PL1888604T3 - Sposób wytwarzania (alfa S, beta R)-6-bromo-alfa-[2-(dimetyloamino)etylo]-2-metoksy-alfa-1-naftalenylo-beta-fenylo-3-chinolinetanolu - Google Patents

Sposób wytwarzania (alfa S, beta R)-6-bromo-alfa-[2-(dimetyloamino)etylo]-2-metoksy-alfa-1-naftalenylo-beta-fenylo-3-chinolinetanolu

Info

Publication number: PL1888604T3
Authority: PL; Poland
Prior art keywords: alpha; beta; quinolineethanol; naphthalenyl; dimethylamino
Prior art date: 2005-05-25

Application number

PL06755275T

Other languages

English (en)

Inventor

Frank Ralf Porstmann

Stefan Horns

Thomas Bader

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-25

Filing date

2006-05-22

Publication date

2012-08-31

2006-05-22 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2012-08-31 Publication of PL1888604T3 publication Critical patent/PL1888604T3/pl

Links

238000004519 manufacturing process Methods 0.000 title 1
JEHUZVBIUCAMRZ-UHFFFAOYSA-N 1,1'-binaphthyl-2,2'-diyl hydrogenphosphate Chemical compound O1P(O)(=O)OC2=CC=C(C=CC=C3)C3=C2C2=C1C=CC1=CC=CC=C21 JEHUZVBIUCAMRZ-UHFFFAOYSA-N 0.000 abstract 1
QUIJNHUBAXPXFS-UHFFFAOYSA-N 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol Chemical compound COC1=NC2=CC=C(Br)C=C2C=C1C(C(O)(CCN(C)C)C=1C2=CC=CC=C2C=CC=1)C1=CC=CC=C1 QUIJNHUBAXPXFS-UHFFFAOYSA-N 0.000 abstract 1
QUIJNHUBAXPXFS-XLJNKUFUSA-N bedaquiline Chemical compound C1([C@H](C2=CC3=CC(Br)=CC=C3N=C2OC)[C@@](O)(CCN(C)C)C=2C3=CC=CC=C3C=CC=2)=CC=CC=C1 QUIJNHUBAXPXFS-XLJNKUFUSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)

PL06755275T 2005-05-25 2006-05-22 Sposób wytwarzania (alfa S, beta R)-6-bromo-alfa-[2-(dimetyloamino)etylo]-2-metoksy-alfa-1-naftalenylo-beta-fenylo-3-chinolinetanolu PL1888604T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05104482		2005-05-25
EP06755275A EP1888604B1 (en)	2005-05-25	2006-05-22	Process for preparing (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
PCT/EP2006/062502 WO2006125769A1 (en)	2005-05-25	2006-05-22	Process for preparing (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol

Publications (1)

Publication Number	Publication Date
PL1888604T3 true PL1888604T3 (pl)	2012-08-31

Family

ID=36013279

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06755275T PL1888604T3 (pl)	2005-05-25	2006-05-22	Sposób wytwarzania (alfa S, beta R)-6-bromo-alfa-[2-(dimetyloamino)etylo]-2-metoksy-alfa-1-naftalenylo-beta-fenylo-3-chinolinetanolu

Country Status (27)

Country	Link
US (2)	US8039628B2 (pl)
EP (1)	EP1888604B1 (pl)
JP (1)	JP5410749B2 (pl)
KR (2)	KR101712835B1 (pl)
CN (1)	CN101180302B (pl)
AT (1)	ATE549343T1 (pl)
AU (1)	AU2006251208B2 (pl)
BR (1)	BRPI0611166B1 (pl)
CA (1)	CA2606675C (pl)
CY (1)	CY1113383T1 (pl)
DK (1)	DK1888604T3 (pl)
EA (1)	EA011770B1 (pl)
ES (1)	ES2383908T3 (pl)
HR (1)	HRP20120429T1 (pl)
IL (1)	IL186913A (pl)
ME (1)	ME01445B (pl)
MX (1)	MX2007014874A (pl)
NO (1)	NO341633B1 (pl)
NZ (1)	NZ563819A (pl)
PL (1)	PL1888604T3 (pl)
PT (1)	PT1888604E (pl)
RS (1)	RS52316B (pl)
SG (1)	SG162724A1 (pl)
SI (1)	SI1888604T1 (pl)
UA (1)	UA92484C2 (pl)
WO (1)	WO2006125769A1 (pl)
ZA (1)	ZA200710150B (pl)

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JP2668715B2 (ja)	1988-10-21	1997-10-27	住友重機械工業株式会社	コイル集束装置における切断制御法
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RU2486175C2 (ru) *	2011-09-12	2013-06-27	Закрытое Акционерное Общество "Фарм-Синтез"	Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений
US9572809B2 (en)	2012-07-18	2017-02-21	Spero Trinem, Inc.	Combination therapy to treat Mycobacterium diseases
CN105017147B (zh) *	2014-04-30	2019-02-01	中国医学科学院药物研究所	一种回收和利用Bedaquiline立体化学异构体的方法
CN105085395B (zh) *	2014-05-07	2017-09-26	国药集团国瑞药业有限公司	贝达喹啉的制备方法
CN105085396B (zh) *	2014-05-07	2017-08-08	国药集团国瑞药业有限公司	用于制备贝达喹啉的中间体及其制备方法和应用
CN105198808B (zh) *	2014-05-27	2017-08-25	北京万生药业有限责任公司	一种高效生产贝达喹啉的方法
CN105175329B (zh) *	2014-06-10	2017-09-19	重庆圣华曦药业股份有限公司	一种贝达喹啉消旋体的合成路线及方法
CZ2014708A3 (cs)	2014-10-16	2016-04-27	Zentiva, K.S.	Soli Bedaquilinu
CZ201535A3 (cs)	2015-01-21	2016-08-03	Zentiva, K.S.	Nové možnosti chirální resoluce bedaquilinu
CZ201533A3 (cs)	2015-01-21	2016-08-03	Zentiva, K.S.	Způsob izolace směsi enantiomerů
CZ201534A3 (cs)	2015-01-21	2016-08-03	Zentiva, K.S.	Nové možnosti chirální resoluce bedaquilinu
AU2016212116B2 (en) *	2015-01-27	2021-07-15	Janssen Pharmaceutica Nv	Dispersible compositions
CZ2015391A3 (cs)	2015-06-09	2016-12-21	Zentiva, K.S.	Sůl bedaquilinu s kyselinou citronovou
CN107848978B (zh) *	2015-07-24	2021-04-02	浙江海正药业股份有限公司	一种分离贝达喹啉非对映异构体a的方法
AU2017229128B2 (en)	2016-03-07	2022-04-07	Janssen Pharmaceutica Nv	Antibacterial compounds and uses thereof
CN107602464B (zh) *	2016-07-12	2020-02-18	宜昌人福药业有限责任公司	利用光学拆分制备双芳基喹啉类抗生素的方法
CN106866525B (zh) *	2017-03-24	2019-04-19	福建省微生物研究所	用于合成(1r,2s)-贝达喹啉的手性诱导剂
US11141384B2 (en)	2017-07-14	2021-10-12	Janssen Pharmaceutica Nv	Long-acting formulations
CN109422679B (zh) *	2017-08-30	2021-06-25	武汉武药科技有限公司	一种贝达喹啉的纯化及稳定晶型的制备方法
CN107857727B (zh) *	2017-10-26	2019-10-18	江苏天和制药有限公司	一种（1r，2s）和（1s，2r）-贝达喹啉的制备方法
CN110759885B (zh) *	2018-07-27	2021-10-22	中国医学科学院药物研究所	制备光活依格鲁特的方法
WO2020161743A1 (en) *	2019-02-08	2020-08-13	Mylan Laboratories Limited	Process for the preparation of bedaquiline fumarate
KR102303635B1 (ko) *	2020-07-01	2021-09-17	동아에스티 주식회사	(1r,2s)-1-(6-브로모-2-메톡시퀴놀린-3-일)-4-디메틸아미노-2-(1-나프틸)-1-페닐-부탄-2-올 및 이의 약제학적으로 허용 가능한 염의 제조방법
US20230355606A1 (en)	2020-07-09	2023-11-09	Janssen Pharmaceutica Nv	Long-acting formulations
MX2023000439A (es)	2020-07-09	2023-02-09	Janssen Pharmaceutica Nv	Formulaciones a largo plazo.
JP2023532981A (ja)	2020-07-09	2023-08-01	ヤンセンファーマシューティカエヌ．ベー．	長時間作用型配合物
WO2024068693A1 (en)	2022-09-28	2024-04-04	Janssen Pharmaceutica Nv	Long-acting formulations
JP2025532272A (ja)	2022-09-28	2025-09-29	ヤンセンファーマシューティカエヌ．ベー．	長時間作用型製剤
JP7728461B1 (ja)	2023-08-01	2025-08-22	上海交通大学	低温で連続フローによりベダキリンを調製する方法及びこの方法により調製された製品

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2006
- 2006-05-22 RS RS20120212A patent/RS52316B/sr unknown
- 2006-05-22 EA EA200702611A patent/EA011770B1/ru unknown
- 2006-05-22 KR KR1020147036245A patent/KR101712835B1/ko active Active
- 2006-05-22 CN CN2006800174755A patent/CN101180302B/zh active Active
- 2006-05-22 PT PT06755275T patent/PT1888604E/pt unknown
- 2006-05-22 AT AT06755275T patent/ATE549343T1/de active
- 2006-05-22 SG SG201003636-6A patent/SG162724A1/en unknown
- 2006-05-22 ES ES06755275T patent/ES2383908T3/es active Active
- 2006-05-22 SI SI200631344T patent/SI1888604T1/sl unknown
- 2006-05-22 JP JP2008512822A patent/JP5410749B2/ja active Active
- 2006-05-22 ME MEP-2012-64A patent/ME01445B/me unknown
- 2006-05-22 US US11/915,204 patent/US8039628B2/en active Active
- 2006-05-22 PL PL06755275T patent/PL1888604T3/pl unknown
- 2006-05-22 AU AU2006251208A patent/AU2006251208B2/en not_active Ceased
- 2006-05-22 KR KR1020077028419A patent/KR101534021B1/ko active Active
- 2006-05-22 UA UAA200711767A patent/UA92484C2/ru unknown
- 2006-05-22 MX MX2007014874A patent/MX2007014874A/es active IP Right Grant
- 2006-05-22 CA CA2606675A patent/CA2606675C/en active Active
- 2006-05-22 NZ NZ563819A patent/NZ563819A/en not_active IP Right Cessation
- 2006-05-22 BR BRPI0611166-1A patent/BRPI0611166B1/pt active IP Right Grant
- 2006-05-22 DK DK06755275.2T patent/DK1888604T3/da active
- 2006-05-22 HR HRP20120429TT patent/HRP20120429T1/hr unknown
- 2006-05-22 WO PCT/EP2006/062502 patent/WO2006125769A1/en not_active Ceased
- 2006-05-22 EP EP06755275A patent/EP1888604B1/en active Active
2007
- 2007-10-25 IL IL186913A patent/IL186913A/en active IP Right Grant
- 2007-11-26 ZA ZA2007/10150A patent/ZA200710150B/en unknown
- 2007-12-19 NO NO20076542A patent/NO341633B1/no unknown
2011
- 2011-09-06 US US13/225,647 patent/US8350040B2/en active Active
2012
- 2012-06-12 CY CY20121100534T patent/CY1113383T1/el unknown

Also Published As

Publication number	Publication date
SG162724A1 (en)	2010-07-29
HRP20120429T1 (hr)	2012-06-30
WO2006125769A1 (en)	2006-11-30
PT1888604E (pt)	2012-05-28
KR20080010453A (ko)	2008-01-30
SI1888604T1 (sl)	2012-08-31
JP5410749B2 (ja)	2014-02-05
IL186913A (en)	2013-12-31
CY1113383T1 (el)	2016-06-22
US8039628B2 (en)	2011-10-18
IL186913A0 (en)	2008-02-09
EP1888604B1 (en)	2012-03-14
EA011770B1 (ru)	2009-06-30
HK1118061A1 (en)	2009-01-30
BRPI0611166A2 (pt)	2010-08-17
KR101534021B1 (ko)	2015-07-06
DK1888604T3 (da)	2012-06-18
ZA200710150B (en)	2012-06-27
RS52316B (sr)	2012-12-31
BRPI0611166B1 (pt)	2022-01-25
US20080200683A1 (en)	2008-08-21
CA2606675A1 (en)	2006-11-30
NZ563819A (en)	2011-01-28
EA200702611A1 (ru)	2008-04-28
CN101180302A (zh)	2008-05-14
CN101180302B (zh)	2013-06-19
JP2008545675A (ja)	2008-12-18
AU2006251208B2 (en)	2012-11-29
ME01445B (me)	2013-12-20
US8350040B2 (en)	2013-01-08
UA92484C2 (en)	2010-11-10
ES2383908T3 (es)	2012-06-27
KR20150008196A (ko)	2015-01-21
NO20076542L (no)	2007-12-19
AU2006251208A1 (en)	2006-11-30
NO341633B1 (no)	2017-12-11
EP1888604A1 (en)	2008-02-20
ATE549343T1 (de)	2012-03-15
MX2007014874A (es)	2008-02-15
KR101712835B1 (ko)	2017-03-07
CA2606675C (en)	2013-02-19
US20110319623A1 (en)	2011-12-29

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