PL1842920T5 - Komórki koekspresjonujące reduktazę witaminy K i białko zależne od witaminy K oraz ich zastosowanie do poprawienia wydajności wytwarzania tego białka zależnego od witaminy K - Google Patents

Komórki koekspresjonujące reduktazę witaminy K i białko zależne od witaminy K oraz ich zastosowanie do poprawienia wydajności wytwarzania tego białka zależnego od witaminy K

Info

Publication number
PL1842920T5
PL1842920T5 PL07109353T PL07109353T PL1842920T5 PL 1842920 T5 PL1842920 T5 PL 1842920T5 PL 07109353 T PL07109353 T PL 07109353T PL 07109353 T PL07109353 T PL 07109353T PL 1842920 T5 PL1842920 T5 PL 1842920T5
Authority
PL
Poland
Prior art keywords
vitamin
dependent protein
reductase
productivity
improve
Prior art date
Application number
PL07109353T
Other languages
English (en)
Other versions
PL1842920T3 (pl
Inventor
Darrel Stafford
Tao Li
Original Assignee
University Of North Carolina At Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34393028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1842920(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University Of North Carolina At Chapel Hill filed Critical University Of North Carolina At Chapel Hill
Publication of PL1842920T3 publication Critical patent/PL1842920T3/pl
Publication of PL1842920T5 publication Critical patent/PL1842920T5/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
PL07109353T 2003-09-23 2004-09-23 Komórki koekspresjonujące reduktazę witaminy K i białko zależne od witaminy K oraz ich zastosowanie do poprawienia wydajności wytwarzania tego białka zależnego od witaminy K PL1842920T5 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50552703P 2003-09-23 2003-09-23
EP04789039.7A EP1670947B1 (en) 2003-09-23 2004-09-23 Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin k epoxide reductase gene and warfarin dosage
EP07109353.8A EP1842920B2 (en) 2003-09-23 2004-09-23 Cells coexpressing vitamin K reductase and vitamin K dependent protein and use thereof to improve the productivity of said vitamin K dependent protein

Publications (2)

Publication Number Publication Date
PL1842920T3 PL1842920T3 (pl) 2010-06-30
PL1842920T5 true PL1842920T5 (pl) 2018-04-30

Family

ID=34393028

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07109353T PL1842920T5 (pl) 2003-09-23 2004-09-23 Komórki koekspresjonujące reduktazę witaminy K i białko zależne od witaminy K oraz ich zastosowanie do poprawienia wydajności wytwarzania tego białka zależnego od witaminy K

Country Status (12)

Country Link
US (6) US7687233B2 (pl)
EP (4) EP1670947B1 (pl)
JP (4) JP2007506433A (pl)
AT (1) ATE455174T1 (pl)
AU (2) AU2004275828B2 (pl)
CA (1) CA2539434C (pl)
DE (1) DE602004025157D1 (pl)
DK (2) DK2380985T3 (pl)
ES (2) ES2339710T5 (pl)
PL (1) PL1842920T5 (pl)
PT (1) PT2380985E (pl)
WO (1) WO2005030039A2 (pl)

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GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
DE602004026897D1 (de) * 2003-10-14 2010-06-10 Baxter Healthcare Sa Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
WO2006012902A2 (en) * 2004-08-02 2006-02-09 Novozymes A/S Creation of diversity in polypeptides
WO2006044686A2 (en) * 2004-10-18 2006-04-27 University Of Washington Methods and compositions for predicting drug responses
US7445896B2 (en) 2004-10-18 2008-11-04 University Of Washington Methods and compositions for detecting VKORC1 single nucleotide polymorphisms
ES2347167T3 (es) * 2004-12-21 2010-10-26 Academia Sinica Variantes geneticas de vkorc1 que predicen la sensibilidad a warfarina.
PL1853700T3 (pl) 2005-02-28 2013-05-31 Baxalta Inc Koekspresja przez rekombinowanie podjednostki 1 reduktazy epoksydu witaminy K w celu poprawy ekspresji białka zależnego od witaminy K
CA2601574C (en) 2005-03-15 2014-12-02 University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
CN101198696B (zh) * 2005-04-13 2014-02-26 阿斯利康(瑞典)有限公司 包含产生需要γ-羧化的蛋白质用的载体的宿主细胞
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US20070298426A1 (en) * 2006-06-02 2007-12-27 Academia Sinica Warfarin dosage prediction
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US9631002B2 (en) 2010-12-21 2017-04-25 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin K-dependent proteins
JP2012139232A (ja) * 2012-03-15 2012-07-26 Univ Of North Carolina At Chapel Hill 活性ビタミンｋ依存性タンパク質を生産するための方法及び組成物
JP2014221048A (ja) * 2014-06-16 2014-11-27 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 活性ビタミンｋ依存性タンパク質を生産するための方法及び組成物
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CA2601574C (en) 2005-03-15 2014-12-02 University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
CN101198696B (zh) 2005-04-13 2014-02-26 阿斯利康(瑞典)有限公司 包含产生需要γ-羧化的蛋白质用的载体的宿主细胞
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Also Published As

Publication number Publication date
US7687233B2 (en) 2010-03-30
AU2010203318A1 (en) 2010-08-12
HK1093223A1 (en) 2007-02-23
US7482141B2 (en) 2009-01-27
US8097410B2 (en) 2012-01-17
ES2453895T3 (es) 2014-04-08
JP5840539B2 (ja) 2016-01-06
EP1670947A4 (en) 2008-11-05
DK1842920T3 (da) 2010-05-03
DK1842920T4 (da) 2017-08-21
CA2539434A1 (en) 2005-04-07
EP2380985B1 (en) 2014-01-01
AU2010203318B2 (en) 2012-07-12
EP1670947A2 (en) 2006-06-21
JP2012161315A (ja) 2012-08-30
EP1842920B1 (en) 2010-01-13
US20090215061A1 (en) 2009-08-27
DK2380985T3 (en) 2014-03-17
EP2380985A1 (en) 2011-10-26
EP1842920A1 (en) 2007-10-10
AU2004275828A1 (en) 2005-04-07
EP1842920B2 (en) 2017-06-21
JP2015180205A (ja) 2015-10-15
US7858318B2 (en) 2010-12-28
PT2380985E (pt) 2014-03-26
JP2010268803A (ja) 2010-12-02
US20070009950A1 (en) 2007-01-11
DE602004025157D1 (de) 2010-03-04
PL1842920T3 (pl) 2010-06-30
AU2004275828B2 (en) 2010-04-29
US20070190614A1 (en) 2007-08-16
US7524665B2 (en) 2009-04-28
WO2005030039A3 (en) 2005-07-21
ES2339710T3 (es) 2010-05-24
EP1670947B1 (en) 2015-04-01
ES2339710T5 (es) 2017-10-05
WO2005030039A2 (en) 2005-04-07
CA2539434C (en) 2014-03-18
US20090215045A1 (en) 2009-08-27
JP5094920B2 (ja) 2012-12-12
EP2336360A1 (en) 2011-06-22
US20110124000A1 (en) 2011-05-26
ATE455174T1 (de) 2010-01-15
JP2007506433A (ja) 2007-03-22
US8426128B2 (en) 2013-04-23
US20060240440A1 (en) 2006-10-26

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