PL1789434T3 - Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek - Google Patents

Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek

Info

Publication number
PL1789434T3
PL1789434T3 PL05775826T PL05775826T PL1789434T3 PL 1789434 T3 PL1789434 T3 PL 1789434T3 PL 05775826 T PL05775826 T PL 05775826T PL 05775826 T PL05775826 T PL 05775826T PL 1789434 T3 PL1789434 T3 PL 1789434T3
Authority
PL
Poland
Prior art keywords
aminomethane
hydroxymethyl
polypeptides
peptides
stabilization
Prior art date
Application number
PL05775826T
Other languages
English (en)
Inventor
Ingun Christiansen
Arne Staby
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of PL1789434T3 publication Critical patent/PL1789434T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL05775826T 2004-08-31 2005-08-26 Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek PL1789434T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200401310 2004-08-31
PCT/EP2005/054209 WO2006024631A2 (en) 2004-08-31 2005-08-26 Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
EP05775826.0A EP1789434B1 (en) 2004-08-31 2005-08-26 Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins

Publications (1)

Publication Number Publication Date
PL1789434T3 true PL1789434T3 (pl) 2014-07-31

Family

ID=35311457

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05775826T PL1789434T3 (pl) 2004-08-31 2005-08-26 Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek

Country Status (6)

Country Link
US (1) US8710181B2 (pl)
EP (1) EP1789434B1 (pl)
JP (1) JP4965446B2 (pl)
ES (1) ES2442223T3 (pl)
PL (1) PL1789434T3 (pl)
WO (1) WO2006024631A2 (pl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
WO2007117706A2 (en) * 2006-04-07 2007-10-18 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
CN102046192B (zh) * 2008-05-07 2014-11-19 默里昂研究Ⅲ有限公司 GnRH相关化合物的组合物及制备方法
TWI451876B (zh) * 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
US8907059B2 (en) * 2008-11-14 2014-12-09 Bio-Rad Laboratories, Inc. Phosphopeptide enrichment of compositions by fractionation on ceramic hydroxyapatite
WO2010099255A1 (en) * 2009-02-25 2010-09-02 Merrion Research Iii Limited Composition and drug delivery of bisphosphonates
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
WO2012094598A2 (en) 2011-01-07 2012-07-12 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
WO2013158276A1 (en) * 2012-04-20 2013-10-24 Children's Hospital Medical Center Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
JP2016506401A (ja) 2012-12-21 2016-03-03 サノフイ 二重glp1/gipまたは三方glp1/gip/グルカゴンアゴニストとしてのエキセンジン−4誘導体
CN103321100B (zh) * 2013-06-26 2015-07-22 广东工业大学 一种纸张脱酸剂及其使用方法
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽-4(exendin-4)胜肽類似物
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重glp-1/gip受體促效劑
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
EP3080150B1 (en) 2013-12-13 2018-08-01 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自exendin-4之雙重glp-1/升糖素受體促效劑
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
US10265384B2 (en) 2015-01-29 2019-04-23 Novo Nordisk A/S Tablets comprising GLP-1 agonist and enteric coating
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物
CN110526982B (zh) * 2018-05-23 2023-08-01 信立泰(成都)生物技术有限公司 一种人胰高血糖素样肽-1类似物融合蛋白的纯化方法
CN109851667A (zh) * 2018-12-29 2019-06-07 江苏万邦医药科技有限公司 一种德谷胰岛素前体的纯化方法
GB202102258D0 (en) * 2021-02-17 2021-03-31 Arecor Ltd Novel composition
MX2024002569A (es) * 2021-09-10 2024-04-30 Zealand Pharma As Proceso para formular composiciones que comprenden analogos de peptido 2 similar a glucagon (glp-2).

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4468346A (en) * 1983-10-27 1984-08-28 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies to porcine immunoglobulins
AU616411B2 (en) * 1987-05-14 1991-10-31 Commonwealth Scientific And Industrial Research Organisation Whey protein fractions
JPH03505401A (ja) 1988-06-27 1991-11-28 ジェネックス・コーポレーション 組換えタンパク質の培養培地への熱放出
DE69013471T2 (de) 1989-12-05 1995-03-30 Merck & Co Inc Methode zur Stabilisierung von rekombinanten Hepatitis-B-Virus-Oberflächenproteinen aus Hefe.
DE4002066A1 (de) 1990-01-25 1991-08-01 Basf Ag Verfahren zur abtrennung von riboflavin aus fermentationssuspensionen
US5272135A (en) * 1991-03-01 1993-12-21 Chiron Ophthalmics, Inc. Method for the stabilization of methionine-containing polypeptides
SE9101381D0 (sv) 1991-05-07 1991-05-07 Tomas Moks Peptide hormone solution
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
SG45449A1 (en) 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
US6284727B1 (en) * 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
GB9320782D0 (en) 1993-10-08 1993-12-01 Univ Leeds Innovations Ltd Stabilising of proteins on solution
CA2176462A1 (en) 1993-11-19 1995-05-26 Larry P. Feigen Transdermal composition of n-[n-[5-[4-(aminoiminomethyl)phenyl]-1-oxopentyl]-l-.alpha.-aspartyl]-l-phenylalanine or its esters and their pharmaceutically acceptable salts
US5705483A (en) * 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
WO1995022560A1 (en) 1994-02-22 1995-08-24 The Syntex-Synergen Neuroscience Joint Venture Pharmaceutical formulations of cntf
US5652216A (en) * 1994-05-26 1997-07-29 Novo Nordisk A/S Pharmaceutical preparation
DE69531283T2 (de) 1994-08-05 2004-04-22 Bausch & Lomb, Inc., Claremont Vorrichtung zum einsetzen einer flexiblen intraokularen linse
CA2157219C (en) 1994-08-31 2010-10-05 Munehiro Noda Process for purifying recombinant human serum albumin
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
WO1996020005A1 (en) 1994-12-23 1996-07-04 Novo Nordisk A/S Protracted glp-1 compositions
US5834428A (en) * 1995-04-14 1998-11-10 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
US6184201B1 (en) * 1995-04-14 2001-02-06 Nps Allelix Corp. Intestinotrophic glucagon-like peptide-2 analogs
AU5996996A (en) 1995-06-02 1996-12-18 Novo Nordisk A/S Al/fe-treatment of a protein solution, followed by membrane concentration
US5631347A (en) 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
JPH10101696A (ja) 1996-08-08 1998-04-21 Shinotesuto:Kk 形質転換体にて発現される蛋白質に含まれる夾雑物質の除去方法及び精製蛋白質
JP3149958B2 (ja) 1996-08-30 2001-03-26 ノボ ノルディスク アクティーゼルスカブ Glp―1誘導体
US6268343B1 (en) * 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
KR20000070338A (ko) * 1997-01-20 2000-11-25 나가시마 카쭈시게, 노미야마 아키히코 펩티드의 안정화 방법 및 당해 방법을 이용한 펩티드 함유 동결건조 의약조성물
CA2236519C (en) * 1997-05-02 2011-09-13 1149336 Ontario Inc. Methods of enhancing functioning of the large intestine
CA2306024C (en) 1997-10-01 2011-04-26 Flemington Pharmaceutical Corporation Buccal, polar and non-polar spray or capsule
WO1999021889A1 (en) * 1997-10-24 1999-05-06 Genentech, Inc. Purification of molecules
CA2312190A1 (en) 1997-12-05 1999-06-17 Eli Lilly And Company Glp-1 formulations
US6380357B2 (en) 1997-12-16 2002-04-30 Eli Lilly And Company Glucagon-like peptide-1 crystals
JP2002504518A (ja) 1998-02-27 2002-02-12 ノボ ノルディスク アクティーゼルスカブ 部分的に構造化されたミセルー様凝集体を形成する、25%を超えるヘリックス−含有率を有するglp−1誘導体
WO1999043706A1 (en) 1998-02-27 1999-09-02 Novo Nordisk A/S Derivatives of glp-1 analogs
AU2610899A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S N-terminally modified glp-1 derivatives
ATE269103T1 (de) * 1998-03-13 2004-07-15 Novo Nordisk As Stabilisierte wässerige glukagonlösungen enthaltend detergenzien
BR9913857A (pt) 1998-09-17 2001-06-12 Lilly Co Eli Formulações de proteìna
CA2358107C (en) 1998-12-22 2011-08-23 Eli Lilly And Company Shelf-stable formulation of glucagon-like peptide-1
CN101181236A (zh) 1999-01-14 2008-05-21 安米林药品公司 新型exendin激动剂制剂及其给药方法
US6444788B1 (en) * 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
HUP0200297A3 (en) 1999-03-17 2002-09-30 Novo Nordisk As Method for acylating peptides and the glutaminic acid derivatives as acylating agents
CA2369839A1 (en) 1999-06-25 2001-01-04 Minimed, Inc. Compositions of insulin and insulin-related peptide for treating diabetes
US7022674B2 (en) * 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
DE60018105T2 (de) 1999-12-16 2005-12-29 Eli Lilly And Co., Indianapolis Polypeptidzusammensetzungen mit verbesserter stabilität
GB9930882D0 (en) * 1999-12-30 2000-02-23 Nps Allelix Corp GLP-2 formulations
WO2001052937A1 (en) 2000-01-24 2001-07-26 Medtronic Minimed, Inc. Mixed buffer system for stabilizing polypeptide formulations
HUP0204281A3 (en) 2000-01-27 2007-03-28 Lilly Co Eli Process for sulubilizing glucagon-like peptide 1 (glp-1) compounds
EP1396499A3 (en) 2000-01-27 2004-12-29 Eli Lilly And Company Process for solubilizing glucagon-like peptide 1 (GLP-1) compounds
US6844321B2 (en) * 2000-01-31 2005-01-18 Novo Nordisk A/S Crystallization of a GLP-1 analogue
WO2001077141A1 (en) 2000-04-06 2001-10-18 Novo Nordisk A/S Shock heat treatment of polypeptides
PT1695983E (pt) * 2000-06-16 2009-05-05 Lilly Co Eli Análogos do peptídeo-1 do tipo glucagon
JP4798833B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 加熱処理工程を含むヒト血清アルブミンの製造方法
US7199217B2 (en) 2000-12-13 2007-04-03 Eli Lilly And Company Amidated glucagon-like peptide-1
US20020151467A1 (en) * 2000-12-21 2002-10-17 Leung Frank K. Methods and compositions for oral insulin delivery
GB2371227A (en) 2001-01-10 2002-07-24 Grandis Biotech Gmbh Crystallisation - resistant aqueous growth hormone formulations
ATE396202T1 (de) * 2001-02-16 2008-06-15 Conjuchem Biotechnologies Inc Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen
US6573237B2 (en) * 2001-03-16 2003-06-03 Eli Lilly And Company Protein formulations
US20030119734A1 (en) 2001-06-28 2003-06-26 Flink James M. Stable formulation of modified GLP-1
CN1335182A (zh) 2001-08-08 2002-02-13 华中科技大学 胰岛素口腔喷剂及其制备工艺
CA2452044A1 (en) 2001-08-28 2003-03-13 Eli Lilly And Company Pre-mixes of glp-1 and basal insulin
CA2463803A1 (en) 2001-10-19 2003-05-01 Eli Lilly And Company Biphasic mixtures of glp-1 and insulin
PT1344533E (pt) 2002-03-15 2007-01-31 Natimmune As Composições farmacêuticas compreendendo lectina de ligação a manose
JP2005535569A (ja) * 2002-04-04 2005-11-24 ノボ・ノルデイスク・エー/エス Glp−1アゴニスト及び心臓血管合併症
DE60321473D1 (de) 2002-09-25 2008-07-17 Novo Nordisk As Aufreinigungsverfahren, das eine mikrofiltration bei erhöhten temperaturen beinhaltet
WO2004089985A1 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S Stable pharmaceutical compositions
ES2425221T3 (es) 2003-05-30 2013-10-14 Amylin Pharmaceuticals, Llc Nuevos métodos y composiciones para suministro por vía transmucosa potenciado de péptidos y proteínas
WO2004105790A1 (en) * 2003-06-03 2004-12-09 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
CN1812808B (zh) * 2003-06-03 2012-07-04 诺沃挪第克公司 稳定化的药物肽组合物
WO2004105781A2 (en) 2003-06-03 2004-12-09 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
ES2373660T3 (es) 2003-11-13 2012-02-07 Novo Nordisk A/S Composición farmacéutica que comprende un análogo insulinotrópico de glp-1 (7-37), insulina asp(b28) y un tensioactivo.
US20060287221A1 (en) * 2003-11-13 2006-12-21 Novo Nordisk A/S Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia
EP1789075A4 (en) 2004-08-25 2009-07-01 Uab Research Foundation ABSORPTION ENHANCER FOR DRUG ADMINISTRATION

Also Published As

Publication number Publication date
US8710181B2 (en) 2014-04-29
EP1789434A2 (en) 2007-05-30
JP2008511583A (ja) 2008-04-17
EP1789434B1 (en) 2013-11-20
WO2006024631A3 (en) 2006-06-15
WO2006024631A2 (en) 2006-03-09
US20080171848A1 (en) 2008-07-17
ES2442223T3 (es) 2014-02-10
JP4965446B2 (ja) 2012-07-04

Similar Documents

Publication Publication Date Title
IL183405A0 (en) Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
DK1680443T3 (da) Stabiliserede alfa-helix-peptider og anvendelser heraf
WO2006017538A3 (en) Hk1-binding proteins
EP1732581A4 (en) POLYPEPTIDE TRANSDUCTION AND FUSOGENIC PEPTIDES
IL177403A0 (en) Pancreatic polypeptide family polypeptides and pharmaceutical compositions containing the same
EP1699920A4 (en) NEW RECOMBINANT PROTEINS WITH FREE N-TERMINAL THIOL
GB0324368D0 (en) Polypeptides including modified constant regions
IL171109A (en) Glycopegylation methods and proteins/peptides produced by the methods
WO2007007192A8 (en) Use of ionic matrices for maldi mass spectrometry analysis of tissue sections
WO2004087874A3 (en) Novel nucleic acids and polypeptides
WO2005037236A3 (en) Novel heat shock protein 20-related polypeptides and uses therefor
EP1614695A4 (en) POLYPEPTIDE
ZA200508028B (en) Glycopegylation methods and proteins/peptides produced by the methods
FI20040655L (fi) Proteiini- ja peptidistabilointi
SG10201505948VA (en) Pancreatic Polypeptide Family Motifs, Polypeptides And Methods Comprising The Same
GB0322317D0 (en) Expansin polypeptide
MY142798A (en) Methods for preventing glyconoylation of proteins
GB0521490D0 (en) RFamide-related peptide precursor proteins and RFamide peptides
GB0422110D0 (en) Recombinant proteins
ATE432473T1 (de) Peptide zur unterscheidung von prionen
AU2003280316A8 (en) Zymogen-like protein c polypeptides
GB2441941B (en) An isolated recombinant vaccinia virus complement control protein (HRVCP) polypeptide
WO2006020541A3 (en) Methods for synthesizing polypeptides
DK1615945T3 (da) Glycopegyleringsfremgangsmåder og proteiner/peptider fremstillet ved fremgangsmåderne
GB2415195B (en) Peptides of IRF-1