PL1999259T3 - Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek - Google Patents
Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczekInfo
- Publication number
- PL1999259T3 PL1999259T3 PL07752295T PL07752295T PL1999259T3 PL 1999259 T3 PL1999259 T3 PL 1999259T3 PL 07752295 T PL07752295 T PL 07752295T PL 07752295 T PL07752295 T PL 07752295T PL 1999259 T3 PL1999259 T3 PL 1999259T3
- Authority
- PL
- Poland
- Prior art keywords
- molecules
- site
- amino acids
- specific incorporation
- incorporation
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 238000010348 incorporation Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77937506P | 2006-03-03 | 2006-03-03 | |
| US77937606P | 2006-03-03 | 2006-03-03 | |
| PCT/US2007/005581 WO2007103307A2 (en) | 2006-03-03 | 2007-03-05 | Site-specific incorporation of amino acids into molecules |
| EP07752295.1A EP1999259B1 (en) | 2006-03-03 | 2007-03-05 | Site-specific incorporation of amino acids into molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1999259T3 true PL1999259T3 (pl) | 2015-01-30 |
Family
ID=38462077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07752295T PL1999259T3 (pl) | 2006-03-03 | 2007-03-05 | Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8518666B2 (pl) |
| EP (1) | EP1999259B1 (pl) |
| JP (2) | JP5808882B2 (pl) |
| AU (2) | AU2007224019A1 (pl) |
| CA (1) | CA2644474A1 (pl) |
| DK (1) | DK1999259T3 (pl) |
| ES (1) | ES2504521T3 (pl) |
| PL (1) | PL1999259T3 (pl) |
| PT (1) | PT1999259E (pl) |
| SI (1) | SI1999259T1 (pl) |
| WO (1) | WO2007103307A2 (pl) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050287639A1 (en) * | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| US20080096819A1 (en) * | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| EP2444499A3 (en) * | 2006-05-02 | 2012-05-09 | Allozyne, Inc. | Amino acid substituted molecules |
| CA2707840A1 (en) * | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| US20090148887A1 (en) * | 2007-11-02 | 2009-06-11 | The Scripps Research Institute | Genetically encoded boronate amino acid |
| WO2010081110A1 (en) | 2009-01-12 | 2010-07-15 | Sutro Biopharma, Inc. | Dual charging system for selectively introducing non-native amino acids into proteins using an in vitro synthesis method |
| EP2403864B1 (en) | 2009-02-27 | 2015-08-12 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| CN102762589A (zh) * | 2009-12-11 | 2012-10-31 | 卡斯西部储备大学 | 带有氯化氨基酸的胰岛素类似物 |
| AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
| EP2563382B1 (en) | 2010-04-27 | 2017-06-07 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl trna synthetases |
| CN103096911B (zh) | 2010-04-27 | 2018-05-29 | Atyr 医药公司 | 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| US9068177B2 (en) | 2010-04-29 | 2015-06-30 | Atyr Pharma, Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
| CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
| CN103118693B (zh) | 2010-04-29 | 2017-05-03 | Atyr 医药公司 | 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103108655B (zh) | 2010-05-03 | 2017-04-05 | Atyr 医药公司 | 与丝氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103096925A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| WO2011140135A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
| ES2623805T3 (es) | 2010-05-03 | 2017-07-12 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas |
| AU2011248101B2 (en) | 2010-05-04 | 2016-10-20 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex |
| CA2798301C (en) | 2010-05-04 | 2020-09-15 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-trna synthetases |
| US8945541B2 (en) | 2010-05-14 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
| AU2011256366C1 (en) | 2010-05-17 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
| EP2575857B1 (en) | 2010-06-01 | 2018-01-24 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| NZ603813A (en) | 2010-07-12 | 2015-03-27 | Atyr Pharma Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| WO2012009289A2 (en) | 2010-07-12 | 2012-01-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
| CN103118695B (zh) | 2010-07-12 | 2016-08-03 | Atyr医药公司 | 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| US9029506B2 (en) | 2010-08-25 | 2015-05-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases |
| JP6121904B2 (ja) | 2010-09-08 | 2017-04-26 | ハロザイム インコーポレイテッド | 条件的活性治療用タンパク質を評価および同定する、または発展させる方法 |
| EP2624857B1 (en) | 2010-10-06 | 2017-08-02 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl trna synthetases |
| WO2012149160A2 (en) * | 2011-04-29 | 2012-11-01 | The Research Foundation Of State University Of New York | Viruses modified with unnatural moieties and methods of use thereof |
| WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
| WO2013065048A1 (en) | 2011-11-03 | 2013-05-10 | Yeda Research And Development Co. Ltd. | Transgenic plants resistant to non-protein amino acids |
| WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
| WO2013086216A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Improved aspartyl-trna synthetases |
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| AU2012368189B2 (en) | 2011-12-29 | 2017-08-31 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetase-Fc conjugates |
| WO2013188635A2 (en) * | 2012-06-14 | 2013-12-19 | The Trustees Of The University Of Pennsylvania | Novel methods of identifying proteins via n-terminal tagging and selective pull-down |
| JP6397479B2 (ja) | 2013-03-15 | 2018-09-26 | エータイアー ファーマ， インコーポレイテッド | ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート |
| EP2979168A4 (en) * | 2013-03-29 | 2016-11-23 | Univ Washington Ct Commerciali | SYSTEMS, ALGORITHMS AND SOFTWARE FOR THE DESIGN OF A MOLECULAR INVERSION PROBE (MIP) |
| EP2876165A1 (en) | 2013-11-22 | 2015-05-27 | ACIB GmbH | Improved method for producing modifed target polypeptides |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| EP3269809B1 (en) | 2015-03-13 | 2022-07-27 | Chugai Seiyaku Kabushiki Kaisha | MODIFIED AMINOACYL-tRNA SYNTHETASE AND USE THEREOF |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| GB201600512D0 (en) | 2016-01-12 | 2016-02-24 | Univ York | Recombinant protein production |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| EP3591048A4 (en) | 2017-01-31 | 2020-12-23 | Chugai Seiyaku Kabushiki Kaisha | PEPTIDES SYNTHESIS PROCESS IN A CELLLESS TRANSLATION SYSTEM |
| US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| JP6917050B2 (ja) * | 2017-03-06 | 2021-08-11 | 学校法人早稲田大学 | 最適特性を有する非天然型タンパク質の製造方法 |
| AU2018256435B2 (en) | 2017-04-20 | 2025-03-13 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
| JP7229158B2 (ja) | 2017-06-09 | 2023-02-27 | 中外製薬株式会社 | Ｎ－置換アミノ酸を含むペプチドの合成方法 |
| JP7295841B2 (ja) * | 2017-07-25 | 2023-06-21 | バイオコン・リミテッド | インスリン＆インスリン類似体の配列の同定のためのペプチドマッピング方法 |
| CN111479819B (zh) | 2017-12-15 | 2024-06-14 | 中外制药株式会社 | 制备肽的方法和处理碱的方法 |
| CN108588040B (zh) * | 2018-06-08 | 2021-06-15 | 中国医学科学院病原生物学研究所 | 重组MtMetRS、其晶体及它们在制备抗结核药物中的应用 |
| EP3849614B1 (en) * | 2018-09-11 | 2023-12-20 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
| JP7279073B2 (ja) | 2018-11-07 | 2023-05-22 | 中外製薬株式会社 | Ｏ－置換セリン誘導体の製造方法 |
| EP3889164A4 (en) | 2018-11-30 | 2022-11-02 | Chugai Seiyaku Kabushiki Kaisha | DEPROTECTION METHODS AND RESIN REMOVAL METHODS IN THE SOLID PHASE REACTION FOR PEPTIDE COMPOUND OR AMIDE COMPOUND AND METHODS FOR PRODUCTION OF A PEPTIDE COMPOUND |
| KR20250133795A (ko) | 2018-12-26 | 2025-09-08 | 추가이 세이야쿠 가부시키가이샤 | 코돈 확장을 위한 변이 tRNA |
| MA55295A (fr) * | 2019-03-13 | 2022-01-19 | St Jude Childrens Res Hospital | Compositions vaccinales et méthodes de réduction de la transmission de streptococcus pneumoniae |
| JP7472101B2 (ja) | 2019-03-15 | 2024-04-22 | 中外製薬株式会社 | 芳香族アミノ酸誘導体の製造方法 |
| SG10202111127YA (en) | 2019-11-07 | 2021-11-29 | Chugai Pharmaceutical Co Ltd | Cyclic Peptide Compound Having Kras Inhibitory Action |
| US20230108274A1 (en) | 2019-12-26 | 2023-04-06 | Chugai Seiyaku Kabushiki Kaisha | Composition for translation, and method for producing peptide |
| EP4126058A1 (en) | 2020-03-31 | 2023-02-08 | Protomer Technologies Inc. | Conjugates for selective responsiveness to vicinal diols |
| CN115551875A (zh) | 2020-05-05 | 2022-12-30 | 基因泰克公司 | 用于酪氨酸酶介导的位点特异性蛋白质缀合的系统和方法 |
| KR20230028363A (ko) | 2020-06-25 | 2023-02-28 | 추가이 세이야쿠 가부시키가이샤 | 개변된 유전 암호표를 갖는 번역계 |
| IL301109A (en) * | 2020-10-17 | 2023-05-01 | Sun Pharmaceutical Ind Ltd | Dual GLP-1/GIP agonists |
| PH12023500012A1 (en) | 2020-11-19 | 2024-03-11 | Protomer Tech Inc | Aromatic boron-containing compounds and insulin analogs |
| WO2023069816A2 (en) | 2021-09-20 | 2023-04-27 | The Broad Institute, Inc. | Compositions and methods for multiplex decoding of quadruplet codons |
| PE20251287A1 (es) | 2022-05-18 | 2025-05-14 | Protomer Tech Inc | Compuestos aromaticos que contienen boro y analogos de insulina relacionados |
| JP2025525377A (ja) * | 2022-06-22 | 2025-08-05 | ザ・ユニバーシティ・オブ・シカゴ | 操作されたｔＲＮＡおよび使用方法 |
| CN116376851A (zh) * | 2022-08-25 | 2023-07-04 | 凯莱英医药集团（天津）股份有限公司 | 氨酰tRNA合酶突变体及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69231127D1 (de) | 1991-03-18 | 2000-07-06 | Scripps Research Inst La Jolla | Oligosaccharide als enzymsubstrate und -inhibitoren: verfahren und zusammensetzungen |
| AU751331B2 (en) | 1997-04-11 | 2002-08-15 | California Institute Of Technology | Apparatus and method for automated protein design |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| DK2128246T3 (da) | 2001-04-19 | 2014-05-12 | Univ California | Fremgangsmåder og sammensætninger til fremstilling af ortogonale tRNA-aminoacyl-tRNA-syntetasepar. |
| EP1490677A4 (en) * | 2002-02-27 | 2006-01-18 | California Inst Of Techn | COMPUTER METHOD FOR DESIGNING ENZYMES FOR THE INCORPORATION OF AMINO ACID ANALOGUES INTO PROTEINS |
| ES2333422T3 (es) | 2002-10-16 | 2010-02-22 | The Scripps Research Institute | Sintesis de glicoproteinas. |
| NZ548256A (en) | 2004-02-02 | 2010-02-26 | Ambrx Inc | Modified human four helical bundle polypeptides and their uses |
| US20050260711A1 (en) | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| MX2007000728A (es) | 2004-07-21 | 2007-03-15 | Ambrx Inc | Polipeptidos biosinteticos que utilizan amino acidos no naturalmente codificados. |
| WO2006034410A2 (en) | 2004-09-21 | 2006-03-30 | The Scripps Resarch Institute | Adding photoregulated amino acids to the genetic code |
| US7378263B2 (en) | 2004-10-20 | 2008-05-27 | The Scripps Research Institute | In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria |
| CA2927595C (en) | 2004-12-22 | 2023-01-31 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| AU2005319518B2 (en) | 2004-12-22 | 2010-09-09 | Ambrx, Inc. | Compositions of aminoacyl-tRNA synthetase and uses thereof |
| MX2007015106A (es) | 2005-06-03 | 2008-02-15 | Ambrx Inc | Incorporacion de aminoacidos codificadores de manera no natural en proteinas. |
| EP1937824B1 (en) | 2005-08-18 | 2013-03-13 | Ambrx, Inc. | COMPOSITIONS OF tRNA AND USES THEREOF |
| US20080317670A1 (en) | 2005-12-14 | 2008-12-25 | Ambrx, Inc. | Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides |
| CN101384711A (zh) | 2006-01-19 | 2009-03-11 | Ambrx公司 | 具有经调节的免疫原性的非天然氨基酸多肽 |
-
2007
- 2007-03-05 WO PCT/US2007/005581 patent/WO2007103307A2/en not_active Ceased
- 2007-03-05 PL PL07752295T patent/PL1999259T3/pl unknown
- 2007-03-05 AU AU2007224019A patent/AU2007224019A1/en not_active Abandoned
- 2007-03-05 ES ES07752295.1T patent/ES2504521T3/es active Active
- 2007-03-05 JP JP2008557434A patent/JP5808882B2/ja active Active
- 2007-03-05 SI SI200731519T patent/SI1999259T1/sl unknown
- 2007-03-05 US US11/682,272 patent/US8518666B2/en not_active Expired - Fee Related
- 2007-03-05 CA CA002644474A patent/CA2644474A1/en not_active Abandoned
- 2007-03-05 DK DK07752295.1T patent/DK1999259T3/da active
- 2007-03-05 EP EP07752295.1A patent/EP1999259B1/en not_active Not-in-force
- 2007-03-05 PT PT77522951T patent/PT1999259E/pt unknown
-
2013
- 2013-04-30 JP JP2013095341A patent/JP2013146274A/ja active Pending
- 2013-08-16 US US13/969,368 patent/US8980581B2/en active Active
-
2014
- 2014-05-20 AU AU2014202733A patent/AU2014202733A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007103307A2 (en) | 2007-09-13 |
| SI1999259T1 (sl) | 2014-11-28 |
| US8518666B2 (en) | 2013-08-27 |
| DK1999259T3 (da) | 2014-10-06 |
| AU2007224019A1 (en) | 2007-09-13 |
| CA2644474A1 (en) | 2007-09-13 |
| JP5808882B2 (ja) | 2015-11-10 |
| US20080044854A1 (en) | 2008-02-21 |
| WO2007103307B1 (en) | 2008-05-02 |
| JP2009528824A (ja) | 2009-08-13 |
| PT1999259E (pt) | 2014-09-24 |
| EP1999259A2 (en) | 2008-12-10 |
| JP2013146274A (ja) | 2013-08-01 |
| US8980581B2 (en) | 2015-03-17 |
| US20140045261A1 (en) | 2014-02-13 |
| AU2014202733A1 (en) | 2014-06-12 |
| EP1999259B1 (en) | 2014-06-25 |
| WO2007103307A3 (en) | 2008-03-13 |
| ES2504521T3 (es) | 2014-10-08 |
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