PL1877364T3 - Pochodne fenyloacetylenu o powinowactwie do receptora mGluR5 - Google Patents

Pochodne fenyloacetylenu o powinowactwie do receptora mGluR5

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Publication number
PL1877364T3
PL1877364T3 PL06724538T PL06724538T PL1877364T3 PL 1877364 T3 PL1877364 T3 PL 1877364T3 PL 06724538 T PL06724538 T PL 06724538T PL 06724538 T PL06724538 T PL 06724538T PL 1877364 T3 PL1877364 T3 PL 1877364T3
Authority
PL
Poland
Prior art keywords
receptor affinity
mglur5 receptor
phenylacetylene derivatives
phenylacetylene
derivatives
Prior art date
Application number
PL06724538T
Other languages
English (en)
Inventor
Ralf Glatthar
Thomas J Troxler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL1877364T3 publication Critical patent/PL1877364T3/pl

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    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
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    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
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    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Thiazole And Isothizaole Compounds (AREA)
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PL06724538T 2005-04-25 2006-04-24 Pochodne fenyloacetylenu o powinowactwie do receptora mGluR5 PL1877364T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0508318.3A GB0508318D0 (en) 2005-04-25 2005-04-25 Organic compounds
EP06724538A EP1877364B1 (en) 2005-04-25 2006-04-24 Phenylacetylene derivatives having mglur5 receptor affinity
PCT/EP2006/003764 WO2006114260A1 (en) 2005-04-25 2006-04-24 Phenylacetylene derivatives having mglur5 receptor affinity

Publications (1)

Publication Number Publication Date
PL1877364T3 true PL1877364T3 (pl) 2009-09-30

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PL06724538T PL1877364T3 (pl) 2005-04-25 2006-04-24 Pochodne fenyloacetylenu o powinowactwie do receptora mGluR5

Country Status (17)

Country Link
US (1) US20080188490A1 (pl)
EP (1) EP1877364B1 (pl)
JP (1) JP2008538775A (pl)
KR (1) KR20070122224A (pl)
CN (1) CN101163662A (pl)
AT (1) ATE427927T1 (pl)
AU (1) AU2006239545A1 (pl)
BR (1) BRPI0610337A2 (pl)
CA (1) CA2605262A1 (pl)
DE (1) DE602006006170D1 (pl)
ES (1) ES2323288T3 (pl)
GB (1) GB0508318D0 (pl)
MX (1) MX2007013238A (pl)
PL (1) PL1877364T3 (pl)
PT (1) PT1877364E (pl)
RU (1) RU2007143507A (pl)
WO (1) WO2006114260A1 (pl)

Families Citing this family (20)

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CN100381083C (zh) 2003-04-29 2008-04-16 韩力 一种非可燃性电子喷雾香烟
CN2719043Y (zh) * 2004-04-14 2005-08-24 韩力 雾化电子烟
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0508319D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508314D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
CN201067079Y (zh) * 2006-05-16 2008-06-04 韩力 仿真气溶胶吸入器
MX2010003913A (es) * 2007-10-12 2010-04-27 Novartis Ag Moduladores de los receptores de glutamato metabotropicos para el tratamiento de enfermedades de parkinson.
WO2009047303A2 (en) * 2007-10-12 2009-04-16 Novartis Ag Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder
JPWO2009130900A1 (ja) * 2008-04-24 2011-08-11 日本曹達株式会社 オキシム誘導体、中間体化合物および植物病害防除剤
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
WO2011030537A1 (ja) 2009-09-08 2011-03-17 杏林製薬株式会社 ４－（５－メチルピリジン－２－イルアミノ）ピペリジン－１－カルボン酸誘導体の製造方法
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
WO2012004400A1 (en) 2010-07-09 2012-01-12 Recordati Ireland Limited Novel spiroheterocyclic compounds as mglu5 antagonists
WO2013042139A1 (en) 2011-09-23 2013-03-28 Advinus Therapeutics Limited Amide compounds, compositions and applications thereof
WO2014124560A1 (en) * 2013-02-18 2014-08-21 Hua Medicine (Shanghai) Ltd. Mglur regulators
KR20180067010A (ko) 2016-12-12 2018-06-20 김선권 금속판에 다양한 곡면을 성형하는 방법
KR20180067030A (ko) 2016-12-12 2018-06-20 김성갑 금속판에 다양한 곡면을 성형하는 방법
JP7456621B2 (ja) * 2018-08-07 2024-03-27 慶應義塾 神経機能調節物質の動態の検出剤、及び神経機能調節物質の検出方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991064A (en) * 1975-01-17 1976-11-09 Warner-Lambert Company Benzonaphthyridines
US5576336A (en) * 1993-03-18 1996-11-19 Merck Sharp & Dohme Limited Indole derivatives as dopamine D4 antagonists
EP0689535B1 (en) * 1993-03-18 1998-09-23 MERCK SHARP & DOHME LTD. Benzimidazole derivatives
US5521297A (en) * 1993-06-04 1996-05-28 Salk Institute Biotechnology/Industrial Associates Nucleic acids encoding human metabotropic glutamate receptors
EP0757686A1 (en) * 1994-04-28 1997-02-12 MERCK SHARP & DOHME LTD. Benzofuran derivatives as d 4? receptor antagonists
AU699196B2 (en) * 1994-08-10 1998-11-26 Merck Sharp & Dohme Limited Tetrahydropyridinylmethyl derivatives of pyrrolo 2,3-b pyridine
US5688798A (en) * 1995-10-10 1997-11-18 Hoffmann-La Roche Inc. Pyrimidine compounds
AUPR201600A0 (en) * 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
GB0128996D0 (en) * 2001-12-04 2002-01-23 Novartis Ag Organic compounds
US6806279B2 (en) * 2001-12-17 2004-10-19 Sunesis Pharmaceuticals, Inc. Small-molecule inhibitors of interleukin-2
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0508319D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508314D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds

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BRPI0610337A2 (pt) 2010-06-15
DE602006006170D1 (de) 2009-05-20
MX2007013238A (es) 2008-01-24
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EP1877364B1 (en) 2009-04-08
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US20080188490A1 (en) 2008-08-07
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