PL146477B2 - Method of obtaining novel monoazo dyes - Google Patents

Method of obtaining novel monoazo dyes Download PDF

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PL146477B2
PL146477B2 PL26207186A PL26207186A PL146477B2 PL 146477 B2 PL146477 B2 PL 146477B2 PL 26207186 A PL26207186 A PL 26207186A PL 26207186 A PL26207186 A PL 26207186A PL 146477 B2 PL146477 B2 PL 146477B2
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chloro
monoazo dyes
methylthieno
ethoxycarbonyl
pyridine
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PL26207186A
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Polish (pl)
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PL262071A2 (en
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Description

Przedmiotem wynalazku jest sposób otrzymywania nowych barwników monoazowych o ogólnym wzorze 1, w którym Ar oznacza grupe 2-hydroksy-l-naftylowa lub 2-chloro-N,N/dieta- nolo/fenylowa. Barwniki te barwia poliamid i welne ewentualnie poliester na kolor oranzowy lub fioletowy.Sposobem wedlug wynalazku na 3-cyjano-4-metylo-2,6-dichloropirydyne dziala sie merkap- tooctanem etylu w srodowisku bezwodnego etanolu wobec weglanu sodu lub potasu, po czym uzyskana 3-amino-6-chloro-2-etoksykarbonylo -4-metylotieno[2,3-b]pirydyne o wzorze 2 poddaje sie reakcji diazowania i sprzega wytworzony zwiazek diazoniowy z 2-naftolem lub z m-chloro- N,N/2-hydroksyetylo/anilina. Uzyskiwana w sposobie wedlug wynalazku jako zwiazek przejs¬ ciowy 3-amino-6—chloro-2-etoksykarbonylo 4-metylotieno[2,3-b]pirydyna jest równiez zwiazkiem nowym.Sposób wedlug wynalazku ilustruja nastepujace przyklady, w których procenty ozanczaja procenty wagowe, a stopnie temperatury podano w stopniach Celsjusza: Przyklad I. Do mieszaniny 9,4 g (0,05 mola) 3-cyjano-4-metylo-2,6-dichloropirydyny, 5,3 g bezwodnego weglanu sodu i 100 cm3 absolutnego alkoholu etylowego, ogrzanej do temperatury 40°, dodano w ciagu 2 godzin, mieszajac, 6,0 g (0,05 mola) merkaptooctanu etylu. Calosc utrzymy¬ wano, mieszajac, w ciagu 8 godzin w temperaturze 40-42°, a nastepnie — w ciagu dalszych 8 godzin w temperaturze wrzenia. Z mieszaniny poreakcyjnej oddestylowano rozpuszczalnik, a pozostalosc przemyto trzykrotnie porcjami po 100 cm3 wody i po wysuszeniu rozpuszczono w benzenie i oczyszczono chromatograficznie na obojetnym tlenku glinu. Po oddzieleniu nieprzereagowanej 3-cyjano-4-metylo-2,6-dichloropirydyny i powstajacej ubocznie 3-cyjano-4-metylo-2—chloro -6- etoksykarbonylometylotiopirydyny wydzielono uzyskana 3-amino-6-chloro-2-etoksykarbonylo - 4-metylotieno[2,3-b]pirydyne, która krystalizowano z alkoholu etylowego (temperatura topnienia 138-139°).Oddzielnie dodano do 1,7 cm3 stezonego kwasu siarkowego w temperaturze -5-0°, 0,4 g azotynu sodowego i utrzymywano calosc w tej temperaturze w ciagu 30 minut, a nastepnie ogrzano ostroznie do temperatury 65° i utrzymywano w tych warunkach przy mieszaniu w ciagu 5 minut.Uzyskany w ten sposób kwas niktrozylosiarkowy ochlodzono do temperatury -5° i dodano do niego 2,5 cm stezonego kwasu siarkowego. Do wytworzonej mieszaniny dodano nastepnie w2 146 477 temperaturze - 5-0° 1,35 g (0,005 mola) otrzymanej opisanym wyzej sposobem 3-amino-6-chloro-2- -etoksykarbonylo -4-metylotieno[2,3-b]pirydyny w postaci pasty uzyskanej przy uzyciu 5 cm3 lodowatego kwasu octowego i 2,5 cm3 stezonego kwasu siarkowego. Paste przeniesiono ilosciowo do kwasu nitrozylosiarkowego, wyplukujac ja dwukrotnie porcjami po 1,5 cm3 kwasu octowego.Diazowanie prowadzono w ciagu 4 godzin w temperaturze - 2-0°. Sól diazoniowa wylano do 25 g lodu i odsaczono od niewielkiej ilosci czesci nierozpuszczalnych. Nastepnie klarowny roztwór dodano w ciagu 5 minut do 1,1 g (0,005 mola) m-chloro-N,N/2-hydroksyetylo/aniliny, rozpu¬ szczonej w 3 cm3 lodowatego kwasu octowego. Calosc alkalizowano, mieszajac, poczatkowo octatnem sodu, a nastepnie 20% wodnym roztworem wodorotlenku sodowego do pH okolo 6, chlodzac równoczesnie w lazni lodowej do temperatury 5-10°. Mieszanine sprzegajaca pozosta¬ wiono na 12 godzin w temperaturze 5-10°. Wydzielony osad odsaczono, rozdrobniono i zawie¬ szono w 200 cm3 wody, a nastepnie mieszano w ciagu 1 godziny. Przemyty w ten sposób osad wysuszono pod zmniejszonym cisnieniem nad stalym wodorotlenkiem potasu przez 3 doby.Jednorodnosc barwnika sprawdzono za pomoca chromatografii cienkowarstwowej. Uzyskano 1,62 g (wydajnosc 65,2%) barwnika w postaci czerwonego ciala stalego o temperaturze topnienia 80-85°. Barwnik ten barwi poliamid i welne na kolor oranzowy.IR (CHC13): 3400 (OH); 1720 (C = 0); 1260 (C-O) UV-vis (CH3OH): ^max = 420 nm, e = (l,24X 104) Przyklad II. Synteze i diazowanie 3-amino-6-chloro-2-etoksykarbonylo -4-metylotieno[2,3- -b]pirydyny prowadzono sposobem opisanym w przykladzie I. Uzyskany roztwór zwiazku diazo- nowego dodano nastepnie w ciagu 1 godziny do 0,73 g (0,005 mola) 2-naftolu, rozpuszczonego w 15 cm3 15% wodnego roztworu wodorotlenkusodowego. Podczas laczenia skladników mieszanine reakcyjna mieszano, chlodzono w lazni lodowej do temperatury 5-10° i alkalizowano 40% wodnym roztworem wodorotlenku sodowego do odczynu slabo alkalicznego. Nastepnie pozostawiono calosc na 12 godzin w temperaturze pokojowej. Osad barwnika wraz z domieszka soli nieorgani¬ cznych odsaczono, wilgotny osad zawieszono w 300 cm3 wody i mieszano w ciagu 1 godziny, a nastepnie odsaczono i wysuszono pod zmniejszonym cisnieniem nad stalym wodorotlenkiem potasu. Jednorodnosc barwnika sprawdzono za pomoca chromatografii cienkowarstwowej. Uzy¬ skano 1,95 g (91,5% wydajnosci) barwnika w postaci ciemnoczerwonego ciala stalego topiacego sie powyzej 280° z rozkladem. Barwnik ten barwi poliamid i welne na kolor czerwonooranzowy, a po zaprawie chromowej — poliamid, welne i poliester na kolor ciemnofioletowy.IR (KBr): 3400 (OH); 1700 (C = 0); 1250 (C-O) UV-vis (CH3OH): ;\max = 480 nm, £ = (0,77X 104) Zastrzezenie patentowe Sposób otrzymywania nowych barwników monoazowych o ogólnym wzorze 1, w którym Ar oznacza grupe 2-hydroksy-l-naftylowa lub 2-chloro-N,N/dietanolo/fenylowa, znamienny tym, ze na 3-cyjano-4-metylo-2,6-dichloropirydyne dziala sie merkaptooctanem etylu w srodowisku bez¬ wodnego etanolu wobec weglanu sodu lub potasu, po czym uzyskana 3-amino-6-chloro-2— - etoksykarbonylo-4-metylotieno[2,3-b]pirydyne o wzorze 2 poddaje sie reakcji diazowania i sprzega wytworzony zwiazek diazoniowy z 2-naftolem lub z m-chloro-N,N/2-hydroksyetylo/anilina.146477 CH3 N=N-Ar WZffR i CH3 NHa fYyCOOC2H5 mm 2 PLThe subject of the invention is a process for the preparation of new monoazo dyes of general formula I, in which Ar is a 2-hydroxy-1-naphthyl or 2-chloro-N, N / diethanol / phenyl group. These dyes dyes polyamide and wool or polyester an orange or violet color. According to the invention, 3-cyano-4-methyl-2,6-dichloropyridine is treated with ethyl mercaptoacetate in an anhydrous ethanol environment against sodium or potassium carbonate, and then obtained 3-amino-6-chloro-2-ethoxycarbonyl -4-methylthieno [2,3-b] pyridine of formula II is diazotized and the resulting diazonium compound is coupled with 2-naphthol or with m-chloro-N, N / 2 -hydroxyethyl / aniline. The 3-amino-6-chloro-2-ethoxycarbonyl 4-methylthieno [2,3-b] pyridine transition compound obtained in the process according to the invention is also a novel compound. and the temperature degrees are given in degrees Celsius: Example I. To a mixture of 9.4 g (0.05 mol) of 3-cyano-4-methyl-2,6-dichloropyridine, 5.3 g of anhydrous sodium carbonate and 100 cm3 of absolute alcohol heated to 40 ° C, 6.0 g (0.05 mol) of ethyl mercaptoacetate was added with stirring over a period of 2 hours. It was kept under stirring for 8 hours at 40-42 ° C, and then for a further 8 hours at reflux. The solvent was distilled off from the reaction mixture, the residue was washed three times with 100 cm3 of water each time, and after drying, it was dissolved in benzene and purified by chromatography over inert alumina. After separation of unreacted 3-cyano-4-methyl-2,6-dichloropyridine and the 3-cyano-4-methyl-2-chloro-6-ethoxycarbonylmethylthiopyridine byproduct, the resulting 3-amino-6-chloro-2-ethoxycarbonyl-4 was isolated. methylthieno [2,3-b] pyridine, which was crystallized from ethyl alcohol (m.p. 138-139 °). Separately, 0.4 g of sodium nitrite was added to 1.7 cm 3 of concentrated sulfuric acid at -5-0 ° and kept there. all at this temperature for 30 minutes, then heated carefully to 65 ° C and kept under these conditions with stirring for 5 minutes. The nicrosylsulfuric acid obtained in this way was cooled to -5 ° and 2.5 cm of conc. sulfuric acid. To the resulting mixture was then added at - 5-0 ° 1.35 g (0.005 mol) of the 3-amino-6-chloro-2-ethoxycarbonyl -4-methylthieno [2,3-b] pyridine prepared by the method described above. in the form of a paste obtained with 5 cm3 of glacial acetic acid and 2.5 cm3 of concentrated sulfuric acid. The paste was quantitatively transferred to nitrosyl sulfuric acid, rinsing it twice with 1.5 ml of acetic acid each. Diazotization was carried out for 4 hours at a temperature of -2-0 °. The diazonium salt was poured into 25 g of ice and a small amount of insoluble matter was filtered off. The clear solution was then added over 5 minutes to 1.1 g (0.005 mol) of m-chloro-N, N (2-hydroxyethyl) aniline, dissolved in 3 cm 3 of glacial acetic acid. The whole was made alkaline with stirring, initially with sodium acetate and then with 20% aqueous sodium hydroxide solution to a pH of about 6, while cooling in an ice bath to 5-10 °. The binder mixture was left for 12 hours at 5-10 °. The separated precipitate is filtered off, ground and suspended in 200 cm 3 of water, and then stirred for 1 hour. The thus washed precipitate was dried in vacuo over solid potassium hydroxide for 3 days. The homogeneity of the dye was checked by thin-layer chromatography. The yield was 1.62 g (yield 65.2%) of the red solid dye, mp 80-85 °. This dye dyes polyamide and wool amber. IR (CHC13): 3400 (OH); 1720 (C = 0); 1260 (C-O) UV-vis (CH3OH): ^ max = 420 nm, e = (1.24X104). Example II. The synthesis and diazotization of 3-amino-6-chloro-2-ethoxycarbonyl-4-methylthieno [2,3-b] pyridine was carried out as described in example I. The resulting diazonium solution was then added to 0.73 over 1 hour. g (0.005 mol) of 2-naphthol dissolved in 15 cm3 of a 15% aqueous sodium hydroxide solution. While combining the components, the reaction mixture was stirred, cooled in an ice bath to 5-10 ° and made alkaline with 40% aqueous sodium hydroxide solution until slightly alkaline. It was then left completely for 12 hours at room temperature. The precipitate of dye together with the admixture of inorganic salts was filtered off, the wet precipitate was suspended in 300 cm 3 of water and stirred for 1 hour, then filtered off and dried under reduced pressure over solid potassium hydroxide. Dye homogeneity was checked by thin layer chromatography. The yield was 1.95 g (91.5% yield) of a dark red solid dye that melts above 280 ° with decomposition. This dye dyes polyamide and wool reddish orange, and after the chrome mortar - polyamide, wool and polyester dark purple IR (KBr): 3400 (OH); 1700 (C = 0); 1250 (CO) UV-vis (CH3OH):; \ max = 480 nm, E = (0.77X104) Patent claim Method for the preparation of new monoazo dyes of general formula 1, where Ar is a 2-hydroxy-1-naphthyl group or 2-chloro-N, N (diethanol) phenyl, characterized in that the 3-cyano-4-methyl-2,6-dichloropyridine is treated with ethyl mercaptoacetate in an anhydrous ethanol environment in the presence of sodium or potassium carbonate, and then obtained 3-amino-6-chloro-2-ethoxycarbonyl-4-methylthieno [2,3-b] pyridine of formula II is diazotized and the resulting diazonium compound is reacted with 2-naphthol or with m-chloro-N, N) 2-Hydroxyethyl / aniline. 146477 CH3 N = N-Ar WZffR and CH3 NHa fYyCOOC2H5 mm 2 PL

Claims (1)

1. Zastrzezenie patentowe Sposób otrzymywania nowych barwników monoazowych o ogólnym wzorze 1, w którym Ar oznacza grupe 2-hydroksy-l-naftylowa lub 2-chloro-N,N/dietanolo/fenylowa, znamienny tym, ze na 3-cyjano-4-metylo-2,6-dichloropirydyne dziala sie merkaptooctanem etylu w srodowisku bez¬ wodnego etanolu wobec weglanu sodu lub potasu, po czym uzyskana 3-amino-6-chloro-2— - etoksykarbonylo-4-metylotieno[2,3-b]pirydyne o wzorze 2 poddaje sie reakcji diazowania i sprzega wytworzony zwiazek diazoniowy z 2-naftolem lub z m-chloro-N,N/2-hydroksyetylo/anilina.146477 CH3 N=N-Ar WZffR i CH3 NHa fYyCOOC2H5 mm 2 PLClaim 1. A process for the preparation of new monoazo dyes of general formula I, in which Ar is a 2-hydroxy-1-naphthyl or 2-chloro-N, N / diethanol / phenyl group, characterized by the fact that 3-cyano-4 is Methyl-2,6-dichloropyridine is treated with ethyl mercaptoacetate in an anhydrous ethanol environment in the presence of sodium or potassium carbonate, and the resulting 3-amino-6-chloro-2-ethoxycarbonyl-4-methylthieno [2,3-b] pyridine of formula 2 is subjected to a diazotization reaction and the resulting diazonium compound is coupled with 2-naphthol or with m-chloro-N, N / 2-hydroxyethyl / aniline. 146477 CH3 N = N-Ar WZffR and CH3 NHa fYyCOOC2H5 mm 2 EN
PL26207186A 1986-10-27 1986-10-27 Method of obtaining novel monoazo dyes PL146477B2 (en)

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