PL1638933T3 - Pochodne n-pirolidyn-3-yloamidu jako inhibitory wychwytu zwrotnego serotoniny i noradrenaliny - Google Patents

Pochodne n-pirolidyn-3-yloamidu jako inhibitory wychwytu zwrotnego serotoniny i noradrenaliny

Info

Publication number: PL1638933T3
Authority: PL; Poland
Prior art keywords: noradrenaline; serotonin; pyrrolidin; amide derivatives; uptake inhibitors
Prior art date: 2003-06-17

Application number

PL04736241T

Other languages

English (en)

Inventor

Paul Vincent Fish

Michael Jonathan Fray

Alan Stobie

Florian Wakenhut

Gavin Alistair Whitlock

Alan Daniel Brown

Mark David Andrews;

Mark Ian Lansdell

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-17

Filing date

2004-06-07

Publication date

2008-10-31

2003-06-17 Priority claimed from GBGB0314048.0A external-priority patent/GB0314048D0/en

2004-06-07 Application filed by Pfizer filed Critical Pfizer

2008-10-31 Publication of PL1638933T3 publication Critical patent/PL1638933T3/pl

Links

QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
239000003112 inhibitor Substances 0.000 title 1
230000000966 norepinephrine reuptake Effects 0.000 title 1
NGXSWUFDCSEIOO-UHFFFAOYSA-N pyrrolidin-3-amine Chemical class NC1CCNC1 NGXSWUFDCSEIOO-UHFFFAOYSA-N 0.000 title 1
229940076279 serotonin Drugs 0.000 title 1
230000000697 serotonin reuptake Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Psychology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

PL04736241T 2003-06-17 2004-06-07 Pochodne n-pirolidyn-3-yloamidu jako inhibitory wychwytu zwrotnego serotoniny i noradrenaliny PL1638933T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB0314048.0A GB0314048D0 (en)	2003-06-17	2003-06-17	Novel compounds
US49312603P	2003-08-06	2003-08-06
PCT/IB2004/001943 WO2004110995A1 (en)	2003-06-17	2004-06-07	N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors
EP04736241A EP1638933B1 (en)	2003-06-17	2004-06-07	N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors

Publications (1)

Publication Number	Publication Date
PL1638933T3 true PL1638933T3 (pl)	2008-10-31

Family

ID=33554153

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04736241T PL1638933T3 (pl)	2003-06-17	2004-06-07	Pochodne n-pirolidyn-3-yloamidu jako inhibitory wychwytu zwrotnego serotoniny i noradrenaliny

Country Status (31)

Country	Link
US (2)	US7378436B2 (pl)
EP (1)	EP1638933B1 (pl)
JP (1)	JP4137159B2 (pl)
KR (1)	KR100803796B1 (pl)
AP (1)	AP2005003467A0 (pl)
AR (1)	AR044715A1 (pl)
AT (1)	ATE398107T1 (pl)
AU (1)	AU2004247487B2 (pl)
BR (1)	BRPI0411594A (pl)
CA (1)	CA2530159C (pl)
CY (1)	CY1110434T1 (pl)
DE (1)	DE602004014372D1 (pl)
DK (1)	DK1638933T3 (pl)
EA (1)	EA009881B1 (pl)
EC (1)	ECSP056232A (pl)
ES (1)	ES2305776T3 (pl)
HR (2)	HRP20080339T3 (pl)
IL (1)	IL172063A0 (pl)
IS (1)	IS8136A (pl)
MA (1)	MA27885A1 (pl)
MX (1)	MXPA05013960A (pl)
NL (1)	NL1026438C2 (pl)
NZ (1)	NZ544046A (pl)
PA (1)	PA8605301A1 (pl)
PE (1)	PE20050631A1 (pl)
PL (1)	PL1638933T3 (pl)
PT (1)	PT1638933E (pl)
SI (1)	SI1638933T1 (pl)
TW (1)	TW200505852A (pl)
UY (1)	UY28360A1 (pl)
WO (1)	WO2004110995A1 (pl)

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GB0425766D0 (en) *	2004-11-23	2004-12-22	Pfizer Ltd	Novel compounds
US7122683B2 (en)	2004-11-23	2006-10-17	Pfizer Inc.	Amides useful as monoamine re-uptake inhibitors
WO2006064336A2 (en) *	2004-12-14	2006-06-22	Pfizer Limited	N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenalin re-uptake inhibitors
WO2006064332A1 (en) *	2004-12-14	2006-06-22	Pfizer Limited	N-pyrrolidin-3yl-amide derivatives as serotonin and noradrenalin re-uptake inhibitors
TWI449692B (zh)	2005-05-13	2014-08-21	Otsuka Pharma Co Ltd	吡咯烷化合物（三）
ES2330788T3 (es)	2005-06-02	2009-12-15	F. Hoffmann-La Roche Ag	Derivados de piperidin-4-il-amida y su uso como antagonistas del subtipo 5 del receptor sst.
WO2007135530A2 (en) *	2006-05-22	2007-11-29	Pfizer Limited	Pharmaceutically & veterinarily suitable salt
US20080014152A1 (en) *	2006-07-13	2008-01-17	Di Mauro Thomas M	Intranasal delivery of clenbuterol across the cribriform plate and into the brain
JP5219465B2 (ja) *	2006-11-10	2013-06-26	大塚製薬株式会社	医薬
EP2119702A4 (en) *	2007-01-31	2010-12-08	Dainippon Sumitomo Pharma Co	amide derivative
JP2010189275A (ja) *	2007-06-14	2010-09-02	Dainippon Sumitomo Pharma Co Ltd	ナフタレン誘導体
US8263652B2 (en)	2007-10-31	2012-09-11	Sk Biopharmaceuticals Co., Ltd.	Stabilized pediatric suspension of carisbamate
JP5484069B2 (ja) *	2007-12-19	2014-05-07	大日本住友製薬株式会社	二環性へテロ環誘導体
ES2434250T3 (es)	2008-07-24	2013-12-16	Theravance, Inc.	Compuestos de 3-(fenoxifenilmetil)pirrolidina
NZ592543A (en)	2008-11-14	2013-02-22	Theravance Inc	4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
JP2012524098A (ja) *	2009-04-15	2012-10-11	セラヴァンス，インコーポレーテッド	３−（フェノキシピロリジン−３−イル−メチル）ヘテロアリール、３−（フェニルピロリジン−３−イルメトキシ）ヘテロアリールおよび３−（ヘテロアリールピロリジン−３−イルメトキシ）ヘテロアリール化合物
KR20120109292A (ko)	2009-06-24	2012-10-08	다이닛본 스미토모 세이야꾸 가부시끼가이샤	Ｎ-치환-시클릭 아미노 유도체
US7994209B2 (en)	2009-07-13	2011-08-09	Theravance, Inc.	3-phenoxymethylpyrrolidine compounds
JP5714580B2 (ja)	2009-07-21	2015-05-07	セラヴァンスバイオファーマアール＆ディーアイピー，エルエルシー	３−フェノキシメチルピロリジン化合物
US8778949B2 (en) *	2010-01-11	2014-07-15	Theravance Biopharma R&D Ip, Llc	1-(2-phenoxymethylphenyl)piperazine compounds
JP5769348B2 (ja) *	2010-03-22	2015-08-26	セラヴァンスバイオファーマアール＆ディーアイピー，エルエルシー	１−（２−フェノキシメチルヘテロアリール）ピペリジン化合物および１−（２−フェノキシメチルヘテロアリール）ピペラジン化合物
JP5873877B2 (ja)	2010-10-11	2016-03-01	セラヴァンスバイオファーマアール＆ディーアイピー，エルエルシー	セロトニン再取込みインヒビター
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WO2004009549A2 (en)	2002-07-18	2004-01-29	Actelion Pharmaceuticals Ltd	Piperidines useful for the treatment of central nervous system disorders
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KR101061352B1 (ko)	2002-12-20	2011-08-31	케모센트릭스	인간 종양-발현된 ｃｃｘｃｋｒ2의 저해물질
MXPA05013960A (es) *	2003-06-17	2006-02-24	Pfizer	Nuevos compuestos.

2004
- 2004-06-07 MX MXPA05013960A patent/MXPA05013960A/es active IP Right Grant
- 2004-06-07 AU AU2004247487A patent/AU2004247487B2/en not_active Expired - Fee Related
- 2004-06-07 ES ES04736241T patent/ES2305776T3/es not_active Expired - Lifetime
- 2004-06-07 AP AP2005003467A patent/AP2005003467A0/xx unknown
- 2004-06-07 DE DE602004014372T patent/DE602004014372D1/de not_active Expired - Lifetime
- 2004-06-07 CA CA002530159A patent/CA2530159C/en not_active Expired - Fee Related
- 2004-06-07 NZ NZ544046A patent/NZ544046A/en unknown
- 2004-06-07 DK DK04736241T patent/DK1638933T3/da active
- 2004-06-07 HR HR20080339T patent/HRP20080339T3/xx unknown
- 2004-06-07 HR HR20050993A patent/HRP20050993A2/hr not_active Application Discontinuation
- 2004-06-07 PT PT04736241T patent/PT1638933E/pt unknown
- 2004-06-07 KR KR1020057024147A patent/KR100803796B1/ko not_active Expired - Fee Related
- 2004-06-07 SI SI200430767T patent/SI1638933T1/sl unknown
- 2004-06-07 JP JP2006516540A patent/JP4137159B2/ja not_active Expired - Fee Related
- 2004-06-07 AT AT04736241T patent/ATE398107T1/de not_active IP Right Cessation
- 2004-06-07 BR BRPI0411594-5A patent/BRPI0411594A/pt not_active IP Right Cessation
- 2004-06-07 PL PL04736241T patent/PL1638933T3/pl unknown
- 2004-06-07 WO PCT/IB2004/001943 patent/WO2004110995A1/en not_active Ceased
- 2004-06-07 EA EA200501730A patent/EA009881B1/ru not_active IP Right Cessation
- 2004-06-07 EP EP04736241A patent/EP1638933B1/en not_active Expired - Lifetime
- 2004-06-14 UY UY28360A patent/UY28360A1/es not_active Application Discontinuation
- 2004-06-14 PE PE2004000590A patent/PE20050631A1/es not_active Application Discontinuation
- 2004-06-16 AR ARP040102082A patent/AR044715A1/es not_active Application Discontinuation
- 2004-06-16 PA PA20048605301A patent/PA8605301A1/es unknown
- 2004-06-16 TW TW093117317A patent/TW200505852A/zh unknown
- 2004-06-17 NL NL1026438A patent/NL1026438C2/nl not_active IP Right Cessation
- 2004-06-17 US US10/872,160 patent/US7378436B2/en not_active Expired - Fee Related
2005
- 2005-11-20 IL IL172063A patent/IL172063A0/en unknown
- 2005-11-21 IS IS8136A patent/IS8136A/is unknown
- 2005-12-16 MA MA28674A patent/MA27885A1/fr unknown
- 2005-12-16 EC EC2005006232A patent/ECSP056232A/es unknown
2008
- 2008-05-21 US US12/124,755 patent/US20080306123A1/en not_active Abandoned
- 2008-08-14 CY CY20081100869T patent/CY1110434T1/el unknown

Also Published As

Publication number	Publication date
TW200505852A (en)	2005-02-16
NZ544046A (en)	2009-08-28
NL1026438A1 (nl)	2004-12-20
UY28360A1 (es)	2005-01-31
CY1110434T1 (el)	2015-04-29
IL172063A0 (en)	2009-02-11
PA8605301A1 (es)	2005-02-04
DE602004014372D1 (de)	2008-07-24
AR044715A1 (es)	2005-09-21
PE20050631A1 (es)	2005-09-14
BRPI0411594A (pt)	2006-08-29
AU2004247487A1 (en)	2004-12-23
EA200501730A1 (ru)	2006-08-25
CA2530159A1 (en)	2004-12-23
EP1638933B1 (en)	2008-06-11
PT1638933E (pt)	2008-07-22
DK1638933T3 (da)	2008-07-28
US20050137229A1 (en)	2005-06-23
NL1026438C2 (nl)	2005-09-20
CA2530159C (en)	2010-02-02
US7378436B2 (en)	2008-05-27
KR100803796B1 (ko)	2008-02-14
JP2006527758A (ja)	2006-12-07
MXPA05013960A (es)	2006-02-24
MA27885A1 (fr)	2006-05-02
WO2004110995A8 (en)	2005-04-21
JP4137159B2 (ja)	2008-08-20
AU2004247487B2 (en)	2010-05-20
US20080306123A1 (en)	2008-12-11
HRP20050993A2 (en)	2006-03-31
ATE398107T1 (de)	2008-07-15
WO2004110995A1 (en)	2004-12-23
ES2305776T3 (es)	2008-11-01
HRP20080339T3 (en)	2008-08-31
SI1638933T1 (sl)	2008-10-31
ECSP056232A (es)	2006-04-19
IS8136A (is)	2005-11-21
EA009881B1 (ru)	2008-04-28
AP2005003467A0 (en)	2006-12-31
EP1638933A1 (en)	2006-03-29
KR20060036927A (ko)	2006-05-02

Publication	Publication Date	Title
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AP2048A (en)	2009-09-24	Diazepinoindole derivatives as kinase inhibitors
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PL364580A1 (pl)	2004-12-13	Pochodne cyklopropyloindolu jako selektywne inhibitory zwrotnego wychwytu serotoniny
ZA200603233B (en)	2008-11-26	Dihydrobenzofuranyl alkanamine derivatives as 5HT 2c agonists
SI1492785T1 (sl)	2009-06-30	2-hidroksi-3-heteroarilindolni derivati kot inhibitorji GSK3
IS2732B (is)	2011-04-15	Fenýl-píperidín afleiður sem serótónín endurupptökuhindrar
AU2003271566A8 (en)	2004-03-03	Pyrrolopyrazines as kinase inhibitors
IL165515A0 (en)	2006-01-15	Bisindolyl-maleimid derivatives as kinase inhibitors
AU2003288444A1 (en)	2004-08-23	Methods and compositions for preventing fracture proppant flowback
IL172132A0 (en)	2006-04-10	Thienopyridone derivatives as kinase inhibitors
GB0325192D0 (en)	2003-12-03	Method of use
GB0314054D0 (en)	2003-07-23	Amide derivatives as selective serotonin re-uptake inhibitors
IL169323A0 (en)	2007-07-04	Pyrazole-derivatives as factor xa inhibitors
TWI368482B (en)	2012-07-21	New 2-pyridinylethylbenzamide derivatives
EP1667989A4 (en)	2008-08-20	SUBSTITUTED ISOQUINOLEINONES
IL154343A0 (en)	2003-09-17	Phenoxybenzylamine derivatives as selective serotonin re-uptake inhibitors
PL374581A1 (pl)	2005-10-31	Diaminotiazole przydatne jako selektywne inhibitory CDK4
EP1670739A4 (en)	2007-08-08	CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS
IL173521A0 (en)	2006-07-05	Substituted 2 - carbonylamino - 6 piperidinaminopyidines and substituted 1 - carbonylamino - 3 - piperidinaminobenzenes as 5 - th1f agonists
IL173904A0 (en)	2006-07-05	Combinations comprising alpha-2-delta ligands and serotonin/noradrenaline re-uptake inhibitors
IL172542A0 (en)	2006-04-10	2-hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide
PL373533A1 (pl)	2005-09-05	Pochodne eteru fenylowo-heterocyklilowego jako inhibitory ponownego wychwytu serotoniny
ZA200606070B (en)	2007-12-27	Substituted quinolines and their use as mycrobacterial inhibitors
IL176772A0 (en)	2006-10-31	Acylaminothiazole derivatives and use thereof as beta-amyloid inhibitors