BRPI0412911A - lawsonia intracellularis de origem européia e vacinas, agentes de diagnóstico e métodos de uso da mesma - Google Patents

lawsonia intracellularis de origem européia e vacinas, agentes de diagnóstico e métodos de uso da mesma

Info

Publication number
BRPI0412911A
BRPI0412911A BRPI0412911-3A BRPI0412911A BRPI0412911A BR PI0412911 A BRPI0412911 A BR PI0412911A BR PI0412911 A BRPI0412911 A BR PI0412911A BR PI0412911 A BRPI0412911 A BR PI0412911A
Authority
BR
Brazil
Prior art keywords
intracellularis
european
vaccines
methods
diagnostic agents
Prior art date
Application number
BRPI0412911-3A
Other languages
English (en)
Inventor
Michael B Roof
Jeremy J Kroll
Jeffrey P Knittel
Original Assignee
Boehringer Ingelheim Vetmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34115340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0412911(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed
Publication of BRPI0412911A publication Critical patent/BRPI0412911A/pt
Publication of BRPI0412911B1 publication Critical patent/BRPI0412911B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/825—Bacterial vaccine for porcine species, e.g. swine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"LAWSONIA INTRACELLULARIS DE ORIGEM EUROPéIA E VACINAS, AGENTES DE DIAGNóSTICO E MéTODOS DE USO DA MESMA". A presente invenção refere-se a vacinas de L. intracellularis, e a métodos de proteção contra e diagnóstico de infecção de L. intracellularis. Os produtos e processos da invenção são alcançados, em parte, como resultado de um aperfeiçoado método de cultura em grande escala de L. intracellularis, incluindo um novo isolado de L. intracellularis de origem Européia e um método de preparação de um produto liofilizado contendo o isolado Europeu atenuado como um produto de vacina.
BRPI0412911A 2003-07-25 2004-07-15 "vacina para imunização de um animal e seu método de fabricação, método de cultivo de lawsonia intracellularis, método para o diagnóstico de enteropatia proliferativa em porcos" BRPI0412911B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49000103P 2003-07-25 2003-07-25
PCT/US2004/022704 WO2005011731A1 (en) 2003-07-25 2004-07-15 Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof

Publications (2)

Publication Number Publication Date
BRPI0412911A true BRPI0412911A (pt) 2006-09-26
BRPI0412911B1 BRPI0412911B1 (pt) 2020-01-21

Family

ID=34115340

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412911A BRPI0412911B1 (pt) 2003-07-25 2004-07-15 "vacina para imunização de um animal e seu método de fabricação, método de cultivo de lawsonia intracellularis, método para o diagnóstico de enteropatia proliferativa em porcos"

Country Status (23)

Country Link
US (2) US7312065B2 (pt)
EP (1) EP1651260B2 (pt)
JP (1) JP2006528882A (pt)
KR (1) KR101131845B1 (pt)
CN (2) CN101423811A (pt)
AT (1) ATE442163T2 (pt)
AU (1) AU2004260657B2 (pt)
BR (1) BRPI0412911B1 (pt)
CA (1) CA2533559C (pt)
CY (1) CY1109652T1 (pt)
DE (1) DE602004023094D1 (pt)
DK (1) DK1651260T4 (pt)
ES (1) ES2333334T5 (pt)
MX (1) MXPA06000994A (pt)
MY (1) MY140208A (pt)
PL (1) PL1651260T5 (pt)
PT (1) PT1651260E (pt)
RU (1) RU2420570C2 (pt)
SG (1) SG144909A1 (pt)
SI (1) SI1651260T2 (pt)
UA (1) UA87665C2 (pt)
WO (1) WO2005011731A1 (pt)
ZA (1) ZA200510081B (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2772047B1 (fr) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
AU2012207016B2 (en) * 2005-03-14 2015-01-15 Boehringer Ingelheim Animal Health USA Inc. Immunogenic compositions comprising Lawsonia intracellularis
US8398994B2 (en) * 2005-07-15 2013-03-19 Boehringer Ingelheim Vetmedica, Inc. Lawsonia vaccine and methods of use thereof
MX338626B (es) 2005-12-29 2016-04-26 Boehringer Ingelheim Vetmed Uso de una composicion inmunogenica de pcv2 para producir los sintomas clinicos en cerdos.
EP1968630B1 (en) 2005-12-29 2018-01-24 Boehringer Ingelheim Vetmedica, Inc. Multivalent pcv2 immunogenic compositions
US8470336B2 (en) * 2006-05-25 2013-06-25 Boehringer Ingelheim Vetmedica, Inc. Vaccination of young animals against Lawsonia intracellularis infections
US20080241190A1 (en) * 2006-11-13 2008-10-02 Boehringer Ingelheim Vetmedica, Inc. Vaccination of horses against lawsonia intracellularis
EP2099927A4 (en) * 2006-11-22 2010-05-05 Boehringer Ingelheim Vetmed Methods of reducing porcine circovirus-associated disease outbreaks
EP2859900A1 (en) 2006-12-11 2015-04-15 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
JP5200223B2 (ja) * 2006-12-15 2013-06-05 ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド Ｐｃｖ２抗原によるブタの処置
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
TW200918666A (en) * 2007-09-11 2009-05-01 Wyeth Corp Attenuated mycoplasma gallisepticum strains
WO2009037262A2 (en) 2007-09-17 2009-03-26 Boehringer Ingelheim Vetmedica, Inc. Method of preventing early lawsonia intracellularis infections
WO2009088950A2 (en) * 2007-12-31 2009-07-16 Boehringer Ingelheim Vetmedica, Inc. Pcv2 orf2 virus like particle with foreign amino acid insertion
KR20100113582A (ko) * 2008-01-23 2010-10-21 베링거잉겔하임베트메디카인코퍼레이티드 Ｐｃｖ2 마이코플라즈마 히오뉴모니에 면역원성 조성물 및 당해 조성물의 생산 방법
US20110033495A1 (en) * 2008-02-15 2011-02-10 Boehringer Ingelheim Vetmedica, Inc. Methods and compositions for reducing the impact of enteric diseases
TWI551295B (zh) 2008-04-18 2016-10-01 英特威特國際股份有限公司 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）用疫苗
TWI449533B (zh) * 2008-04-18 2014-08-21 Intervet Int Bv 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）、豬肺炎黴漿菌（Ｍｙｃｏｐｌａｓｍａ ｈｙｏｐｎｅｕｍｏｎｉａｅ）及豬環狀病毒（Ｐｏｒｃｉｎｅ ｃｉｒｃｏ ｖｉｒｕｓ）用疫苗
US8557254B2 (en) 2008-07-22 2013-10-15 Intervet Inc. Lawsonia intracellularis bacterium of a novel serotype, vaccine based on that bacterium, antibodies suitable for diagnosing the novel Lawsonia intracellularis serotype and hybridomas for producing the said antibodies
US8142760B2 (en) * 2008-09-05 2012-03-27 Nathan Len Winkelman Vaccination for Lawsonia intracellularis
WO2011006880A1 (en) * 2009-07-14 2011-01-20 Intervet International B.V. Lawsonia intracellularis propagation
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
US8530223B2 (en) 2009-11-09 2013-09-10 Intervet International B.V. Method to grow Lawsonia intracellularis bacteria in persistently infected McCoy cells
AU2011230619C1 (en) 2010-03-25 2016-06-23 Oregon Health & Science University CMV glycoproteins and recombinant vectors
HUE037408T2 (hu) 2011-06-10 2018-08-28 Univ Oregon Health & Science CMV glikoproteinek és rekombináns vektorok
EP3049106A1 (en) 2013-09-25 2016-08-03 Zoetis Services LLC Pcv2b divergent vaccine composition and methods of use
US9505808B2 (en) 2013-10-02 2016-11-29 Boehringer Ingelheim Vetmedica, Inc. PCV2 ORF2 protein variant and virus like particles composed thereof
JP6488304B2 (ja) 2013-12-03 2019-03-20 インターベット インターナショナル ベー． フェー． ローソニア・イントラセルラリス（ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）及びブタサーコウイルス（ｐｏｒｃｉｎｅ ｃｉｒｃｏｖｉｒｕｓ）２に対するワクチン
CN103823063B (zh) * 2014-02-25 2015-09-30 上海理工大学 检测猪霍乱沙门氏菌的方法及其单抗
ES2798282T3 (es) 2015-02-04 2020-12-10 Intervet Int Bv Una vacuna para usar contra la infección asintomática por Lawsonia en un cerdo
KR101893827B1 (ko) * 2016-01-04 2018-08-31 전북대학교 산학협력단 약독화된 살모넬라 변이주를 유효성분으로 포함하는 돼지 증식성 회장염 및 살모넬라증 동시 예방 또는 치료용 백신 조성물
BR112020017520A2 (pt) 2018-02-28 2020-12-22 Boehringer Ingelheim Vetmedica Gmbh Método para redução de escatol e/ou indol em animais
KR102249189B1 (ko) * 2020-01-09 2021-05-07 전북대학교 산학협력단 항원성이 증진된 항원을 발현하는 약독화된 살모넬라 변이주를 유효성분으로 포함하는 돼지 증식성 회장염 및 살모넬라증 동시 예방 또는 치료용 백신 조성물
JP7657287B2 (ja) 2020-07-24 2025-04-04 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 組合せブタワクチン
CN111961627A (zh) * 2020-08-27 2020-11-20 南京农业大学 一种胞内劳森菌的分离与培养方法
MX2024005116A (es) * 2021-11-01 2024-05-16 Boehringer Ingelheim Vetmedica Gmbh Composiciones de gel inmunogenas.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885823A (en) * 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
US5714375A (en) * 1995-06-05 1998-02-03 Nobl Laboratories, Inc. Ileal symbiont intracellularis propagation in suspended host cells

Also Published As

Publication number Publication date
AU2004260657A1 (en) 2005-02-10
ATE442163T2 (de) 2009-09-15
US7758870B2 (en) 2010-07-20
SI1651260T1 (sl) 2010-01-29
DK1651260T4 (en) 2018-10-08
AU2004260657B2 (en) 2012-06-07
CY1109652T1 (el) 2014-08-13
JP2006528882A (ja) 2006-12-28
CN1829529A (zh) 2006-09-06
ES2333334T3 (es) 2010-02-19
EP1651260A1 (en) 2006-05-03
CN1829529B (zh) 2011-05-04
KR101131845B1 (ko) 2012-03-30
UA87665C2 (ru) 2009-08-10
EP1651260B2 (en) 2018-06-27
CA2533559C (en) 2013-07-02
US20050031647A1 (en) 2005-02-10
WO2005011731A1 (en) 2005-02-10
RU2006105715A (ru) 2007-09-10
CA2533559A1 (en) 2005-02-10
SG144909A1 (en) 2008-08-28
US7312065B2 (en) 2007-12-25
EP1651260B1 (en) 2009-09-09
MXPA06000994A (es) 2006-05-15
RU2420570C2 (ru) 2011-06-10
BRPI0412911B1 (pt) 2020-01-21
KR20060054352A (ko) 2006-05-22
CN101423811A (zh) 2009-05-06
ZA200510081B (en) 2006-08-30
DE602004023094D1 (de) 2009-10-22
PL1651260T3 (pl) 2010-02-26
SI1651260T2 (sl) 2018-09-28
PT1651260E (pt) 2009-09-24
ES2333334T5 (es) 2018-08-06
DK1651260T3 (da) 2010-01-11
US20080112980A1 (en) 2008-05-15
MY140208A (en) 2009-11-30
PL1651260T5 (pl) 2018-11-30

Similar Documents

Publication Publication Date Title
BRPI0412911A (pt) lawsonia intracellularis de origem européia e vacinas, agentes de diagnóstico e métodos de uso da mesma
MX2024006606A (es) Composiciones que comprenden conjugados de polisacarido de streptococcus pneumoniae con proteina y metodos de uso de estos.
MY180698A (en) Immunization protocol against the 4 dengue serotypes
BRPI0620193B8 (pt) composição imunogênica e vacina a compreendendo, bem como processo para preparar a vacina
WO2005116270A3 (en) Influenza virus vaccine composition and method of use
FR13C0040I2 (fr) Vaccins polypeptidiques offrant une large protection contre des lignees de meningocoques hypervirulentes
BRPI0813307B8 (pt) composição imunogênica, vacina, e, processo para fabricar a vacina
ES2156110T3 (es) Analogos de sub-unidades de toxina del colera derivados de adn recombinante.
MX2010005014A (es) Vacuna viva avirulenta de mycoplasma hyopneumoniae con adyuvante.
BR0006291A (pt) Bactéria do gênero salmonella, vacina para aproteção de animais contra a salmonelose, uso deuma bactéria, e, processo para a preparação deuma vacina
DE60038099D1 (de) Neisseria impfstoffzusammensetzungen und methoden
NZ603854A (en) West nile virus vaccine
DK1796717T3 (da) Kombinationsvaccine
WO2007135420A3 (en) Defective interfering virus
SE9903534D0 (sv) Vaccin
NZ598459A (en) Adjuvant comprising aluminium, oligonucleotide and polycation
ATE353223T1 (de) Multi-komponenten impfstoff zum schutz vor krankheiten die durch haemophilus influenza und moxarella catarrhalis ausgelöst werden
TW200510524A (en) Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof
NZ591738A (en) Non-typhoidal salmonella vaccines comprising a polypeptide which is an outer membrane protein d of non typoidal salmonella
HUP9700975A2 (hu) Élő, legyengített, Pasteurellaceae családba tartozó, RTX-termelő baktériumok
BR0002602A (pt) Vacina viva atenuada, uso de uma bactéria viva atenuada, e, processo para a preparação de uma vacina
WO2009030676A3 (en) Pharmaceutical composition comprising a japanese encephalitis virus for vaccination of patients of at least 40 years of age
Bhattacharya et al. A sudden increase in occurrence of salmonella paratyphi a infection in rourkela, western odisha
US11065321B2 (en) Live attenuated bacterial strain and its use as a vaccine
WO2007049805A8 (ja) 合成リポペプチドおよびその医薬用途

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ARTIGO 8O C/C 13 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/01/2020, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC. (US)

B25G Requested change of headquarter approved

Owner name: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC. (US)