PH31469A - Tricyclic diazepine vasopressin antagonists and oxytocin antagonists. - Google Patents

Tricyclic diazepine vasopressin antagonists and oxytocin antagonists.

Info

Publication number: PH31469A
Authority: PH; Philippines
Prior art keywords: opt; substd; antagonists; satd; membered aromatic
Prior art date: 1993-07-29

Application number

PH48700A

Other languages

English (en)

Inventor

Jay D Albright

Marvin F Reich

Sum Fuk-Wah

Santos Efren G Delos

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-29

Filing date

1994-07-27

Publication date

1998-11-03

1994-07-27 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1998-11-03 Publication of PH31469A publication Critical patent/PH31469A/en

Links

LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 title abstract 2
229940116211 Vasopressin antagonist Drugs 0.000 title 1
239000003336 oxytocin antagonist Substances 0.000 title 1
229940121361 oxytocin antagonists Drugs 0.000 title 1
239000003038 vasopressin antagonist Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 4
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

PH48700A 1993-07-29 1994-07-27 Tricyclic diazepine vasopressin antagonists and oxytocin antagonists. PH31469A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10000493A	1993-07-29	1993-07-29

Publications (1)

Publication Number	Publication Date
PH31469A true PH31469A (en)	1998-11-03

Family

ID=22277643

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH48700A PH31469A (en)	1993-07-29	1994-07-27	Tricyclic diazepine vasopressin antagonists and oxytocin antagonists.

Country Status (28)

Country	Link
US (2)	US5516774A (pl)
EP (1)	EP0636625B1 (pl)
JP (1)	JP3782475B2 (pl)
KR (1)	KR100347479B1 (pl)
CN (2)	CN1039908C (pl)
AT (1)	ATE176234T1 (pl)
AU (1)	AU683660B2 (pl)
BR (1)	BR1100563A (pl)
CA (1)	CA2128956C (pl)
CZ (1)	CZ291322B6 (pl)
DE (1)	DE69416211T2 (pl)
DK (1)	DK0636625T3 (pl)
EC (1)	ECSP941137A (pl)
ES (1)	ES2129090T3 (pl)
FI (3)	FI110944B (pl)
GR (1)	GR3030069T3 (pl)
HU (1)	HU220707B1 (pl)
IL (1)	IL110435A (pl)
LV (1)	LV12497B (pl)
NO (1)	NO301827B1 (pl)
NZ (1)	NZ264115A (pl)
PE (1)	PE17895A1 (pl)
PH (1)	PH31469A (pl)
PL (1)	PL178563B1 (pl)
RU (1)	RU2126006C1 (pl)
SG (1)	SG47522A1 (pl)
SK (1)	SK280836B6 (pl)
ZA (1)	ZA945603B (pl)

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US5536718A (en) *	1995-01-17	1996-07-16	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
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US6511974B1 (en)	1997-07-30	2003-01-28	Wyeth	Tricyclic vasopressin agonists
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US6420358B1 (en)	1999-09-27	2002-07-16	American Cyanamid Company	Vasopressin antagonist and diuretic combination
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US7022699B2 (en)	2001-04-12	2006-04-04	Wyeth	Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US7326700B2 (en) *	2001-04-12	2008-02-05	Wyeth	Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
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US7064120B2 (en) *	2001-04-12	2006-06-20	Wyeth	Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7202239B2 (en) *	2001-04-12	2007-04-10	Wyeth	Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
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1994
- 1994-06-13 US US08/254,822 patent/US5516774A/en not_active Expired - Lifetime
- 1994-07-15 ES ES94111039T patent/ES2129090T3/es not_active Expired - Lifetime
- 1994-07-15 DK DK94111039T patent/DK0636625T3/da active
- 1994-07-15 AT AT94111039T patent/ATE176234T1/de active
- 1994-07-15 DE DE69416211T patent/DE69416211T2/de not_active Expired - Lifetime
- 1994-07-15 EP EP94111039A patent/EP0636625B1/en not_active Expired - Lifetime
- 1994-07-15 SG SG1996002643A patent/SG47522A1/en unknown
- 1994-07-20 SK SK881-94A patent/SK280836B6/sk not_active IP Right Cessation
- 1994-07-25 IL IL11043594A patent/IL110435A/xx not_active IP Right Cessation
- 1994-07-26 CZ CZ19941799A patent/CZ291322B6/cs not_active IP Right Cessation
- 1994-07-26 PE PE1994247526A patent/PE17895A1/es not_active Application Discontinuation
- 1994-07-27 PH PH48700A patent/PH31469A/en unknown
- 1994-07-27 CA CA002128956A patent/CA2128956C/en not_active Expired - Fee Related
- 1994-07-28 KR KR1019940018496A patent/KR100347479B1/ko not_active Expired - Fee Related
- 1994-07-28 NO NO942816A patent/NO301827B1/no not_active IP Right Cessation
- 1994-07-28 EC EC1994001137A patent/ECSP941137A/es unknown
- 1994-07-28 AU AU68777/94A patent/AU683660B2/en not_active Ceased
- 1994-07-28 NZ NZ264115A patent/NZ264115A/en not_active IP Right Cessation
- 1994-07-28 RU RU94027583A patent/RU2126006C1/ru not_active IP Right Cessation
- 1994-07-28 JP JP19585794A patent/JP3782475B2/ja not_active Expired - Lifetime
- 1994-07-28 HU HU9402219A patent/HU220707B1/hu not_active IP Right Cessation
- 1994-07-28 FI FI943543A patent/FI110944B/fi not_active IP Right Cessation
- 1994-07-28 ZA ZA945603A patent/ZA945603B/xx unknown
- 1994-07-29 PL PL94304498A patent/PL178563B1/pl not_active IP Right Cessation
- 1994-07-29 CN CN94108769A patent/CN1039908C/zh not_active Expired - Fee Related
1995
- 1995-06-06 US US08/468,737 patent/US5624923A/en not_active Expired - Lifetime
1997
- 1997-05-13 BR BR1100563-7A patent/BR1100563A/pt active IP Right Grant
1998
- 1998-02-10 CN CN98103834A patent/CN1056374C/zh not_active Expired - Fee Related
1999
- 1999-04-26 GR GR990401154T patent/GR3030069T3/el unknown
2000
- 2000-01-27 LV LVP-00-13A patent/LV12497B/lv unknown
2001
- 2001-06-07 FI FI20011207A patent/FI113868B/fi not_active IP Right Cessation
- 2001-06-07 FI FI20011206A patent/FI113867B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0636625A3 (en)	1995-05-17
CN1039908C (zh)	1998-09-23
HK1011363A1 (en)	1999-07-09
CN1205335A (zh)	1999-01-20
FI20011206L (fi)	2001-06-07
IL110435A0 (en)	1994-10-21
KR950003295A (ko)	1995-02-16
PL178563B1 (pl)	2000-05-31
ES2129090T3 (es)	1999-06-01
JPH07157486A (ja)	1995-06-20
RU94027583A (ru)	1996-07-20
PE17895A1 (es)	1995-07-18
BR1100563A (pt)	2000-02-08
AU6877794A (en)	1995-02-09
CN1056374C (zh)	2000-09-13
NO301827B1 (no)	1997-12-15
ATE176234T1 (de)	1999-02-15
CZ291322B6 (cs)	2003-02-12
LV12497A (en)	2000-06-20
EP0636625B1 (en)	1999-01-27
SK280836B6 (sk)	2000-08-14
KR100347479B1 (ko)	2002-12-06
US5624923A (en)	1997-04-29
EP0636625A2 (en)	1995-02-01
CA2128956C (en)	2004-10-05
US5516774A (en)	1996-05-14
DK0636625T3 (da)	1999-09-13
SG47522A1 (en)	1998-04-17
CA2128956A1 (en)	1995-01-30
CZ179994A3 (en)	1995-02-15
DE69416211D1 (de)	1999-03-11
FI113868B (fi)	2004-06-30
AU683660B2 (en)	1997-11-20
RU2126006C1 (ru)	1999-02-10
HU9402219D0 (en)	1994-09-28
DE69416211T2 (de)	1999-09-02
FI943543A0 (fi)	1994-07-28
FI943543L (fi)	1995-01-30
NO942816D0 (no)	1994-07-28
FI20011207L (fi)	2001-06-07
CN1106812A (zh)	1995-08-16
FI113867B (fi)	2004-06-30
GR3030069T3 (en)	1999-07-30
NZ264115A (en)	1997-10-24
ECSP941137A (es)	1995-02-27
NO942816L (no)	1995-01-30
HU220707B1 (hu)	2002-04-29
ZA945603B (en)	1995-03-09
HUT71495A (en)	1995-11-28
SK88194A3 (en)	1995-04-12
PL304498A1 (en)	1995-02-06
IL110435A (en)	2003-11-23
LV12497B (lv)	2000-09-20
JP3782475B2 (ja)	2006-06-07
FI110944B (fi)	2003-04-30

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NZ332605A (en)	2000-09-29	Tricyclic benzazepine vasopressin antagonists
HUT70962A (en)	1995-11-28	Hetero cyclic compounds condensed with benzene or thiophene ring and pharmaceutical compositions containing them
CA2318368A1 (en)	1999-08-05	Novel tricyclic compound
FI962043A0 (fi)	1996-05-14	Substituoidut 5-rengas-heterosyklit, niiden valmistus ja niiden käyttö
SE9002206D0 (sv)	1990-06-20	New compounds
PL309281A1 (en)	1995-10-02	Derivatives of 1,4-benzodiazepine and their application as cck modulators
GB9225347D0 (en)	1993-01-27	Photo reactive material
AU553859B2 (en)	1986-07-31	Tricyclic oxindole carboxamides
ES2141096T3 (es)	2000-03-16	Compuestos de cefalosporina y composiciones farmaceuticas de los mismos.
DE60218646D1 (de)	2007-04-19	N-biphenylcarbonyl- und n-phenylpyridylcarbonyl substituierte bi- and tricyclische azepine und diazepine als vasopressin-agonisten
GB9117979D0 (en)	1991-10-09	1-(n'-cyanoguanyl) derivatives of n-containing five-membered ring heterocycles
SE9401353D0 (sv)	1994-04-21	Novel antitumour compounds with antimitotic activity
KR950700225A (ko)	1995-01-16	Cck-수용체 길항제로써 유용한 벤조디아제핀 유도체(benzodiazepin derivatives useful as cck-receptor antagonists)
AP9400644A0 (en)	1995-11-26	Substituted pyrazolines.
GB1073227A (en)	1967-06-21	Azo dyes containing a dicarboximido group