PL1771157T3 - Wielocząstkowa postać leku dla słabo rozpuszczalnych substancji czynnych oraz sposób wytwarzania tej postaci leku - Google Patents

Wielocząstkowa postać leku dla słabo rozpuszczalnych substancji czynnych oraz sposób wytwarzania tej postaci leku

Info

Publication number
PL1771157T3
PL1771157T3 PL05758133T PL05758133T PL1771157T3 PL 1771157 T3 PL1771157 T3 PL 1771157T3 PL 05758133 T PL05758133 T PL 05758133T PL 05758133 T PL05758133 T PL 05758133T PL 1771157 T3 PL1771157 T3 PL 1771157T3
Authority
PL
Poland
Prior art keywords
pharmaceutical dosage
dosage form
active agent
multiparticle
polymer
Prior art date
Application number
PL05758133T
Other languages
English (en)
Inventor
Rosario Lizio
Hans-Ulrich Petereit
Peter Langguth
Marcus Knöll
Original Assignee
Evonik Roehm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm Gmbh filed Critical Evonik Roehm Gmbh
Publication of PL1771157T3 publication Critical patent/PL1771157T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL05758133T 2004-07-27 2005-07-08 Wielocząstkowa postać leku dla słabo rozpuszczalnych substancji czynnych oraz sposób wytwarzania tej postaci leku PL1771157T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004036437A DE102004036437A1 (de) 2004-07-27 2004-07-27 Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
EP05758133A EP1771157B1 (de) 2004-07-27 2005-07-08 Multipartikuläre arzneiform für wenig lösliche wirkstoffe sowie ein verfahren zur herstellung der arzneiform
PCT/EP2005/007427 WO2006010453A1 (de) 2004-07-27 2005-07-08 Multipartikuläre arzneiform für wenig lösliche wirkstoffe sowie ein verfahren zur herstellung der arzneiform

Publications (1)

Publication Number Publication Date
PL1771157T3 true PL1771157T3 (pl) 2008-08-29

Family

ID=35169905

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05758133T PL1771157T3 (pl) 2004-07-27 2005-07-08 Wielocząstkowa postać leku dla słabo rozpuszczalnych substancji czynnych oraz sposób wytwarzania tej postaci leku

Country Status (14)

Country Link
US (1) US8273375B2 (pl)
EP (1) EP1771157B1 (pl)
JP (1) JP5455305B2 (pl)
KR (1) KR101216750B1 (pl)
AT (1) ATE388692T1 (pl)
BR (1) BRPI0513904B8 (pl)
CA (1) CA2570608C (pl)
DE (2) DE102004036437A1 (pl)
ES (1) ES2302209T3 (pl)
IL (1) IL180943A (pl)
MX (1) MX2007000955A (pl)
PL (1) PL1771157T3 (pl)
SI (1) SI1771157T1 (pl)
WO (1) WO2006010453A1 (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10332160A1 (de) * 2003-07-15 2005-02-03 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Peptid- oder Protein-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102004059792A1 (de) * 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102005007059A1 (de) 2005-02-15 2006-08-24 Röhm GmbH & Co. KG Teilneutralisiertes anionisches (Meth)acrylat-Copolymer
US8048413B2 (en) 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
DE102006035549A1 (de) * 2006-07-27 2008-01-31 Evonik Röhm Gmbh Arzneiform mit mindestens zweischichtiger Trennschicht
DE102007031697A1 (de) * 2007-07-06 2009-01-08 Walter Rau Neusser Öl und Fett AG Kosmetische oder pharmazeutische Zubereitung
RU2604861C2 (ru) 2010-02-25 2016-12-10 Эвоник Рем ГмбХ Фармацевтический или нутрицевтический состав
US8796338B2 (en) 2011-01-07 2014-08-05 Elcelyx Therapeutics, Inc Biguanide compositions and methods of treating metabolic disorders
US9211263B2 (en) 2012-01-06 2015-12-15 Elcelyx Therapeutics, Inc. Compositions and methods of treating metabolic disorders
US11759441B2 (en) 2011-01-07 2023-09-19 Anji Pharmaceuticals Inc. Biguanide compositions and methods of treating metabolic disorders
US11974971B2 (en) 2011-01-07 2024-05-07 Anji Pharmaceuticals Inc. Compositions and methods for treating metabolic disorders
US9572784B2 (en) 2011-01-07 2017-02-21 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
EP3763419A1 (en) 2011-01-07 2021-01-13 Anji Pharma (US) LLC Chemosensory receptor ligand-based therapies
WO2012103411A2 (en) 2011-01-28 2012-08-02 Zx Pharma, Llc Controlled-release melatonin composition and related methods
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
MX2013009253A (es) 2011-02-11 2013-12-16 Zx Pharma Llc Formulaciones multiparticuladas de l-mentol y metodos relacionados.
PL2720681T3 (pl) * 2011-06-17 2017-05-31 Evonik Röhm Gmbh Kompozycja powlekająca odpowiednia do farmaceutycznych lub nutraceutycznych postaci dawkowania
EA033067B1 (ru) 2012-01-06 2019-08-30 Элселикс Терапьютикс, Инк. Способ лечения метаболических расстройств у пациента, имеющего противопоказание к назначению бигуанидного соединения
EA201491335A1 (ru) 2012-01-06 2015-04-30 Элселикс Терапьютикс, Инк. Бигуанидные композиции и способы лечения метаболических расстройств
WO2014175916A1 (en) 2013-04-23 2014-10-30 Zx Pharma, Llc Enteric coated multiparticulate composition with proteinaceous subcoat
BR112015027824B1 (pt) * 2013-05-06 2021-06-08 Dsm Ip Assets B.V. composição na forma de pó, processo para produção da mesma, uso de uma composição na forma de pó e formulação líquida
US20160022644A1 (en) * 2014-07-22 2016-01-28 Tsu-I Catherine Wang Oral Transmucosal Compositions Including Aromatase Inhibitors for Treating Female Infertility
US10588866B2 (en) * 2014-11-11 2020-03-17 Verdure Sciences Stable solid lipid particle composition for improved bioavailability of lipophilic compounds for age-related diseases
CA2990190A1 (en) * 2015-06-26 2016-12-29 Advanced Bionutrition Corp. Composition for delivery of active agents to an animal
CN119236191A (zh) 2018-05-24 2025-01-03 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件
MX2020012458A (es) 2018-05-24 2021-04-28 Celanese Eva Performance Polymers Llc Dispositivo implantable para liberacion sostenida de un compuesto de farmaco macromolecular.
US11689849B2 (en) 2018-05-24 2023-06-27 Nureva, Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
IT202000009922A1 (it) * 2020-05-05 2021-11-05 Vetagro Int S R L Composizioni comprendenti timolo per uso nel trattamento di disturbi intestinali infiammatori o funzionali mediante modulazione del sistema endocannabinoide
JP2024515220A (ja) 2021-04-26 2024-04-05 セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー 高分子薬剤化合物の持続放出用の埋め込み型デバイス
CN115154661A (zh) * 2022-07-29 2022-10-11 广州莱度品牌管理有限公司 一种仿生角质膜的制备方法
WO2025043236A1 (en) * 2023-08-24 2025-02-27 Joseph Fuisz Edible oral films, compositions, method of manufacture and packaging systems

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW209174B (pl) * 1991-04-19 1993-07-11 Takeda Pharm Industry Co Ltd
US5938990A (en) * 1994-07-01 1999-08-17 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby
AU2002319653A1 (en) 2001-07-20 2003-03-03 Samir Mitragotri Method for oral drug delivery
US7670627B2 (en) * 2002-12-09 2010-03-02 Salvona Ip Llc pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients
DE10332160A1 (de) * 2003-07-15 2005-02-03 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Peptid- oder Protein-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE10353196A1 (de) 2003-11-13 2005-06-16 Röhm GmbH & Co. KG Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
DE10353186A1 (de) 2003-11-13 2005-06-16 Röhm GmbH & Co. KG Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz
EP1732513A2 (en) * 2003-12-31 2006-12-20 Alpharma, Inc. Rosiglitazone formulations
US20040224019A1 (en) * 2004-03-03 2004-11-11 Adi Shefer Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs
DE102006035549A1 (de) 2006-07-27 2008-01-31 Evonik Röhm Gmbh Arzneiform mit mindestens zweischichtiger Trennschicht

Also Published As

Publication number Publication date
KR101216750B1 (ko) 2012-12-28
US20080166416A1 (en) 2008-07-10
ES2302209T3 (es) 2008-07-01
CA2570608A1 (en) 2006-02-02
JP5455305B2 (ja) 2014-03-26
US8273375B2 (en) 2012-09-25
SI1771157T1 (sl) 2008-06-30
DE502005003223D1 (de) 2008-04-24
ATE388692T1 (de) 2008-03-15
EP1771157A1 (de) 2007-04-11
KR20070046089A (ko) 2007-05-02
JP2008508204A (ja) 2008-03-21
IL180943A0 (en) 2007-07-04
BRPI0513904A (pt) 2008-05-20
BRPI0513904B8 (pt) 2021-05-25
BRPI0513904B1 (pt) 2019-02-05
CA2570608C (en) 2015-07-07
MX2007000955A (es) 2007-04-16
WO2006010453A1 (de) 2006-02-02
IL180943A (en) 2010-12-30
EP1771157B1 (de) 2008-03-12
DE102004036437A1 (de) 2006-03-23

Similar Documents

Publication Publication Date Title
IL180943A (en) Multiparticle pharmaceutical dosage form for a low-soluble active substances and method for producing said pharmaceutical dosage form
WO2005007139A3 (de) Multipartikuläre arzneiform, enthaltend mucoadhaesiv formulierte peptid- oder protein-wirkstoffe, sowie ein verfahren zur herstellung der arzneiform
WO2003090726A3 (en) Chewable soft capsule
EA201400972A1 (ru) Лекарственные формы немедленного высвобождения с защитой от несанкционированного применения
HRP20120587T1 (hr) Proizvodi otporni na neovlašteno otvaranje za primjenu opioida i ostalih lijekova pogodnih za zlouporabu
HRP20100372T1 (hr) Farmaceutski sastavi neuroaktivnog steroida i njihova uporaba
WO2006039022A3 (en) Controlled regional oral delivery
ATE482694T1 (de) Zusammensetzung zur kontrollierten wirkstoffabgabe
HRP20161329T1 (hr) Oralni oblici doziranja koji sadrže likarbazepin acetat
EA200700049A1 (ru) Препаративные формы оральных лекарственных форм мемантина с модифицированным высвобождением
CA2400567A1 (en) Tamper-resistant oral opioid agonist formulations
WO2007000778A3 (en) Modified release pharmaceutical compositions on the basis of two polymers and processes thereof
BRPI0417043A (pt) composição farmacêutica, forma de dosagem sólida, método de manufatura de forma de dosagem sólida, e, uso da composição
TW200635617A (en) Multiparticulate pharmaceutical form comprising mucoadhesively formulated nucleic acid active ingredients, and a process for producing the pharmaceutical form
JP2008037863A (ja) 不快味を呈する薬物含有製剤粒子
WO2006044049A3 (en) Method of providing customized drug delivery systems
DE50307321D1 (de) Schmelzextrusion von wirkstoffsalzen
MX2008001645A (es) Composiciones de fexofendina en suspension farmaceutica oral.
WO2006060681A3 (en) Pharmaceutical composition containing an anti-nucleating agent
CA2516327A1 (en) Therapeutic system comprising amoxicillin and clavulanic acid
WO2007120838A3 (en) Rapidly disintegrating solid oral dosage form of liquid dispersions
IS6553A (is) Kvarnaðar agnir með duldu bragði
UA80872C2 (uk) Фармацевтична композиція, що містить як активну речовину платиновий комплекс, і спосіб її виготовлення
JP2004522780A5 (pl)
WO1999042087A3 (en) Controlled release potassium chloride pellet based pharmaceutical compositions having a high active ingredient content