IL49161A (en) *	1975-08-07	1982-04-30	Sparamedica Ag	Imidazo(1,5-a)(1,4)-diazepine derivatives,their manufacture and pharmaceutical compositions containing them
DE2609486A1 (de) *	1975-08-07	1977-05-12	Hoffmann La Roche	Imidazo eckige klammer auf 1,5-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepin-verbindungen und verfahren zu ihrer herstellung
FI63033C (fi) *	1977-07-21	1983-04-11	Boehringer Sohn Ingelheim	Foerfarande foer framstaellning av anxiolytiska tranquilliserande sedativa och/eller neuroleptiska substituerade 1-piperazinyl-4h-s-triazolo(3,4-c)tieno(2,3-e)-1,4-diazepiner
DK151808C (da) *	1982-11-16	1988-06-20	Ferrosan As	Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
IL74070A (en) *	1984-01-19	1988-12-30	Hoffmann La Roche	Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
AU587802B2 (en) *	1985-03-08	1989-08-31	Ferrosan A/S	Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622320A (en) *	1985-05-17	1986-11-11	As Ferrosan	Oxadiazolylimidazobenzodiazepine, compositions, and method
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DK174086D0 (da) *	1986-04-16	1986-04-16	Ferrosan As	Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4904654A (en) *	1989-07-26	1990-02-27	Merck & Co., Inc.	7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
US4939139A (en) *	1989-07-26	1990-07-03	Merck & Co., Inc.	7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine

1995
- 1995-02-23 CA CA002143246A patent/CA2143246C/en not_active Expired - Lifetime
- 1995-03-03 DE DE59509432T patent/DE59509432D1/de not_active Expired - Lifetime
- 1995-03-03 PT PT95103028T patent/PT672666E/pt unknown
- 1995-03-03 EP EP95103028A patent/EP0672666B1/de not_active Expired - Lifetime
- 1995-03-03 AT AT95103028T patent/ATE203536T1/de active
- 1995-03-03 ES ES95103028T patent/ES2160646T3/es not_active Expired - Lifetime
- 1995-03-03 DK DK95103028T patent/DK0672666T3/da active
- 1995-03-10 AU AU14760/95A patent/AU679608B2/en not_active Expired
- 1995-03-10 NZ NZ270685A patent/NZ270685A/en not_active IP Right Cessation
- 1995-03-10 IL IL112955A patent/IL112955A/en not_active IP Right Cessation
- 1995-03-10 PH PH50110A patent/PH31443A/en unknown
- 1995-03-13 HU HU9500743A patent/HU219987B/hu not_active IP Right Cessation
- 1995-03-14 RU RU95103921A patent/RU2139873C1/ru active
- 1995-03-15 CN CN95102481A patent/CN1036995C/zh not_active Expired - Lifetime
- 1995-03-15 LV LVP-95-59A patent/LV11327B/lv unknown
- 1995-03-15 RO RO95-00534A patent/RO117698B1/ro unknown
- 1995-03-15 MA MA23807A patent/MA23479A1/fr unknown
- 1995-03-15 IS IS4273A patent/IS4273A/is unknown
- 1995-03-15 CZ CZ1995663A patent/CZ288594B6/cs not_active IP Right Cessation
- 1995-03-15 SK SK339-95A patent/SK33995A3/sk unknown
- 1995-03-15 NO NO950999A patent/NO303731B1/no not_active IP Right Cessation
- 1995-03-16 BG BG99505A patent/BG62210B1/bg unknown
- 1995-03-16 JP JP7057227A patent/JP2690282B2/ja not_active Expired - Lifetime
- 1995-03-16 FI FI951251A patent/FI112487B/fi not_active IP Right Cessation
- 1995-03-16 KR KR1019950005414A patent/KR100214800B1/ko not_active Expired - Lifetime
1996
- 1996-01-16 US US08/586,439 patent/US5665718A/en not_active Expired - Lifetime
2001
- 2001-10-25 GR GR20010401890T patent/GR3037019T3/el unknown

Also Published As

Publication number	Publication date
CN1036995C (zh)	1998-01-14
FI951251A7 (fi)	1995-09-17
RU95103921A (ru)	1996-12-10
RU2139873C1 (ru)	1999-10-20
NZ270685A (en)	1996-05-28
FI112487B (fi)	2003-12-15
HU9500743D0 (en)	1995-04-28
EP0672666B1 (de)	2001-07-25
CA2143246A1 (en)	1995-09-17
CZ66395A3 (en)	1995-10-18
BG99505A (en)	1996-01-31
LV11327B (en)	1996-10-20
IL112955A0 (en)	1995-06-29
SK33995A3 (en)	1995-10-11
EP0672666A3 (de)	1995-11-08
BG62210B1 (bg)	1999-05-31
CZ288594B6 (cs)	2001-07-11
HU219987B (hu)	2001-10-28
IL112955A (en)	1998-02-08
ATE203536T1 (de)	2001-08-15
PT672666E (pt)	2002-01-30
AU1476095A (en)	1995-09-28
NO303731B1 (no)	1998-08-24
EP0672666A2 (de)	1995-09-20
KR100214800B1 (ko)	1999-08-02
RO117698B1 (ro)	2002-06-28
JP2690282B2 (ja)	1997-12-10
HUT71817A (en)	1996-02-28
LV11327A (lv)	1996-06-20
CA2143246C (en)	2000-08-22
GR3037019T3 (en)	2002-01-31
CN1111632A (zh)	1995-11-15
AU679608B2 (en)	1997-07-03
FI951251A0 (fi)	1995-03-16
MA23479A1 (fr)	1995-10-01
IS4273A (is)	1995-09-17
ES2160646T3 (es)	2001-11-16
JPH07258260A (ja)	1995-10-09
US5665718A (en)	1997-09-09
NO950999L (no)	1995-09-18
KR950032199A (ko)	1995-12-20
DE59509432D1 (de)	2001-08-30
NO950999D0 (no)	1995-03-15
DK0672666T3 (da)	2001-11-12

Publication	Publication Date	Title
HU9500743D0 (en)	1995-04-28	Imidazodiazepine
DE3468878D1 (en)	1988-02-25	7-amino-azoloû1,5-a¨pyrimidines and fungicides containing them
EP0256503A3 (en)	1989-07-19	Pyridinecarboxamide derivatives and their use as fungicide
HUT38309A (en)	1986-05-28	Process for preparing new prostaglandin derivatives and pharmaceutical compositions containing such active substance
GR3005072T3 (is)	1993-05-24
IN164295B (is)	1989-02-11
IL93061A0 (en)	1990-11-05	Benzo(1,8)naphthyridine derivatives,their preparation and compositions containing them
ES2068413T3 (es)	1995-04-16	Derivados de 4-fenilftalazina.
HU9402119D0 (en)	1994-09-28	Alkyl derivatives of trazodone
GR3007846T3 (is)	1993-08-31
AU631209B2 (en)	1992-11-19	Carboxamide derivatives
IL93062A0 (en)	1990-11-05	Benzo(1,8)naphthyridine derivatives,their preparation and compositions containing them
AU3626189A (en)	1989-12-14	New derivatives of phenothiazine, their preparation and the compositions which contain them
ES479378A1 (es)	1980-01-16	Un procedimiento para la preparacion de compuestos de cefa- losporina.
DE3362723D1 (en)	1986-04-30	Pyrido-triazoloquinazolines, their preparation and use
EP0443474A3 (en)	1992-04-22	1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents
CA2011668A1 (en)	1990-09-30	Germicidal composition
IL80373A (en)	1990-09-17	Bisthiophosphate derivatives,their preparation and pesticidal compositions containing them