PL1945631T3 - Pochodne 4-(3-aminopirazolo)pirymidyny do stosowania jako inhibitory kinazy tyrozynowej do leczenia raka - Google Patents
Pochodne 4-(3-aminopirazolo)pirymidyny do stosowania jako inhibitory kinazy tyrozynowej do leczenia rakaInfo
- Publication number
- PL1945631T3 PL1945631T3 PL06794902T PL06794902T PL1945631T3 PL 1945631 T3 PL1945631 T3 PL 1945631T3 PL 06794902 T PL06794902 T PL 06794902T PL 06794902 T PL06794902 T PL 06794902T PL 1945631 T3 PL1945631 T3 PL 1945631T3
- Authority
- PL
- Poland
- Prior art keywords
- aminopyrazole
- cancer
- treatment
- tyrosine kinase
- kinase inhibitors
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73129905P | 2005-10-28 | 2005-10-28 | |
| US80306106P | 2006-05-24 | 2006-05-24 | |
| EP06794902A EP1945631B8 (en) | 2005-10-28 | 2006-10-26 | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
| PCT/GB2006/003978 WO2007049041A1 (en) | 2005-10-28 | 2006-10-26 | 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1945631T3 true PL1945631T3 (pl) | 2012-12-31 |
Family
ID=37575154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06794902T PL1945631T3 (pl) | 2005-10-28 | 2006-10-26 | Pochodne 4-(3-aminopirazolo)pirymidyny do stosowania jako inhibitory kinazy tyrozynowej do leczenia raka |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20080287475A1 (pl) |
| EP (2) | EP1945631B8 (pl) |
| JP (1) | JP2009513615A (pl) |
| KR (1) | KR20080063846A (pl) |
| AR (1) | AR056210A1 (pl) |
| AU (1) | AU2006307657B2 (pl) |
| BR (1) | BRPI0618011A2 (pl) |
| CA (1) | CA2626375A1 (pl) |
| DK (1) | DK1945631T3 (pl) |
| EC (1) | ECSP088450A (pl) |
| ES (1) | ES2391783T3 (pl) |
| HR (1) | HRP20120824T1 (pl) |
| IL (1) | IL190935A0 (pl) |
| MX (1) | MX2008005398A (pl) |
| NO (1) | NO20081893L (pl) |
| NZ (1) | NZ567584A (pl) |
| PL (1) | PL1945631T3 (pl) |
| PT (1) | PT1945631E (pl) |
| RU (1) | RU2463302C2 (pl) |
| TW (1) | TW200800963A (pl) |
| UY (1) | UY29886A1 (pl) |
| WO (1) | WO2007049041A1 (pl) |
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| CA2430539C (en) * | 2000-12-05 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| DK2383268T3 (en) * | 2005-02-04 | 2015-09-14 | Astrazeneca Ab | PYRAZOLYLAMINOPYRIDINDERIVATER useful as kinase inhibitors |
| KR101362621B1 (ko) * | 2005-02-16 | 2014-02-13 | 아스트라제네카 아베 | 화합물 |
| CA2608009A1 (en) * | 2005-05-16 | 2006-11-23 | Astrazeneca Ab | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
| BRPI0618011A2 (pt) * | 2005-10-28 | 2011-08-16 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável do mesmo, processo para a preparação do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, métodos para produzir um efeito anti-proliferativo e um efeito pró-apoptósico em um animal de sangue quente, para tratar doença e para produzir um efeito inibidor de jak em um animal de sangue quente |
| HUE028588T2 (hu) | 2005-12-13 | 2016-12-28 | Incyte Holdings Corp | Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok |
| WO2008023159A1 (en) | 2006-08-24 | 2008-02-28 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| WO2008061370A1 (en) * | 2006-11-24 | 2008-05-29 | Mcmaster University | Diagnostic method to detect endometriosis |
| CN101679429A (zh) * | 2007-04-18 | 2010-03-24 | 阿斯利康(瑞典)有限公司 | 5-氨基吡唑-3-基-3h-咪唑并[4,5-b]吡啶衍生物及其治疗癌的用途 |
| UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
| JP2010526048A (ja) * | 2007-05-04 | 2010-07-29 | アストラゼネカ アクチボラグ | アミノ−チアゾリル−ピリミジン誘導体、および癌の治療のための該誘導体の使用 |
| EP2740731B1 (en) | 2007-06-13 | 2016-03-23 | Incyte Holdings Corporation | Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| WO2009007750A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
| WO2009007753A2 (en) * | 2007-07-11 | 2009-01-15 | Astrazeneca Ab | 4- (3-aminopyrazole) -pyrimidine derivativee and their use as tyrosine kinase inhibitors for the treatment of cancer |
| WO2009013545A2 (en) * | 2007-07-26 | 2009-01-29 | Astrazeneca Ab | Chemical compounds |
| TW200906818A (en) * | 2007-07-31 | 2009-02-16 | Astrazeneca Ab | Chemical compounds |
| EA020777B1 (ru) | 2007-11-16 | 2015-01-30 | Инсайт Корпорейшн | 4-пиразолил-n-арилпиримидин-2-амины, 4-пиразолил-n-пиразолилпиримидин-2-амины и 4-пиразолил-n-пиридилпиримидин-2-амины в качестве ингибиторов киназ janus |
| WO2009095712A2 (en) * | 2008-01-29 | 2009-08-06 | Astrazeneca Ab | Chemical compounds |
| MX2010013682A (es) * | 2008-06-11 | 2011-03-15 | Astrazeneca Ab | Derivados de 2,4-diamino-l,3,5-triazina triciclicos utiles para el tratamiento del cancer y trastornos mieloproliferativos. |
| TW201011017A (en) * | 2008-08-19 | 2010-03-16 | Astrazeneca Ab | Chemical compounds 495-1 |
| JP2012504157A (ja) * | 2008-09-30 | 2012-02-16 | アストラゼネカ アクチボラグ | 複素環式ｊａｋキナーゼ阻害剤 |
| BRPI1012108B8 (pt) | 2009-05-22 | 2021-05-25 | Incyte Corp | composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico |
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| US8729265B2 (en) | 2009-08-14 | 2014-05-20 | Boehringer Ingelheim International Gmbh | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| CA2792508C (en) | 2010-03-10 | 2018-01-16 | Incyte Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| EA202091303A3 (ru) | 2010-05-21 | 2021-05-31 | Инсайт Холдингс Корпорейшн | Композиция ингибитора jak для местного применения |
| SA111320519B1 (ar) | 2010-06-11 | 2014-07-02 | Astrazeneca Ab | مركبات بيريميدينيل للاستخدام كمثبطات atr |
| EP2625170A1 (en) | 2010-10-07 | 2013-08-14 | Takeda Pharmaceutical Company Limited | 1,4-oxazepane derivatives |
| JP2012102088A (ja) * | 2010-10-14 | 2012-05-31 | Sumitomo Chemical Co Ltd | ヘテロ芳香環化合物およびその有害生物防除用途 |
| ES2536415T3 (es) | 2010-11-19 | 2015-05-25 | Incyte Corporation | Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK |
| CA2818542A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| US8691807B2 (en) | 2011-06-20 | 2014-04-08 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors |
| EP2554544A1 (en) * | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| CA2844729A1 (en) * | 2011-08-25 | 2013-02-28 | F. Hoffmann-La Roche Ag | Serine/threonine pak1 inhibitors |
| JP2014525418A (ja) * | 2011-09-05 | 2014-09-29 | 浙江海正薬業股▲ふん▼有限公司 | タンパク質キナーゼ阻害活性を有する４−置換−（３−置換−１ｈ−ピラゾール−５−アミノ）−ピリミジン誘導体及びその使用 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| RU2014129740A (ru) * | 2011-12-22 | 2016-02-10 | Ф.Хоффманн-Ля Рош Аг | Производные 2,4-диаминопиримидина в качестве ингибиторов серин/треонин киназы |
| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
| KR102242077B1 (ko) | 2012-11-15 | 2021-04-20 | 인사이트 홀딩스 코포레이션 | 룩솔리티니브의 서방성 제형 |
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| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
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| TWI759829B (zh) | 2019-08-23 | 2022-04-01 | 財團法人生物技術開發中心 | 作為第iii型受體酪胺酸激酶抑制劑之雜環吡唑衍生物 |
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| BR0116493A (pt) | 2000-12-21 | 2003-09-30 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
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| SE0101675D0 (sv) | 2001-05-11 | 2001-05-11 | Astrazeneca Ab | Novel composition |
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| US7015231B2 (en) | 2001-09-27 | 2006-03-21 | Smithkline Beecham Corporation | Chemical compounds |
| US6747461B2 (en) | 2001-10-25 | 2004-06-08 | Pioneer Hi-Bred International, Inc. | Apparatus and method for monitoring drying of an agricultural porous medium such as grain or seed |
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| BRPI0618011A2 (pt) | 2005-10-28 | 2011-08-16 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável do mesmo, processo para a preparação do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, métodos para produzir um efeito anti-proliferativo e um efeito pró-apoptósico em um animal de sangue quente, para tratar doença e para produzir um efeito inibidor de jak em um animal de sangue quente |
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| TW200817391A (en) | 2006-06-30 | 2008-04-16 | Astrazeneca Ab | Novel compounds |
| TW200823196A (en) | 2006-11-01 | 2008-06-01 | Astrazeneca Ab | New use |
| TW200826937A (en) | 2006-11-01 | 2008-07-01 | Astrazeneca Ab | New use |
-
2006
- 2006-10-26 BR BRPI0618011-6A patent/BRPI0618011A2/pt not_active IP Right Cessation
- 2006-10-26 AU AU2006307657A patent/AU2006307657B2/en not_active Ceased
- 2006-10-26 WO PCT/GB2006/003978 patent/WO2007049041A1/en not_active Ceased
- 2006-10-26 PL PL06794902T patent/PL1945631T3/pl unknown
- 2006-10-26 KR KR1020087011816A patent/KR20080063846A/ko not_active Ceased
- 2006-10-26 ES ES06794902T patent/ES2391783T3/es active Active
- 2006-10-26 MX MX2008005398A patent/MX2008005398A/es not_active Application Discontinuation
- 2006-10-26 DK DK06794902.4T patent/DK1945631T3/da active
- 2006-10-26 HR HRP20120824TT patent/HRP20120824T1/hr unknown
- 2006-10-26 EP EP06794902A patent/EP1945631B8/en active Active
- 2006-10-26 JP JP2008537190A patent/JP2009513615A/ja active Pending
- 2006-10-26 RU RU2008120848/04A patent/RU2463302C2/ru not_active IP Right Cessation
- 2006-10-26 US US12/091,382 patent/US20080287475A1/en not_active Abandoned
- 2006-10-26 NZ NZ567584A patent/NZ567584A/en not_active IP Right Cessation
- 2006-10-26 TW TW095139565A patent/TW200800963A/zh unknown
- 2006-10-26 CA CA002626375A patent/CA2626375A1/en not_active Abandoned
- 2006-10-26 EP EP11177767A patent/EP2388259A1/en not_active Withdrawn
- 2006-10-26 PT PT06794902T patent/PT1945631E/pt unknown
- 2006-10-27 AR ARP060104713A patent/AR056210A1/es not_active Application Discontinuation
- 2006-10-27 UY UY29886A patent/UY29886A1/es not_active Application Discontinuation
-
2008
- 2008-04-17 IL IL190935A patent/IL190935A0/en unknown
- 2008-04-22 NO NO20081893A patent/NO20081893L/no not_active Application Discontinuation
- 2008-05-14 EC EC2008008450A patent/ECSP088450A/es unknown
-
2010
- 2010-02-26 US US12/713,695 patent/US8088784B2/en not_active Expired - Fee Related
-
2011
- 2011-12-01 US US13/308,584 patent/US20120071480A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2463302C2 (ru) | 2012-10-10 |
| ECSP088450A (es) | 2008-06-30 |
| PT1945631E (pt) | 2012-10-15 |
| KR20080063846A (ko) | 2008-07-07 |
| CA2626375A1 (en) | 2007-05-03 |
| NO20081893L (no) | 2008-05-20 |
| UY29886A1 (es) | 2007-05-31 |
| DK1945631T3 (da) | 2012-10-22 |
| RU2008120848A (ru) | 2009-12-10 |
| MX2008005398A (es) | 2008-09-24 |
| EP2388259A1 (en) | 2011-11-23 |
| EP1945631B8 (en) | 2013-01-02 |
| AR056210A1 (es) | 2007-09-26 |
| US20080287475A1 (en) | 2008-11-20 |
| IL190935A0 (en) | 2009-09-22 |
| ES2391783T3 (es) | 2012-11-29 |
| WO2007049041A8 (en) | 2012-11-01 |
| TW200800963A (en) | 2008-01-01 |
| WO2007049041A1 (en) | 2007-05-03 |
| EP1945631A1 (en) | 2008-07-23 |
| NZ567584A (en) | 2011-08-26 |
| AU2006307657A1 (en) | 2007-05-03 |
| HRP20120824T1 (hr) | 2012-11-30 |
| BRPI0618011A2 (pt) | 2011-08-16 |
| AU2006307657B2 (en) | 2010-10-28 |
| EP1945631B1 (en) | 2012-08-08 |
| US20120071480A1 (en) | 2012-03-22 |
| US20100160325A1 (en) | 2010-06-24 |
| US8088784B2 (en) | 2012-01-03 |
| JP2009513615A (ja) | 2009-04-02 |
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