PL1954690T3 - Związki benzamidowe użyteczne jako inhibitory deacetylazy histonów - Google Patents

Związki benzamidowe użyteczne jako inhibitory deacetylazy histonów

Info

Publication number: PL1954690T3
Authority: PL; Poland
Prior art keywords: compounds useful; histone deacetylase; deacetylase inhibitors; benzamide compounds; benzamide
Prior art date: 2005-10-19

Application number

PL06794783T

Other languages

English (en)

Inventor

David Michael Andrews

Elaine Sophie Elizabeth Stokes

Andrew Turner

Michael James Waring

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-19

Filing date

2006-10-17

Publication date

2013-09-30

2006-10-17 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2013-09-30 Publication of PL1954690T3 publication Critical patent/PL1954690T3/pl

Links

150000003936 benzamides Chemical class 0.000 title 1
229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
239000003276 histone deacetylase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL06794783T 2005-10-19 2006-10-17 Związki benzamidowe użyteczne jako inhibitory deacetylazy histonów PL1954690T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0521244.4A GB0521244D0 (en)	2005-10-19	2005-10-19	Benzamide compounds
EP06794783.8A EP1954690B1 (en)	2005-10-19	2006-10-17	Benzamide compounds useful as histone deacetylase inhibitors
PCT/GB2006/003838 WO2007045844A1 (en)	2005-10-19	2006-10-17	Benzamide compounds useful as histone deacetylase inhibitors

Publications (1)

Publication Number	Publication Date
PL1954690T3 true PL1954690T3 (pl)	2013-09-30

Family

ID=35458263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06794783T PL1954690T3 (pl)	2005-10-19	2006-10-17	Związki benzamidowe użyteczne jako inhibitory deacetylazy histonów

Country Status (31)

Country	Link
US (2)	US8207202B2 (pl)
EP (1)	EP1954690B1 (pl)
JP (1)	JP5340736B2 (pl)
KR (1)	KR101464004B1 (pl)
CN (1)	CN101331123B (pl)
AR (1)	AR057162A1 (pl)
AU (1)	AU2006303111B2 (pl)
BR (1)	BRPI0617654B8 (pl)
CA (1)	CA2625970C (pl)
CY (1)	CY1114521T1 (pl)
DK (1)	DK1954690T3 (pl)
EC (1)	ECSP088457A (pl)
ES (1)	ES2422859T3 (pl)
GB (1)	GB0521244D0 (pl)
HR (1)	HRP20130683T1 (pl)
IL (1)	IL190429A (pl)
ME (1)	ME01595B (pl)
MY (1)	MY145569A (pl)
NO (1)	NO340878B1 (pl)
NZ (1)	NZ566944A (pl)
PL (1)	PL1954690T3 (pl)
PT (1)	PT1954690E (pl)
RS (1)	RS52881B (pl)
RU (1)	RU2448965C2 (pl)
SA (1)	SA06270384B1 (pl)
SI (1)	SI1954690T1 (pl)
TW (1)	TWI385162B (pl)
UA (1)	UA98757C2 (pl)
UY (1)	UY29869A1 (pl)
WO (1)	WO2007045844A1 (pl)
ZA (1)	ZA200803096B (pl)

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DE102007028198A1 (de)	2007-06-16	2008-12-24	Schebo (R) . Biotech Ag	Neue Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Therapie
WO2009118370A1 (en)	2008-03-27	2009-10-01	Janssen Pharmaceutica Nv	Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
AU2009289649B2 (en)	2008-09-03	2016-05-05	Biomarin Pharmaceutical Inc.	Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
KR20120031170A (ko) *	2009-06-08	2012-03-30	길리애드 사이언시즈, 인코포레이티드	알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물
US10059723B2 (en)	2011-02-28	2018-08-28	Biomarin Pharmaceutical Inc.	Histone deacetylase inhibitors
US9540395B2 (en)	2011-02-28	2017-01-10	Biomarin Pharmaceutical Inc.	Histone deacetylase inhibitors
US8957066B2 (en)	2011-02-28	2015-02-17	Biomarin Pharmaceutical Inc.	Histone deacetylase inhibitors
US9617259B2 (en)	2013-03-14	2017-04-11	Chdi Foundation, Inc.	Histone deacetylase inhibitors and compositions and methods of use thereof
HK1220407A1 (zh)	2013-03-14	2017-05-05	Chdi Foundation, Inc.	组蛋白去乙酰酶抑制剂，其组合物及其使用方法
WO2014159214A1 (en) *	2013-03-14	2014-10-02	Chdi Foundation, Inc.	Histone deacetylase inhibitors and compositions and methods of use thereof
DK2970139T3 (en)	2013-03-15	2018-08-13	Biomarin Pharm Inc	HDAC inhibitors
BR112015027114B1 (pt) *	2013-04-29	2021-12-21	Chong Kun Dang Pharmaceutical Corp	Compostos inibidores seletivos de histona desacetilase e seu uso
KR20170012404A (ko)	2014-06-02	2017-02-02	씨에이치디아이 파운데이션, 인코포레이티드	히스톤 데아세틸라제 억제제 및 그것의 조성물 및 사용 방법
KR102236356B1 (ko)	2017-11-24	2021-04-05	주식회사 종근당	루푸스의 예방 또는 치료를 위한 조성물
GB201913988D0 (en) *	2019-09-27	2019-11-13	Celleron Therapeutics Ltd	Novel treatment
GB201914006D0 (en) *	2019-09-27	2019-11-13	Celleron Therapeutics Ltd	Combination Therapy
CN118772107B (zh) *	2023-04-06	2026-04-17	微境生物医药科技(上海)有限公司	Hdac抑制剂及其用途
GB202315149D0 (en)	2023-10-03	2023-11-15	Celleron Therapeutics Ltd	Combination therapy

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CH117273A4 (pl)	1973-01-26	1976-07-15
CH187973A4 (de)	1973-02-09	1977-03-31	Hoechst Ag	Verfahren zum optischen Aufhellen von Textilmaterialien
DE2918965A1 (de)	1979-05-11	1980-11-20	Bayer Ag	Benzofuranverbindungen sowie deren verwendung als optische aufheller
IT1232252B (it)	1989-02-22	1992-01-28	Rotta Research Lab	Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione
JPH05239069A (ja)	1992-02-28	1993-09-17	Canon Inc	液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置
JP4405602B2 (ja)	1998-04-16	2010-01-27	バイエル・シエーリング・ファーマアクチエンゲゼルシャフト	ヒストン脱アセチル化酵素阻害剤
GB9826412D0 (en)	1998-12-03	1999-01-27	Glaxo Group Ltd	Chemical compounds
JP4390024B2 (ja)	1999-04-23	2009-12-24	アステラス製薬株式会社	新規なジアゼパン誘導体又はその塩
US6632815B2 (en)	1999-09-17	2003-10-14	Millennium Pharmaceuticals, Inc.	Inhibitors of factor Xa
CZ2002959A3 (cs)	1999-09-17	2002-07-17	Millennium Pharmaceuticals, Inc.	Inhibitory faktoru Xa
EP1748046A3 (en)	1999-11-23	2007-08-22	Methylgene, Inc.	Inhibitors of histone deacetylase
AU776053B2 (en)	2000-03-31	2004-08-26	Astellas Pharma Inc.	Diazepan derivatives or salts thereof
EP1217000A1 (en)	2000-12-23	2002-06-26	Aventis Pharma Deutschland GmbH	Inhibitors of factor Xa and factor VIIa
CN101851173A (zh)	2001-09-14	2010-10-06	梅特希尔基因公司	组蛋白脱乙酰化酶抑制剂
DE10204115A1 (de)	2002-02-01	2003-08-07	Bayer Cropscience Ag	DELTA·1·-Pyrroline
TWI319387B (en)	2002-04-05	2010-01-11	Astrazeneca Ab	Benzamide derivatives
GB0209715D0 (en)	2002-04-27	2002-06-05	Astrazeneca Ab	Chemical compounds
US20040072770A1 (en)	2002-07-03	2004-04-15	Besterman Jeffrey M.	Methods for specifically inhibiting histone deacetylase-7 and 8
TW200505902A (en)	2003-03-20	2005-02-16	Schering Corp	Cannabinoid receptor ligands
WO2005030705A1 (en)	2003-09-24	2005-04-07	Methylgene, Inc.	Inhibitors of histone deacetylase
MXPA06010900A (es)	2004-03-26	2007-02-21	Methylgene Inc	Inhibidores de histona desacetilasa.
AR050926A1 (es)	2004-09-03	2006-12-06	Astrazeneca Ab	Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac)
GB0427758D0 (en)	2004-12-18	2005-01-19	Astrazeneca Ab	Novel benzamide compounds
GB0500828D0 (en)	2005-01-15	2005-02-23	Astrazeneca Ab	Benzamide derivatives
GB0501146D0 (en)	2005-01-20	2005-02-23	Astrazeneca Ab	Novel benzamide derivatives
GB0526352D0 (en)	2005-12-23	2006-02-01	Astrazeneca Ab	Benzamide derivatives
GB0526351D0 (en)	2005-12-23	2006-02-01	Astrazeneca Ab	Novel benzamide derivatives

2005
- 2005-10-19 GB GBGB0521244.4A patent/GB0521244D0/en not_active Ceased
2006
- 2006-10-17 UA UAA200805465A patent/UA98757C2/ru unknown
- 2006-10-17 BR BRPI0617654A patent/BRPI0617654B8/pt active IP Right Grant
- 2006-10-17 AU AU2006303111A patent/AU2006303111B2/en active Active
- 2006-10-17 JP JP2008536114A patent/JP5340736B2/ja active Active
- 2006-10-17 EP EP06794783.8A patent/EP1954690B1/en active Active
- 2006-10-17 PT PT67947838T patent/PT1954690E/pt unknown
- 2006-10-17 NZ NZ566944A patent/NZ566944A/en unknown
- 2006-10-17 RU RU2008119411/04A patent/RU2448965C2/ru active
- 2006-10-17 SI SI200631627T patent/SI1954690T1/sl unknown
- 2006-10-17 PL PL06794783T patent/PL1954690T3/pl unknown
- 2006-10-17 US US12/090,611 patent/US8207202B2/en active Active
- 2006-10-17 WO PCT/GB2006/003838 patent/WO2007045844A1/en not_active Ceased
- 2006-10-17 KR KR1020087011411A patent/KR101464004B1/ko active Active
- 2006-10-17 ES ES06794783T patent/ES2422859T3/es active Active
- 2006-10-17 HR HRP20130683TT patent/HRP20130683T1/hr unknown
- 2006-10-17 CN CN200680047678.9A patent/CN101331123B/zh active Active
- 2006-10-17 ME MEP-2013-85A patent/ME01595B/me unknown
- 2006-10-17 RS RS20130325A patent/RS52881B/sr unknown
- 2006-10-17 DK DK06794783.8T patent/DK1954690T3/da active
- 2006-10-17 CA CA2625970A patent/CA2625970C/en active Active
- 2006-10-18 UY UY29869A patent/UY29869A1/es not_active Application Discontinuation
- 2006-10-19 AR ARP060104581A patent/AR057162A1/es active IP Right Grant
- 2006-10-19 TW TW095138558A patent/TWI385162B/zh not_active IP Right Cessation
- 2006-10-28 SA SA6270384A patent/SA06270384B1/ar unknown
2008
- 2008-03-25 IL IL190429A patent/IL190429A/en active IP Right Grant
- 2008-04-01 NO NO20081582A patent/NO340878B1/no unknown
- 2008-04-08 ZA ZA200803096A patent/ZA200803096B/xx unknown
- 2008-04-16 MY MYPI20081121A patent/MY145569A/en unknown
- 2008-05-17 EC EC2008008457A patent/ECSP088457A/es unknown
2012
- 2012-05-15 US US13/472,095 patent/US8735429B2/en active Active
2013
- 2013-07-31 CY CY20131100650T patent/CY1114521T1/el unknown

Also Published As

Publication number	Publication date
UY29869A1 (es)	2007-05-31
TW200800944A (en)	2008-01-01
BRPI0617654A2 (pt)	2011-08-02
SI1954690T1 (sl)	2013-08-30
ECSP088457A (es)	2008-06-30
JP5340736B2 (ja)	2013-11-13
WO2007045844A1 (en)	2007-04-26
HRP20130683T1 (en)	2013-10-11
RS52881B (sr)	2014-02-28
CA2625970A1 (en)	2007-04-26
ES2422859T3 (es)	2013-09-16
ME01595B (me)	2014-09-20
MY145569A (en)	2012-02-29
DK1954690T3 (da)	2013-07-29
UA98757C2 (ru)	2012-06-25
CA2625970C (en)	2015-12-01
GB0521244D0 (en)	2005-11-30
HK1121749A1 (en)	2009-04-30
AR057162A1 (es)	2007-11-21
NZ566944A (en)	2011-05-27
US8735429B2 (en)	2014-05-27
RU2448965C2 (ru)	2012-04-27
EP1954690B1 (en)	2013-05-15
PT1954690E (pt)	2013-07-31
BRPI0617654B1 (pt)	2020-09-15
AU2006303111A1 (en)	2007-04-26
KR101464004B1 (ko)	2014-11-20
CN101331123B (zh)	2015-11-25
SA06270384B1 (ar)	2010-08-02
CN101331123A (zh)	2008-12-24
US20080269294A1 (en)	2008-10-30
AU2006303111B2 (en)	2010-11-25
ZA200803096B (en)	2009-02-25
IL190429A0 (en)	2008-11-03
EP1954690A1 (en)	2008-08-13
US8207202B2 (en)	2012-06-26
CY1114521T1 (el)	2016-10-05
JP2009512668A (ja)	2009-03-26
RU2008119411A (ru)	2009-11-27
KR20080067656A (ko)	2008-07-21
TWI385162B (zh)	2013-02-11
BRPI0617654B8 (pt)	2021-05-25
NO20081582L (no)	2008-05-06
IL190429A (en)	2012-08-30
NO340878B1 (no)	2017-07-03
US20120225907A1 (en)	2012-09-06

Publication	Publication Date	Title
ZA200803096B (en)	2009-02-25	Benzamide compounds useful as histone deacetylase inhibitors
IL188692A0 (en)	2008-08-07	Histone deacetylase inhibitors
ZA200801351B (en)	2009-09-30	Sulphonypyrrole hydrochloride salts as histone deacetylases inhibitors
EP1745022A4 (en)	2012-03-07	PRODRUGS OF HISTONDEACETYLASEINHIBITORS
EP1735319A4 (en)	2010-06-09	Histone deacetylase INHIBITORS
EP1755601A4 (en)	2009-12-02	HISTONE DEACETYLASE INHIBITORS
AU2008300827A8 (en)	2010-06-03	Novel tetrahydrofusedpyridines as histone deacetylase inhibitors
EG25655A (en)	2012-05-02	Benzamide derivatives useful as histone deacetylase inhibitors
IL187790A0 (en)	2008-08-07	Fk 228 derivatives as hdac inhibitors
ZA201002841B (en)	2010-12-29	Histone deacetylase inhibitors
ZA200801394B (en)	2009-12-30	Novel sulphonylpyrroles as inhibitors of HDAC S novel sulphonylpyrroles
IL193458A0 (en)	2009-08-03	Histone deacetylase inhibitors
IL198263A0 (en)	2009-12-24	Hydroxamates as inhibitors of histone deacetylase
EP1789381A4 (en)	2009-11-11	INHIBITORS OF HISTONE DEACETYLASE
ZA200703390B (en)	2008-10-29	New histone deacetylases inhibitors
EP2217588A4 (en)	2013-12-04	INHIBITORS OF HISTONE DEACETYLASE
ZA200906609B (en)	2010-05-26	Inhibitors of histone deacetylase
EP2134680A4 (en)	2012-03-07	Histone deacetylase INHIBITORS
EP1963258A4 (en)	2011-06-29	HISTONE DEACETYLASE INHIBITORS FOR INCREASING THE ACTIVITY OF ANTIFUNGAL AGENTS
SI1725528T1 (sl)	2013-11-29	Sulfonilpiroli kot HDAC inhibitorji
EP2205563A4 (en)	2012-01-25	NEW HISTONDEACETYLASE INHIBITORS
ZA201001972B (en)	2012-06-27	Novel teteahydrofusedpyridines as histone deacetylase inhibitors
EP1817020A4 (en)	2012-11-21	INHIBITORS OF HISTONATE ACETYLASE
GB0620823D0 (en)	2006-11-29	Histone deacetylase inhibitors
ZA200706012B (en)	2008-09-25	N-sulphonylpyrroles and their use as histone deacetylase inhibitors