PL2032698T3 - Systematyczna ocena związków sekwencji i aktywności przy zastosowaniu bibliotek typu "ocena pozycji" do inżynierii wielorakich właściwości - Google Patents

Systematyczna ocena związków sekwencji i aktywności przy zastosowaniu bibliotek typu "ocena pozycji" do inżynierii wielorakich właściwości

Info

Publication number
PL2032698T3
PL2032698T3 PL07796357T PL07796357T PL2032698T3 PL 2032698 T3 PL2032698 T3 PL 2032698T3 PL 07796357 T PL07796357 T PL 07796357T PL 07796357 T PL07796357 T PL 07796357T PL 2032698 T3 PL2032698 T3 PL 2032698T3
Authority
PL
Poland
Prior art keywords
evaluation
sequence
activity relationships
multiple properties
libraries
Prior art date
Application number
PL07796357T
Other languages
English (en)
Inventor
Wolfgang Aehle
David A Estell
Original Assignee
Danisco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38659837&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2032698(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Danisco Us Inc filed Critical Danisco Us Inc
Publication of PL2032698T3 publication Critical patent/PL2032698T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL07796357T 2006-06-23 2007-06-22 Systematyczna ocena związków sekwencji i aktywności przy zastosowaniu bibliotek typu "ocena pozycji" do inżynierii wielorakich właściwości PL2032698T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81620206P 2006-06-23 2006-06-23
US93331207P 2007-06-06 2007-06-06
EP07796357A EP2032698B1 (en) 2006-06-23 2007-06-22 Systematic evaluation of sequence and activity relationships using site evaluation libraries for engineering multiple properties
PCT/US2007/014556 WO2008002472A2 (en) 2006-06-23 2007-06-22 Systematic evaluation of sequence and activity relationships using site evaluation libraries for engineering multiple properties

Publications (1)

Publication Number Publication Date
PL2032698T3 true PL2032698T3 (pl) 2012-11-30

Family

ID=38659837

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07796357T PL2032698T3 (pl) 2006-06-23 2007-06-22 Systematyczna ocena związków sekwencji i aktywności przy zastosowaniu bibliotek typu "ocena pozycji" do inżynierii wielorakich właściwości

Country Status (11)

Country Link
US (3) US20080004186A1 (pl)
EP (1) EP2032698B1 (pl)
JP (1) JP5785686B2 (pl)
KR (1) KR101486087B1 (pl)
CN (1) CN101473036B (pl)
CA (1) CA2654269C (pl)
DK (1) DK2032698T3 (pl)
ES (1) ES2388753T3 (pl)
PL (1) PL2032698T3 (pl)
PT (1) PT2032698E (pl)
WO (1) WO2008002472A2 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2159279A3 (en) 2001-05-15 2010-05-12 Novozymes A/S Alpha-amylase variant with altered properties
US7985569B2 (en) * 2003-11-19 2011-07-26 Danisco Us Inc. Cellulomonas 69B4 serine protease variants
BRPI0812446A2 (pt) * 2007-06-06 2014-10-14 Danisco Us Inc Genecor Division Métodos para aperfeiçoamento de propriedades de proteína múltiplas
US8173410B2 (en) 2008-04-23 2012-05-08 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
PL2447361T3 (pl) * 2008-06-06 2015-03-31 Danisco Us Inc Warianty alfa-amylazy (AMYS) z Geobacillus stearothermophilus o poprawionych właściwościach
US9090887B2 (en) * 2008-06-06 2015-07-28 Danisco Us Inc. Variant alpha-amylases from Bacillus subtilis and methods of use, thereof
EP2902487A3 (en) 2009-04-01 2015-11-18 Danisco US Inc. Compositions and methods comprising alpha-amylase variants with altered properties
US8518686B2 (en) 2009-04-23 2013-08-27 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
EP2510092A1 (en) 2009-12-09 2012-10-17 The Procter & Gamble Company Fabric and home care products
CN103052704A (zh) 2010-07-22 2013-04-17 荷兰联合利华有限公司 用于提高清洁的鼠李糖脂和酶的组合物
JP2014502148A (ja) * 2010-10-27 2014-01-30 ダニスコ・ユーエス・インク イソプレン生産の向上を目的としたイソプレン合成酵素変異体
US20120157448A1 (en) 2010-11-22 2012-06-21 Adam Cook Compounds for treating neurodegenerative diseases
MX2013009177A (es) * 2011-02-16 2013-08-29 Novozymes As Composiciones detergentes que comprenden metaloproteasas de m7 o m35.
US9434932B2 (en) 2011-06-30 2016-09-06 Novozymes A/S Alpha-amylase variants
DE102011118027A1 (de) * 2011-09-12 2013-03-14 Henkel Ag & Co. Kgaa Verfahren zur Anpassung eines Hydrolytischen Enzyms an eine das hydrolytische Enzym stabilisierende Komponente
CN104350149A (zh) 2012-01-26 2015-02-11 诺维信公司 具有蛋白酶活性的多肽在动物饲料和洗涤剂中的用途
JP6067409B2 (ja) 2012-04-10 2017-01-25 花王株式会社 アルカリプロテアーゼの溶解性向上方法
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
EP2863759A2 (en) * 2012-06-20 2015-04-29 Novozymes Biopolymer A/S Use of polypeptides having protease activity in animal feed and detergents
WO2014122161A2 (en) 2013-02-06 2014-08-14 Novozymes A/S Polypeptides having protease activity

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5763257A (en) * 1984-05-29 1998-06-09 Genencor International, Inc. Modified subtilisins having amino acid alterations
US5972682A (en) * 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5322770A (en) * 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5340735A (en) 1991-05-29 1994-08-23 Cognis, Inc. Bacillus lentus alkaline protease variants with increased stability
US5830837A (en) * 1994-11-22 1998-11-03 Novo Nordisk A/S Amylase variants
ATE512227T1 (de) 1994-02-24 2011-06-15 Henkel Ag & Co Kgaa Verbesserte enzyme und detergentien damit
US6682924B1 (en) * 1995-05-05 2004-01-27 Novozymes A/S Protease variants and compositions
DE19530816A1 (de) 1995-08-23 1997-02-27 Cognis Bio Umwelt Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten
US6355255B1 (en) * 1998-12-07 2002-03-12 Regents Of The University Of Minnesota Streptococcal C5a peptidase vaccine
AR015977A1 (es) 1997-10-23 2001-05-30 Genencor Int Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes
CA2310454C (en) * 1997-11-21 2012-01-24 Novo Nordisk A/S Protease variants and compositions
AU2207099A (en) 1997-12-24 1999-07-19 Genencor International, Inc. An improved method of assaying for a preferred enzyme and/or preferred detergentcomposition
US6376450B1 (en) * 1998-10-23 2002-04-23 Chanchal Kumar Ghosh Cleaning compositions containing multiply-substituted protease variants
US6933140B1 (en) * 1999-11-05 2005-08-23 Genencor International, Inc. Enzymes useful for changing the properties of polyester
US6582914B1 (en) * 2000-10-26 2003-06-24 Genencor International, Inc. Method for generating a library of oligonucleotides comprising a controlled distribution of mutations
DE10129187A1 (de) * 2001-06-19 2003-01-02 Studiengesellschaft Kohle Mbh Optimierung von synthetischen Katalysatoren durch gerichtete Evolution
DK1523553T3 (da) 2002-01-16 2010-04-19 Genencor Int Multi-substituerede proteasevarianter
EP1644511A1 (en) * 2003-07-11 2006-04-12 Novozymes A/S Method of screening for improved specific activity of enzymes
CA2544076A1 (en) * 2003-10-22 2005-05-06 Nascacell Ip Gmbh Method for the identification of enzymes having desired properties by immobilisation of the reaction product on the surface of enzyme-presenting organisms
US7985569B2 (en) * 2003-11-19 2011-07-26 Danisco Us Inc. Cellulomonas 69B4 serine protease variants
CA2546451A1 (en) 2003-11-19 2005-06-09 Genencor International, Inc. Serine proteases, nucleic acids encoding serine enzymes and vectors and host cells incorporating same
CN103333870A (zh) * 2003-12-03 2013-10-02 丹尼斯科美国公司 过水解酶
US20060040327A1 (en) * 2004-08-18 2006-02-23 Terry Amiss Methods of screening proteins
CN105200027B (zh) * 2005-10-12 2019-05-31 金克克国际有限公司 储存稳定的中性金属蛋白酶的用途和制备

Also Published As

Publication number Publication date
DK2032698T3 (da) 2012-09-03
HK1128934A1 (en) 2009-11-13
US20080004186A1 (en) 2008-01-03
EP2032698A2 (en) 2009-03-11
CA2654269C (en) 2015-09-22
WO2008002472A3 (en) 2008-03-13
JP5785686B2 (ja) 2015-09-30
ES2388753T3 (es) 2012-10-18
US20140187440A1 (en) 2014-07-03
PT2032698E (pt) 2012-09-24
CA2654269A1 (en) 2008-12-03
JP2009540862A (ja) 2009-11-26
EP2032698B1 (en) 2012-06-27
US8648015B2 (en) 2014-02-11
KR20090023408A (ko) 2009-03-04
CN101473036A (zh) 2009-07-01
US20110082048A1 (en) 2011-04-07
KR101486087B1 (ko) 2015-01-26
WO2008002472A2 (en) 2008-01-03
CN101473036B (zh) 2012-12-12

Similar Documents

Publication Publication Date Title
PT2032698E (pt) Avaliação sistemática de relações entre sequência e actividade utilizando bibliotecas de avaliação de locais em relação a múltiplas propriedades de engenharia
PL1989231T3 (pl) Terapia kombinatoryczna z udziałem antagonistów alfa5beta1
ATE509113T1 (de) Verbesserte grg23-epsp-synthasen: zusammensetzungen und verfahren zu ihrer verwendung
IL251673A0 (en) Clinical applications of neurophysiological pattern processing
BRPI0719195A8 (pt) inibidores de quinase, método de modular uma atividade quinase e composição farmacêutica
PT2848610T (pt) Inibidores da atividade de quinases
IL195273A0 (en) Pharmaceutical use of substituted piperidine carboxamides
PT2397142T (pt) Utilizações de inibidores da dpp iv
PL1999136T3 (pl) Peptydomimetyczne inhibitory PSMA, związki je zawierające i sposoby ich zastosowania
IL196956A0 (en) Aza-benzofuranyl compounds and methods of use
EP2054063A4 (en) 4-AMINOCHINAZOLINE DERIVATIVES AND METHOD FOR THEIR USE
EP2010310A4 (en) SUBSTANCE MIXING SYSTEMS AND DEVICES AND METHODS FOR THEIR MANUFACTURE
BRPI0716300A2 (pt) Artigo e mistura
IL190968A0 (en) Inhibitors of akt activity
HRP20130429T1 (en) Inhibitors of akt activity
EP2038228A4 (en) DECONTAMINATION FLUIDS AND METHODS OF USE THEREOF
IL194028A0 (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
DK2001556T3 (da) Thioninium-forbindelser og anvendelse deraf
ZA200900896B (en) Aza-benzofuranyl compounds and methods of use
GB0712245D0 (en) Combinatorial libraries and related methods
IL198940A0 (en) Stable s-nitrosothiols, method of synthesis and use
ZA200901009B (en) Aza-benzothiophenyl compounds and methods of use
DK2099460T3 (da) 6-alkoxyalkylestradiolderivater og fremgangsmåder til anvendelse
EP1948185A4 (en) INHIBITORS OF AKT ACTIVITY
ZA200807754B (en) Combinatorial therapy involving alpha5beta1 antagonists