PL1931705T3 - Sposób amidowania polipeptydów z C-końcowymi zasadowymi aminokwasami z zastosowaniem specyficznych endoproteaz - Google Patents

Sposób amidowania polipeptydów z C-końcowymi zasadowymi aminokwasami z zastosowaniem specyficznych endoproteaz

Info

Publication number: PL1931705T3
Authority: PL; Poland
Prior art keywords: amidating; polypeptides; terminals; specific endoproteases; basic aminoacid
Prior art date: 2005-09-27

Application number

PL06792022T

Other languages

English (en)

Inventor

Sebastian Rissom

Paul Habermann

Christophe Salagnad

Frank Zocher

Laure Landric-Burtain

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-27

Filing date

2006-09-13

Publication date

2012-02-29

2006-09-13 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2012-02-29 Publication of PL1931705T3 publication Critical patent/PL1931705T3/pl

Links

101710118538 Protease Proteins 0.000 title 1
230000002862 amidating effect Effects 0.000 title 1
235000001014 amino acid Nutrition 0.000 title 1
150000001413 amino acids Chemical class 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Analytical Chemistry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL06792022T 2005-09-27 2006-09-13 Sposób amidowania polipeptydów z C-końcowymi zasadowymi aminokwasami z zastosowaniem specyficznych endoproteaz PL1931705T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE102005046113A DE102005046113A1 (de)	2005-09-27	2005-09-27	Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen
EP06792022A EP1931705B1 (de)	2005-09-27	2006-09-13	Verfahren zur amidierung von polypeptiden mit c-terminalen basischen aminosäuren unter verwendung spezifischer endoproteasen
PCT/EP2006/008903 WO2007036299A2 (de)	2005-09-27	2006-09-13	Verfahren zur amidierung von polypeptiden mit c-terminalen basischen aminosäuren unter verwendung spezifischer endoproteasen

Publications (1)

Publication Number	Publication Date
PL1931705T3 true PL1931705T3 (pl)	2012-02-29

Family

ID=37735179

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06792022T PL1931705T3 (pl)	2005-09-27	2006-09-13	Sposób amidowania polipeptydów z C-końcowymi zasadowymi aminokwasami z zastosowaniem specyficznych endoproteaz

Country Status (20)

Country	Link
US (1)	US8765910B2 (pl)
EP (1)	EP1931705B1 (pl)
JP (1)	JP5352234B2 (pl)
KR (1)	KR101363299B1 (pl)
CN (1)	CN101268097A (pl)
AR (1)	AR055179A1 (pl)
AT (1)	ATE523522T1 (pl)
AU (1)	AU2006296818B2 (pl)
BR (1)	BRPI0616712B8 (pl)
CA (1)	CA2623547C (pl)
CY (1)	CY1112182T1 (pl)
DE (1)	DE102005046113A1 (pl)
DK (1)	DK1931705T3 (pl)
ES (1)	ES2373237T3 (pl)
IL (1)	IL190229A (pl)
MY (1)	MY148447A (pl)
PL (1)	PL1931705T3 (pl)
PT (1)	PT1931705E (pl)
SI (1)	SI1931705T1 (pl)
WO (1)	WO2007036299A2 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006031955A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
KR101853606B1 (ko)	2009-07-06	2018-05-03	사노피-아벤티스 도이칠란트 게엠베하	메티오닌을 함유하는 수성 인슐린 제제
KR101337322B1 (ko)	2009-11-13	2013-12-06	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
DK2498802T3 (en)	2009-11-13	2015-04-13	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine
US9587006B2 (en) *	2010-02-11	2017-03-07	Hoffmann-La Roche Inc.	IGF-I poly (ethylene glycol) conjugates
ES2606554T3 (es)	2010-08-30	2017-03-24	Sanofi-Aventis Deutschland Gmbh	Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl)	2011-08-29	2015-12-31	Sanofi Aventis Deutschland	Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
TWI641381B (zh)	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
SG11201604706TA (en)	2014-01-09	2016-07-28	Sanofi Sa	Stabilized pharmaceutical formulations of insulin aspart
EP3091965A1 (en)	2014-01-09	2016-11-16	Sanofi	Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
CN112957455A (zh)	2014-01-09	2021-06-15	赛诺菲	胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂
AU2015359376B2 (en)	2014-12-12	2021-09-09	Sanofi-Aventis Deutschland Gmbh	Insulin glargine/lixisenatide fixed ratio formulation
WO2016135041A1 (en)	2015-02-26	2016-09-01	INSERM (Institut National de la Santé et de la Recherche Médicale)	Fusion proteins and antibodies comprising thereof for promoting apoptosis
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
CN108226362B (zh) *	2016-12-21	2021-05-25	鲁南制药集团股份有限公司	一种聚乙二醇化促胰岛素分泌肽类似物中间体的分析检测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5332664A (en) *	1981-07-15	1994-07-26	Celltech Limited	Human calcitonin precursor polyprotein structural gene
US5416073A (en) *	1983-08-10	1995-05-16	The Adminstrators Of The Tulane Educational Fund	Growth hormone-releasing peptides and method of treating animals, therewith
US5496924A (en) *	1985-11-27	1996-03-05	Hoechst Aktiengesellschaft	Fusion protein comprising an interleukin-2 fragment ballast portion
DK220890D0 (da) *	1990-09-14	1990-09-14	Ole Buchardt	Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
ATE119916T1 (de) *	1990-12-10	1995-04-15	Hoffmann La Roche	Verfahren zur enzymatischen herstellung von grf(1-44)nh2.
DE69332377T2 (de) *	1992-07-13	2003-07-03	Bionebraska, Inc.	Verfahren zur modifizierung rekombinanter polypeptide
DE19944870A1 (de) *	1999-09-18	2001-03-29	Aventis Pharma Gmbh	Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium
US7638618B2 (en) *	2001-02-20	2009-12-29	Sanofi-Aventis Deutschland Gmbh	Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
BR0314996A (pt) *	2002-10-02	2005-08-09	Zealand Pharma As	Composição, composição farmaceuticamente aceitável, método para produzir a composição, métodos para estabilizar a exendina-4 (1-39) ou uma sua variante, derivado ou análogo contra a degradação, antes, durante ou após o uso pretendido, para tratar doenças, para tratar de estados de doenças associados com nìveis elevados de glicose do sangue, para a regulação dos nìveis de glicose do sangue, para a regulação do esvaziamento gástrico, para estimular a liberação de insulina em um mamìfero para reduzir o nìvel de glicose do sangue em um mamìfero, para reduzir o nìvel de lipìdeos plasmáticos em um mamìfero, para reduzir a mortalidade e a morbidez após o infarto miocárdico em um mamìfero, para estimular a liberação de insulina em um mamìfero, e para produzir uma exendina (1-39) estabilizada, e, exendina (1-39) estabilizada
CN101010425B (zh)	2004-08-13	2010-05-26	霍夫曼-拉罗奇有限公司	多肽的c-末端修饰
DE102004058306A1 (de) *	2004-12-01	2006-07-27	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Carboxy-terminal amidierten Peptiden
DE102006031955A1 (de) *	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) *	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
BRPI0907119A2 (pt) *	2008-01-09	2015-07-14	Sanofi Aventis Deutschland	Derivados de insulina tendo um perfil de ação de tempo extremamente retardado
AU2009203809B2 (en) *	2008-01-09	2013-07-25	Sanofi-Aventis Deutschland Gmbh	Novel insulin derivatives having an extremely delayed time-action profile

2005
- 2005-09-27 DE DE102005046113A patent/DE102005046113A1/de not_active Withdrawn
2006
- 2006-09-13 CA CA2623547A patent/CA2623547C/en not_active Expired - Fee Related
- 2006-09-13 PT PT06792022T patent/PT1931705E/pt unknown
- 2006-09-13 US US12/065,643 patent/US8765910B2/en active Active
- 2006-09-13 SI SI200631178T patent/SI1931705T1/sl unknown
- 2006-09-13 EP EP06792022A patent/EP1931705B1/de not_active Not-in-force
- 2006-09-13 WO PCT/EP2006/008903 patent/WO2007036299A2/de not_active Ceased
- 2006-09-13 ES ES06792022T patent/ES2373237T3/es active Active
- 2006-09-13 PL PL06792022T patent/PL1931705T3/pl unknown
- 2006-09-13 BR BRPI0616712A patent/BRPI0616712B8/pt not_active IP Right Cessation
- 2006-09-13 DK DK06792022.3T patent/DK1931705T3/da active
- 2006-09-13 JP JP2008532625A patent/JP5352234B2/ja not_active Expired - Fee Related
- 2006-09-13 AU AU2006296818A patent/AU2006296818B2/en not_active Ceased
- 2006-09-13 CN CNA2006800340261A patent/CN101268097A/zh active Pending
- 2006-09-13 AT AT06792022T patent/ATE523522T1/de active
- 2006-09-13 KR KR1020087007470A patent/KR101363299B1/ko not_active Expired - Fee Related
- 2006-09-13 MY MYPI20080633A patent/MY148447A/en unknown
- 2006-09-25 AR ARP060104168A patent/AR055179A1/es active IP Right Grant
2008
- 2008-03-17 IL IL190229A patent/IL190229A/en active IP Right Grant
2011
- 2011-12-06 CY CY20111101215T patent/CY1112182T1/el unknown

Also Published As

Publication number	Publication date
JP2009509515A (ja)	2009-03-12
ATE523522T1 (de)	2011-09-15
ES2373237T3 (es)	2012-02-01
CN101268097A (zh)	2008-09-17
WO2007036299A3 (de)	2007-05-31
CA2623547A1 (en)	2007-04-05
IL190229A0 (en)	2011-08-01
PT1931705E (pt)	2011-12-05
EP1931705A2 (de)	2008-06-18
IL190229A (en)	2012-12-31
BRPI0616712A2 (pt)	2011-06-28
MY148447A (en)	2013-04-30
BRPI0616712B8 (pt)	2021-05-25
AU2006296818A1 (en)	2007-04-05
DK1931705T3 (da)	2012-01-09
CA2623547C (en)	2015-08-11
BRPI0616712B1 (pt)	2018-10-16
AU2006296818B2 (en)	2012-03-01
CY1112182T1 (el)	2015-12-09
WO2007036299A2 (de)	2007-04-05
AR055179A1 (es)	2007-08-08
KR101363299B1 (ko)	2014-02-21
US8765910B2 (en)	2014-07-01
KR20080061367A (ko)	2008-07-02
EP1931705B1 (de)	2011-09-07
US20100311112A1 (en)	2010-12-09
SI1931705T1 (sl)	2011-12-30
JP5352234B2 (ja)	2013-11-27
DE102005046113A1 (de)	2007-03-29

Publication	Publication Date	Title
IL190229A0 (en)	2011-08-01	Method for amidating polypeptides with basic aminoacid c- terminals by means of specific endoproteases
EP1928237A4 (en)	2011-03-09	NEW HETEROCYCLES BASED ON IMIDAZO
GB0524788D0 (en)	2006-01-11	Polypeptides
GB0524486D0 (en)	2006-01-11	An electrolysis apparatus
GB0523019D0 (en)	2005-12-21	Automated immunoassay apparatus
EP1899375A4 (en)	2009-05-06	NEW METHOD FOR THE PURIFICATION OF LACTOFERRIN
GB0601976D0 (en)	2006-03-15	Proteins
AP2008004512A0 (en)	2008-06-30	Bacteriocion inducer peptides
GB0620735D0 (en)	2006-11-29	Proteins
GB0523239D0 (en)	2005-12-21	Quantification method
GB0516901D0 (en)	2005-09-28	Illumination apparatus
GB0612623D0 (en)	2006-08-02	Proteins
EP1860943A4 (en)	2008-06-18	NOVEL PROCEDURE
GB0614371D0 (en)	2006-08-30	Lighting apparatus
HU3590U (en)	2009-05-28	Lighting apparatus
GB0614682D0 (en)	2006-08-30	Proteins
GB0511861D0 (en)	2005-07-20	Proteins
GB0517685D0 (en)	2005-10-05	Novel method
GB0621280D0 (en)	2006-12-06	Lighting apparatus
GB0523523D0 (en)	2005-12-28	Lighting apparatus
AU306889S (en)	2006-05-23	Lighting apparatus
GB2432432B (en)	2009-04-15	Timekeeping apparatus
GB2431606B (en)	2007-12-12	Method for joining components
IL177448A0 (en)	2007-07-04	Methods for protein production
GB0521391D0 (en)	2005-11-30	Assays for the N-terminal propeptide of type II collagen