PL1638938T3 - Związki, kompozycje i sposoby do leczenia i zapobiegania infekcjom ortopokswirusami i powiązanym chorobom - Google Patents

Związki, kompozycje i sposoby do leczenia i zapobiegania infekcjom ortopokswirusami i powiązanym chorobom

Info

Publication number
PL1638938T3
PL1638938T3 PL04776765T PL04776765T PL1638938T3 PL 1638938 T3 PL1638938 T3 PL 1638938T3 PL 04776765 T PL04776765 T PL 04776765T PL 04776765 T PL04776765 T PL 04776765T PL 1638938 T3 PL1638938 T3 PL 1638938T3
Authority
PL
Poland
Prior art keywords
prevention
compositions
compounds
treatment
methods
Prior art date
Application number
PL04776765T
Other languages
English (en)
Inventor
Robert Jordan
Thomas R Bailey
Susan R Rippin
Original Assignee
Siga Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siga Tech Inc filed Critical Siga Tech Inc
Publication of PL1638938T3 publication Critical patent/PL1638938T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL04776765T 2003-06-20 2004-06-18 Związki, kompozycje i sposoby do leczenia i zapobiegania infekcjom ortopokswirusami i powiązanym chorobom PL1638938T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48018203P 2003-06-20 2003-06-20
PCT/US2004/019552 WO2004112718A2 (en) 2003-06-20 2004-06-18 Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
EP04776765.2A EP1638938B1 (en) 2003-06-20 2004-06-18 Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases

Publications (1)

Publication Number Publication Date
PL1638938T3 true PL1638938T3 (pl) 2017-10-31

Family

ID=33539267

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04776765T PL1638938T3 (pl) 2003-06-20 2004-06-18 Związki, kompozycje i sposoby do leczenia i zapobiegania infekcjom ortopokswirusami i powiązanym chorobom

Country Status (11)

Country Link
EP (1) EP1638938B1 (pl)
JP (2) JP4884216B2 (pl)
AU (1) AU2004249250C1 (pl)
BE (1) BE2022C521I2 (pl)
CA (1) CA2529761C (pl)
DK (1) DK1638938T3 (pl)
ES (1) ES2632313T3 (pl)
FR (1) FR22C1022I1 (pl)
NL (1) NL301177I2 (pl)
PL (1) PL1638938T3 (pl)
WO (1) WO2004112718A2 (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8530509B2 (en) 2003-06-20 2013-09-10 Siga Technologies, Inc. Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
AU2012268859B2 (en) * 2003-06-20 2016-05-05 Siga Technologies, Inc. Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US7737168B2 (en) 2003-06-20 2010-06-15 Siga Technologies, Inc. Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
EP1638938B1 (en) * 2003-06-20 2017-04-12 Siga Technologies Inc. Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
MY141198A (en) * 2004-08-30 2010-03-31 Janssen Pharmaceutica Nv Tricyclic adamantylamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
US8410149B2 (en) 2004-12-06 2013-04-02 Siga Technologies Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
CA2590962A1 (en) 2004-12-06 2006-06-15 Siga Technologies, Inc. Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
US7994221B2 (en) 2004-12-06 2011-08-09 Siga Technologies, Inc. Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses
JP2008535862A (ja) * 2005-04-08 2008-09-04 キメリクス，インコーポレイテッド ポックスウイルス感染の治療のための化合物、組成物および方法
JP2008538354A (ja) * 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
EP3006425A1 (en) 2007-04-23 2016-04-13 Siga Technologies, Inc. Pharmaceutical composition for use in the treatment and prevention of orthopoxvirus infections and associated diseases
EP2254582B1 (en) 2008-01-25 2016-01-20 Chimerix, Inc. Methods of treating viral infections
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
RU2412168C1 (ru) * 2009-12-02 2011-02-20 Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФГУН ГНЦ ВБ "Вектор" Роспотребнадзора) Гидрат n-{3,5-диоксо-4-азатетрацикло[5.3.2.02,6.08,10]додец-11-ен-4-ил}-2-гидроксибензамида, обладающий противовирусной активностью в отношении ортопоксвирусов
RU2412167C1 (ru) * 2009-12-02 2011-02-20 Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФГУН ГНЦ ВБ "Вектор" Роспотребнадзора) {3,5-диоксо-4-азатетрацикло[5.3.2.02,6.08,10]додец-11-ен-4-ил}тиомочевина, обладающая противовирусной активностью в отношении ортопоксвирусов
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
SG184201A1 (en) 2010-03-23 2012-10-30 Siga Technologies Inc Polymorphic forms st-246 and methods of preparation
US9278135B2 (en) 2010-04-26 2016-03-08 Chimerix Inc. Methods of treating retroviral infections and related dosage regimes
CN103281898A (zh) * 2010-08-05 2013-09-04 西佳科技股份有限公司 St-246液体配制物以及方法
CN101906064A (zh) * 2010-08-09 2010-12-08 中国人民解放军军事医学科学院微生物流行病研究所 St-246的立体异构体的制备方法
RU2440983C1 (ru) * 2010-09-28 2012-01-27 Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) Метил, хлор и нитропроизводные n-{3, 5-диоксо-4-азатетрацикло[5.3.2.02,6.08,10]додец-11-ен-4-ил}-2-гидроксибензамида-противовирусные препараты, ингибирующие репликацию различных видов ортопоксвирусов
EP3321253B1 (en) 2012-08-16 2020-02-12 Siga Technologies, Inc. Method of preparing tecovirimat
CA3246369A1 (en) * 2013-07-19 2025-10-30 Siga Technologies, Inc. Amorphous tecovirimat preparation
JP2025510303A (ja) * 2022-03-27 2025-04-14 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ラノステロール合成酵素の低分子阻害剤
CN116003309B (zh) * 2022-08-12 2025-03-04 深圳微芯生物科技股份有限公司 一类酰肼类化合物、其制备方法及其应用
CN116730995B (zh) * 2022-08-12 2024-06-25 深圳微芯生物科技股份有限公司 一类酰肼类化合物、其制备方法及其应用

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US2906755A (en) * 1956-11-16 1959-09-29 Schenley Ind Inc N-acyl derivatives of alpha-pyridine carboxylic acid hydrazide
US4061763A (en) * 1975-05-09 1977-12-06 Merck & Co., Inc. Tricyclicdicarboximides
JPS5247844A (en) * 1975-10-15 1977-04-16 Ube Ind Ltd Elastomer compositions
JPS6483065A (en) * 1987-09-25 1989-03-28 Hitachi Chemical Co Ltd Endo-cis-3,6-cyclopropylene-tetra(or hexa)hydrophthalic acid imide derivative and antiarhythmic agent
US5068356A (en) * 1990-02-20 1991-11-26 Atochem North America, Inc. Hindered phenolic n-(amido)imides
US6596771B2 (en) 2001-01-12 2003-07-22 Schering Corporation Drugs for treating viral infections
US6433016B1 (en) * 2001-01-12 2002-08-13 Vassil Stefanov Georgiev Drugs for treating viral infections
US20040087548A1 (en) * 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP1638938B1 (en) * 2003-06-20 2017-04-12 Siga Technologies Inc. Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases

Also Published As

Publication number Publication date
ES2632313T3 (es) 2017-09-12
NL301177I2 (nl) 2022-08-23
JP2011252019A (ja) 2011-12-15
AU2004249250A1 (en) 2004-12-29
DK1638938T3 (en) 2017-07-31
JP4884216B2 (ja) 2012-02-29
FR22C1022I1 (fr) 2022-07-22
EP1638938A2 (en) 2006-03-29
JP5657489B2 (ja) 2015-01-21
NL301177I1 (nl) 2022-06-08
JP2007521273A (ja) 2007-08-02
BE2022C521I2 (pl) 2024-04-23
AU2004249250B2 (en) 2011-09-01
WO2004112718A3 (en) 2005-04-07
EP1638938B1 (en) 2017-04-12
EP1638938A4 (en) 2008-09-17
WO2004112718A2 (en) 2004-12-29
AU2004249250C1 (en) 2012-04-12
CA2529761C (en) 2013-08-13
CA2529761A1 (en) 2004-12-29

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