PL1755743T3 - Beta-hydroksymaślan i pochodne do leczenia depresji i lęku - Google Patents
Beta-hydroksymaślan i pochodne do leczenia depresji i lękuInfo
- Publication number
- PL1755743T3 PL1755743T3 PL05742109T PL05742109T PL1755743T3 PL 1755743 T3 PL1755743 T3 PL 1755743T3 PL 05742109 T PL05742109 T PL 05742109T PL 05742109 T PL05742109 T PL 05742109T PL 1755743 T3 PL1755743 T3 PL 1755743T3
- Authority
- PL
- Poland
- Prior art keywords
- anxiety
- derivatives
- treating depression
- beta hydroxybutyrate
- hydroxybutyrate
- Prior art date
Links
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 title 1
- 230000036506 anxiety Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57013704P | 2004-05-12 | 2004-05-12 | |
| GB0420856A GB0420856D0 (en) | 2004-09-20 | 2004-09-20 | Cns modulators |
| PCT/GB2005/001835 WO2005107875A2 (en) | 2004-05-12 | 2005-05-12 | Triglycerides, fatty acids, alcohols as cns modulators |
| EP05742109.1A EP1755743B1 (en) | 2004-05-12 | 2005-05-12 | Beta hydroxybutyrate and derivatives for treating depression and anxiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1755743T3 true PL1755743T3 (pl) | 2013-08-30 |
Family
ID=33306877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10184846T PL2316530T3 (pl) | 2004-05-12 | 2005-05-12 | Triglicerydy, kwasy tłuszczowe i alkohole jako modulatory oun |
| PL05742109T PL1755743T3 (pl) | 2004-05-12 | 2005-05-12 | Beta-hydroksymaślan i pochodne do leczenia depresji i lęku |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10184846T PL2316530T3 (pl) | 2004-05-12 | 2005-05-12 | Triglicerydy, kwasy tłuszczowe i alkohole jako modulatory oun |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20080058416A1 (pl) |
| EP (2) | EP1755743B1 (pl) |
| DK (2) | DK2316530T3 (pl) |
| ES (2) | ES2513890T3 (pl) |
| GB (1) | GB0420856D0 (pl) |
| PL (2) | PL2316530T3 (pl) |
| PT (1) | PT1755743E (pl) |
| WO (1) | WO2005107875A2 (pl) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0427145D0 (en) * | 2004-12-10 | 2005-01-12 | Ketocytonyx Inc | Compositions for use in surgery |
| CA2684213A1 (en) | 2007-04-12 | 2008-10-23 | Regents Of The University Of Minnesota | Ischemia/reperfusion protection compositions and methods of using |
| SG11201506780RA (en) | 2013-03-19 | 2015-10-29 | Univ South Florida | Compositions and methods for producing elevated and sustained ketosis |
| US10568854B2 (en) | 2014-05-30 | 2020-02-25 | The Johns Hopkins University | Compositions and methods for treating kabuki syndrome and related disorders |
| US10980764B1 (en) * | 2016-02-01 | 2021-04-20 | University Of South Florida | Exogenous ketone supplements for reducing anxiety-related behavior |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11185518B2 (en) | 2017-12-19 | 2021-11-30 | Axcess Global Sciences, Llc | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer |
| US10973786B2 (en) | 2016-03-11 | 2021-04-13 | Axcess Global Sciences, Llc | R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions |
| US10736861B2 (en) | 2016-03-11 | 2020-08-11 | Axcess Global Sciences, Llc | Mixed salt compositions for producing elevated and sustained ketosis |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US10973792B2 (en) | 2019-02-13 | 2021-04-13 | Axcess Global Sciences, Llc | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use |
| WO2017184788A1 (en) * | 2016-04-19 | 2017-10-26 | Keto Patent Group, Inc. | Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US11026929B2 (en) | 2016-04-19 | 2021-06-08 | Keto Patent Group, Inc. | Administration of berberine metabolites |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| WO2018009208A1 (en) * | 2016-07-08 | 2018-01-11 | Cognate Nutritionals, Inc. | Nutritional mitiggation of the cns effects of traumatic brain injury |
| US20180057846A1 (en) | 2016-08-30 | 2018-03-01 | KetoneAid Inc. | Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy |
| US10307398B2 (en) | 2016-09-20 | 2019-06-04 | Regents Of The University Of Minnesota | Resuscitation composition and methods of making and using |
| WO2018081118A1 (en) | 2016-10-24 | 2018-05-03 | University Of South Florida | Delaying latency to seizure by combinations of ketone supplements |
| US20180177753A1 (en) * | 2016-12-23 | 2018-06-28 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for migraine symptom management |
| US9925164B1 (en) | 2017-01-12 | 2018-03-27 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for traumatic brain injury |
| US10376528B2 (en) | 2017-03-10 | 2019-08-13 | Tecton Group, Llc | Composition comprising ketone body and nicotinamide adenine dinucleotide modulator and methyl donor |
| US12171735B2 (en) | 2017-04-19 | 2024-12-24 | Axcess Global Sciences, Llc | Administration of butyrate, beta-hydroxybutyrate, cannabidiol, and related compounds in humans |
| US11760963B2 (en) | 2017-08-23 | 2023-09-19 | KetoneAid Inc. | Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11129802B2 (en) | 2018-08-27 | 2021-09-28 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
| US11419836B2 (en) | 2019-02-13 | 2022-08-23 | Axcess Global Sciences, Llc | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions |
| US11241401B2 (en) | 2020-02-06 | 2022-02-08 | Axcess Global Sciences, Llc | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions |
| US10980772B2 (en) | 2018-08-27 | 2021-04-20 | Axcess Global Sciences, Llc | Compositions and methods for delivering tetrahydrocannabinol and ketone bodies |
| US20200061023A1 (en) * | 2018-08-27 | 2020-02-27 | Axcess Global Sciences, Llc | Compositions and methods for delivering tetrahydrocannabinol and ketone bodies |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| PL3976021T3 (pl) | 2019-05-30 | 2025-07-21 | Neuroenergy Ventures, Inc. | Tri(beta-hydroksymaślan) glicerolu do zastosowania w leczeniu i zapobieganiu przemijającym atakom niedokrwiennym neuronów |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US11033553B2 (en) | 2019-06-21 | 2021-06-15 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12396974B2 (en) | 2020-03-27 | 2025-08-26 | KetoneAid | Ketone ester as a therapeutic treatment of Covid-19 and related viral infections |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| TWI804037B (zh) | 2021-11-02 | 2023-06-01 | 長庚醫療財團法人高雄長庚紀念醫院 | 生酮飲食之評估系統及其運作方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE637726A (pl) * | 1962-09-26 | |||
| GB1476624A (en) * | 1973-05-30 | 1977-06-16 | Cepbepe | Tranquiliser medicaments |
| US4363815A (en) * | 1975-07-23 | 1982-12-14 | Yu Ruey J | Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions |
| DE2733202A1 (de) * | 1976-08-04 | 1978-02-09 | Agroferm Ag | Verfahren zur herstellung der d(-)-3-hydroxybuttersaeure |
| US4067999A (en) * | 1976-12-15 | 1978-01-10 | Food Technology Products | Control of hemorrhagic enteritis in turkeys |
| US4234599A (en) * | 1978-10-04 | 1980-11-18 | Scott Eugene J Van | Treatment of skin keratoses with α-hydroxy acids and related compounds |
| US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
| US4351835A (en) * | 1981-04-01 | 1982-09-28 | Montefiore Hospital | Method for preventing body fat deposition in mammals |
| FR2521857B1 (fr) * | 1982-02-23 | 1985-10-31 | Solvay | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
| DE3229955A1 (de) * | 1982-08-12 | 1984-02-16 | Erichsen, Friedrich Karl, Dr., 2351 Schillsdorf | Arzneimittel mit analgetischer wirkung |
| US4701443A (en) * | 1983-03-22 | 1987-10-20 | Baxter Travenol Laboratories, Inc. | Nutrient polyesters |
| EP0215138B1 (fr) * | 1985-09-06 | 1991-01-16 | Societe Des Produits Nestle S.A. | Préservation des tissus vivants |
| GB8525666D0 (en) * | 1985-10-17 | 1985-11-20 | Ici Plc | Chemical process |
| AU6776887A (en) * | 1985-12-18 | 1987-07-15 | Veech, R.L. | Fluid therapy with l-lactate and/or pyruvate anions |
| US5719119A (en) * | 1985-12-18 | 1998-02-17 | British Technology Group, Ltd. | Parenteral nutrition therapy with amino acids |
| WO1987003809A1 (en) * | 1985-12-20 | 1987-07-02 | Veech Richard L | Preparation of electrolyte solutions and containers |
| US5126373A (en) * | 1987-11-19 | 1992-06-30 | Henri Brunengraber | Composition for parenteral and oral nutrition |
| US4997976A (en) * | 1988-11-15 | 1991-03-05 | Henri Brunengraber | Use of 1,3-butanediol acetoacetate in parenteral oral nutrition |
| US5292774A (en) * | 1988-07-26 | 1994-03-08 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Substitution fluid preparation comprising 3-hydroxy-butyric acid (β-hydroxybutric acid) and its salts |
| US5116868A (en) * | 1989-05-03 | 1992-05-26 | The Johns Hopkins University | Effective ophthalmic irrigation solution |
| US5286842A (en) * | 1991-07-01 | 1994-02-15 | Mitsubishi Kasei Corporation | Process for producing a biodegradable polymer |
| US5654266A (en) * | 1992-02-10 | 1997-08-05 | Chen; Chung-Ho | Composition for tissues to sustain viability and biological functions in surgery and storage |
| US5348979A (en) * | 1992-12-23 | 1994-09-20 | Iowa State University Research Foundation Inc. | Method of promoting nitrogen retention in humans |
| WO1995009144A1 (en) * | 1993-09-30 | 1995-04-06 | Eastman Chemical Company | Nutritive water soluble glycerol esters of hydroxy butyric acid |
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| JP4598203B2 (ja) * | 1995-12-01 | 2010-12-15 | ビーティージー・インターナショナル・リミテッド | 脳機能改善剤 |
| JPH10158166A (ja) * | 1996-12-02 | 1998-06-16 | Taisho Pharmaceut Co Ltd | 貼付剤 |
| ES2530753T3 (es) * | 1997-03-17 | 2015-03-05 | Btg Int Ltd | Composiciones terapéuticas que comprenden cuerpos cetónicos y precursores de los mismos |
| US6323237B1 (en) * | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
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| KR100805490B1 (ko) * | 1998-09-15 | 2008-02-20 | 비티지 인터내셔널 리미티드 | 치료 조성물 (ⅱ) |
| US6835750B1 (en) * | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
| ES2323940T3 (es) * | 2000-05-01 | 2009-07-28 | Accera, Inc. | Uso de trigliceridos de cadena media para el tratamiento y prevencion de la enfermedad de alzheimer. |
| AU2002229452A1 (en) * | 2001-02-07 | 2002-08-19 | W. Mcintyre Burnham | Method of treating neurological disorders using acetone derivatives |
| US20020132846A1 (en) * | 2001-02-26 | 2002-09-19 | Caleb Stone | Use of gamma substituted gamma-butyrolactones to increase levels of their corresponding substituted gamma-hydroxybutyrate derivatives in humans |
| WO2002102363A1 (en) * | 2001-06-20 | 2002-12-27 | Lorus Therapeutics Inc. | Biological response modifier composition and uses thereof |
| US6579543B1 (en) * | 2002-02-22 | 2003-06-17 | Jackie H. McClung | Composition for topical application to skin |
| JP2003306430A (ja) * | 2002-04-16 | 2003-10-28 | Lion Corp | 皮膚外用剤組成物 |
| DK1648952T3 (en) * | 2003-06-03 | 2018-05-28 | The Us Gov As Represented By The Department Of Health And Human Services | Dietary supplements and therapeutic compositions comprising (R) -3-hydroxybutyrate derivatives |
| WO2005034874A2 (en) * | 2003-10-08 | 2005-04-21 | The Mclean Hospital Corporation | Enhanced efficacy of omega-3 fatty acid therapy in the treatment of psychiatric disorders and other indications |
| EP1727554A4 (en) * | 2003-10-08 | 2009-09-30 | Mclean Hospital Corp | METHODS OF TREATING PSYCHIATRIC DISORDERS, ALCOHOL AND DRUG ABUSE DISORDERS, AND OTHER DISORDERS USING COMBINATIONS CONTAINING OMEGA 3 FATTY ACIDS |
-
2004
- 2004-09-20 GB GB0420856A patent/GB0420856D0/en not_active Ceased
-
2005
- 2005-05-12 PL PL10184846T patent/PL2316530T3/pl unknown
- 2005-05-12 ES ES10184846.3T patent/ES2513890T3/es not_active Expired - Lifetime
- 2005-05-12 DK DK10184846.3T patent/DK2316530T3/da active
- 2005-05-12 DK DK05742109.1T patent/DK1755743T3/da active
- 2005-05-12 ES ES05742109T patent/ES2410588T3/es not_active Expired - Lifetime
- 2005-05-12 US US11/596,012 patent/US20080058416A1/en not_active Abandoned
- 2005-05-12 PL PL05742109T patent/PL1755743T3/pl unknown
- 2005-05-12 PT PT57421091T patent/PT1755743E/pt unknown
- 2005-05-12 EP EP05742109.1A patent/EP1755743B1/en not_active Expired - Lifetime
- 2005-05-12 EP EP10184846.3A patent/EP2316530B1/en not_active Expired - Lifetime
- 2005-05-12 WO PCT/GB2005/001835 patent/WO2005107875A2/en not_active Ceased
-
2014
- 2014-06-17 US US14/307,231 patent/US20140296337A1/en not_active Abandoned
-
2021
- 2021-12-08 US US17/643,237 patent/US20220202760A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT1755743E (pt) | 2013-06-03 |
| EP2316530A1 (en) | 2011-05-04 |
| EP2316530B1 (en) | 2014-08-13 |
| US20140296337A1 (en) | 2014-10-02 |
| DK1755743T3 (da) | 2013-06-10 |
| ES2513890T3 (es) | 2014-10-27 |
| DK2316530T3 (da) | 2014-11-03 |
| US20220202760A1 (en) | 2022-06-30 |
| US20080058416A1 (en) | 2008-03-06 |
| PL2316530T3 (pl) | 2015-01-30 |
| ES2410588T3 (es) | 2013-07-02 |
| GB0420856D0 (en) | 2004-10-20 |
| WO2005107875A2 (en) | 2005-11-17 |
| WO2005107875A3 (en) | 2006-03-23 |
| EP1755743B1 (en) | 2013-04-24 |
| EP1755743A2 (en) | 2007-02-28 |
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