PL1729797T3 - Doustne kompozycje farmaceutyczne produktów zawierających lipazę, a zwłaszcza pankreatynę, zawierające środki powierzchniowo czynne - Google Patents

Doustne kompozycje farmaceutyczne produktów zawierających lipazę, a zwłaszcza pankreatynę, zawierające środki powierzchniowo czynne

Info

Publication number
PL1729797T3
PL1729797T3 PL05733481T PL05733481T PL1729797T3 PL 1729797 T3 PL1729797 T3 PL 1729797T3 PL 05733481 T PL05733481 T PL 05733481T PL 05733481 T PL05733481 T PL 05733481T PL 1729797 T3 PL1729797 T3 PL 1729797T3
Authority
PL
Poland
Prior art keywords
lipase
pancreatin
pharmaceutical compositions
oral pharmaceutical
containing products
Prior art date
Application number
PL05733481T
Other languages
English (en)
Inventor
George Shlieout
Bernd Boedecker
Siegfried Schaefer
Bernd Thumbeck
Peter-Colin Gregory
Original Assignee
Abbott Laboratories Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04101164.4A external-priority patent/EP1579869A1/de
Application filed by Abbott Laboratories Gmbh filed Critical Abbott Laboratories Gmbh
Publication of PL1729797T3 publication Critical patent/PL1729797T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/745—Polymers of hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL05733481T 2004-03-22 2005-03-21 Doustne kompozycje farmaceutyczne produktów zawierających lipazę, a zwłaszcza pankreatynę, zawierające środki powierzchniowo czynne PL1729797T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55499304P 2004-03-22 2004-03-22
EP04101164.4A EP1579869A1 (de) 2004-03-22 Pharmazeutische Zusammensetzung enthaltend Lipase, insbesondere Pankreatin, und Tenside
PCT/EP2005/051295 WO2005092370A1 (en) 2004-03-22 2005-03-21 Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
EP05733481A EP1729797B1 (en) 2004-03-22 2005-03-21 Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants

Publications (1)

Publication Number Publication Date
PL1729797T3 true PL1729797T3 (pl) 2009-02-27

Family

ID=34964300

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05733481T PL1729797T3 (pl) 2004-03-22 2005-03-21 Doustne kompozycje farmaceutyczne produktów zawierających lipazę, a zwłaszcza pankreatynę, zawierające środki powierzchniowo czynne

Country Status (14)

Country Link
US (3) US8802087B2 (pl)
EP (1) EP1729797B1 (pl)
JP (1) JP5032300B2 (pl)
CN (1) CN1933850B (pl)
AT (1) ATE407693T1 (pl)
AU (1) AU2005227090B2 (pl)
BR (1) BRPI0509148B8 (pl)
CA (1) CA2560613C (pl)
DE (1) DE602005009677D1 (pl)
ES (1) ES2314646T3 (pl)
PL (1) PL1729797T3 (pl)
PT (1) PT1729797E (pl)
RU (1) RU2381813C2 (pl)
WO (1) WO2005092370A1 (pl)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
HUE031042T2 (en) * 2005-07-29 2017-06-28 Abbott Laboratories Gmbh Methods for producing pancreatin powder with low viral content
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
DE102006001554A1 (de) * 2006-01-05 2007-07-12 Ipc Process-Center Gmbh & Co. Micropellets für die Herstellung von Tiernahrungspellets
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
US8273348B2 (en) 2006-12-21 2012-09-25 Novozymes A/S Lipase variants for pharmaceutical use
AU2008218595B2 (en) 2007-02-20 2012-05-24 Allergan Therapeutics LLC Stable digestive enzyme compositions
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
ES2732453T3 (es) 2008-07-01 2019-11-22 Curemark Llc Métodos y composiciones para el tratamiento de síntomas de trastornos neurológicos y de salud mental
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
EP2165717A1 (de) 2008-08-27 2010-03-24 Nordmark Arzneimittel GmbH & Co.KG Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte
JP2012514604A (ja) 2009-01-06 2012-06-28 キュレロン リミテッド ライアビリティ カンパニー 大腸菌（Ｅ．ｃｏｌｉ）による経口感染の治療または予防のための組成物および方法
CA3050530A1 (en) 2009-01-06 2010-07-15 Galenagen, Llc Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces
WO2010085975A1 (de) * 2009-01-29 2010-08-05 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutisches präparat enthaltend lipase bakteriellen ursprungs
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
WO2010144865A2 (en) 2009-06-12 2010-12-16 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
PL2295039T5 (pl) * 2009-08-28 2023-02-27 Nordmark Pharma Gmbh Sposób wytwarzania granulek zawierających pankreatynę, w szczególności mikrogranulek zawierających pankreatynę, oraz wytworzone tym sposobem granulki zawierające pankreatynę
US8784884B2 (en) 2009-09-17 2014-07-22 Stephen Perrett Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
UA111726C2 (uk) 2010-10-01 2016-06-10 Апталіс Фарма Лімітед Препарат панкреліпази низької сили з кишковорозчинним покриттям
EP2489349B1 (de) 2011-02-17 2014-05-28 Nordmark Arzneimittel GmbH & Co.KG Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und Verfahren zu deren Herstellung
MX362974B (es) 2011-04-21 2019-02-28 Curemark Llc Compuestos para el tratamiento de alteraciones neuropsiquiatricas.
MX351014B (es) 2011-08-08 2017-09-28 Aptalis Pharma Ltd Metodo para la prueba de disolucion de composiciones solidas que contienen enzimas digestivas.
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
BR112014016557A8 (pt) * 2012-01-03 2017-07-04 Curemark Llc métodos de tratamento de sintomas comportamentais de distúrbios neurológicos e mentais
US9668474B2 (en) 2012-02-10 2017-06-06 Stepan Company Structured surfactant suspending systems
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
CN105007947B (zh) * 2013-01-14 2019-02-15 因佛斯特医疗有限公司 固溶体组合物及其在心血管疾病中的用途
US10184121B2 (en) 2013-06-28 2019-01-22 Allergan Pharmaceuticals International Limited Methods for removing viral contaminants from pancreatic extracts
CN106163544A (zh) 2013-08-09 2016-11-23 阿勒根制药国际有限公司 适于经肠施用的消化酶组合物
JP2014193909A (ja) * 2014-06-04 2014-10-09 Nordmark Arzneimittel Gmbh & Co Kg 医薬調製物
MX391630B (es) * 2014-11-05 2025-03-19 Abbott Laboratories Gmbh Procesos para la producción de composiciones con perfil de seguridad mejorado teniendo actividad lipasa y composiciones adecuadas para medicamentos
US10739353B2 (en) * 2014-12-31 2020-08-11 Signpath Pharma, Inc. Suppression of cytokine release and cytokine storm
WO2016126970A1 (en) * 2015-02-04 2016-08-11 Abbvie Inc. Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency
CN104730014B (zh) * 2015-03-27 2017-08-04 宁波博泰生物技术有限公司 一种血清脂肪酶测定试剂盒及其制备方法
DE102015114862A1 (de) * 2015-09-04 2017-03-09 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutische Zusammensetzung, enthaltend eine bakterielle Lipase
CN109219442A (zh) 2016-04-04 2019-01-15 Omeza有限公司 鱼油局部组合物
US10836890B2 (en) * 2017-01-25 2020-11-17 Nano And Advanced Materials Institute Limited Mechanically reinforced, transparent, anti-biofouling thermoplastic resin composition and manufacturing method thereof
DE102017104472A1 (de) 2017-03-03 2018-09-06 Nordmark Arzneimittel Gmbh & Co. Kg Schmelztablette enthaltend Burlulipase und daraus hergestellte pharmazeutische Zusammensetzung
DE102017104482A1 (de) * 2017-03-03 2018-09-06 Nordmark Arzneimittel Gmbh & Co. Kg Pharmazeutische Zusammensetzung umfassend Pankreatin und einen lipasehaltigen Überzug
AU2018250823A1 (en) 2017-04-10 2019-10-17 Curemark, Llc Compositions for treating addiction
CN110075279A (zh) * 2019-04-25 2019-08-02 淮安麦德森制药有限公司 胰酶微球及其生产方法
RU2706003C1 (ru) * 2019-09-09 2019-11-13 Акционерное общество "АВВА РУС" Микрогранулы, содержащие панкреатин
US20210236629A1 (en) * 2020-02-05 2021-08-05 Jubilant Pharma Holdings Inc. Self-emulsifying dosage forms of allergen and their preparation thereof
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
EP4082518A1 (en) * 2021-04-28 2022-11-02 Cnce Innovacion, S.L. Fatty acid compositions for the treatment and prevention of hair loss and alopecia
WO2023114383A1 (en) * 2021-12-16 2023-06-22 First Wave BioPharma, Inc. Stable lipase formulations and methods thereof

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3324002A (en) * 1962-09-17 1967-06-06 Armour Pharma Anti-inflammatory preparations containing proteolytic enzymes and adrenal glucocorticoids
US3803305A (en) * 1962-12-28 1974-04-09 Rolland A Lab Process for obtaining extracts from pancreas
US3956483A (en) * 1968-10-24 1976-05-11 Wilson Pharmaceutical & Chemical Corporation Preparing pancreatin
DE2035739A1 (en) 1970-07-18 1972-01-27 Röhm FmbH, 6100 Darmstadt Oral enzyme prepsn - consisting of granulate with gastric juices-resistant coating in tablet or capsule form
US3991180A (en) * 1972-03-06 1976-11-09 Rohm And Haas Company Stabilization of internally administered pancreatic lipase
FR2183546B1 (pl) * 1972-05-10 1975-06-20 Servier Lab
DE2410241A1 (de) 1974-03-04 1975-09-18 Christian Brunnengraeber Chem Granulataehnliche darreichungsform fuer arzneimittel
DE2512746C3 (de) 1975-03-22 1980-04-24 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von keimarmem, faserfreiem Pankreatin
US3986927A (en) * 1975-04-28 1976-10-19 Armour Pharmaceutical Company Process for the purification and sterilization of acidophilic biologicals by extreme acidification at cold temperatures
GB1509866A (en) 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
GB1590432A (en) * 1976-07-07 1981-06-03 Novo Industri As Process for the production of an enzyme granulate and the enzyme granuate thus produced
GB1603640A (en) * 1977-07-20 1981-11-25 Gist Brocades Nv Enzyme particles
JPS5535031A (en) 1978-09-04 1980-03-11 Shin Etsu Chem Co Ltd Enteric coating composition
US4259440A (en) 1979-05-21 1981-03-31 Miles Laboratories, Inc. Hydrolysis and assay of triglycerides
DE2923279C2 (de) 1979-06-08 1987-07-09 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel
JPS5855125B2 (ja) 1980-03-10 1983-12-08 信越化学工業株式会社 固形薬剤用腸溶性コ−テイング剤組成物
JPS57171428A (en) * 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
DE3377506D1 (en) * 1982-12-30 1988-09-01 Nordmark Arzneimittel Gmbh Process for obtaining pancreatin
US4447412A (en) * 1983-02-01 1984-05-08 Bilton Gerald L Enzyme-containing digestive aid compostions
IE55711B1 (en) 1983-10-24 1990-12-19 Bausch & Lomb Improved method for enzymatic cleaning and disinfecting contact lenses
US4490361A (en) * 1983-12-02 1984-12-25 Alpha Therapeutic Corporation Virus inactivating heat treatment of plasma fractions
DK263584D0 (da) 1984-05-29 1984-05-29 Novo Industri As Enzymholdige granulater anvendt som detergentadditiver
US4689297A (en) 1985-03-05 1987-08-25 Miles Laboratories, Inc. Dust free particulate enzyme formulation
US4707287A (en) 1985-06-28 1987-11-17 The Procter & Gamble Company Dry bleach stable enzyme composition
US4775536A (en) * 1986-02-24 1988-10-04 Bristol-Myers Company Enteric coated tablet and process for making
US5766912A (en) * 1986-03-17 1998-06-16 Novo Nordisk A/S Humicola lipase produced in aspergillus
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5536661A (en) * 1987-03-10 1996-07-16 Novo Nordisk A/S Process for the production of protein products in aspergillus
US5874558A (en) * 1986-03-17 1999-02-23 Novo Nordisk Nucleic acid encoding a recombinant humicola sp. lipase
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
WO1987007292A1 (en) 1986-05-21 1987-12-03 Novo Industri A/S Coated detergent enzymes
DE3642853A1 (de) 1986-12-16 1988-06-23 Ulrich Von Dr Ing Pidoll Arzneimittel
DK435587D0 (da) 1987-08-21 1987-08-21 Novo Industri As Fremgangsmaade til fremstilling af et enzymholdigt granulat
DK435687D0 (da) 1987-08-21 1987-08-21 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
DE3854249T2 (de) 1987-08-28 1996-02-29 Novonordisk As Rekombinante Humicola-Lipase und Verfahren zur Herstellung von rekombinanten Humicola-Lipasen.
US5068110A (en) * 1987-09-29 1991-11-26 Warner-Lambert Company Stabilization of enteric coated dosage form
IL88961A (en) * 1988-01-29 1992-07-15 Basf Ag Stable mixtures containing oxidation-sensitive compounds
WO1989008695A1 (en) 1988-03-14 1989-09-21 Novo-Nordisk A/S Stabilized particulate composition
DK78089D0 (da) 1989-02-20 1989-02-20 Novo Industri As Detergentholdigt granulat og fremgangsmaade til fremstilling deraf
DK78189D0 (da) 1989-02-20 1989-02-20 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
US5219572A (en) * 1989-03-17 1993-06-15 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
ES2087156T3 (es) * 1989-06-15 1996-07-16 Rorer Int Overseas Metodos para la inactivacion de virus en composiciones farmaceuticas contaminadas por virus.
GB8915658D0 (en) 1989-07-07 1989-08-23 Unilever Plc Enzymes,their production and use
US5658871A (en) * 1989-07-07 1997-08-19 Lever Brothers Company, Division Of Conopco, Inc. Microbial lipase muteins and detergent compositions comprising same
WO1991006638A1 (en) 1989-10-31 1991-05-16 Genencor International, Inc. Dust-free coated enzyme formulation
GB9007052D0 (en) 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations
US6187572B1 (en) * 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
DK173590D0 (da) * 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
US5618710A (en) * 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
US5801022A (en) * 1990-08-03 1998-09-01 Vertex Pharmaceuticals, Incorporated Method of producing a product with crosslinked crystals of thermolysin
DE69133258T2 (de) 1990-08-03 2004-03-18 Vertex Pharmaceuticals Inc., Cambridge Verwendung von vernetzten kristallen als neuem verfahren zur immobilisierung von enzymen
US5869438A (en) * 1990-09-13 1999-02-09 Novo Nordisk A/S Lipase variants
CA2055572A1 (en) * 1990-12-18 1992-06-19 David Kronenthal Processes and intermediates for thromboxane receptor antagonists
US5254283A (en) 1991-01-17 1993-10-19 Genencor International, Inc. Isophthalic polymer coated particles
ES2157898T3 (es) * 1991-01-24 2001-09-01 Martek Corp Aceites microbianos y usos de los mismos.
DK13491D0 (da) 1991-01-25 1991-01-25 Novo Nordisk As Anvendelse af et enzymholdigt granulat og fremgangsmaade til fremstilling af et forderstof i tabletform
DE4203315A1 (de) 1991-02-14 1992-08-20 Kali Chemie Pharma Gmbh Verfahren zur gewinnung von pankreatin
WO1993000924A1 (de) 1991-07-01 1993-01-21 Basf Aktiengesellschaft Verwendung von lipasen zur herstellung von arzneimitteln
US5225202A (en) * 1991-09-30 1993-07-06 E. R. Squibb & Sons, Inc. Enteric coated pharmaceutical compositions
US5879920A (en) * 1991-10-07 1999-03-09 Genencor International, Inc. Coated enzyme-containing granule
US5324649A (en) * 1991-10-07 1994-06-28 Genencor International, Inc. Enzyme-containing granules coated with hydrolyzed polyvinyl alcohol or copolymer thereof
WO1993007260A1 (en) 1991-10-10 1993-04-15 Genencor International, Inc. Process for dust-free enzyme manufacture
DE4200002A1 (de) 1992-01-02 1993-07-08 Rudolf V Dipl Chem Dr Noronha Reinigungstablette fuer die zahnprothesen
US5260074A (en) * 1992-06-22 1993-11-09 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5302400A (en) * 1992-06-22 1994-04-12 Digestive Care Inc. Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids
DE4227385A1 (de) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pankreatinmikropellets
WO1994008605A1 (en) 1992-10-16 1994-04-28 Smithkline Beecham Corporation Therapeutic microemulsions
WO1994008603A1 (en) 1992-10-16 1994-04-28 Smithkline Beecham Corporation Compositions
JP3264027B2 (ja) * 1993-02-24 2002-03-11 ソニー株式会社 放電セル及びその製造方法
DK39693D0 (da) 1993-04-02 1993-04-02 Novo Nordisk As Enzym
DE4322229A1 (de) * 1993-07-05 1995-01-12 Cognis Bio Umwelt Umhüllte Enzymzubereitung für Wasch- und Reinigungsmittel
AU7656894A (en) 1993-09-15 1995-04-03 Unilever Plc Skin care method and composition
US6312704B1 (en) * 1993-09-30 2001-11-06 Gattefosse, S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
US6054136A (en) * 1993-09-30 2000-04-25 Gattefosse S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
FR2710535B1 (fr) * 1993-09-30 1995-11-24 Gattefosse Ets Sa Composition à usage pharmaceutique ou cosmétique apte à former une microémulsion.
DE4344215A1 (de) 1993-12-23 1995-06-29 Cognis Bio Umwelt Silberkorrosionsschutzmittelhaltige Enzymzubereitung
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
DE4422198C2 (de) 1994-06-24 1997-08-28 Audi Ag Verfahren zum Steuern der elektrischen Beheizung eines Katalysators
JP3355593B2 (ja) * 1994-08-19 2002-12-09 信越化学工業株式会社 固形腸溶製剤の製造方法
DE69519944T2 (de) 1994-11-18 2001-06-13 Genencor International, Inc. Umhüllte enzymgranulate
EP0773984B1 (en) 1995-05-29 1999-11-03 Kao Corporation Enzyme-containing granulated substance and preparation process thereof
DE69634248T2 (de) 1995-05-31 2006-01-12 Medzyme N.V. Zusammensetzungen zur verbesserung der verdaulichkeit und ausnutzung von nähestoffen
AU1200997A (en) 1995-12-22 1997-07-17 Helix Biotechnology Ltd Thermostable proteolytic enzyme from thermoactinomyces thalpophilus thm1
JP4842414B2 (ja) 1996-04-12 2011-12-21 ノボザイムス アクティーゼルスカブ 酵素含有顆粒及びその製造のための方法
ID18663A (id) * 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
DE69737828T2 (de) * 1996-04-29 2008-03-06 Novozymes A/S Flüssige, nichtwässrige enzyme enthaltende zusammensetzungen
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
GB9613858D0 (en) 1996-07-02 1996-09-04 Cortecs Ltd Hydrophobic preparations
DE19724845A1 (de) 1996-08-28 1998-03-05 Solvay Pharm Gmbh Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen
GB9624927D0 (en) * 1996-11-29 1997-01-15 Oxford Glycosciences Uk Ltd Gels and their use
US6140475A (en) * 1997-04-11 2000-10-31 Altus Biologics Inc. Controlled dissolution crosslinked protein crystals
AUPO693397A0 (en) 1997-05-22 1997-06-12 Betatene Limited Carotenoid formulation
NZ330940A (en) 1997-07-24 2000-02-28 F Production of consensus phytases from fungal origin using computer programmes
ES2137862B1 (es) 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
JP3611456B2 (ja) * 1997-09-30 2005-01-19 日研化学株式会社 テオフィリン徐放性錠剤
KR19990072826A (ko) 1998-02-26 1999-09-27 우재영 판크레아틴장용코팅과립의제조방법
US20030021844A1 (en) * 1998-03-04 2003-01-30 Philippe Barthelemy Immediate-release oral pellet comprising polyglycolysed glycerides, and manufacturing process
FR2775597B1 (fr) 1998-03-04 2001-04-20 Gattefosse Ets Sa Pellet administrable par voie orale apte a ameliorer la biodisponibilite de la substance active, procede de fabrication
JP2002506013A (ja) * 1998-03-09 2002-02-26 イスタ ファーマシューティカルズ インコーポレイテッド 酵素角膜矯正術における角膜硬化剤の使用
UA69413C2 (uk) * 1998-05-22 2004-09-15 Брістол-Майерс Сквібб Компані Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції
DE29824797U1 (de) 1998-05-22 2002-08-22 Bristol-Myers Squibb Co., Princeton, N.J. Magensaftresistent überzogene Arzneimittel
US6268329B1 (en) * 1998-06-30 2001-07-31 Nouozymes A/S Enzyme containing granule
DK1092007T3 (da) 1998-06-30 2004-04-05 Novozymes As Ny forbedret enzymholdig granule
DE19848849A1 (de) 1998-10-22 2000-04-27 Knoll Ag Verfahren zur Herstellung von festen, sphärischen Formen, enthaltend eine biologisch aktive Substanz
DE19856415C2 (de) 1998-12-08 2001-06-07 Thomas Fenner Verfahren zur Reinigung bzw. Isolierung viraler Nukleinsäuren
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US20030104048A1 (en) * 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
EP1162995B1 (de) 1999-03-17 2003-06-04 Solvay Pharmaceuticals GmbH Enzyme zur behandlung von diabetes mellitus typ i
WO2000073429A1 (en) 1999-05-27 2000-12-07 Amano Enzyme Inc. Enzyme liquor and process for producing the same, enzyme preparation, protease preparations and protease-producing bacterium
CN100378218C (zh) 1999-10-01 2008-04-02 诺沃奇梅兹有限公司 喷雾干燥的酶产品
EP1138333B1 (en) 1999-10-12 2004-02-25 Daiichi Suntory Pharma Co., Ltd. Medicinal compositions for oral use
PT1225897E (pt) * 1999-11-01 2005-01-31 John Rhodes Composicao para o tratamento da obstipacao e do sindroma do intestino irritavel
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
ATE308896T1 (de) * 1999-12-30 2005-11-15 Kemin Ind Inc Verfahren zur verbesserung der aktivitaet von enzymen
KR20020077421A (ko) 2000-02-08 2002-10-11 에프. 호프만-라 로슈 아게 동물 사료에서 산-안정성 서브틸리신 프로테아제의 사용
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
KR20010100194A (ko) 2000-03-13 2001-11-14 박호군 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US20020146451A1 (en) * 2000-07-15 2002-10-10 Sharma Virender K. Method for the administration of acid-labile drugs
WO2002020746A1 (en) 2000-09-08 2002-03-14 Novozymes A/S Lubricated granules
EP1324751B1 (en) 2000-10-02 2006-05-24 Novozymes A/S Coated particles containing an active substance
JP4139215B2 (ja) * 2000-11-02 2008-08-27 シリアン アクチェンゲゼルシャフト 消化を促進するための薬剤としての繊毛虫から得られた酵素の使用
IT1319655B1 (it) * 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
AR032392A1 (es) 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
US6692771B2 (en) * 2001-02-23 2004-02-17 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
US6676933B2 (en) * 2001-05-23 2004-01-13 Osmotica Corp. Pharmaceutical composition containing mosapride and pancreatin
DE60124895D1 (de) 2001-07-26 2007-01-11 Ethypharm Sa Umgehüllte Allylamine oder Benzylamine enthaltende Granulate, Verfahren zur Herstellung und in der Mundhöhle dispergierbare Tabletten enthaltend die umgehüllten Granulate
FR2827770B1 (fr) * 2001-07-27 2005-08-19 Gattefosse Ets Sa Composition pharmaceutique a usage oral comprenant un principe actif susceptible de subir un important effet de premier passage intestinal
US6749851B2 (en) * 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes
MXPA04005260A (es) 2001-12-03 2005-03-23 Novacea Inc Composiciones farmaceuticas que comprenden compuestos activos de vitamina d.
AU2002351749A1 (en) 2001-12-21 2003-07-15 Novozymes A/S Salt coatings
AU2003214037A1 (en) 2002-03-27 2003-10-08 Novozymes A/S Granules with filamentous coatings
US20040161423A1 (en) * 2002-07-18 2004-08-19 Sanjeev Kumar (Mendiratta) Polymer modified anti-angiogenic serpins
AU2004208860A1 (en) 2003-02-06 2004-08-19 Novozymes A/S Human heavy chain antibody expression in filamentous fungi
US20040213847A1 (en) * 2003-04-23 2004-10-28 Matharu Amol Singh Delayed release pharmaceutical compositions containing proton pump inhibitors
AU2004260961B2 (en) * 2003-07-29 2010-05-20 Abbott Laboratories Gmbh Analytical method for pancreatin and comparable compositions
WO2005070962A1 (en) 2004-01-21 2005-08-04 Novozymes A/S Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell
ITMI20040891A1 (it) 2004-05-04 2004-08-04 Ibsa Inst Biochimique Sa Nuovo metodo per la partizione ed inattivazione di contaminanti virali e prionici
SI1809320T1 (sl) 2004-10-14 2010-11-30 Cystic Fibrosis Foundation Therapeutics Inc Sestavki ki vsebujejo lipazo proteazo in amilazo za zdravljenje pankreasne insuficience
US20090047266A1 (en) 2005-06-24 2009-02-19 Novozymes A/S Lipases for Pharmaceutical Use
HUE031042T2 (en) 2005-07-29 2017-06-28 Abbott Laboratories Gmbh Methods for producing pancreatin powder with low viral content
US11266607B2 (en) * 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
JP5284092B2 (ja) 2005-08-15 2013-09-11 アボット ラボラトリーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 腸溶コーティングに適したパンクレアチンマイクロペレットコア
US9198871B2 (en) * 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US10072256B2 (en) * 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
US8273348B2 (en) 2006-12-21 2012-09-25 Novozymes A/S Lipase variants for pharmaceutical use
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
WO2009109856A2 (en) * 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations

Also Published As

Publication number Publication date
JP5032300B2 (ja) 2012-09-26
BRPI0509148B1 (pt) 2016-07-12
ATE407693T1 (de) 2008-09-15
EP1729797B1 (en) 2008-09-10
US20140302000A1 (en) 2014-10-09
US8802087B2 (en) 2014-08-12
US20190275122A1 (en) 2019-09-12
EP1729797A1 (en) 2006-12-13
US20050250817A1 (en) 2005-11-10
CA2560613A1 (en) 2005-10-06
AU2005227090A1 (en) 2005-10-06
WO2005092370A1 (en) 2005-10-06
RU2381813C2 (ru) 2010-02-20
BRPI0509148B8 (pt) 2021-05-25
HK1101342A1 (en) 2007-10-18
JP2007530503A (ja) 2007-11-01
RU2006137325A (ru) 2008-04-27
DE602005009677D1 (de) 2008-10-23
ES2314646T3 (es) 2009-03-16
PT1729797E (pt) 2008-12-17
CA2560613C (en) 2015-11-24
AU2005227090B2 (en) 2010-12-09
BRPI0509148A (pt) 2007-09-11
CN1933850B (zh) 2011-01-12
CN1933850A (zh) 2007-03-21

Similar Documents

Publication Publication Date Title
PT1729797E (pt) Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos
HUP0500560A2 (hu) Mikróbás enzimek új keverékei
WO2008021987A3 (en) Proteolytic enzyme formulations
NO20080437L (no) Lipaser til farmasoytisk anvendelse
BRPI0510817A (pt) protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de uma doença
WO2007053619A3 (en) A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency
WO2008079685A3 (en) Lipase variants for pharmaceutical use
WO2011063394A3 (en) Compositions and methods comprising serratia peptidase for inhibition and treatment of biofilms related to certain conditions
CY1106180T1 (el) Σκευασματα διασπορας τα οποια πepιεχουν αναστολεις λιπασης
WO2010065455A3 (en) Enzymes with lipase activity
ES2572160T3 (es) Una nueva preparación farmacéutica para preeclampsia
WO2002051424A8 (en) Drugs against articular failure
WO2007081755A3 (en) Indole-benzimidazole and indazole inhibitors of tyrosine phosphatases
WO2006020040A3 (en) Apolipoprotein a1 mimetics and uses thereof
MY159075A (en) Modified lecithin-cholesterol acyltransferase enzymes
EA201070746A1 (ru) Фармацевтическая композиция, содержащая по меньшей мере один белковый активный ингредиент, защищенный от расщепления ферментами
EA201070826A1 (ru) Антитела против pcrv
BR112012005837A8 (pt) Composição de enzimas digestivas em multipartículas, forma de dosagem, método para o tratamento da dor proveniente da pancreatite, método para o tratamento da dor proveniente da pancreatite e da insuficiência pancreática, método para o tratamento da insuficiência pancreática exócrina e método para o tratamento da dor pancreática
DE50106273D1 (de) Verwendung von aus ciliaten gewonnenen enzymen als verdauungsfördernde arzneimittel
IN2012DN00592A (pl)
MX2010005690A (es) Variantes de proteasa para uso farmaceutico.
WO2007089334A3 (en) Assay for parkinson's disease therapeutics and enzymatically active parkin preparations useful therein
WO2005062952A3 (en) Compositions and methods for modulating sirtuin activity
AR030593A1 (es) Sistema tensioactivo
WO2006017124A3 (en) Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases