PL117946B1 - Process for preparing novel thioethers of clavulanic acidjj kisloty - Google Patents
Process for preparing novel thioethers of clavulanic acidjj kisloty Download PDFInfo
- Publication number
- PL117946B1 PL117946B1 PL1977211081A PL21108177A PL117946B1 PL 117946 B1 PL117946 B1 PL 117946B1 PL 1977211081 A PL1977211081 A PL 1977211081A PL 21108177 A PL21108177 A PL 21108177A PL 117946 B1 PL117946 B1 PL 117946B1
- Authority
- PL
- Poland
- Prior art keywords
- group
- formula
- carbon atoms
- optionally substituted
- alkyl group
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003568 thioethers Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 239000007800 oxidant agent Substances 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 150000004967 organic peroxy acids Chemical group 0.000 claims 4
- 101100496169 Arabidopsis thaliana CLH1 gene Proteins 0.000 claims 3
- 101100044057 Mesocricetus auratus SYCP3 gene Proteins 0.000 claims 3
- 101100080600 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nse6 gene Proteins 0.000 claims 3
- 101150111293 cor-1 gene Proteins 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 229960003324 clavulanic acid Drugs 0.000 claims 2
- -1 clavulanic acid thioethers Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3892/76A GB1574906A (en) | 1976-01-31 | 1976-01-31 | Therapeutic compounds containing - lactams |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL117946B1 true PL117946B1 (en) | 1981-09-30 |
Family
ID=9766848
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1977211081A PL117946B1 (en) | 1976-01-31 | 1977-01-31 | Process for preparing novel thioethers of clavulanic acidjj kisloty |
| PL1977195694A PL107409B1 (pl) | 1976-01-31 | 1977-01-31 | Sposob wytwarzania nowych tioeterow kwasu klawulanowego |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1977195694A PL107409B1 (pl) | 1976-01-31 | 1977-01-31 | Sposob wytwarzania nowych tioeterow kwasu klawulanowego |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE850779A (fr) |
| GB (1) | GB1574906A (fr) |
| PL (2) | PL117946B1 (fr) |
| ZA (1) | ZA77258B (fr) |
| ZM (1) | ZM277A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE1550T1 (de) * | 1978-09-05 | 1982-09-15 | Beecham Group Plc | Clavulansaeurederivate, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen. |
| DE3062168D1 (en) * | 1979-04-21 | 1983-04-07 | Beecham Group Plc | Clavulanic acid derivatives, their preparation and use in pharmaceutical compositions |
| EP0127636A1 (fr) * | 1982-11-25 | 1984-12-12 | Beecham Group Plc | Composes contenant des beta-lactames |
-
1976
- 1976-01-31 GB GB3892/76A patent/GB1574906A/en not_active Expired
-
1977
- 1977-01-13 ZM ZM2/77A patent/ZM277A1/xx unknown
- 1977-01-19 ZA ZA77258A patent/ZA77258B/xx unknown
- 1977-01-26 BE BE174404A patent/BE850779A/fr not_active IP Right Cessation
- 1977-01-31 PL PL1977211081A patent/PL117946B1/pl unknown
- 1977-01-31 PL PL1977195694A patent/PL107409B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA77258B (en) | 1977-11-30 |
| PL107409B1 (pl) | 1980-02-29 |
| GB1574906A (en) | 1980-09-10 |
| BE850779A (fr) | 1977-07-26 |
| ZM277A1 (en) | 1977-09-21 |
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