PL1611144T3 - Pochodne kwasu 2-(8,9-diokso-2,6-diazabicyklo(5.2.0)non-1(7)-en-2-ylo)alkilofosfonowego i ich zastosowanie jako antagonistów receptora N-metylo-D-asparaginianu (NMDA) - Google Patents

Pochodne kwasu 2-(8,9-diokso-2,6-diazabicyklo(5.2.0)non-1(7)-en-2-ylo)alkilofosfonowego i ich zastosowanie jako antagonistów receptora N-metylo-D-asparaginianu (NMDA)

Info

Publication number: PL1611144T3
Authority: PL; Poland
Prior art keywords: recetor; nmda; dioxo; diazabicyclo; aspartate
Prior art date: 2003-04-09

Application number

PL04759168T

Other languages

English (en)

Inventor

Reinhardt Bernhard Baudy

John Anthony Butera

Original Assignee

Wyeth Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-09

Filing date

2004-04-07

Publication date

2011-03-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33299828&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1611144(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-04-07 Application filed by Wyeth Llc filed Critical Wyeth Llc

2011-03-31 Publication of PL1611144T3 publication Critical patent/PL1611144T3/pl

Links

HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 2
-1 alkyl phosphonic acid Chemical compound 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Hematology (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Obesity (AREA)
Psychology (AREA)
Molecular Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL04759168T 2003-04-09 2004-04-07 Pochodne kwasu 2-(8,9-diokso-2,6-diazabicyklo(5.2.0)non-1(7)-en-2-ylo)alkilofosfonowego i ich zastosowanie jako antagonistów receptora N-metylo-D-asparaginianu (NMDA) PL1611144T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US46149003P	2003-04-09	2003-04-09
EP04759168A EP1611144B1 (en)	2003-04-09	2004-04-07	Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists
PCT/US2004/010596 WO2004092189A1 (en)	2003-04-09	2004-04-07	Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists

Publications (1)

Publication Number	Publication Date
PL1611144T3 true PL1611144T3 (pl)	2011-03-31

Family

ID=33299828

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04759168T PL1611144T3 (pl)	2003-04-09	2004-04-07	Pochodne kwasu 2-(8,9-diokso-2,6-diazabicyklo(5.2.0)non-1(7)-en-2-ylo)alkilofosfonowego i ich zastosowanie jako antagonistów receptora N-metylo-D-asparaginianu (NMDA)

Country Status (19)

Country	Link
US (2)	US7253153B2 (pl)
EP (1)	EP1611144B1 (pl)
JP (1)	JP4621659B2 (pl)
CN (1)	CN1863810B (pl)
AR (1)	AR044013A1 (pl)
AT (1)	ATE481103T1 (pl)
AU (1)	AU2004230895B2 (pl)
BR (1)	BRPI0409255A (pl)
CA (1)	CA2521313A1 (pl)
CL (1)	CL2004000769A1 (pl)
CY (1)	CY1110863T1 (pl)
DE (1)	DE602004029146D1 (pl)
DK (1)	DK1611144T3 (pl)
ES (1)	ES2350449T3 (pl)
MX (1)	MXPA05010760A (pl)
PL (1)	PL1611144T3 (pl)
PT (1)	PT1611144E (pl)
TW (1)	TWI349674B (pl)
WO (1)	WO2004092189A1 (pl)

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US7687080B2 (en)	2002-11-25	2010-03-30	Taraxos Inc.	Treatment of neuropathy
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
TW200514775A (en) *	2003-10-22	2005-05-01	Wyeth Corp	Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
ATE449780T1 (de) *	2004-10-08	2009-12-15	Wyeth Corp	Derivate von ä2-(8,9-dioxo-2,6- diazabicycloä5.2.0ünon-1(7)-en-2- yl)alkylüphosphonsäure und verfahren zu deren herstellung
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
US9126987B2 (en)	2006-11-30	2015-09-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase
JP5930573B2 (ja)	2007-03-01	2016-06-15	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤の新規使用
JP5667440B2 (ja)	2007-04-18	2015-02-12	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
EP2195031A1 (en) *	2007-08-27	2010-06-16	Wyeth a Corporation of the State of Delaware	Compositions and methods employing nmda antagonists for achieving an anesthetic-sparing effect
MY153749A (en)	2007-11-29	2015-03-13	Actelion Pharmaceuticals Ltd	Phosphonic acid derivates and their use as p2y12 receptor antagonists
AR071652A1 (es)	2008-04-11	2010-07-07	Actelion Pharmaceuticals Ltd	Derivados 2- fenil-piridina substituidos
AR071653A1 (es)	2008-04-11	2010-07-07	Actelion Pharmaceuticals Ltd	Derivados 2-fenil-4-ciclopropil-pirimidina
WO2010036937A1 (en) *	2008-09-27	2010-04-01	Taraxos Inc.	Topical formulations for treatment of neuropathy
KR101694563B1 (ko)	2009-04-08	2017-01-09	액테리온 파마슈티칼 리미티드	Ａｄｐ 수용체 길항제로서 6-(3-아자-비시클로〔3.1.0〕헥스-3-일)-2-페닐-피리미딘
PL2475428T3 (pl)	2009-09-11	2015-12-31	Probiodrug Ag	Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
EP2542549B1 (en)	2010-03-03	2016-05-11	Probiodrug AG	Inhibitors of glutaminyl cyclase
US8269019B2 (en)	2010-03-10	2012-09-18	Probiodrug Ag	Inhibitors
US8541596B2 (en)	2010-04-21	2013-09-24	Probiodrug Ag	Inhibitors
US8530670B2 (en)	2011-03-16	2013-09-10	Probiodrug Ag	Inhibitors
JP2014514300A (ja) *	2011-04-08	2014-06-19	スファエラファーマピーティーイーリミテッド	置換メチルホルミル試薬並びに化合物の物理化学的性質及び／又は薬物動態学的性質を改質するためのそれらの使用方法
DK3515924T3 (da)	2016-09-22	2022-03-21	Idorsia Pharmaceuticals Ltd	Krystallinske former
MY205605A (en)	2017-03-15	2024-10-29	Idorsia Pharmaceuticals Ltd	Subcutaneous administration of a p2y12 receptor antagonist
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa
US10902020B2 (en) *	2018-06-08	2021-01-26	International Business Machines Corporation	Multiple cache processing of streaming data

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DK1000072T3 (da)	1997-08-01	2003-04-22	Wyeth Corp	Fremgangsmåde til fremstilling af [2-((8,9)- dioxo-2,6-diazabicylo-[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonsyre
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US20040082543A1 (en)	2002-10-29	2004-04-29	Pharmacia Corporation	Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
MXPA05010763A (es) *	2003-04-09	2005-12-12	Wyeth Corp	Composiciones farmaceuticas para administracion intranasal de acido [2-(8, 9-dioxo-2, 6-diazabiciclo [5.2.0] non-1(7) -en-2-il) alquil- fosfonico] y metodos de uso del mismo.
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US20050142192A1 (en)	2003-10-15	2005-06-30	Wyeth	Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives

2004
- 2004-04-07 BR BRPI0409255-4A patent/BRPI0409255A/pt not_active IP Right Cessation
- 2004-04-07 MX MXPA05010760A patent/MXPA05010760A/es active IP Right Grant
- 2004-04-07 EP EP04759168A patent/EP1611144B1/en not_active Expired - Lifetime
- 2004-04-07 AT AT04759168T patent/ATE481103T1/de active
- 2004-04-07 DK DK04759168.0T patent/DK1611144T3/da active
- 2004-04-07 ES ES04759168T patent/ES2350449T3/es not_active Expired - Lifetime
- 2004-04-07 PL PL04759168T patent/PL1611144T3/pl unknown
- 2004-04-07 CN CN200480009542XA patent/CN1863810B/zh not_active Expired - Fee Related
- 2004-04-07 US US10/820,216 patent/US7253153B2/en not_active Expired - Fee Related
- 2004-04-07 PT PT04759168T patent/PT1611144E/pt unknown
- 2004-04-07 CA CA002521313A patent/CA2521313A1/en not_active Abandoned
- 2004-04-07 WO PCT/US2004/010596 patent/WO2004092189A1/en not_active Ceased
- 2004-04-07 AU AU2004230895A patent/AU2004230895B2/en not_active Ceased
- 2004-04-07 JP JP2006509747A patent/JP4621659B2/ja not_active Expired - Fee Related
- 2004-04-07 AR ARP040101199A patent/AR044013A1/es not_active Application Discontinuation
- 2004-04-07 DE DE602004029146T patent/DE602004029146D1/de not_active Expired - Lifetime
- 2004-04-08 TW TW093109670A patent/TWI349674B/zh not_active IP Right Cessation
- 2004-04-08 CL CL200400769A patent/CL2004000769A1/es unknown
2007
- 2007-06-01 US US11/757,006 patent/US7879825B2/en not_active Expired - Fee Related
2010
- 2010-10-25 CY CY20101100967T patent/CY1110863T1/el unknown

Also Published As

Publication number	Publication date
ES2350449T3 (es)	2011-01-24
CA2521313A1 (en)	2004-10-28
PT1611144E (pt)	2010-11-12
CN1863810B (zh)	2010-12-01
WO2004092189A1 (en)	2004-10-28
AU2004230895A1 (en)	2004-10-28
AR044013A1 (es)	2005-08-24
DK1611144T3 (da)	2010-11-22
TW200504085A (en)	2005-02-01
JP4621659B2 (ja)	2011-01-26
MXPA05010760A (es)	2005-12-12
US20050004080A1 (en)	2005-01-06
DE602004029146D1 (de)	2010-10-28
EP1611144A1 (en)	2006-01-04
ATE481103T1 (de)	2010-10-15
US20070225257A1 (en)	2007-09-27
AU2004230895B2 (en)	2010-09-09
US7879825B2 (en)	2011-02-01
EP1611144B1 (en)	2010-09-15
US7253153B2 (en)	2007-08-07
JP2006523694A (ja)	2006-10-19
CL2004000769A1 (es)	2005-02-04
CN1863810A (zh)	2006-11-15
TWI349674B (en)	2011-10-01
CY1110863T1 (el)	2015-06-10
BRPI0409255A (pt)	2006-03-28

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SI1611144T1 (sl)	2010-12-31	Derivati 2-(8,9-diokso-2,6-diazabiciklo(5.2.0)non-1(7)-en-2-il)alkil fosfonske kisline in njihova uporaba kot antagonisti N-metil-D-aspartat(NMDA) receptorja
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