PL1651260T3 - Lawsonia intracellularis pochodzenia europejskiego oraz szczepionki, środki diagnostyczne i sposoby ją wykorzystujące - Google Patents

Lawsonia intracellularis pochodzenia europejskiego oraz szczepionki, środki diagnostyczne i sposoby ją wykorzystujące

Info

Publication number: PL1651260T3
Authority: PL; Poland
Prior art keywords: intracellularis; vaccines; methods; diagnostic agents; lawsonia intracellularis
Prior art date: 2003-07-25

Application number

PL04778282T

Other languages

English (en)

Other versions

PL1651260T5 (pl

Inventor

Michael B Roof

Jeremy J Kroll

Jeffrey P Knittel

Original Assignee

Boehringer Ingelheim Vetmedica Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-25

Filing date

2004-07-15

Publication date

2010-02-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34115340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1651260(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-07-15 Application filed by Boehringer Ingelheim Vetmedica Inc filed Critical Boehringer Ingelheim Vetmedica Inc

2010-02-26 Publication of PL1651260T3 publication Critical patent/PL1651260T3/pl

2018-11-30 Publication of PL1651260T5 publication Critical patent/PL1651260T5/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Gram-negative bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/825—Bacterial vaccine for porcine species, e.g. swine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Mycology (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
General Engineering & Computer Science (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL04778282T 2003-07-25 2004-07-15 Lawsonia intracellularis pochodzenia europejskiego oraz szczepionki, środki diagnostyczne i sposoby ją wykorzystujące PL1651260T5 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US49000103P	2003-07-25	2003-07-25
EP04778282.6A EP1651260B2 (en)	2003-07-25	2004-07-15	Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof
PCT/US2004/022704 WO2005011731A1 (en)	2003-07-25	2004-07-15	Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof

Publications (2)

Publication Number	Publication Date
PL1651260T3 true PL1651260T3 (pl)	2010-02-26
PL1651260T5 PL1651260T5 (pl)	2018-11-30

Family

ID=34115340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL04778282T PL1651260T5 (pl)	2003-07-25	2004-07-15	Lawsonia intracellularis pochodzenia europejskiego oraz szczepionki, środki diagnostyczne i sposoby ją wykorzystujące

Country Status (23)

Country	Link
US (2)	US7312065B2 (pl)
EP (1)	EP1651260B2 (pl)
JP (1)	JP2006528882A (pl)
KR (1)	KR101131845B1 (pl)
CN (2)	CN101423811A (pl)
AT (1)	ATE442163T2 (pl)
AU (1)	AU2004260657B2 (pl)
BR (1)	BRPI0412911B1 (pl)
CA (1)	CA2533559C (pl)
CY (1)	CY1109652T1 (pl)
DE (1)	DE602004023094D1 (pl)
DK (1)	DK1651260T4 (pl)
ES (1)	ES2333334T5 (pl)
MX (1)	MXPA06000994A (pl)
MY (1)	MY140208A (pl)
PL (1)	PL1651260T5 (pl)
PT (1)	PT1651260E (pl)
RU (1)	RU2420570C2 (pl)
SG (1)	SG144909A1 (pl)
SI (1)	SI1651260T2 (pl)
UA (1)	UA87665C2 (pl)
WO (1)	WO2005011731A1 (pl)
ZA (1)	ZA200510081B (pl)

Families Citing this family (41)

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FR2772047B1 (fr) *	1997-12-05	2004-04-09	Ct Nat D Etudes Veterinaires E	Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
UA95602C2 (ru)	2004-12-30	2011-08-25	Берингер Ингельхейм Ветмедика, Инк.	Иммуногенная композиция цвс2 и способы приготовления такой композиции
US7833707B2 (en)	2004-12-30	2010-11-16	Boehringer Ingelheim Vetmedica, Inc.	Methods of overexpression and recovery of porcine circovirus type 2 ORF2
US8834891B2 (en)	2005-03-14	2014-09-16	Boehringer Ingelheim Vetmedica, Inc.	Immunogenic compositions comprising Lawsonia intracellularis
AU2012207016B2 (en) *	2005-03-14	2015-01-15	Boehringer Ingelheim Animal Health USA Inc.	Immunogenic compositions comprising Lawsonia intracellularis
US8398994B2 (en) *	2005-07-15	2013-03-19	Boehringer Ingelheim Vetmedica, Inc.	Lawsonia vaccine and methods of use thereof
MX338626B (es)	2005-12-29	2016-04-26	Boehringer Ingelheim Vetmed	Uso de una composicion inmunogenica de pcv2 para producir los sintomas clinicos en cerdos.
EP1968630B1 (en)	2005-12-29	2018-01-24	Boehringer Ingelheim Vetmedica, Inc.	Multivalent pcv2 immunogenic compositions
US8470336B2 (en) *	2006-05-25	2013-06-25	Boehringer Ingelheim Vetmedica, Inc.	Vaccination of young animals against Lawsonia intracellularis infections
US20080241190A1 (en) *	2006-11-13	2008-10-02	Boehringer Ingelheim Vetmedica, Inc.	Vaccination of horses against lawsonia intracellularis
EP2099927A4 (en) *	2006-11-22	2010-05-05	Boehringer Ingelheim Vetmed	Methods of reducing porcine circovirus-associated disease outbreaks
EP2859900A1 (en)	2006-12-11	2015-04-15	Boehringer Ingelheim Vetmedica, Inc.	Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
JP5200223B2 (ja) *	2006-12-15	2013-06-05	ベーリンガーインゲルハイムフェトメディカインコーポレイテッド	Ｐｃｖ２抗原によるブタの処置
EP1941903A1 (en)	2007-01-03	2008-07-09	Boehringer Ingelheim Vetmedica Gmbh	Prophylaxis and treatment of PRDC
EP1958644A1 (en)	2007-02-13	2008-08-20	Boehringer Ingelheim Vetmedica Gmbh	Prevention and treatment of sub-clinical pcvd
US7829274B2 (en)	2007-09-04	2010-11-09	Boehringer Ingelheim Vetmedica, Inc.	Reduction of concomitant infections in pigs by the use of PCV2 antigen
TW200918666A (en) *	2007-09-11	2009-05-01	Wyeth Corp	Attenuated mycoplasma gallisepticum strains
WO2009037262A2 (en)	2007-09-17	2009-03-26	Boehringer Ingelheim Vetmedica, Inc.	Method of preventing early lawsonia intracellularis infections
WO2009088950A2 (en) *	2007-12-31	2009-07-16	Boehringer Ingelheim Vetmedica, Inc.	Pcv2 orf2 virus like particle with foreign amino acid insertion
KR20100113582A (ko) *	2008-01-23	2010-10-21	베링거잉겔하임베트메디카인코퍼레이티드	Ｐｃｖ2 마이코플라즈마 히오뉴모니에 면역원성 조성물 및 당해 조성물의 생산 방법
US20110033495A1 (en) *	2008-02-15	2011-02-10	Boehringer Ingelheim Vetmedica, Inc.	Methods and compositions for reducing the impact of enteric diseases
TWI551295B (zh)	2008-04-18	2016-10-01	英特威特國際股份有限公司	防備胞內勞森菌（Ｌａｗｓｏｎｉａｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）用疫苗
TWI449533B (zh) *	2008-04-18	2014-08-21	Intervet Int Bv	防備胞內勞森菌（Ｌａｗｓｏｎｉａｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）、豬肺炎黴漿菌（Ｍｙｃｏｐｌａｓｍａｈｙｏｐｎｅｕｍｏｎｉａｅ）及豬環狀病毒（Ｐｏｒｃｉｎｅｃｉｒｃｏｖｉｒｕｓ）用疫苗
US8557254B2 (en)	2008-07-22	2013-10-15	Intervet Inc.	Lawsonia intracellularis bacterium of a novel serotype, vaccine based on that bacterium, antibodies suitable for diagnosing the novel Lawsonia intracellularis serotype and hybridomas for producing the said antibodies
US8142760B2 (en) *	2008-09-05	2012-03-27	Nathan Len Winkelman	Vaccination for Lawsonia intracellularis
WO2011006880A1 (en) *	2009-07-14	2011-01-20	Intervet International B.V.	Lawsonia intracellularis propagation
AR078253A1 (es)	2009-09-02	2011-10-26	Boehringer Ingelheim Vetmed	Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
US8530223B2 (en)	2009-11-09	2013-09-10	Intervet International B.V.	Method to grow Lawsonia intracellularis bacteria in persistently infected McCoy cells
AU2011230619C1 (en)	2010-03-25	2016-06-23	Oregon Health & Science University	CMV glycoproteins and recombinant vectors
HUE037408T2 (hu)	2011-06-10	2018-08-28	Univ Oregon Health & Science	CMV glikoproteinek és rekombináns vektorok
EP3049106A1 (en)	2013-09-25	2016-08-03	Zoetis Services LLC	Pcv2b divergent vaccine composition and methods of use
US9505808B2 (en)	2013-10-02	2016-11-29	Boehringer Ingelheim Vetmedica, Inc.	PCV2 ORF2 protein variant and virus like particles composed thereof
JP6488304B2 (ja)	2013-12-03	2019-03-20	インターベットインターナショナルベー．フェー．	ローソニア・イントラセルラリス（ｌａｗｓｏｎｉａｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）及びブタサーコウイルス（ｐｏｒｃｉｎｅｃｉｒｃｏｖｉｒｕｓ）２に対するワクチン
CN103823063B (zh) *	2014-02-25	2015-09-30	上海理工大学	检测猪霍乱沙门氏菌的方法及其单抗
ES2798282T3 (es)	2015-02-04	2020-12-10	Intervet Int Bv	Una vacuna para usar contra la infección asintomática por Lawsonia en un cerdo
KR101893827B1 (ko) *	2016-01-04	2018-08-31	전북대학교 산학협력단	약독화된 살모넬라 변이주를 유효성분으로 포함하는 돼지 증식성 회장염 및 살모넬라증 동시 예방 또는 치료용 백신 조성물
BR112020017520A2 (pt)	2018-02-28	2020-12-22	Boehringer Ingelheim Vetmedica Gmbh	Método para redução de escatol e/ou indol em animais
KR102249189B1 (ko) *	2020-01-09	2021-05-07	전북대학교 산학협력단	항원성이 증진된 항원을 발현하는 약독화된 살모넬라 변이주를 유효성분으로 포함하는 돼지 증식성 회장염 및 살모넬라증 동시 예방 또는 치료용 백신 조성물
JP7657287B2 (ja)	2020-07-24	2025-04-04	ベーリンガーインゲルハイムアニマルヘルスユーエスエイインコーポレイテッド	組合せブタワクチン
CN111961627A (zh) *	2020-08-27	2020-11-20	南京农业大学	一种胞内劳森菌的分离与培养方法
MX2024005116A (es) *	2021-11-01	2024-05-16	Boehringer Ingelheim Vetmedica Gmbh	Composiciones de gel inmunogenas.

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US5885823A (en) *	1995-06-05	1999-03-23	Nobl Laboratories, Inc.	Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
US5714375A (en) *	1995-06-05	1998-02-03	Nobl Laboratories, Inc.	Ileal symbiont intracellularis propagation in suspended host cells

2004
- 2004-07-15 KR KR1020067001755A patent/KR101131845B1/ko not_active Expired - Lifetime
- 2004-07-15 CA CA2533559A patent/CA2533559C/en not_active Expired - Lifetime
- 2004-07-15 PL PL04778282T patent/PL1651260T5/pl unknown
- 2004-07-15 BR BRPI0412911A patent/BRPI0412911B1/pt active IP Right Grant
- 2004-07-15 MX MXPA06000994A patent/MXPA06000994A/es active IP Right Grant
- 2004-07-15 DE DE602004023094T patent/DE602004023094D1/de not_active Expired - Lifetime
- 2004-07-15 CN CNA2008101760745A patent/CN101423811A/zh active Pending
- 2004-07-15 RU RU2006105715/10A patent/RU2420570C2/ru active
- 2004-07-15 WO PCT/US2004/022704 patent/WO2005011731A1/en not_active Ceased
- 2004-07-15 JP JP2006521125A patent/JP2006528882A/ja active Pending
- 2004-07-15 SG SG200805019-7A patent/SG144909A1/en unknown
- 2004-07-15 US US10/891,745 patent/US7312065B2/en not_active Expired - Lifetime
- 2004-07-15 AU AU2004260657A patent/AU2004260657B2/en not_active Expired
- 2004-07-15 ES ES04778282.6T patent/ES2333334T5/es not_active Expired - Lifetime
- 2004-07-15 AT AT04778282T patent/ATE442163T2/de active
- 2004-07-15 DK DK04778282.6T patent/DK1651260T4/en active
- 2004-07-15 CN CN200480021627XA patent/CN1829529B/zh not_active Expired - Lifetime
- 2004-07-15 UA UAA200601775A patent/UA87665C2/ru unknown
- 2004-07-15 SI SI200431296T patent/SI1651260T2/sl unknown
- 2004-07-15 EP EP04778282.6A patent/EP1651260B2/en not_active Expired - Lifetime
- 2004-07-15 PT PT04778282T patent/PT1651260E/pt unknown
- 2004-07-23 MY MYPI20042965A patent/MY140208A/en unknown
2005
- 2005-12-12 ZA ZA200510081A patent/ZA200510081B/en unknown
2007
- 2007-11-06 US US11/935,447 patent/US7758870B2/en not_active Expired - Lifetime
2009
- 2009-11-25 CY CY20091101223T patent/CY1109652T1/el unknown

Also Published As

Publication number	Publication date
AU2004260657A1 (en)	2005-02-10
ATE442163T2 (de)	2009-09-15
US7758870B2 (en)	2010-07-20
SI1651260T1 (sl)	2010-01-29
BRPI0412911A (pt)	2006-09-26
DK1651260T4 (en)	2018-10-08
AU2004260657B2 (en)	2012-06-07
CY1109652T1 (el)	2014-08-13
JP2006528882A (ja)	2006-12-28
CN1829529A (zh)	2006-09-06
ES2333334T3 (es)	2010-02-19
EP1651260A1 (en)	2006-05-03
CN1829529B (zh)	2011-05-04
KR101131845B1 (ko)	2012-03-30
UA87665C2 (ru)	2009-08-10
EP1651260B2 (en)	2018-06-27
CA2533559C (en)	2013-07-02
US20050031647A1 (en)	2005-02-10
WO2005011731A1 (en)	2005-02-10
RU2006105715A (ru)	2007-09-10
CA2533559A1 (en)	2005-02-10
SG144909A1 (en)	2008-08-28
US7312065B2 (en)	2007-12-25
EP1651260B1 (en)	2009-09-09
MXPA06000994A (es)	2006-05-15
RU2420570C2 (ru)	2011-06-10
BRPI0412911B1 (pt)	2020-01-21
KR20060054352A (ko)	2006-05-22
CN101423811A (zh)	2009-05-06
ZA200510081B (en)	2006-08-30
DE602004023094D1 (de)	2009-10-22
SI1651260T2 (sl)	2018-09-28
PT1651260E (pt)	2009-09-24
ES2333334T5 (es)	2018-08-06
DK1651260T3 (da)	2010-01-11
US20080112980A1 (en)	2008-05-15
MY140208A (en)	2009-11-30
PL1651260T5 (pl)	2018-11-30

Publication	Publication Date	Title
SI1651260T2 (sl)	2018-09-28	Lawsonia intracellularis evropskega izvora in vakcine, diagnostična sredstva in postopki za njihovo uporabo
SI2351579T1 (sl)	2017-05-31	Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam
WO2008112344A3 (en)	2009-12-30	Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
WO2007064742A3 (en)	2007-08-09	Identification of protective antigenic determinants of porcine reproductive and respiratory syndrome virus (prrsv) and uses thereof
CY1107950T1 (el)	2013-09-04	Νεϊσσεριακες συνθεσεις εμβολιου και μεθοδοι
DK1185691T3 (da)	2009-06-22	Genomiske neisseriasekvenser og fremgangmåder til anvendelse deraf
CY1109210T1 (el)	2014-07-02	Διαγραφεισες αλληλουχιες στο μ. bovis bcg/m. bovis ΄η μ. tuberculosis, μεθοδος ανιχνευσεως μυκοβακτηριων που χρησιμοποιουν αυτες τις αλληλουχιες και εμβολια
SG163598A1 (en)	2010-08-30	Lawsonia vaccine and methods of use thereof
WO2002034773A3 (en)	2003-03-13	Streptococcal genes
MX2012003827A (es)	2012-08-03	Toxina rtx citolitica de gallibacterium anatis.
da Silva et al.	2014	Identification of linear B epitopes of pertactin of Bordetella pertussis induced by immunization with whole and acellular vaccine
PL1796717T3 (pl)	2012-08-31	Szczepionka skojarzona
TW200510524A (en)	2005-03-16	Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof
IL148741A0 (en)	2002-09-12	Vaccine
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