ECSP088457A - Compuestos de benzamida útiles como inhibidores de la histona deacetilasa - Google Patents

Compuestos de benzamida útiles como inhibidores de la histona deacetilasa

Info

Publication number
ECSP088457A
ECSP088457A EC2008008457A ECSP088457A ECSP088457A EC SP088457 A ECSP088457 A EC SP088457A EC 2008008457 A EC2008008457 A EC 2008008457A EC SP088457 A ECSP088457 A EC SP088457A EC SP088457 A ECSP088457 A EC SP088457A
Authority
EC
Ecuador
Prior art keywords
inhibitors
benzamide compounds
compounds
relates
histone
Prior art date
Application number
EC2008008457A
Other languages
English (en)
Inventor
Michael James Waring
David Michael Andrews
Elaine Sophie Elizabeth Stokes
Andrew Turner
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP088457A publication Critical patent/ECSP088457A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La invención se refiere a compuestos de benzamida de la fórmula (I), en donde R1 es un anillo pirazol unido al C, el cual está opcionalmente sustituido por uno o más grupos seleccionados entre alquiloC1?4, cicloalquiloC3-4, alcoxiC1?4 y cicloalcoxiC3-4; o a una sal farmacéuticamente aceptable o a un profármaco de los mismos. La invención también se refiere a procesos para la preparación de dichos compuestos, a composiciones farmacéuticas que los contienen y a su uso en la fabricación de un medicamento para uso como un agente antiproliferativo en la prevención o tratamiento de tumores u otras condiciones proliferativas que son sensibles a la inhibición de la histona deacetilasa (HDAC).
EC2008008457A 2005-10-19 2008-05-17 Compuestos de benzamida útiles como inhibidores de la histona deacetilasa ECSP088457A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0521244.4A GB0521244D0 (en) 2005-10-19 2005-10-19 Benzamide compounds

Publications (1)

Publication Number Publication Date
ECSP088457A true ECSP088457A (es) 2008-06-30

Family

ID=35458263

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008457A ECSP088457A (es) 2005-10-19 2008-05-17 Compuestos de benzamida útiles como inhibidores de la histona deacetilasa

Country Status (31)

Country Link
US (2) US8207202B2 (es)
EP (1) EP1954690B1 (es)
JP (1) JP5340736B2 (es)
KR (1) KR101464004B1 (es)
CN (1) CN101331123B (es)
AR (1) AR057162A1 (es)
AU (1) AU2006303111B2 (es)
BR (1) BRPI0617654B8 (es)
CA (1) CA2625970C (es)
CY (1) CY1114521T1 (es)
DK (1) DK1954690T3 (es)
EC (1) ECSP088457A (es)
ES (1) ES2422859T3 (es)
GB (1) GB0521244D0 (es)
HR (1) HRP20130683T1 (es)
IL (1) IL190429A (es)
ME (1) ME01595B (es)
MY (1) MY145569A (es)
NO (1) NO340878B1 (es)
NZ (1) NZ566944A (es)
PL (1) PL1954690T3 (es)
PT (1) PT1954690E (es)
RS (1) RS52881B (es)
RU (1) RU2448965C2 (es)
SA (1) SA06270384B1 (es)
SI (1) SI1954690T1 (es)
TW (1) TWI385162B (es)
UA (1) UA98757C2 (es)
UY (1) UY29869A1 (es)
WO (1) WO2007045844A1 (es)
ZA (1) ZA200803096B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007028198A1 (de) 2007-06-16 2008-12-24 Schebo (R) . Biotech Ag Neue Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Therapie
JP5564033B2 (ja) 2008-03-27 2014-07-30 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規インヒビターとしてのアザ−ビシクロヘキシル置換インドリルアルキルアミノ誘導体
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
KR20120031170A (ko) * 2009-06-08 2012-03-30 길리애드 사이언시즈, 인코포레이티드 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
JP6250403B2 (ja) 2011-02-28 2017-12-20 バイオマリン ファーマシューティカル インク ヒストン脱アセチル化酵素阻害剤
HK1220406A1 (zh) 2013-03-14 2017-05-05 Chdi Foundation, Inc. 组蛋白去乙酰酶抑制剂及组合物
US9783488B2 (en) 2013-03-14 2017-10-10 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
WO2014159214A1 (en) * 2013-03-14 2014-10-02 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
PT2970139T (pt) 2013-03-15 2018-08-01 Biomarin Pharm Inc Inibidores de hdac
HUE041881T2 (hu) * 2013-04-29 2019-06-28 Chong Kun Dang Pharmaceutical Corp Új vegyületek mint szelektív hiszton dezacetiláz inhibitorok és az ezeket tartalmazó gyógyszerkészítmények
CA2951026A1 (en) 2014-06-02 2015-12-10 Chdi Foundation, Inc. Histone deacetylase inhibitors and compositions and methods of use thereof
KR102236356B1 (ko) * 2017-11-24 2021-04-05 주식회사 종근당 루푸스의 예방 또는 치료를 위한 조성물
GB201914006D0 (en) * 2019-09-27 2019-11-13 Celleron Therapeutics Ltd Combination Therapy
GB201913988D0 (en) * 2019-09-27 2019-11-13 Celleron Therapeutics Ltd Novel treatment
CN118772107B (zh) * 2023-04-06 2026-04-17 微境生物医药科技(上海)有限公司 Hdac抑制剂及其用途
GB202315149D0 (en) 2023-10-03 2023-11-15 Celleron Therapeutics Ltd Combination therapy

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH117273A4 (es) 1973-01-26 1976-07-15
CH187973A4 (de) 1973-02-09 1977-03-31 Hoechst Ag Verfahren zum optischen Aufhellen von Textilmaterialien
DE2918965A1 (de) 1979-05-11 1980-11-20 Bayer Ag Benzofuranverbindungen sowie deren verwendung als optische aufheller
IT1232252B (it) 1989-02-22 1992-01-28 Rotta Research Lab Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione
JPH05239069A (ja) 1992-02-28 1993-09-17 Canon Inc 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置
JP4405602B2 (ja) 1998-04-16 2010-01-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト ヒストン脱アセチル化酵素阻害剤
GB9826412D0 (en) 1998-12-03 1999-01-27 Glaxo Group Ltd Chemical compounds
JP4390024B2 (ja) 1999-04-23 2009-12-24 アステラス製薬株式会社 新規なジアゼパン誘導体又はその塩
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
JP2003509412A (ja) 1999-09-17 2003-03-11 シーオーアール セラピューティクス インコーポレイテッド Ｘａ因子阻害剤
CA2391952C (en) 1999-11-23 2012-01-31 Methylgene Inc. Inhibitors of histone deacetylase
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
WO2003024448A2 (en) 2001-09-14 2003-03-27 Methylgene, Inc. Inhibitors of histone deacetylase
DE10204115A1 (de) 2002-02-01 2003-08-07 Bayer Cropscience Ag DELTA·1·-Pyrroline
TWI319387B (en) * 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
GB0209715D0 (en) * 2002-04-27 2002-06-05 Astrazeneca Ab Chemical compounds
US20040072770A1 (en) 2002-07-03 2004-04-15 Besterman Jeffrey M. Methods for specifically inhibiting histone deacetylase-7 and 8
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
CA2539117A1 (en) 2003-09-24 2005-04-07 Methylgene Inc. Inhibitors of histone deacetylase
EP1735319B1 (en) 2004-03-26 2017-05-03 MethylGene Inc. Inhibitors of histone deacetylase
AR050926A1 (es) 2004-09-03 2006-12-06 Astrazeneca Ab Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac)
GB0427758D0 (en) 2004-12-18 2005-01-19 Astrazeneca Ab Novel benzamide compounds
GB0500828D0 (en) 2005-01-15 2005-02-23 Astrazeneca Ab Benzamide derivatives
GB0501146D0 (en) 2005-01-20 2005-02-23 Astrazeneca Ab Novel benzamide derivatives
GB0526352D0 (en) 2005-12-23 2006-02-01 Astrazeneca Ab Benzamide derivatives
GB0526351D0 (en) 2005-12-23 2006-02-01 Astrazeneca Ab Novel benzamide derivatives

Also Published As

Publication number Publication date
AU2006303111B2 (en) 2010-11-25
PT1954690E (pt) 2013-07-31
US20120225907A1 (en) 2012-09-06
NO20081582L (no) 2008-05-06
RU2008119411A (ru) 2009-11-27
BRPI0617654B8 (pt) 2021-05-25
CN101331123B (zh) 2015-11-25
IL190429A0 (en) 2008-11-03
MY145569A (en) 2012-02-29
HK1121749A1 (en) 2009-04-30
CA2625970A1 (en) 2007-04-26
NO340878B1 (no) 2017-07-03
ZA200803096B (en) 2009-02-25
US8735429B2 (en) 2014-05-27
AU2006303111A1 (en) 2007-04-26
BRPI0617654B1 (pt) 2020-09-15
US8207202B2 (en) 2012-06-26
CN101331123A (zh) 2008-12-24
UY29869A1 (es) 2007-05-31
SA06270384B1 (ar) 2010-08-02
TWI385162B (zh) 2013-02-11
CA2625970C (en) 2015-12-01
TW200800944A (en) 2008-01-01
KR20080067656A (ko) 2008-07-21
GB0521244D0 (en) 2005-11-30
AR057162A1 (es) 2007-11-21
EP1954690B1 (en) 2013-05-15
NZ566944A (en) 2011-05-27
EP1954690A1 (en) 2008-08-13
RS52881B (sr) 2014-02-28
CY1114521T1 (el) 2016-10-05
ES2422859T3 (es) 2013-09-16
UA98757C2 (ru) 2012-06-25
DK1954690T3 (da) 2013-07-29
ME01595B (me) 2014-09-20
RU2448965C2 (ru) 2012-04-27
KR101464004B1 (ko) 2014-11-20
IL190429A (en) 2012-08-30
PL1954690T3 (pl) 2013-09-30
SI1954690T1 (sl) 2013-08-30
JP2009512668A (ja) 2009-03-26
JP5340736B2 (ja) 2013-11-13
BRPI0617654A2 (pt) 2011-08-02
HRP20130683T1 (en) 2013-10-11
US20080269294A1 (en) 2008-10-30
WO2007045844A1 (en) 2007-04-26

Similar Documents

Publication Publication Date Title
NO20081582L (no) Benzamidforbindelser anvendbare som histon-deacetylaseinhibitorer
ECSP20027480A (es) Indolil alquil amino derivados sustituidos como nuevos inhibidores de la histona desacetilasa
UY30107A1 (es) Nuevos derivados de pirimidina, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
EA200970156A1 (ru) Пиридизиноновые производные
ECSP099371A (es) INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA
DOP2007000079A (es) Compuestos fenil amido heterocíclicos condensados
ECSP045004A (es) Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades andrógeno dependientes
AR053162A1 (es) Compuesto 5 - oxo - pirrolidin sustituido, composicion farmaceutica que lo comprende y su uso para preparar un medicamento para el tratamiento del glaucoma.
ECSP066653A (es) Derivados de bencenosulfonilamino-piridin-2-il y compuestos relacionados como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa tipo 1(ii-beta-hsd-1) para el tratamiento de la diabetes y de la obesidad
CL2008000959A1 (es) Compuestos derivados de 1,2,4-tiadiazina o 1,4-tiazina; composiciones farmaceuticas que los contienen; y su uso para la prevencion y/o tratamiento de infecciones producidas por el virus de la hepatitis c.
BR0308908A (pt) Composto, composição, uso de um composto, e, métodos para inibir a hdac em uma célula, para o tratamento de uma condição mediada pela hdac, de um condição proliferativa, de câncer e de psorìase
UY29886A1 (es) Derivados de pirazol novedosos, composiciones farmaccuticas que los contienen, procedimientos para la preparacinn de los mismos y aplicaciones
BR112012008849A2 (pt) composto, composição farmacêutica, e, uso de um composto
BRPI0410727A (pt) composto, composição farmacêutica, e, uso de um composto
BRPI0806789B8 (pt) composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto ou de um sal farmaceuticamente aceitável do mesmo
BRPI0408353A (pt) composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto
CO2020004669A2 (es) Derivados de bencimidazol y sus usos
UY37837A (es) Nuevos compuestos heterocíclicos como inhibidores de cdk8/19
NI202100012A (es) Dioxociclobutenilamino-3-hidroxi-picolinamidas n-sustituidas útiles como inhibidores de ccr6
AR078142A1 (es) Compuestos inhibidores heteroarilicos biciclicos de pde4, las composiciones farmaceuticas que los contienen y el uso de los mismos para la preparacion de medicamentos.
BR112016030733A2 (pt) Derivados de indano e indolina e uso dos mesmos como ativadores de guanilato ciclase solúveis
UY29169A1 (es) Derivados de 2-amido-4 feniltiazol, su preparacion y su aplicacion en terapeutica
NO20090234L (no) Tricyklisk sammensetning og farmasoytisk anvendelse derav
ES2340502T3 (es) Compuestos de 1,4,8-triazaespiro(4,5)decan-2-ona sustituidos para el tratamiento de la obesidad.
AR077429A1 (es) Compuestos hidroxiasenapina sus derivados y composiciones farmaceuticas que comprenden los mismos