PL1648426T3 - Pochodne benzimidazolu i ich zastosowanie jako inhibitorów kinaz białkowych - Google Patents
Pochodne benzimidazolu i ich zastosowanie jako inhibitorów kinaz białkowychInfo
- Publication number
- PL1648426T3 PL1648426T3 PL04743172T PL04743172T PL1648426T3 PL 1648426 T3 PL1648426 T3 PL 1648426T3 PL 04743172 T PL04743172 T PL 04743172T PL 04743172 T PL04743172 T PL 04743172T PL 1648426 T3 PL1648426 T3 PL 1648426T3
- Authority
- PL
- Poland
- Prior art keywords
- protein kinases
- benzimidazole derivatives
- kinases inhibitors
- inhibitors
- benzimidazole
- Prior art date
Links
- 102000001253 Protein Kinase Human genes 0.000 title 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 108060006633 protein kinase Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48468503P | 2003-07-03 | 2003-07-03 | |
| GBGB0315657.7A GB0315657D0 (en) | 2003-07-03 | 2003-07-03 | Pharmaceutical compounds |
| US51437403P | 2003-10-24 | 2003-10-24 | |
| GB0324919A GB0324919D0 (en) | 2003-10-24 | 2003-10-24 | Pharmaceutical compounds |
| PCT/GB2004/002824 WO2005002552A2 (en) | 2003-07-03 | 2004-07-05 | Benzimidazole derivatives and their use as protein kinases inhibitors |
| EP04743172.1A EP1648426B1 (en) | 2003-07-03 | 2004-07-05 | Benzimidazole derivatives and their use as protein kinases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1648426T3 true PL1648426T3 (pl) | 2014-05-30 |
Family
ID=46045485
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04743172T PL1648426T3 (pl) | 2003-07-03 | 2004-07-05 | Pochodne benzimidazolu i ich zastosowanie jako inhibitorów kinaz białkowych |
| PL10195498T PL2305250T3 (pl) | 2003-07-03 | 2004-07-05 | Pochodne benzimidazolu i ich zastosowanie jako inhibitorów kinaz białkowych |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10195498T PL2305250T3 (pl) | 2003-07-03 | 2004-07-05 | Pochodne benzimidazolu i ich zastosowanie jako inhibitorów kinaz białkowych |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7977477B2 (pl) |
| EP (2) | EP2305250B1 (pl) |
| JP (1) | JP4833059B2 (pl) |
| CN (1) | CN1845734B (pl) |
| AU (1) | AU2004253338B2 (pl) |
| CA (1) | CA2531050C (pl) |
| DK (2) | DK2305250T3 (pl) |
| ES (2) | ES2443995T3 (pl) |
| MX (1) | MXPA05014223A (pl) |
| NZ (1) | NZ543959A (pl) |
| PL (2) | PL1648426T3 (pl) |
| PT (2) | PT1648426E (pl) |
| SI (2) | SI2305250T1 (pl) |
| TW (1) | TWI372050B (pl) |
| WO (1) | WO2005002552A2 (pl) |
Families Citing this family (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| CA2532965C (en) | 2003-07-22 | 2013-05-14 | Astex Therapeutics Limited | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| EP1694686A1 (en) | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
| MXPA06008606A (es) | 2004-01-30 | 2007-04-13 | Vertex Pharma | Moduladores de transportadores con casete de union a atp. |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| JP2008505167A (ja) * | 2004-07-05 | 2008-02-21 | アステックス、セラピューティックス、リミテッド | 医薬組成物 |
| WO2006023931A2 (en) | 2004-08-18 | 2006-03-02 | Takeda San Diego, Inc. | Kinase inhibitors |
| EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| EP1807074B1 (en) | 2004-11-03 | 2013-10-23 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| JP2008526721A (ja) | 2004-12-30 | 2008-07-24 | アステックス、セラピューティックス、リミテッド | Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するチアゾールおよびイソチアゾール誘導体 |
| WO2006070198A1 (en) * | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
| MX2007008008A (es) * | 2004-12-30 | 2007-11-12 | Astex Therapeutics Ltd | Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora. |
| CN101146532B (zh) * | 2005-01-21 | 2012-05-09 | 阿斯泰克斯治疗有限公司 | 药物化合物 |
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| RU2436575C2 (ru) * | 2005-01-21 | 2011-12-20 | Астекс Терапьютикс Лимитед | Соединения для использования в фармацевтике |
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| US20040242559A1 (en) | 2003-04-25 | 2004-12-02 | Aventis Pharma S.A. | Novel indole derivatives, preparation thereof as medicinal products and pharmaceutical compositions, and especially as KDR inhibitors |
| FR2854159B1 (fr) * | 2003-04-25 | 2008-01-11 | Aventis Pharma Sa | Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr |
| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| GB0315657D0 (en) | 2003-07-03 | 2003-08-13 | Astex Technology Ltd | Pharmaceutical compounds |
| US20050032869A1 (en) | 2003-07-08 | 2005-02-10 | Pharmacia Italia S.P.A. | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| WO2005028624A2 (en) | 2003-09-15 | 2005-03-31 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
| CA2545942C (en) | 2003-11-14 | 2012-07-10 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| JP3977411B2 (ja) | 2004-03-10 | 2007-09-19 | 株式会社クレハ | アミン系塩基性化合物とその用途 |
| JP2008526721A (ja) | 2004-12-30 | 2008-07-24 | アステックス、セラピューティックス、リミテッド | Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するチアゾールおよびイソチアゾール誘導体 |
| MX2007008008A (es) | 2004-12-30 | 2007-11-12 | Astex Therapeutics Ltd | Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora. |
| US8399442B2 (en) * | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
| EP2043635A2 (en) | 2006-06-29 | 2009-04-08 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5523829B2 (ja) | 2006-06-29 | 2014-06-18 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| EP2073807A1 (en) * | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
-
2004
- 2004-07-02 TW TW093120042A patent/TWI372050B/zh not_active IP Right Cessation
- 2004-07-05 PL PL04743172T patent/PL1648426T3/pl unknown
- 2004-07-05 PT PT47431721T patent/PT1648426E/pt unknown
- 2004-07-05 EP EP10195498.0A patent/EP2305250B1/en not_active Expired - Lifetime
- 2004-07-05 SI SI200432146T patent/SI2305250T1/sl unknown
- 2004-07-05 CN CN2004800249288A patent/CN1845734B/zh not_active Expired - Fee Related
- 2004-07-05 JP JP2006518329A patent/JP4833059B2/ja not_active Expired - Fee Related
- 2004-07-05 MX MXPA05014223A patent/MXPA05014223A/es active IP Right Grant
- 2004-07-05 US US10/564,166 patent/US7977477B2/en not_active Expired - Fee Related
- 2004-07-05 PT PT101954980T patent/PT2305250E/pt unknown
- 2004-07-05 CA CA2531050A patent/CA2531050C/en not_active Expired - Fee Related
- 2004-07-05 ES ES04743172.1T patent/ES2443995T3/es not_active Expired - Lifetime
- 2004-07-05 DK DK10195498.0T patent/DK2305250T3/da active
- 2004-07-05 PL PL10195498T patent/PL2305250T3/pl unknown
- 2004-07-05 NZ NZ543959A patent/NZ543959A/en not_active IP Right Cessation
- 2004-07-05 SI SI200432125T patent/SI1648426T1/sl unknown
- 2004-07-05 ES ES10195498.0T patent/ES2457466T3/es not_active Expired - Lifetime
- 2004-07-05 EP EP04743172.1A patent/EP1648426B1/en not_active Expired - Lifetime
- 2004-07-05 WO PCT/GB2004/002824 patent/WO2005002552A2/en not_active Ceased
- 2004-07-05 DK DK04743172.1T patent/DK1648426T3/da active
- 2004-07-05 AU AU2004253338A patent/AU2004253338B2/en not_active Ceased
-
2011
- 2011-05-26 US US13/116,121 patent/US20110224203A1/en not_active Abandoned
-
2013
- 2013-05-24 US US13/902,325 patent/US20140010892A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2531050A1 (en) | 2005-01-13 |
| US7977477B2 (en) | 2011-07-12 |
| AU2004253338A1 (en) | 2005-01-13 |
| US20140010892A1 (en) | 2014-01-09 |
| WO2005002552A3 (en) | 2005-06-16 |
| SI2305250T1 (sl) | 2014-06-30 |
| US20070135477A1 (en) | 2007-06-14 |
| CN1845734B (zh) | 2011-06-22 |
| SI1648426T1 (sl) | 2014-04-30 |
| WO2005002552A2 (en) | 2005-01-13 |
| ES2443995T3 (es) | 2014-02-21 |
| TW200524598A (en) | 2005-08-01 |
| US20110224203A1 (en) | 2011-09-15 |
| EP1648426B1 (en) | 2014-01-08 |
| DK1648426T3 (da) | 2014-02-10 |
| TWI372050B (en) | 2012-09-11 |
| JP2007516194A (ja) | 2007-06-21 |
| JP4833059B2 (ja) | 2011-12-07 |
| PL2305250T3 (pl) | 2014-07-31 |
| EP2305250B1 (en) | 2014-03-26 |
| NZ543959A (en) | 2009-08-28 |
| EP1648426A2 (en) | 2006-04-26 |
| AU2004253338B2 (en) | 2010-02-18 |
| EP2305250A1 (en) | 2011-04-06 |
| CN1845734A (zh) | 2006-10-11 |
| MXPA05014223A (es) | 2006-07-03 |
| PT1648426E (pt) | 2014-03-07 |
| ES2457466T3 (es) | 2014-04-25 |
| PT2305250E (pt) | 2014-05-19 |
| CA2531050C (en) | 2013-04-09 |
| DK2305250T3 (da) | 2014-04-22 |
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