PL1628979T3 - Związki diaminopirolochinazolinowe jako inhibitory białkowej fosfatazy tyrozynowej - Google Patents

Związki diaminopirolochinazolinowe jako inhibitory białkowej fosfatazy tyrozynowej

Info

Publication number: PL1628979T3
Authority: PL; Poland
Prior art keywords: protein tyrosine; tyrosine phosphatase; phosphatase inhibitors; compounds; diaminopyrroloquinazolines
Prior art date: 2003-05-15

Application number

PL04731581T

Other languages

English (en)

Inventor

Steven Joseph Berthel

Adrian Wai-Hing Cheung

Kyungjin Kim

Kshitij Chhabilbhai Thakkar

Weiya Yun

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-15

Filing date

2004-05-07

Publication date

2008-08-29

2004-05-07 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-08-29 Publication of PL1628979T3 publication Critical patent/PL1628979T3/pl

Links

WJIPXHXGFHECTD-UHFFFAOYSA-N C1=CC2=NC=CC2=C2NC(N)=NC(N)=C21 Chemical class C1=CC2=NC=CC2=C2NC(N)=NC(N)=C21 WJIPXHXGFHECTD-UHFFFAOYSA-N 0.000 title 1
239000003806 protein tyrosine phosphatase inhibitor Substances 0.000 title 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
101001087394 Homo sapiens Tyrosine-protein phosphatase non-receptor type 1 Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
102000002727 Protein Tyrosine Phosphatase Human genes 0.000 abstract 1
102100033001 Tyrosine-protein phosphatase non-receptor type 1 Human genes 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
108020000494 protein-tyrosine phosphatase Proteins 0.000 abstract 1
ACMYQAYEINJXQI-UHFFFAOYSA-N pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical class N1=CN=NC2=NC(N)=NC(N)=C21 ACMYQAYEINJXQI-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL04731581T 2003-05-15 2004-05-07 Związki diaminopirolochinazolinowe jako inhibitory białkowej fosfatazy tyrozynowej PL1628979T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US47080303P	2003-05-15	2003-05-15
US56358404P	2004-04-19	2004-04-19
PCT/EP2004/004896 WO2004101568A1 (en)	2003-05-15	2004-05-07	Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
EP04731581A EP1628979B1 (en)	2003-05-15	2004-05-07	Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors

Publications (1)

Publication Number	Publication Date
PL1628979T3 true PL1628979T3 (pl)	2008-08-29

Family

ID=33457200

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04731581T PL1628979T3 (pl)	2003-05-15	2004-05-07	Związki diaminopirolochinazolinowe jako inhibitory białkowej fosfatazy tyrozynowej

Country Status (15)

Country	Link
US (2)	US7262297B2 (pl)
EP (1)	EP1628979B1 (pl)
JP (1)	JP4551401B2 (pl)
KR (1)	KR100754624B1 (pl)
CN (1)	CN100344629C (pl)
AT (1)	ATE389657T1 (pl)
AU (1)	AU2004238512B2 (pl)
BR (1)	BRPI0410384A (pl)
CA (1)	CA2523960C (pl)
DE (1)	DE602004012552T2 (pl)
ES (1)	ES2301989T3 (pl)
MX (1)	MXPA05012207A (pl)
PL (1)	PL1628979T3 (pl)
RU (1)	RU2345079C2 (pl)
WO (1)	WO2004101568A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006028970A1 (en)	2004-09-02	2006-03-16	Cengent Therapeutics, Inc.	Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases
CN102918044A (zh) *	2010-05-21	2013-02-06	深圳信立泰药业股份有限公司	一种稠环喹唑啉类衍生物及其应用
EP3811945A1 (en)	2019-10-25	2021-04-28	UMC Utrecht Holding B.V.	Compounds for treating and preventing growth hormone receptor-dependent conditions
WO2025195460A1 (zh) *	2024-03-22	2025-09-25	深圳湾实验室坪山生物医药研发转化中心	稠环衍生物
WO2025253326A1 (ko) *	2024-06-05	2025-12-11	에스케이바이오팜 주식회사	Kras 저해제로서 신규한 3환 화합물 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE45427B1 (en) *	1976-07-09	1982-08-25	American Home Prod	Pyrrold 3,2if quinazoline-1,3-diamine and related compounds
US4451466A (en)	1982-07-02	1984-05-29	Shell Oil Company	Use of pyrroloquinazolinediamines as pesticides
ES2067744T3 (es) *	1989-06-09	1995-04-01	Upjohn Co	Aminas heterociclicas con actividad sobre el sistema nervioso central.
GB9123916D0 (en) *	1991-11-11	1992-01-02	Wellcome Found	Heterocyclic compounds
US6121271A (en)	1998-05-12	2000-09-19	American Home Products Corporation	Naphtho[2,3-B]heteroar-4-yl derivatives
US6110962A (en)	1998-05-12	2000-08-29	American Home Products Corporation	11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia
EP1370560B1 (en)	2001-02-23	2004-11-10	Ortho-McNeil Pharmaceutical, Inc.	Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists
US7226915B2 (en) *	2003-05-15	2007-06-05	Hoffmann-La Roche Inc.	Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors

2004
- 2004-04-30 US US10/836,507 patent/US7262297B2/en not_active Expired - Fee Related
- 2004-05-07 DE DE602004012552T patent/DE602004012552T2/de not_active Expired - Lifetime
- 2004-05-07 CN CNB2004800132363A patent/CN100344629C/zh not_active Expired - Fee Related
- 2004-05-07 PL PL04731581T patent/PL1628979T3/pl unknown
- 2004-05-07 WO PCT/EP2004/004896 patent/WO2004101568A1/en not_active Ceased
- 2004-05-07 KR KR1020057021803A patent/KR100754624B1/ko not_active Expired - Fee Related
- 2004-05-07 EP EP04731581A patent/EP1628979B1/en not_active Expired - Lifetime
- 2004-05-07 ES ES04731581T patent/ES2301989T3/es not_active Expired - Lifetime
- 2004-05-07 RU RU2005138897/04A patent/RU2345079C2/ru not_active IP Right Cessation
- 2004-05-07 BR BRPI0410384-0A patent/BRPI0410384A/pt not_active IP Right Cessation
- 2004-05-07 JP JP2006529760A patent/JP4551401B2/ja not_active Expired - Fee Related
- 2004-05-07 CA CA002523960A patent/CA2523960C/en not_active Expired - Fee Related
- 2004-05-07 AT AT04731581T patent/ATE389657T1/de active
- 2004-05-07 AU AU2004238512A patent/AU2004238512B2/en not_active Ceased
- 2004-05-07 MX MXPA05012207A patent/MXPA05012207A/es active IP Right Grant
2007
- 2007-06-27 US US11/823,776 patent/US20070270445A1/en not_active Abandoned

Also Published As

Publication number	Publication date
RU2005138897A (ru)	2007-06-27
CN1791603A (zh)	2006-06-21
KR20060012619A (ko)	2006-02-08
RU2345079C2 (ru)	2009-01-27
EP1628979B1 (en)	2008-03-19
DE602004012552D1 (de)	2008-04-30
CA2523960A1 (en)	2004-11-25
MXPA05012207A (es)	2006-02-08
ATE389657T1 (de)	2008-04-15
JP2006528216A (ja)	2006-12-14
BRPI0410384A (pt)	2006-07-18
CN100344629C (zh)	2007-10-24
US20040235872A1 (en)	2004-11-25
CA2523960C (en)	2009-09-22
US20070270445A1 (en)	2007-11-22
AU2004238512A1 (en)	2004-11-25
EP1628979A1 (en)	2006-03-01
WO2004101568A1 (en)	2004-11-25
JP4551401B2 (ja)	2010-09-29
KR100754624B1 (ko)	2007-09-05
ES2301989T3 (es)	2008-07-01
US7262297B2 (en)	2007-08-28
AU2004238512B2 (en)	2007-07-19
DE602004012552T2 (de)	2009-04-30

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