PL1919883T3 - N-TLENKI JAKO PROLEKI PIPERAZYNOWYCH oraz PIPERYDYNOWYCH POCHODNYCH - Google Patents

N-TLENKI JAKO PROLEKI PIPERAZYNOWYCH oraz PIPERYDYNOWYCH POCHODNYCH

Info

Publication number: PL1919883T3
Authority: PL; Poland
Prior art keywords: art; relates; disease; manufacture; disclosed
Prior art date: 2005-08-22

Application number

PL06778284T

Other languages

English (en)

Inventor

Theodorus S M Koopman

Hendrik J Koster

Amsterdam Peter H Van

Roelof W Feenstra

Marinus Verhage

Andrew C Mccreary

Mayke B Hesselink

Scharrenburg Gustaaf J M Van

Original Assignee

Solvay Pharm Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-22

Filing date

2006-08-21

Publication date

2009-06-30

2006-08-21 Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv

2009-06-30 Publication of PL1919883T3 publication Critical patent/PL1919883T3/pl

Links

150000001204 N-oxides Chemical class 0.000 title abstract 2
150000004885 piperazines Chemical class 0.000 title 1
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
239000003814 drug Substances 0.000 abstract 3
238000004519 manufacturing process Methods 0.000 abstract 3
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
230000009286 beneficial effect Effects 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010003805 Autism Diseases 0.000 abstract 1
208000020706 Autistic disease Diseases 0.000 abstract 1
206010012335 Dependence Diseases 0.000 abstract 1
208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000020114 Schizophrenia and other psychotic disease Diseases 0.000 abstract 1
208000012886 Vertigo Diseases 0.000 abstract 1
230000016571 aggressive behavior Effects 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
230000019771 cognition Effects 0.000 abstract 1
235000019788 craving Nutrition 0.000 abstract 1
208000029364 generalized anxiety disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
208000019906 panic disease Diseases 0.000 abstract 1
150000003053 piperidines Chemical class 0.000 abstract 1
231100000889 vertigo Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

PL06778284T 2005-08-22 2006-08-21 N-TLENKI JAKO PROLEKI PIPERAZYNOWYCH oraz PIPERYDYNOWYCH POCHODNYCH PL1919883T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US70982105P	2005-08-22	2005-08-22
EP05107671		2005-08-22
PCT/EP2006/065477 WO2007023141A1 (en)	2005-08-22	2006-08-21	N-oxides as prodrugs of piperazine & piperidine derivatives
EP06778284A EP1919883B1 (en)	2005-08-22	2006-08-21	N-oxides as prodrugs of piperazine&piperidine derivatives

Publications (1)

Publication Number	Publication Date
PL1919883T3 true PL1919883T3 (pl)	2009-06-30

Family

ID=39246895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06778284T PL1919883T3 (pl)	2005-08-22	2006-08-21	N-TLENKI JAKO PROLEKI PIPERAZYNOWYCH oraz PIPERYDYNOWYCH POCHODNYCH

Country Status (17)

Country	Link
EP (1)	EP1919883B1 (pl)
JP (1)	JP2009504799A (pl)
KR (1)	KR20080046205A (pl)
AT (1)	ATE417834T1 (pl)
AU (1)	AU2006283882B2 (pl)
CA (1)	CA2621158A1 (pl)
DE (1)	DE602006004363D1 (pl)
DK (1)	DK1919883T3 (pl)
ES (1)	ES2318783T3 (pl)
HR (1)	HRP20090143T3 (pl)
IL (1)	IL188903A0 (pl)
NO (1)	NO20081435L (pl)
PL (1)	PL1919883T3 (pl)
PT (1)	PT1919883E (pl)
RU (1)	RU2394821C2 (pl)
SI (1)	SI1919883T1 (pl)
WO (1)	WO2007023141A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7964604B2 (en)	2005-02-18	2011-06-21	Solvay Pharmaceuticals B.V.	Bifeprunox mesylate maintenance dose compositions and methods for using the same
US7423040B2 (en)	2005-02-18	2008-09-09	Irene Eijgendaal	Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
US7786126B2 (en)	2006-06-16	2010-08-31	Solvay Pharmaceuticals B.V.	Combination preparations comprising SLV308 and a dopamine agonist
CA2654719A1 (en) *	2006-06-16	2007-12-21	Solvay Pharmaceuticals B.V.	Combination preparations comprising slv308 and a l-dopa
AU2007291234A1 (en)	2006-08-31	2008-03-06	Solvay Pharmaceuticals B.V.	Titration schedule for bifeprunox for treating schizophrenia and kits for use therein
CN101711236B (zh) *	2007-04-12	2012-10-31	Nsab神经研究瑞典公司分公司	表现出改善的心血管副作用特性的多巴胺受体稳定剂/调节剂的n-氧化物和/或二-n-氧化物衍生物
EP2234990A1 (en) *	2008-01-15	2010-10-06	Abbott Healthcare Products B.V.	Bifeprunox derivatives
WO2011023796A1 (en)	2009-08-31	2011-03-03	Abbott Healthcare Products B.V.	Bifeprunox for treating addiction
MX347209B (es)	2011-12-08	2017-04-19	Teva Pharmaceuticals Int Gmbh	La sal de bromhidrato de pridopidina.
AU2013243461A1 (en)	2012-04-04	2014-11-06	Teva Pharmaceuticals International Gmbh	Pharmaceutical compositions for combination therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE503170A (pl) *	1975-09-02
AU708053B2 (en) *	1996-03-29	1999-07-29	Duphar International Research B.V.	Piperazine and piperidine compounds
UA71590C2 (en) *	1998-11-13	2004-12-15	Duphar Int Res	Piperazine and piperidine derivatives
US6911448B2 (en) *	2000-05-12	2005-06-28	Solvay Pharmaceuticals B.V.	Piperazine and piperidine compounds
RU2301806C2 (ru) *	2002-01-16	2007-06-27	Янссен Фармацевтика Н.В.	Прукалоприд-n-оксид

2006
- 2006-08-21 AT AT06778284T patent/ATE417834T1/de active
- 2006-08-21 DK DK06778284T patent/DK1919883T3/da active
- 2006-08-21 JP JP2008527453A patent/JP2009504799A/ja active Pending
- 2006-08-21 RU RU2008110945/04A patent/RU2394821C2/ru not_active IP Right Cessation
- 2006-08-21 KR KR1020087006996A patent/KR20080046205A/ko not_active Ceased
- 2006-08-21 PL PL06778284T patent/PL1919883T3/pl unknown
- 2006-08-21 WO PCT/EP2006/065477 patent/WO2007023141A1/en not_active Ceased
- 2006-08-21 SI SI200630214T patent/SI1919883T1/sl unknown
- 2006-08-21 PT PT06778284T patent/PT1919883E/pt unknown
- 2006-08-21 CA CA002621158A patent/CA2621158A1/en not_active Abandoned
- 2006-08-21 HR HR20090143T patent/HRP20090143T3/xx unknown
- 2006-08-21 DE DE602006004363T patent/DE602006004363D1/de active Active
- 2006-08-21 AU AU2006283882A patent/AU2006283882B2/en not_active Ceased
- 2006-08-21 ES ES06778284T patent/ES2318783T3/es active Active
- 2006-08-21 EP EP06778284A patent/EP1919883B1/en not_active Not-in-force
2008
- 2008-01-21 IL IL188903A patent/IL188903A0/en unknown
- 2008-03-19 NO NO20081435A patent/NO20081435L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
PT1919883E (pt)	2009-03-26
EP1919883B1 (en)	2008-12-17
HRP20090143T3 (hr)	2009-04-30
WO2007023141A1 (en)	2007-03-01
DK1919883T3 (da)	2009-04-14
RU2394821C2 (ru)	2010-07-20
IL188903A0 (en)	2008-04-13
DE602006004363D1 (de)	2009-01-29
ES2318783T3 (es)	2009-05-01
AU2006283882A1 (en)	2007-03-01
ATE417834T1 (de)	2009-01-15
JP2009504799A (ja)	2009-02-05
EP1919883A1 (en)	2008-05-14
RU2008110945A (ru)	2009-09-27
AU2006283882B2 (en)	2011-06-23
CA2621158A1 (en)	2007-03-01
SI1919883T1 (sl)	2009-04-30
KR20080046205A (ko)	2008-05-26
NO20081435L (no)	2008-05-16

Publication	Publication Date	Title
IL188903A0 (en)	2008-04-13	N-oxides as prodrugs of piperazine & piperidine derivatives
TW200505907A (en)	2005-02-16	Piperidine-benzenesulfonamide derivatives
NO20051826L (no)	2005-04-15	Heterosyklisk substituerte piperaziner for behandling av schizofreni
NZ537341A (en)	2006-04-28	Quinuclidine amide derivatives as antimuscarinic agents to treat respiratory disorders
NZ595571A (en)	2013-04-26	Pyrazole compounds and uses thereof
ATE493407T1 (de)	2011-01-15	3-(heteroaryloxy)-2-alkyl-1- azabicycloalkylderivate als alpha.7-nachr- liganden zur behandlung von zns-erkrankungen
WO2005079802A8 (en)	2006-11-09	Bipyridyl amides as modulators of metabotropic glutamate receptor-5
NO20060768L (no)	2006-06-06	1-(2-amino-benzol)-piperazinderivater som glycinopptaks-inhibitorer for behandling av psykoser
NZ597107A (en)	2013-12-20	Heterocyclic compounds for the treatment of neurological and psychological disorders
ES2162257T3 (es)	2001-12-16	N-aminoalquildibenzofurancarboxamidas como ligandos especificos del subtipo de receptor de la dopamina.
UA85707C2 (ru)	2009-02-25	Бензоксазины для лечения заболеваний дыхательных путей
IL186777A0 (en)	2008-02-09	(3,4-dihydro-quinazolin-2-yl) - (2-aryloxy-ethyl) - amines having an activity on the 5 - ht receptor
WO2006119504A3 (en)	2009-06-11	Fused heterocyclic compounds, and compositions and uses thereof
DE602004005502D1 (de)	2007-05-03	Comt-inhibitoren
EP1921077A4 (en)	2009-01-28	MEANS FOR THE TREATMENT AND / OR PREVENTION OF SLEEP DISORDERS
NZ592563A (en)	2012-10-26	1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands
MX2009010727A (es)	2009-10-26	Heterociclos como antagonistas de orexina.
NO20072972L (no)	2007-08-23	Terapeutiske pyrazolo[3,4-B]pyridiner og indazoler
GB0412314D0 (en)	2004-07-07	Compounds
ZA200906573B (en)	2011-11-30	Dibenzo[1,4]oxazapine compounds
NZ607031A (en)	2014-06-27	Arylosulfonamides for the treatment of cns diseases
UA94718C2 (ru)	2011-06-10	N-оксиды в качестве пролекарств производных пиперазина и пиперидина
IL176914A0 (en)	2006-12-10	Heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, method for the production thereof and their use as medicaments
UA96756C2 (en)	2011-12-12	N-oxides of pyridylmethylpiperazine and -piperidine derivatives
ATE334980T1 (de)	2006-08-15	Verfahren zur herstellung von 2-methyl piperazine derivaten.