PL1969118T5 - Wyizolowane komórki macierzyste wątroby - Google Patents

Wyizolowane komórki macierzyste wątroby

Info

Publication number
PL1969118T5
PL1969118T5 PL06819033T PL06819033T PL1969118T5 PL 1969118 T5 PL1969118 T5 PL 1969118T5 PL 06819033 T PL06819033 T PL 06819033T PL 06819033 T PL06819033 T PL 06819033T PL 1969118 T5 PL1969118 T5 PL 1969118T5
Authority
PL
Poland
Prior art keywords
stem cells
liver
relates
present
progenitor stem
Prior art date
Application number
PL06819033T
Other languages
English (en)
Other versions
PL1969118T3 (pl
Inventor
Etienne Sokal
Mustapha Najimi
Original Assignee
Univ Catholique Louvain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37775557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1969118(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Catholique Louvain filed Critical Univ Catholique Louvain
Publication of PL1969118T3 publication Critical patent/PL1969118T3/pl
Publication of PL1969118T5 publication Critical patent/PL1969118T5/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Nutrition Science (AREA)
PL06819033T 2005-12-21 2006-12-14 Wyizolowane komórki macierzyste wątroby PL1969118T5 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05447286 2005-12-21
EP2006010014 2006-10-17
PCT/EP2006/012046 WO2007071339A1 (en) 2005-12-21 2006-12-14 Isolated liver stem cells
EP06819033.9A EP1969118B2 (en) 2005-12-21 2006-12-14 Isolated liver stem cells

Publications (2)

Publication Number Publication Date
PL1969118T3 PL1969118T3 (pl) 2011-07-29
PL1969118T5 true PL1969118T5 (pl) 2015-06-30

Family

ID=37775557

Family Applications (2)

Application Number Title Priority Date Filing Date
PL10192665T PL2281875T3 (pl) 2005-12-21 2006-12-14 Wyizolowane komórki macierzyste wątroby
PL06819033T PL1969118T5 (pl) 2005-12-21 2006-12-14 Wyizolowane komórki macierzyste wątroby

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL10192665T PL2281875T3 (pl) 2005-12-21 2006-12-14 Wyizolowane komórki macierzyste wątroby

Country Status (13)

Country Link
US (5) US8673635B2 (pl)
EP (2) EP2281875B1 (pl)
JP (1) JP5250423B2 (pl)
CN (1) CN103989710B (pl)
AT (1) ATE498005T1 (pl)
AU (1) AU2006328988B2 (pl)
CA (1) CA2634510C (pl)
DE (1) DE602006020071D1 (pl)
DK (2) DK1969118T4 (pl)
ES (1) ES2672205T3 (pl)
PL (2) PL2281875T3 (pl)
PT (1) PT2281875T (pl)
WO (1) WO2007071339A1 (pl)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673635B2 (en) * 2005-12-21 2014-03-18 Universite Catholique De Louvain Isolated liver stem cells
JP2010534065A (ja) * 2007-07-20 2010-11-04 セルアーティス アーベー ヒト胚盤胞幹細胞に、胚体内胚葉（ＤＥ‐ｈｅｐ）を介して由来する新規な肝細胞の集団
EP2412800A1 (en) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
EP2393917B1 (en) 2009-02-03 2016-04-06 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells.
JPWO2011102532A1 (ja) * 2010-02-16 2013-06-17 国立大学法人九州大学 誘導肝細胞
WO2012005690A1 (en) * 2010-07-07 2012-01-12 Massachusetts Institute Of Technology Methods of reconstituting human hepatocytes and human hematopoietic cells in non-human mammals
US8858934B2 (en) * 2010-08-12 2014-10-14 Abag Verwaltungs Gmbh Method for producing cells having characteristics of hepatocytes
SG192124A1 (en) 2011-01-25 2013-08-30 Univ Catholique Louvain Compositions and methods for cell transplantation
JP6095272B2 (ja) * 2011-03-25 2017-03-15 国立大学法人京都大学 上皮系体性幹細胞の製造方法
EP2554176B1 (en) 2011-08-04 2016-07-27 ETHIANUM Betriebsgesellschaft mbH & Co. KG Means for liver regeneration
JP5950235B2 (ja) 2011-09-30 2016-07-13 公立大学法人横浜市立大学 肝細胞の分化誘導方法、ヒト化肝臓キメラ非ヒト動物の作製方法
EP2806879B1 (en) 2012-01-25 2019-03-06 Université Catholique de Louvain Compositions and methods for cell transplantation
WO2014089554A1 (en) * 2012-12-07 2014-06-12 Antria, Inc. Formulations containing and kit for using adipose-derived stem cells and use thereof
ES2759228T3 (es) 2013-07-05 2020-05-08 Univ Catholique Louvain Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
ES2764408T3 (es) * 2013-08-28 2020-06-03 Promethera Biosciences S A / N V Procedimiento para la producción de células progenitoras hepáticas adultas
WO2016001839A1 (en) * 2014-06-30 2016-01-07 Stempeutics Research Pvt. Ltd. Management of liver disease using pooled mesenchymal stromal cells
KR102101060B1 (ko) * 2014-08-28 2020-04-16 프로메테라 바이오사이언시즈 에스.에이./엔.브이. 성체 간 전구 세포의 제조 방법
US9808490B2 (en) * 2014-11-26 2017-11-07 Accelerated Biosciences Corp. Induced hepatocytes and uses thereof
FR3035407B1 (fr) 2015-04-23 2022-06-17 Francais Du Sang Ets Procede de conservation de cellules, tissus ou organes en hypothermie
WO2016183231A1 (en) 2015-05-12 2016-11-17 Baker Group, LLP Method and system for a bioartificial organ
JP6582044B2 (ja) * 2015-05-14 2019-09-25 株式会社セルテクノロジー 凍結間葉系細胞の製造方法、及び、移植用治療材の製造方法
WO2016200340A1 (en) 2015-06-12 2016-12-15 Agency For Science, Technology And Research Derivation of hepatic stem cells and mature liver cell types and uses thereof
WO2017024206A1 (en) 2015-08-05 2017-02-09 Colorado State University Research Foundation Engineered platforms to stabilize both hepatocytes and endothelial cells in vitro
US10287543B2 (en) * 2015-11-19 2019-05-14 Miltenyi Biotec, Gmbh Process and device for isolating cells from biological tissue
RU2018128598A (ru) * 2016-01-08 2020-02-11 Кинити Ко., Лтд. Способ продуцирования стволовых клеток/клеток-предшественников печени из зрелых клеток печени с использованием низкомолекулярного соединения
JP6704617B2 (ja) * 2016-01-29 2020-06-03 北海道公立大学法人 札幌医科大学 小型肝細胞の継代培養方法
JP7174408B2 (ja) 2016-02-10 2022-11-17 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 肝線維症のモデル系ならびにその作製および使用方法
CN108779440A (zh) 2016-03-02 2018-11-09 鲁汶大学 改进的成体肝脏祖细胞制备物
WO2017205407A1 (en) * 2016-05-24 2017-11-30 Albert Li Novel cell culture method, cell culture system and uses thereof
WO2018208628A1 (en) 2017-05-06 2018-11-15 Memphis Meats, Inc. Compositions and methods for increasing the culture density of a cellular biomass within a cultivation infrastructure
MX2019014027A (es) 2017-05-24 2020-08-03 Thoeris Gmbh Uso de glutamina sintetasa para tratar hiperamonemia.
WO2019014652A1 (en) * 2017-07-13 2019-01-17 Memphis Meats, Inc. COMPOSITIONS AND METHODS FOR INCREASING THE EFFICACY OF CELL CULTURES USED IN FOOD PRODUCTION
US11407979B2 (en) 2017-09-01 2022-08-09 Colorado State University Research Foundation Intermittent starvation techniques to prolong functional lifetime of liver cells in culture
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures
CN110269867B (zh) 2018-03-14 2022-06-21 必康生技（香港）有限公司 用于生物流体净化的组合物
CN108823146A (zh) * 2018-06-22 2018-11-16 安徽 一种肝脏干细胞制备和提取方法
TW202043463A (zh) 2018-12-14 2020-12-01 比利時商普羅米修亞生物科技股份有限公司 包含表現hla-e之肝先驅細胞之細胞組成物
TW202035682A (zh) 2018-12-14 2020-10-01 比利時商普羅米修亞生物科技股份有限公司 表現hla-g之肝先驅細胞及取得包含該等細胞之此等細胞組成物之方法與其用途
CN109735485B (zh) * 2019-01-29 2021-04-16 深圳市拓普生物科技有限公司 人源化肝脏动物模型及其构建方法和应用
AU2020245045A1 (en) * 2019-03-26 2021-11-18 Promethera Therapeutics Sa Adult liver progenitor cells for treating acute-on-chronic liver failure
WO2020193715A1 (en) 2019-03-26 2020-10-01 Promethera Biosciences S.A./N.V. Adult liver progenitor cells for treating non-alcoholic fatty liver disease
JP7284985B2 (ja) * 2019-03-29 2023-06-01 国立大学法人 長崎大学 肝前駆細胞を含む細胞集団を製造する方法
JP2022530620A (ja) * 2019-04-30 2022-06-30 プロメセラ セラピューティクス エスエイ ヒト同種肝臓由来前駆細胞の調製
TW202106874A (zh) 2019-04-30 2021-02-16 比利時商普羅米修亞生物科技股份有限公司 人類同種異體肝衍生前驅細胞的製備(一)
JP7556502B2 (ja) * 2019-05-09 2024-09-26 フジフィルム セルラー ダイナミクス，インコーポレイテッド ヘパトサイトの作製方法
AU2020320861A1 (en) * 2019-07-26 2022-03-03 Cytotheryx, Inc. Methods and compositions for producing hepatocytes
JP2022551293A (ja) 2019-10-09 2022-12-08 セライオン エスアー 血管透過性亢進を特徴とする疾患における肝臓前駆細胞または幹細胞、その溶解物、および／または馴化培地の使用
CA3175071A1 (en) 2020-03-11 2021-09-16 Bit Bio Limited Method of generating hepatic cells
IL296353A (en) * 2020-03-13 2022-11-01 Goliver Therapeutics Hepatic stem-like cells for the treatment and/or the prevention of liver disorders
EP3881853A1 (en) 2020-03-20 2021-09-22 Promethera Therapeutics Sa Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation
EP3929280A1 (en) * 2020-06-26 2021-12-29 Medizinische Hochschule Hannover Process for producing liver cells
CN113755432B (zh) * 2020-07-17 2022-06-10 上海我武干细胞科技有限公司 干细胞培养方法
WO2023180122A1 (en) 2022-03-24 2023-09-28 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence
WO2023240152A1 (en) 2022-06-07 2023-12-14 Upside Foods, Inc. Engineering cell lines capable of proliferation in growth factor free media formulations
WO2024200809A1 (en) 2023-03-31 2024-10-03 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing hepatocellular carcinoma

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989007136A2 (en) * 1988-02-05 1989-08-10 Whitehead Institute For Biomedical Research Modified hepatocytes and uses therefor
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
ES2157225T3 (es) 1992-10-09 2001-08-16 Advanced Tissue Sciences Inc Celulas hepaticas de reserva.
US5869243A (en) 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
IL129222A0 (en) 1996-10-01 2000-02-17 Geron Corp Telomerase reverse transcriptase
US6774120B1 (en) * 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US8778899B2 (en) * 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
WO2001053462A1 (en) * 2000-01-19 2001-07-26 University Of North Carolina At Chapel Hill Liver tissue source
ATE371018T1 (de) 2001-06-22 2007-09-15 Stemcells Inc Le-zellen (liver engrafting cells), assays und verwendungen davon
US6617152B2 (en) 2001-09-04 2003-09-09 Corning Inc Method for creating a cell growth surface on a polymeric substrate
CA2463914A1 (en) * 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
AU2004236573B2 (en) 2003-05-12 2009-10-22 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US20050074876A1 (en) * 2003-10-03 2005-04-07 Inserm Bipotential liver cell lines from wild-type mammalian liver tissue
WO2005035738A1 (en) * 2003-10-07 2005-04-21 Biomaster Inc. Cell differentiation of adipose-derived precursor cells
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
US8673635B2 (en) * 2005-12-21 2014-03-18 Universite Catholique De Louvain Isolated liver stem cells

Also Published As

Publication number Publication date
US8673635B2 (en) 2014-03-18
US9931360B2 (en) 2018-04-03
AU2006328988A1 (en) 2007-06-28
US9107910B2 (en) 2015-08-18
US20150306147A1 (en) 2015-10-29
PL1969118T3 (pl) 2011-07-29
DE602006020071D1 (de) 2011-03-24
EP1969118B2 (en) 2014-09-10
CA2634510A1 (en) 2007-06-28
JP5250423B2 (ja) 2013-07-31
US8778607B2 (en) 2014-07-15
ATE498005T1 (de) 2011-02-15
EP1969118A1 (en) 2008-09-17
DK2281875T3 (en) 2018-06-06
US20140127676A1 (en) 2014-05-08
ES2672205T3 (es) 2018-06-13
DK1969118T4 (en) 2014-12-15
EP1969118B1 (en) 2011-02-09
EP2281875A1 (en) 2011-02-09
US20080311094A1 (en) 2008-12-18
EP2281875B1 (en) 2018-03-21
PL2281875T3 (pl) 2018-08-31
WO2007071339A1 (en) 2007-06-28
AU2006328988B2 (en) 2012-08-02
CA2634510C (en) 2018-01-09
JP2009520474A (ja) 2009-05-28
DK1969118T3 (da) 2011-05-16
US9775863B2 (en) 2017-10-03
CN103989710B (zh) 2019-11-15
US20140286917A1 (en) 2014-09-25
PT2281875T (pt) 2018-06-11
US20170354687A1 (en) 2017-12-14
CN103989710A (zh) 2014-08-20

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