PL1648899T3 - Imidazo-pirymidyny i triazolo-pirymidyny: ligandy benzodiazepinowego receptora - Google Patents

Imidazo-pirymidyny i triazolo-pirymidyny: ligandy benzodiazepinowego receptora

Info

Publication number
PL1648899T3
PL1648899T3 PL04779031T PL04779031T PL1648899T3 PL 1648899 T3 PL1648899 T3 PL 1648899T3 PL 04779031 T PL04779031 T PL 04779031T PL 04779031 T PL04779031 T PL 04779031T PL 1648899 T3 PL1648899 T3 PL 1648899T3
Authority
PL
Poland
Prior art keywords
pyrimidines
triazolo
imidazo
receptor ligands
benzodiazepine receptor
Prior art date
Application number
PL04779031T
Other languages
English (en)
Inventor
Linghong Xie
Bingsong Han
Yuelian Xu
George Maynard
Bertrand L Chenard
Kenneth Shaw
Yang Gao
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of PL1648899T3 publication Critical patent/PL1648899T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL04779031T 2003-07-25 2004-07-23 Imidazo-pirymidyny i triazolo-pirymidyny: ligandy benzodiazepinowego receptora PL1648899T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49000603P 2003-07-25 2003-07-25
US54308304P 2004-02-09 2004-02-09
PCT/US2004/023794 WO2005012306A2 (en) 2003-07-25 2004-07-23 Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
EP04779031A EP1648899B1 (en) 2003-07-25 2004-07-23 Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands

Publications (1)

Publication Number Publication Date
PL1648899T3 true PL1648899T3 (pl) 2007-06-29

Family

ID=34118813

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04779031T PL1648899T3 (pl) 2003-07-25 2004-07-23 Imidazo-pirymidyny i triazolo-pirymidyny: ligandy benzodiazepinowego receptora

Country Status (20)

Country Link
US (2) US7271170B2 (pl)
EP (1) EP1648899B1 (pl)
JP (1) JP2007500130A (pl)
KR (1) KR20060098425A (pl)
AR (1) AR045117A1 (pl)
AT (1) ATE350382T1 (pl)
AU (1) AU2004261591A1 (pl)
BR (1) BRPI0412908A (pl)
CA (1) CA2537331A1 (pl)
CY (1) CY1107565T1 (pl)
DE (1) DE602004004143T2 (pl)
DK (1) DK1648899T3 (pl)
ES (1) ES2278345T3 (pl)
IL (1) IL173265A0 (pl)
MX (1) MXPA06000887A (pl)
NZ (1) NZ544262A (pl)
PL (1) PL1648899T3 (pl)
PT (1) PT1648899E (pl)
TW (1) TW200524937A (pl)
WO (1) WO2005012306A2 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482366B2 (en) * 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
EP1619948A4 (en) * 2003-05-05 2007-02-14 Neurogen Corp SUBSTITUTED IMIDAZOLOPYRAZINE AND TRIAZOLOPYRAZINE DERIVATIVES: GABAA RECEPTOR LIGANDS
WO2006093911A2 (en) * 2005-03-02 2006-09-08 Neurogen Corporation Thiazolylmethyl and oxazolylmethyl heteroaryl derivatives
EP1928237A4 (en) 2005-09-02 2011-03-09 Abbott Lab NEW HETEROCYCLES BASED ON IMIDAZO
JP2010523716A (ja) * 2007-04-11 2010-07-15 サイプレス バイオサイエンシズ，インク． ベンゾジアゼピン受容体拮抗薬を用いるダウン症候群の治療
US8546394B2 (en) 2007-04-17 2013-10-01 Bristol-Myers Squibb Company Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
US20090270373A1 (en) * 2008-04-11 2009-10-29 Cypress Biosciences, Inc. Treatment of down syndrom with benzodiazepine receptor antagonists

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US544057A (en) * 1895-08-06 Bill and letter file
DE60014339T8 (de) * 1999-04-02 2006-04-27 Neurogen Corp., Branford Aryl- und heteroaryl-kondensierte aminoalkyl-imidazol-derivate: selektive modulatoren der gabaa-rezeptoren
US6737242B1 (en) 1999-05-07 2004-05-18 Neurogen Corporation Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9929687D0 (en) 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
US6552037B2 (en) 2000-06-30 2003-04-22 Neurogen Corporation 2-Substituted imidazo[1,2-A]pyridine derivatives
GB0027561D0 (en) * 2000-11-10 2000-12-27 Merck Sharp & Dohme Therapeutic agents
US6900215B2 (en) * 2000-12-15 2005-05-31 Merck Sharp & Dohme Ltd. Imidazo-pyrimidine derivatives as ligands for gaba receptors
PA8535601A1 (es) * 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
TWI248936B (en) * 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors
US7030128B2 (en) 2001-03-23 2006-04-18 Merck Sharp & Dohme Ltd. Imidazo-pyrimidine derivatives as ligands for GABA receptors
IL159811A0 (en) 2001-07-13 2004-06-20 Neurogen Corp Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
US7030144B2 (en) 2002-05-02 2006-04-18 Neurogen Corporation Substituted imidazole derivatives: GABAA receptor ligands
CA2484936A1 (en) 2002-05-08 2004-05-21 Neurogen Corporation Substituted imidazolylmethyl pyridine and pyrazine derivatives and their use as gabaa receptor ligands
JP2006502974A (ja) 2002-05-17 2006-01-26 ニューロジェン コーポレイション 置換環縮合イミダゾール誘導体：ｇａｂａａ受容体リガンド
CN100579579C (zh) 2002-10-01 2010-01-13 诺华疫苗和诊断公司 抗癌及抗感染性疾病组合物及其使用方法
DE60307499T2 (de) 2002-11-08 2007-02-01 Neurogen Corp., Branford 4-imidazol-1-ylmethylpyrimidinderivate als liganden für gabaa-rezeptoren
EP1619948A4 (en) 2003-05-05 2007-02-14 Neurogen Corp SUBSTITUTED IMIDAZOLOPYRAZINE AND TRIAZOLOPYRAZINE DERIVATIVES: GABAA RECEPTOR LIGANDS

Also Published As

Publication number Publication date
US20050038043A1 (en) 2005-02-17
KR20060098425A (ko) 2006-09-18
NZ544262A (en) 2009-06-26
US7271170B2 (en) 2007-09-18
DE602004004143T2 (de) 2007-10-11
BRPI0412908A (pt) 2006-09-26
WO2005012306A3 (en) 2005-04-14
MXPA06000887A (es) 2006-04-19
TW200524937A (en) 2005-08-01
HK1089446A1 (en) 2006-12-01
EP1648899B1 (en) 2007-01-03
DK1648899T3 (da) 2007-04-02
US20080139580A1 (en) 2008-06-12
ES2278345T3 (es) 2007-08-01
DE602004004143D1 (de) 2007-02-15
WO2005012306A2 (en) 2005-02-10
JP2007500130A (ja) 2007-01-11
ATE350382T1 (de) 2007-01-15
IL173265A0 (en) 2006-06-11
CA2537331A1 (en) 2005-02-10
PT1648899E (pt) 2007-03-30
CY1107565T1 (el) 2013-03-13
AR045117A1 (es) 2005-10-19
AU2004261591A1 (en) 2005-02-10
EP1648899A2 (en) 2006-04-26

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