PL1910348T3 - Związki benzotiazolowe i azabenzotiazolowe użyteczne jako inhibitory kinazy - Google Patents
Związki benzotiazolowe i azabenzotiazolowe użyteczne jako inhibitory kinazyInfo
- Publication number
- PL1910348T3 PL1910348T3 PL06788851.1T PL06788851T PL1910348T3 PL 1910348 T3 PL1910348 T3 PL 1910348T3 PL 06788851 T PL06788851 T PL 06788851T PL 1910348 T3 PL1910348 T3 PL 1910348T3
- Authority
- PL
- Poland
- Prior art keywords
- benzothiazole
- kinase inhibitors
- compounds useful
- azabenzothiazole
- azabenzothiazole compounds
- Prior art date
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 2
- FNQJDLTXOVEEFB-UHFFFAOYSA-N 1,2,3-benzothiadiazole Chemical class C1=CC=C2SN=NC2=C1 FNQJDLTXOVEEFB-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70435105P | 2005-08-01 | 2005-08-01 | |
| US11/494,234 US7473784B2 (en) | 2005-08-01 | 2006-07-27 | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1910348T3 true PL1910348T3 (pl) | 2016-09-30 |
Family
ID=37569657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06788851.1T PL1910348T3 (pl) | 2005-08-01 | 2006-07-28 | Związki benzotiazolowe i azabenzotiazolowe użyteczne jako inhibitory kinazy |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7473784B2 (pl) |
| EP (2) | EP2266981B1 (pl) |
| CY (1) | CY1118723T1 (pl) |
| DK (1) | DK1910348T3 (pl) |
| ES (1) | ES2578278T3 (pl) |
| HU (1) | HUE029733T2 (pl) |
| PL (1) | PL1910348T3 (pl) |
| PT (1) | PT1910348T (pl) |
| SI (1) | SI1910348T1 (pl) |
| WO (1) | WO2007016392A2 (pl) |
Families Citing this family (51)
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| NZ555158A (en) * | 2004-11-18 | 2010-09-30 | Synta Pharmaceuticals Corp | Triazole compounds that modulate Hsp90 activity |
| EP1934185A1 (en) * | 2005-08-12 | 2008-06-25 | Synta Pharmaceuticals Corporation | Pyrazole compounds that modulate hsp90 activity |
| AU2006338265B2 (en) | 2005-08-18 | 2011-04-14 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
| WO2007139960A2 (en) * | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Compounds that modulate hsp90 activity and methods for identifying same |
| EP3308756B1 (en) | 2007-03-13 | 2020-02-19 | Optimedica Corporation | Apparatus for creating incisions to improve intraocular lens placement |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| CA2694136C (en) | 2007-08-02 | 2013-09-17 | Amgen Inc. | Pi3 kinase modulators and methods of use |
| JP5520831B2 (ja) | 2007-12-19 | 2014-06-11 | アムジエン・インコーポレーテツド | Pi3キナーゼの阻害薬 |
| US20090258907A1 (en) * | 2008-04-09 | 2009-10-15 | Abbott Laboratories | Compounds useful as inhibitors of rock kinases |
| AU2009322393B2 (en) | 2008-12-03 | 2017-02-02 | Presidio Pharmaceuticals, Inc. | Inhibitors of HCV NS5A |
| WO2010100144A1 (en) * | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
| CN102427729B (zh) | 2009-03-27 | 2014-09-03 | 默沙东公司 | 丙型肝炎病毒复制的抑制剂 |
| US20190127365A1 (en) | 2017-11-01 | 2019-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus replication |
| JP2012526834A (ja) | 2009-05-12 | 2012-11-01 | シェーリング コーポレイション | ウイルス疾患治療に有用な縮合型三環式アリール化合物 |
| WO2010133534A1 (en) * | 2009-05-19 | 2010-11-25 | Cellzome Limited | Bicyclic amino substituted compounds as pi3k inhibitors |
| EP2435424B1 (en) | 2009-05-29 | 2015-01-21 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| US8772505B2 (en) | 2009-05-29 | 2014-07-08 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis C |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| AU2010341537A1 (en) | 2009-12-22 | 2012-08-09 | Merck Sharp & Dohme Corp. | Fused Tricyclic Compounds and methods of use thereof for the treatment of viral diseases |
| JP2013522202A (ja) * | 2010-03-09 | 2013-06-13 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合三環式シリル化合物およびウイルス疾患の治療のためのその使用方法 |
| EP2560640A1 (en) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| WO2011149856A1 (en) * | 2010-05-24 | 2011-12-01 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| AR082080A1 (es) | 2010-07-02 | 2012-11-07 | Gilead Sciences Inc | Compuestos derivados de acido acetico-2-quinolinicos como compuestos antivirales anti hiv |
| TWI453208B (zh) | 2010-07-02 | 2014-09-21 | Gilead Sciences Inc | 治療性化合物類 |
| WO2012040389A2 (en) | 2010-09-22 | 2012-03-29 | Presidio Pharmaceuticals, Inc. | Substituted bicyclic hcv inhibitors |
| WO2012050848A1 (en) | 2010-09-29 | 2012-04-19 | Schering Corporation | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
| WO2012068546A1 (en) | 2010-11-19 | 2012-05-24 | Ligand Pharmaceuticals Incorporated | Heterocycle amines and uses thereof |
| TWI410425B (zh) | 2010-12-03 | 2013-10-01 | Lilly Co Eli | 唑并[5,4-b]吡啶-5-基化合物 |
| WO2012122716A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Tetracyclic xanthene derivatives and methods of use thereof for treatment of viral diseases |
| PT2699558T (pt) | 2011-04-21 | 2016-12-29 | Gilead Sciences Inc | Compostos de benzotiazole e a sua utilização farmacêutica |
| WO2012175513A1 (en) | 2011-06-20 | 2012-12-27 | Bayer Intellectual Property Gmbh | Thienylpyri(mi)dinylpyrazole |
| WO2013050434A1 (en) | 2011-10-06 | 2013-04-11 | Bayer Intellectual Property Gmbh | Heterocyclylpyri(mi)dinylpyrazole |
| DK2763987T3 (en) | 2011-10-06 | 2018-10-15 | Bayer Cropscience Ag | HETEROCYCLYLPYRY (MI) DINYLPYRAZOLE AS FUNGICIDER |
| AU2012332424A1 (en) | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with platinum-containing agents |
| JP2014532712A (ja) | 2011-11-02 | 2014-12-08 | シンタ ファーマシューティカルズ コーポレーション | トポイソメラーゼi阻害剤とhsp90阻害剤の組合せを使用する癌療法 |
| AU2012339679A1 (en) | 2011-11-14 | 2014-06-12 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with BRAF inhibitors |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| PT3070081T (pt) | 2012-04-20 | 2018-05-21 | Gilead Sciences Inc | Derivados do ácido benzotiazol-6-ilacético e sua utilização para tratar uma infeção por vih |
| WO2014110687A1 (en) | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
| AU2016226468B2 (en) | 2015-03-02 | 2020-10-22 | Bristol-Myers Squibb Company | TGF-beta inhibitors |
| US10807983B2 (en) | 2015-03-16 | 2020-10-20 | Ligand Pharmaceuticals, Inc. | Imidazo-fused heterocycles and uses thereof |
| AU2018282154B2 (en) | 2017-06-05 | 2022-04-07 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| WO2019018718A1 (en) * | 2017-07-21 | 2019-01-24 | Icahn School Of Medicine At Mount Sinai | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS ACTIVATORS OF THE SUMO PROTEIN |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| NZ762856A (en) | 2017-10-05 | 2020-07-31 | Fulcrum Therapeutics Inc | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
| MX2020009957A (es) | 2018-03-27 | 2021-01-15 | Ptc Therapeutics Inc | Compuestos para el tratamiento de enfermedad de hungtinton. |
| PL3814357T3 (pl) | 2018-06-27 | 2024-09-16 | Ptc Therapeutics, Inc. | Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona |
| EA202092899A1 (ru) * | 2018-06-27 | 2021-05-14 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Гетероарильные соединения для лечения болезни гентингтона |
| KR20220022114A (ko) | 2019-05-13 | 2022-02-24 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 화합물 |
| CN114437113B (zh) * | 2022-03-18 | 2023-05-02 | 西安交通大学 | 一种噻唑并吡啶环联三氮唑类化合物及其制备方法和应用 |
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| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5658903A (en) | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| CN1213306A (zh) | 1996-01-11 | 1999-04-07 | 史密丝克莱恩比彻姆公司 | 新的取代咪唑化合物 |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| US5945418A (en) | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
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| PL336990A1 (en) | 1997-05-22 | 2000-07-31 | Searle & Co | 3(5)-heteroaryl group substituted pyrazoles as inhibitors of kinase p 38 |
| AU8381098A (en) | 1997-07-02 | 1999-01-25 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
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| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
| JP2003503456A (ja) | 1999-07-02 | 2003-01-28 | スチュアート エイ. リプトン | 神経傷害またはアポトーシスを軽減する方法 |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| ID29514A (id) | 1999-11-10 | 2001-09-06 | Ortho Mcneil Pharmacetical Inc | 2-ARIL-3-(HETEROARIL)-IMIDAZO [1,2-a]PIRIMIDIN TERSUBSTITUSI, DAN METODE-METODE DAN KOMPOSISI-KOMPOSISI FARMASI YANG TERKAIT |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| US6916813B2 (en) | 2001-12-10 | 2005-07-12 | Bristol-Myers Squibb Co. | (1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase |
| WO2003055860A1 (en) * | 2001-12-21 | 2003-07-10 | Vernalis (Cambridge) Limited | 3,4-diarylpyrazoles and their use in the therapy of cancer |
| AU2003256297A1 (en) | 2002-08-09 | 2004-02-25 | Eli Lilly And Company | Benzimidazoles and benzothiazoles as inhibitors of map kinase |
-
2006
- 2006-07-27 US US11/494,234 patent/US7473784B2/en active Active
- 2006-07-28 PL PL06788851.1T patent/PL1910348T3/pl unknown
- 2006-07-28 SI SI200632054A patent/SI1910348T1/sl unknown
- 2006-07-28 EP EP10184708.5A patent/EP2266981B1/en not_active Not-in-force
- 2006-07-28 HU HUE06788851A patent/HUE029733T2/en unknown
- 2006-07-28 PT PT67888511T patent/PT1910348T/pt unknown
- 2006-07-28 WO PCT/US2006/029520 patent/WO2007016392A2/en not_active Ceased
- 2006-07-28 EP EP06788851.1A patent/EP1910348B1/en not_active Not-in-force
- 2006-07-28 DK DK06788851.1T patent/DK1910348T3/en active
- 2006-07-28 ES ES06788851.1T patent/ES2578278T3/es active Active
-
2008
- 2008-12-12 US US12/333,425 patent/US7994337B2/en active Active
-
2016
- 2016-07-07 CY CY20161100641T patent/CY1118723T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20070185175A1 (en) | 2007-08-09 |
| ES2578278T3 (es) | 2016-07-22 |
| EP1910348A2 (en) | 2008-04-16 |
| HUE029733T2 (en) | 2017-03-28 |
| WO2007016392A3 (en) | 2007-05-24 |
| US7994337B2 (en) | 2011-08-09 |
| US7473784B2 (en) | 2009-01-06 |
| EP2266981A2 (en) | 2010-12-29 |
| CY1118723T1 (el) | 2017-07-12 |
| DK1910348T3 (en) | 2016-08-01 |
| PT1910348T (pt) | 2016-07-11 |
| SI1910348T1 (sl) | 2016-06-30 |
| EP2266981A3 (en) | 2011-05-04 |
| EP2266981B1 (en) | 2016-07-06 |
| WO2007016392A2 (en) | 2007-02-08 |
| EP1910348B1 (en) | 2016-04-13 |
| US20090118272A1 (en) | 2009-05-07 |
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