PL1753713T3 - Synteza tetracyklin oraz ich analogów - Google Patents

Synteza tetracyklin oraz ich analogów

Info

Publication number
PL1753713T3
PL1753713T3 PL05779988T PL05779988T PL1753713T3 PL 1753713 T3 PL1753713 T3 PL 1753713T3 PL 05779988 T PL05779988 T PL 05779988T PL 05779988 T PL05779988 T PL 05779988T PL 1753713 T3 PL1753713 T3 PL 1753713T3
Authority
PL
Poland
Prior art keywords
tetracyclines
analogues
synthesis
Prior art date
Application number
PL05779988T
Other languages
English (en)
Inventor
Andrew G. Myers
Mark G. Charest
Christian D. Lerner
Jason D. Brubacker
Dionicio R. Siegel
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Publication of PL1753713T3 publication Critical patent/PL1753713T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/26—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
PL05779988T 2004-05-21 2005-05-20 Synteza tetracyklin oraz ich analogów PL1753713T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57362304P 2004-05-21 2004-05-21
US66094705P 2005-03-11 2005-03-11

Publications (1)

Publication Number Publication Date
PL1753713T3 true PL1753713T3 (pl) 2017-02-28

Family

ID=35428840

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05779988T PL1753713T3 (pl) 2004-05-21 2005-05-20 Synteza tetracyklin oraz ich analogów

Country Status (19)

Country Link
US (6) US7807842B2 (pl)
EP (2) EP3138831B1 (pl)
JP (5) JP5242161B2 (pl)
KR (2) KR101171408B1 (pl)
CN (3) CN101027279B (pl)
AU (1) AU2005244988C1 (pl)
BR (2) BR122018069604B1 (pl)
CA (3) CA2566464C (pl)
CY (1) CY1118519T1 (pl)
DK (1) DK1753713T3 (pl)
ES (1) ES2607453T3 (pl)
HU (1) HUE030212T2 (pl)
IL (5) IL179467A (pl)
LT (1) LT1753713T (pl)
PL (1) PL1753713T3 (pl)
PT (1) PT1753713T (pl)
SG (1) SG10201810312UA (pl)
SI (1) SI1753713T1 (pl)
WO (1) WO2005112945A2 (pl)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1381372A2 (en) 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
EA201000491A1 (ru) * 2002-03-08 2010-08-30 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
CA2492273C (en) * 2002-07-12 2013-02-05 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
EP2298323A3 (en) 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
PL1753713T3 (pl) 2004-05-21 2017-02-28 President And Fellows Of Harvard College Synteza tetracyklin oraz ich analogów
EP2295419A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2301912A3 (en) * 2004-10-25 2012-07-11 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
WO2007117639A2 (en) 2006-04-07 2007-10-18 The President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
US8440646B1 (en) * 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
EP2479169B1 (en) 2006-10-11 2014-12-03 President and Fellows of Harvard College Synthesis of Enone Intermediate
EP2452935A3 (en) 2006-12-21 2012-08-29 Paratek Pharmaceuticals, Inc. Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
US20080305186A1 (en) * 2007-06-11 2008-12-11 Board Of Regents, The University Of Texas System Method and Composition for the Treatment of Cardiac Hypertrophy
DE102008028334B4 (de) * 2008-06-13 2014-02-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Probenkammer-Adapter für die Kryokonservierung biologischer Proben
EP2307027A4 (en) 2008-07-11 2012-08-15 Neumedics TETRACYCLINE DERIVATIVES WITH REDUCED ANTIBIOTIC ACTIVITY AND NEUROPROTECTIVE PROPERTIES
HUE026562T2 (hu) 2008-08-08 2016-06-28 Tetraphase Pharmaceuticals Inc C7-fluor-helyettesített tetraciklin vegyületek
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
ES2440000T3 (es) * 2009-05-08 2014-01-27 Tetraphase Pharmaceuticals, Inc. Compuestos de 8-aza-tetraciclina
CN107021887A (zh) * 2009-05-08 2017-08-08 四相制药公司 四环素类化合物
WO2010132670A2 (en) * 2009-05-13 2010-11-18 Tetraphase Pharmaceuticals, Inc. Pentacycline compounds
ES2654987T3 (es) 2009-08-28 2018-02-15 Tetraphase Pharmaceuticals, Inc. Compuestos de tetraciclina
WO2011123536A1 (en) * 2010-03-31 2011-10-06 Tetraphase Pharmaceuticals, Inc. Polycyclic tetracycline compounds
WO2012047907A1 (en) 2010-10-04 2012-04-12 President And Fellows Of Harvard College Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
CN102675145B (zh) * 2012-04-27 2013-10-16 山东恩康药业有限公司 一种愈创木酚磺酸多西环素的制备方法
CN103387511B (zh) * 2012-05-08 2016-12-28 成都睿智化学研究有限公司 一种山环素的制备方法
SG11201501516YA (en) 2012-08-31 2015-07-30 Tetraphase Pharmaceuticals Inc Tetracycline compounds
CN103044281A (zh) * 2013-01-02 2013-04-17 湖南赛隆药业有限公司 高纯度替加环素的制法
TW201615221A (zh) * 2014-10-24 2016-05-01 朗齊生物醫學股份有限公司 炎症用藥臨床新應用
KR102628872B1 (ko) * 2015-03-09 2024-01-26 시나이 헬스 시스템 세포의 증식을 제어하기 위해 세포 분열 좌위를 사용하기 위한 도구 및 방법
BR112017020358A2 (pt) 2015-03-23 2018-07-17 Biopharmx Inc composição farmacêutica de tetraciclina para uso dermatológico
CN107188875B (zh) * 2016-03-15 2020-11-10 联化科技股份有限公司 一种取代苯酞类化合物的制备方法及其中间体
CN110582486B (zh) 2016-10-19 2024-01-12 四相制药公司 艾若威四环素的结晶形式
CA3103614C (en) 2018-06-13 2024-05-28 Texas Tech University System Modified tetracycline for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes
GB201914847D0 (en) * 2019-10-14 2019-11-27 Helperby Therapeutics Ltd Combination
CN112979666A (zh) * 2019-12-18 2021-06-18 中国科学院生态环境研究中心 土霉素衍生物、制备方法及其检测方法
CN115340446B (zh) * 2021-05-12 2024-04-19 复旦大学 一种手性苯并环丁烯醇、其合成方法及用途
CN113388556B (zh) * 2021-08-02 2022-12-02 金河生物科技股份有限公司 利用金色链霉菌生产金霉素的方法
CN113929593B (zh) * 2021-09-02 2024-05-31 河北圣雪大成唐山制药有限责任公司 一种土霉素-2,5-二羟基苯甲酸共晶及其制备方法

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2482055A (en) 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
GB935384A (en) * 1959-03-30 1963-08-28 Pfizer & Co C Tetracycline derivatives and preparation thereof
US3019260A (en) * 1959-05-13 1962-01-30 American Cyanamid Co Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
US3338963A (en) 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3219671A (en) * 1961-04-14 1965-11-23 American Cyanamid Co Substituted 6-deoxytetracyclines and 6-demethyl-6-deoxytetracyclines
US3862225A (en) 1961-08-18 1975-01-21 Pfizer D-ring substituted tetracyclines
US3829453A (en) 1961-08-18 1974-08-13 Pfizer Octahydroanthracene-2-aminoacetic acids and esters and mixed anhydrides thereof
US3697552A (en) 1961-08-18 1972-10-10 Pfizer Anthracyclidine-acetic acid derivatives
US3772363A (en) 1961-08-18 1973-11-13 Pfizer 3,4,10-trioxo octahydroanthracene-2-aminoacetic acids and derivatives thereof
GB1013906A (en) 1961-08-18 1965-12-22 Pfizer & Co C Cyclization process and product
US3509184A (en) 1961-08-18 1970-04-28 Pfizer & Co C Anthracyclidine-acetic acid derivatives
FR1365279A (fr) 1961-08-18 1964-07-03 Pfizer & Co C Dérivés d'octahydroanthracènes, et procédé pour leur préparation
US3109007A (en) 1962-10-02 1963-10-29 Pfizer & Co C Derivatives of tetracycline and its analogs
USRE26253E (en) 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
GB1100884A (en) 1965-03-15 1968-01-24 Pfizer & Co C Oxytetracycline esters and preparation thereof
GB1077598A (en) * 1965-05-12 1967-08-02 Pfizer & Co C Preparation of n-demethyl tetracyclines
US3849493A (en) * 1966-08-01 1974-11-19 Pfizer D-ring substituted 6-deoxytetracyclines
US3502660A (en) 1967-01-12 1970-03-24 Pfizer & Co C 2-((5'-(3' and/or 4'-substituted)isoxazoyl) methylidene)-3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes
US4066694A (en) 1971-02-09 1978-01-03 Pfizer Inc. 4-hydroxy-4-dedimethylamino-tetracyclines
US4052467A (en) 1967-11-08 1977-10-04 Phillips Petroleum Company Catalytic reduction of aldehydes to alcohols
US3947517A (en) 1969-06-12 1976-03-30 Research Corporation Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines
US3914299A (en) * 1969-06-12 1975-10-21 Research Corp Tetracyclines
US3699117A (en) 1969-07-29 1972-10-17 Pfizer 2-((5'-(3'-and/or 4'-substituted) isoxazolyl) aminoethyl) - 3,4,10 - trioxo-1,2,3,4,4,9,9,10-octahydroanthracenes and related compounds
BE788479A (fr) 1971-09-06 1973-01-02 Medimpex Gyogyszerkulkereskede Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques
US4060605A (en) 1973-09-28 1977-11-29 Ankerfarm, S.P.A. Water-soluble derivative of 6-deoxy-tetracyclines
US3962330A (en) 1973-09-28 1976-06-08 Ankerfarm, S.P.A. Process for the preparation of 6-demethyl-6-deoxy-6-methylene-tetracyclines
DE2355118A1 (de) 1973-11-03 1975-05-28 Hoechst Ag 2-carboxamido-substituierte tetracycline und verfahren zu ihrer herstellung
JPS5119757A (ja) 1974-06-25 1976-02-17 Farmaceutici Italia Arukirutetorasaikurinjudotainoseizoho
US5589470A (en) 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
DK386784A (da) 1983-08-17 1985-02-18 Hovione Int Ltd Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
ATE211128T1 (de) * 1991-10-04 2002-01-15 American Cyanamid Co 7-substituierte-9-substituierte amino-6-demethyl- 6-deoxy-tetracycline
US6756365B2 (en) 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5688516A (en) 1992-11-12 1997-11-18 Board Of Regents, The University Of Texas System Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices
US5362754A (en) 1992-11-12 1994-11-08 Univ. Of Tx Md Anderson Cancer Center M-EDTA pharmaceutical preparations and uses thereof
US5538954A (en) 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
WO1995022529A1 (en) 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
US5574026A (en) 1994-12-13 1996-11-12 American Cyanamid Company Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth
CA2219277A1 (en) 1995-05-03 1996-11-07 Pfizer Limited Novel tetracycline derivatives
WO1996036229A1 (en) 1995-05-17 1996-11-21 E.I. Du Pont De Nemours And Company Fungicidal cyclic amides
US6165484A (en) 1997-08-26 2000-12-26 Wake Forest University EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections
PT102160B (pt) 1998-05-26 2001-04-30 Hovione Sociedade Quimica S A Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas
US6506740B1 (en) 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
US6581606B2 (en) 1999-07-06 2003-06-24 The Rx Files Corporation Method, apparatus and system for use in treating patient with a drug having an antineoplastic effect to optimize therapy and prevent an adverse drug response
KR100764992B1 (ko) 1999-09-14 2007-10-09 트러스티즈 오브 터프츠 칼리지 전이금속을 이용한 화학반응에 의한 치환 테트라사이클린 제조 방법 및 치환 테트라사이클린 화합물
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6638532B2 (en) 2000-02-24 2003-10-28 Advancis Pharmaceutical Corp. Tetracycline—doxycycline antibiotic composition
US6730320B2 (en) 2000-02-24 2004-05-04 Advancis Pharmaceutical Corp. Tetracycline antibiotic product, use and formulation thereof
MXPA02009482A (es) 2000-03-31 2004-05-14 Tufts College Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino.
AU2001259701A1 (en) 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
AU2001268475A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020128237A1 (en) 2000-06-16 2002-09-12 Nelson Mark L. 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
WO2001098260A1 (en) * 2000-06-16 2001-12-27 Trustees Of Tufts College 7-n-substituted phenyl tetracycline compounds
AU2000254942A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
EP2166000A1 (en) * 2000-07-07 2010-03-24 Trustees Of Tufts College 7-, 8- and 9-substituted tetracycline compounds
SI1301467T1 (sl) * 2000-07-07 2007-02-28 Tufts College 9-substituirane minociklinske spojine
EP1301466A2 (en) * 2000-07-07 2003-04-16 Trustees Of Tufts College 7-substituted tetracycline compounds
AU2000265203A1 (en) * 2000-08-04 2002-02-18 Trustees Of Tufts College 8-substituted tetracycline compounds
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
AU2001271619B2 (en) 2001-03-13 2008-05-15 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
EP1379255A2 (en) 2001-03-14 2004-01-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
EP1381372A2 (en) 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
CA2444899C (en) * 2001-04-24 2011-06-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2332547A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of inflammatory bowel disease
EP1439843A4 (en) 2001-10-05 2007-01-03 Tetragenex Pharmaceuticals Inc TETRACYCLINE DERIVATIVES AND METHODS OF USE
EP2995610A1 (en) * 2002-01-08 2016-03-16 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
ES2555307T3 (es) 2002-03-08 2015-12-30 Eisai R&D Management Co., Ltd. Compuestos macrocíclicos útiles como agentes farmacéuticos
AU2003287218C1 (en) * 2002-10-24 2010-07-15 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy
US20090325909A1 (en) * 2003-09-26 2009-12-31 The Johns Hopkins University Suppression of HIV replication and prevention and treatment of HIV
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
DE102004024674A1 (de) 2004-05-18 2005-12-15 Wolfgang Lorenz Mittel und Verfahren zur Diagnose, Prophylaxe und Therapie von Bindegewebserkrankungen
PL1753713T3 (pl) 2004-05-21 2017-02-28 President And Fellows Of Harvard College Synteza tetracyklin oraz ich analogów
EP1753762B1 (en) 2004-06-08 2014-03-19 Metabasis Therapeutics, Inc. Lewis acid mediated synthesis of cyclic esters
US7327803B2 (en) 2004-10-22 2008-02-05 Parkervision, Inc. Systems and methods for vector power amplification
JP4857634B2 (ja) * 2005-07-22 2012-01-18 三菱瓦斯化学株式会社 ポリアミド樹脂
WO2007067807A1 (en) 2005-12-07 2007-06-14 Alacrity Biosciences, Inc. Tetracyclines for treating ocular diseases and disorders
WO2007112121A2 (en) 2006-03-27 2007-10-04 Government Of The United States Of Americas, As Represented By The Secretary Tetracycline compounds and methods of treatment
WO2007117639A2 (en) 2006-04-07 2007-10-18 The President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
WO2007118237A2 (en) 2006-04-07 2007-10-18 President And Fellows Of Harvard College Nano-scale gas separation device utilizing thin film structures for hydrogen production
EP2479169B1 (en) 2006-10-11 2014-12-03 President and Fellows of Harvard College Synthesis of Enone Intermediate
CN101684101B (zh) 2008-09-16 2011-11-09 山东轩竹医药科技有限公司 哌嗪酮取代的四环素衍生物
WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
WO2012047907A1 (en) 2010-10-04 2012-04-12 President And Fellows Of Harvard College Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto

Also Published As

Publication number Publication date
US20110009371A1 (en) 2011-01-13
EP3138831B1 (en) 2020-07-08
US11192866B2 (en) 2021-12-07
CY1118519T1 (el) 2017-07-12
CN101027279A (zh) 2007-08-29
IL217315A (en) 2014-02-27
US20190345116A1 (en) 2019-11-14
HUE030212T2 (en) 2017-04-28
US20050282787A1 (en) 2005-12-22
US20160340325A1 (en) 2016-11-24
CA2566464A1 (en) 2005-12-01
JP2008500391A (ja) 2008-01-10
ES2607453T3 (es) 2017-03-31
KR101171408B1 (ko) 2012-08-08
WO2005112945A3 (en) 2006-07-13
CN101027279B (zh) 2013-03-27
US8598148B2 (en) 2013-12-03
JP5242161B2 (ja) 2013-07-24
WO2005112945A2 (en) 2005-12-01
US9884830B2 (en) 2018-02-06
KR20110045105A (ko) 2011-05-03
IL217314A (en) 2014-02-27
US20180230111A1 (en) 2018-08-16
IL179467A (en) 2012-02-29
US9365493B2 (en) 2016-06-14
DK1753713T3 (en) 2016-11-28
IL213664A0 (en) 2011-07-31
CN103224474A (zh) 2013-07-31
EP1753713B1 (en) 2016-07-27
EP1753713A4 (en) 2009-07-08
JP6185966B2 (ja) 2017-08-23
BRPI0510113B1 (pt) 2022-09-27
CA2566464C (en) 2012-04-03
IL179467A0 (en) 2007-05-15
LT1753713T (lt) 2016-11-25
CA2767912A1 (en) 2005-12-01
SG10201810312UA (en) 2018-12-28
PT1753713T (pt) 2016-11-08
AU2005244988B2 (en) 2012-02-02
CN103214409A (zh) 2013-07-24
CN103214409B (zh) 2015-10-21
KR20070047245A (ko) 2007-05-04
BRPI0510113A (pt) 2007-09-25
IL217314A0 (en) 2012-02-29
IL217316A (en) 2014-08-31
JP2013227346A (ja) 2013-11-07
CA2767912C (en) 2015-08-11
US10669244B2 (en) 2020-06-02
KR101336462B1 (ko) 2013-12-04
AU2005244988C1 (en) 2012-06-28
SI1753713T1 (sl) 2017-01-31
CA2892332C (en) 2017-03-21
JP2017052797A (ja) 2017-03-16
CA2892332A1 (en) 2005-12-01
IL217315A0 (en) 2012-02-29
US7807842B2 (en) 2010-10-05
JP5971900B2 (ja) 2016-08-17
US20140163238A1 (en) 2014-06-12
CN103224474B (zh) 2016-08-03
BR122018069604B1 (pt) 2021-07-20
IL217316A0 (en) 2012-02-29
JP2011162566A (ja) 2011-08-25
EP3138831A1 (en) 2017-03-08
AU2005244988A1 (en) 2005-12-01
JP2015221832A (ja) 2015-12-10
EP1753713A2 (en) 2007-02-21

Similar Documents

Publication Publication Date Title
PL1753713T3 (pl) Synteza tetracyklin oraz ich analogów
PT1778618E (pt) Síntese de trietilenotetraminas
AP2466A (en) Preparation of pregabalin and related compounds
EP2016044A4 (en) TETRACYCLIN SYNTHESIS AND ANALOGUE OUT OF THIS
SI2072051T1 (sl) Kombinacija azelastina in mometasona
IL227474A (en) Intermediates for Helicondrin B and Similar Fragment C1 – C13
ZA200704902B (en) Compositions comprising azelastine and methods of use thereof
ZA200802501B (en) Indenoisoquinolinone analogs and methods of use thereof
IL176932A0 (en) Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
PL1564203T3 (pl) Nowy sposób przemysłowej syntezy (7-metoksy-1-naftylo)acetonitrylu i jego zastosowanie w syntezie agomelatyny
EP1711484A4 (en) SYNTHESIS OF CYANOIMINO-BENZOIMIDAZOLES
IL172195A0 (en) Thiotungstate analogues and uses thereof
GB2441840B (en) Process for the synthesis of arylfluorenes and analogues thereof
ZA200501255B (en) Process for the synthesis of (7-methoxy-1-naphthyl)acetonitrile and its application in the synthesis of agomelatinie
ZA200610528B (en) Synthesis of tetracyclines and analogues thereof
IL178184A0 (en) Synthesis of pyrrole-2-carbonitriles
IL185548A0 (en) Medical uses of 39-desmethoxyrapamycin and analogues thereof
AU2003217354A8 (en) Synthesis of sulfamidates
HK1097836A (en) Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
IL190233A0 (en) Total synthesis of pladienolide b and pladienolide d
SI1709057T1 (sl) Sinteza spongozina
ZA200609688B (en) Preparation of pregabalin and related compounds
GB0328318D0 (en) Synthesis of spongosine
GB0423342D0 (en) Manufacture of amides