ECSP088457A - Compuestos de benzamida útiles como inhibidores de la histona deacetilasa - Google Patents

Compuestos de benzamida útiles como inhibidores de la histona deacetilasa

Info

Publication number
ECSP088457A
ECSP088457A EC2008008457A ECSP088457A ECSP088457A EC SP088457 A ECSP088457 A EC SP088457A EC 2008008457 A EC2008008457 A EC 2008008457A EC SP088457 A ECSP088457 A EC SP088457A EC SP088457 A ECSP088457 A EC SP088457A
Authority
EC
Ecuador
Prior art keywords
inhibitors
benzamide compounds
compounds
relates
histone
Prior art date
Application number
EC2008008457A
Other languages
English (en)
Inventor
Michael James Waring
David Michael Andrews
Elaine Sophie Elizabeth Stokes
Andrew Turner
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP088457A publication Critical patent/ECSP088457A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere a compuestos de benzamida de la fórmula (I), en donde R1 es un anillo pirazol unido al C, el cual está opcionalmente sustituido por uno o más grupos seleccionados entre alquiloC1?4, cicloalquiloC3-4, alcoxiC1?4 y cicloalcoxiC3-4; o a una sal farmacéuticamente aceptable o a un profármaco de los mismos. La invención también se refiere a procesos para la preparación de dichos compuestos, a composiciones farmacéuticas que los contienen y a su uso en la fabricación de un medicamento para uso como un agente antiproliferativo en la prevención o tratamiento de tumores u otras condiciones proliferativas que son sensibles a la inhibición de la histona deacetilasa (HDAC).
EC2008008457A 2005-10-19 2008-05-17 Compuestos de benzamida útiles como inhibidores de la histona deacetilasa ECSP088457A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0521244.4A GB0521244D0 (en) 2005-10-19 2005-10-19 Benzamide compounds

Publications (1)

Publication Number Publication Date
ECSP088457A true ECSP088457A (es) 2008-06-30

Family

ID=35458263

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008457A ECSP088457A (es) 2005-10-19 2008-05-17 Compuestos de benzamida útiles como inhibidores de la histona deacetilasa

Country Status (31)

Country Link
US (2) US8207202B2 (es)
EP (1) EP1954690B1 (es)
JP (1) JP5340736B2 (es)
KR (1) KR101464004B1 (es)
CN (1) CN101331123B (es)
AR (1) AR057162A1 (es)
AU (1) AU2006303111B2 (es)
BR (1) BRPI0617654B8 (es)
CA (1) CA2625970C (es)
CY (1) CY1114521T1 (es)
DK (1) DK1954690T3 (es)
EC (1) ECSP088457A (es)
ES (1) ES2422859T3 (es)
GB (1) GB0521244D0 (es)
HR (1) HRP20130683T1 (es)
IL (1) IL190429A (es)
ME (1) ME01595B (es)
MY (1) MY145569A (es)
NO (1) NO340878B1 (es)
NZ (1) NZ566944A (es)
PL (1) PL1954690T3 (es)
PT (1) PT1954690E (es)
RS (1) RS52881B (es)
RU (1) RU2448965C2 (es)
SA (1) SA06270384B1 (es)
SI (1) SI1954690T1 (es)
TW (1) TWI385162B (es)
UA (1) UA98757C2 (es)
UY (1) UY29869A1 (es)
WO (1) WO2007045844A1 (es)
ZA (1) ZA200803096B (es)

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DE102007028198A1 (de) 2007-06-16 2008-12-24 Schebo (R) . Biotech Ag Neue Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Therapie
WO2009118370A1 (en) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
CA2763786C (en) * 2009-06-08 2014-09-30 Gilead Sciences, Inc. Alkanoylamino benzamide aniline hdac inihibitor compounds
WO2012118782A1 (en) 2011-02-28 2012-09-07 Repligen Corporation Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
EP2968207A4 (en) 2013-03-14 2016-09-28 Chdi Foundation Inc HISTON DEACETYLASE INHIBITORS AND COMPOSITIONS
US20160031863A1 (en) * 2013-03-14 2016-02-04 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
WO2014159224A1 (en) 2013-03-14 2014-10-02 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
RU2665554C2 (ru) 2013-03-15 2018-08-31 Байомарин Фармасьютикал Инк. Ингибиторы hdac
CA2908542C (en) * 2013-04-29 2017-08-01 Chong Kun Dang Pharmaceutical Corp. Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same
US10065948B2 (en) 2014-06-02 2018-09-04 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
KR102236356B1 (ko) 2017-11-24 2021-04-05 주식회사 종근당 루푸스의 예방 또는 치료를 위한 조성물
GB201914006D0 (en) * 2019-09-27 2019-11-13 Celleron Therapeutics Ltd Combination Therapy
GB201913988D0 (en) 2019-09-27 2019-11-13 Celleron Therapeutics Ltd Novel treatment
CN118772107B (zh) * 2023-04-06 2026-04-17 微境生物医药科技(上海)有限公司 Hdac抑制剂及其用途
GB202315149D0 (en) 2023-10-03 2023-11-15 Celleron Therapeutics Ltd Combination therapy
CN117777096B (zh) * 2023-11-30 2026-05-19 江西师范大学 一种泽贝诺司他的制备方法

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CH187973A4 (de) 1973-02-09 1977-03-31 Hoechst Ag Verfahren zum optischen Aufhellen von Textilmaterialien
DE2918965A1 (de) 1979-05-11 1980-11-20 Bayer Ag Benzofuranverbindungen sowie deren verwendung als optische aufheller
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JPH05239069A (ja) 1992-02-28 1993-09-17 Canon Inc 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置
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TWI319387B (en) * 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
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AU2005225471B2 (en) 2004-03-26 2011-05-12 Methylgene Inc. Inhibitors of histone deacetylase
AR050926A1 (es) 2004-09-03 2006-12-06 Astrazeneca Ab Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac)
GB0427758D0 (en) 2004-12-18 2005-01-19 Astrazeneca Ab Novel benzamide compounds
GB0500828D0 (en) 2005-01-15 2005-02-23 Astrazeneca Ab Benzamide derivatives
GB0501146D0 (en) 2005-01-20 2005-02-23 Astrazeneca Ab Novel benzamide derivatives
GB0526352D0 (en) 2005-12-23 2006-02-01 Astrazeneca Ab Benzamide derivatives
GB0526351D0 (en) 2005-12-23 2006-02-01 Astrazeneca Ab Novel benzamide derivatives

Also Published As

Publication number Publication date
PL1954690T3 (pl) 2013-09-30
WO2007045844A1 (en) 2007-04-26
SA06270384B1 (ar) 2010-08-02
US8735429B2 (en) 2014-05-27
GB0521244D0 (en) 2005-11-30
NO20081582L (no) 2008-05-06
NO340878B1 (no) 2017-07-03
IL190429A (en) 2012-08-30
ZA200803096B (en) 2009-02-25
US20080269294A1 (en) 2008-10-30
HK1121749A1 (en) 2009-04-30
UA98757C2 (ru) 2012-06-25
EP1954690B1 (en) 2013-05-15
RU2008119411A (ru) 2009-11-27
CN101331123A (zh) 2008-12-24
SI1954690T1 (sl) 2013-08-30
NZ566944A (en) 2011-05-27
US8207202B2 (en) 2012-06-26
JP2009512668A (ja) 2009-03-26
RU2448965C2 (ru) 2012-04-27
BRPI0617654B1 (pt) 2020-09-15
ME01595B (me) 2014-09-20
KR101464004B1 (ko) 2014-11-20
EP1954690A1 (en) 2008-08-13
CA2625970C (en) 2015-12-01
JP5340736B2 (ja) 2013-11-13
MY145569A (en) 2012-02-29
CY1114521T1 (el) 2016-10-05
TWI385162B (zh) 2013-02-11
DK1954690T3 (da) 2013-07-29
PT1954690E (pt) 2013-07-31
KR20080067656A (ko) 2008-07-21
HRP20130683T1 (en) 2013-10-11
UY29869A1 (es) 2007-05-31
ES2422859T3 (es) 2013-09-16
AR057162A1 (es) 2007-11-21
BRPI0617654A2 (pt) 2011-08-02
BRPI0617654B8 (pt) 2021-05-25
TW200800944A (en) 2008-01-01
RS52881B (sr) 2014-02-28
CA2625970A1 (en) 2007-04-26
IL190429A0 (en) 2008-11-03
AU2006303111A1 (en) 2007-04-26
CN101331123B (zh) 2015-11-25
US20120225907A1 (en) 2012-09-06
AU2006303111B2 (en) 2010-11-25

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