PL1636169T3 - Sposób dehydratacji podstawionych związków 4-dimetyloamino-2-arylobutan-2-olu i sposób wytwarzania podstawionych związków dimetylo-(3-arylo-butylo)-aminy za pomocą katalizy heterogenicznej - Google Patents

Sposób dehydratacji podstawionych związków 4-dimetyloamino-2-arylobutan-2-olu i sposób wytwarzania podstawionych związków dimetylo-(3-arylo-butylo)-aminy za pomocą katalizy heterogenicznej

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Publication number
PL1636169T3
PL1636169T3 PL04740107T PL04740107T PL1636169T3 PL 1636169 T3 PL1636169 T3 PL 1636169T3 PL 04740107 T PL04740107 T PL 04740107T PL 04740107 T PL04740107 T PL 04740107T PL 1636169 T3 PL1636169 T3 PL 1636169T3
Authority
PL
Poland
Prior art keywords
aryl
substituted
compounds
butyl
butan
Prior art date
Application number
PL04740107T
Other languages
English (en)
Inventor
Utz-Peter Jagusch
Wolfgang Hölderich
Monika Wissler
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of PL1636169T3 publication Critical patent/PL1636169T3/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL04740107T 2003-06-23 2004-06-21 Sposób dehydratacji podstawionych związków 4-dimetyloamino-2-arylobutan-2-olu i sposób wytwarzania podstawionych związków dimetylo-(3-arylo-butylo)-aminy za pomocą katalizy heterogenicznej PL1636169T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10328316A DE10328316A1 (de) 2003-06-23 2003-06-23 Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
PCT/EP2004/006666 WO2005000788A1 (de) 2003-06-23 2004-06-21 Verfahren zur dehydratisierung substituierter 4-dimethylamino-2-aryl-butan-2-ol-verbindungen und verfahren zur herstellung substituierter dimethyl-(3-aryl-butyl)-amin-verbindungen mittels heterogener katalyse
EP04740107A EP1636169B1 (de) 2003-06-23 2004-06-21 Verfahren zur dehydratisierung substituierter 4-dimethylamino-2-aryl-butan-2-ol-verbindungen und verfahren zur herstellung substituierter dimethyl-(3-aryl-butyl)-amin-verbindungen mittels heterogener katalyse

Publications (1)

Publication Number Publication Date
PL1636169T3 true PL1636169T3 (pl) 2010-11-30

Family

ID=33520871

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04740107T PL1636169T3 (pl) 2003-06-23 2004-06-21 Sposób dehydratacji podstawionych związków 4-dimetyloamino-2-arylobutan-2-olu i sposób wytwarzania podstawionych związków dimetylo-(3-arylo-butylo)-aminy za pomocą katalizy heterogenicznej

Country Status (11)

Country Link
US (2) US20060167318A1 (pl)
EP (1) EP1636169B1 (pl)
CN (2) CN101774932B (pl)
AT (1) ATE469877T1 (pl)
DE (2) DE10328316A1 (pl)
ES (1) ES2345658T3 (pl)
IL (1) IL172692A (pl)
PL (1) PL1636169T3 (pl)
PT (1) PT1636169E (pl)
SI (1) SI1636169T1 (pl)
WO (1) WO2005000788A1 (pl)

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DE10328316A1 (de) 2003-06-23 2005-01-20 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE102005052588A1 (de) 2005-11-02 2007-05-10 Grünenthal GmbH Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
TWI496762B (zh) 2006-07-24 2015-08-21 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
BRPI0714671B8 (pt) * 2006-07-24 2023-03-21 Janssen Pharmaceutica Nv Preparação de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina e compostos intermediários
CN102002065B (zh) * 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
US8288592B2 (en) 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
PL2519100T3 (pl) * 2009-12-29 2017-09-29 Mapi Pharma Limited Związki pośrednie i sposoby wytwarzania tapentadolu i pokrewnych związków
EP2542521A2 (en) 2010-03-05 2013-01-09 Actavis Group Ptc Ehf Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
CA2793948A1 (en) 2010-04-05 2011-10-20 Actavis Group Ptc Ehf Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
CN103168025B (zh) 2010-06-15 2015-02-25 格吕伦塔尔有限公司 用于制备取代的3-(1-氨基-2-甲基戊烷-3-基)苯基化合物的方法
CN110015955A (zh) * 2010-07-23 2019-07-16 格吕伦塔尔有限公司 3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚的盐或共晶体
US8853456B2 (en) 2010-08-16 2014-10-07 Indoco Remedies Limited Process for the preparation of tapentadol
EP2619174A4 (en) 2010-09-20 2014-05-14 Ind Swift Lab Ltd PROCESS FOR THE PREPARATION OF L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVES
EP2545028A4 (en) * 2011-01-27 2013-07-03 Symed Labs Ltd STEREOSPECIFIC SYNTHESIS OF (-) (2S, 3S) -1-DIMETHYLAMINO-3- (3-METHOXYPHENYL) -2-METHYLPENTAN-3-OLE
WO2012146978A2 (en) 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
WO2013105109A1 (en) 2011-11-09 2013-07-18 Indoco Remedies Limited Process for the preparation of tapentadol
WO2013090161A1 (en) 2011-12-12 2013-06-20 Boehringer Ingelheim International Gmbh Stereoselective synthesis of tapentadol and its salts
WO2013120466A1 (en) 2012-02-17 2013-08-22 Zentiva, K.S. A new solid form of tapentadol and a method of its preparation
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
US9090539B2 (en) 2013-05-24 2015-07-28 Ampac Fine Chemicals Llc Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
IN2013MU03670A (pl) 2013-11-21 2015-07-31 Unimark Remedies Ltd
EP3083551B1 (en) 2013-12-16 2018-02-14 Farma GRS, d.o.o. Crystalline form of tapentadol intermediate
CZ307492B6 (cs) 2014-02-04 2018-10-17 Zentiva, K.S. Pevná forma maleátu tapentadolu a způsob její přípravy
DK3166923T3 (da) * 2014-07-10 2023-04-11 SpecGx LLC Fremgangsmåde til fremstilling af substituerede phenylalkaner
US9914695B2 (en) 2015-07-10 2018-03-13 Mallinckrodt Llc Two-step process for preparing 3-substituted phenylalkylamines
CN112262121A (zh) * 2018-06-15 2021-01-22 法尔玛赞公司 用于制备他喷他多的新方法

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Also Published As

Publication number Publication date
ATE469877T1 (de) 2010-06-15
PT1636169E (pt) 2010-07-21
DE10328316A1 (de) 2005-01-20
WO2005000788A1 (de) 2005-01-06
US8704002B2 (en) 2014-04-22
US20060167318A1 (en) 2006-07-27
EP1636169A1 (de) 2006-03-22
ES2345658T3 (es) 2010-09-29
CN101774932A (zh) 2010-07-14
CN101774932B (zh) 2013-10-30
IL172692A (en) 2011-03-31
SI1636169T1 (sl) 2010-09-30
DE502004011239D1 (de) 2010-07-15
HK1088598A1 (en) 2006-11-10
US20130060065A1 (en) 2013-03-07
CN1809527A (zh) 2006-07-26
IL172692A0 (en) 2006-04-10
CN1809527B (zh) 2010-05-26
EP1636169B1 (de) 2010-06-02

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