PL205498A1 - Sposob wytwarzania pochodnych morfiny - Google Patents

Sposob wytwarzania pochodnych morfiny

Info

Publication number: PL205498A1
Authority: PL; Poland
Prior art keywords: morphine derivatives; making; making morphine; derivatives; morphine
Prior art date: 1977-03-23

Application number

PL20549878A

Other languages

English (en)

Other versions

PL114723B1 (en

Original Assignee

Reckitt & Colmann Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-23

Filing date

1978-03-22

Publication date

1979-04-09

1978-03-22 Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd

1979-04-09 Publication of PL205498A1 publication Critical patent/PL205498A1/pl

1981-02-28 Publication of PL114723B1 publication Critical patent/PL114723B1/pl

Links

238000004519 manufacturing process Methods 0.000 title 1
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL1978205498A 1977-03-23 1978-03-22 Proces for preparing novel derivatives of morphine PL114723B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB12325/77A GB1593191A (en)	1977-03-23	1977-03-23	Derivatives of morphine

Publications (2)

Publication Number	Publication Date
PL205498A1 true PL205498A1 (pl)	1979-04-09
PL114723B1 PL114723B1 (en)	1981-02-28

Family

ID=10002423

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL1978205498A PL114723B1 (en)	1977-03-23	1978-03-22	Proces for preparing novel derivatives of morphine

Country Status (24)

Country	Link
US (1)	US4241066A (pl)
JP (1)	JPS53119899A (pl)
AT (1)	AT361139B (pl)
AU (1)	AU519643B2 (pl)
BE (1)	BE865183A (pl)
CA (1)	CA1089456A (pl)
CH (1)	CH629809A5 (pl)
CS (1)	CS200542B2 (pl)
DD (1)	DD133950A5 (pl)
DE (1)	DE2812580A1 (pl)
DK (1)	DK149858C (pl)
ES (1)	ES468173A1 (pl)
FI (1)	FI68236C (pl)
FR (1)	FR2384774A1 (pl)
GB (1)	GB1593191A (pl)
IE (1)	IE46443B1 (pl)
IT (1)	IT1105176B (pl)
LU (1)	LU79294A1 (pl)
NL (1)	NL7803083A (pl)
NZ (1)	NZ186692A (pl)
PL (1)	PL114723B1 (pl)
SE (1)	SE436131B (pl)
SU (1)	SU921467A3 (pl)
ZA (1)	ZA781527B (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4362870A (en) *	1980-01-16	1982-12-07	Regents Of The University Of Minnesota	Selective opioid receptor alkylating agents
US4401672A (en) *	1981-10-13	1983-08-30	Regents Of The University Of Minnesota	Non-addictive narcotic antitussive preparation
JPS59500418A (ja) *	1982-03-16	1984-03-15	ザ　ロツクフエラ−　ユニバ−シテイ	胃腸能動作用障害を回復する方法
GB8711558D0 (en) *	1987-05-15	1987-06-17	Reckitt & Colmann Prod Ltd	Derivative of codeine
ES2121988T3 (es) *	1992-01-23	1998-12-16	Toray Industries	Derivado de morfinano y uso medicinal.
IT1269826B (it) *	1994-05-24	1997-04-15	Paolo Minoia	Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate
ES2528669T3 (es)	2003-04-08	2015-02-11	Progenics Pharmaceuticals, Inc.	Formulaciones farmacéuticas que contienen metilnaltrexona
US20060063792A1 (en) *	2004-09-17	2006-03-23	Adolor Corporation	Substituted morphinans and methods of their use
AR057035A1 (es)	2005-05-25	2007-11-14	Progenics Pharm Inc	SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es)	2005-05-25	2007-11-28	Progenics Pharm Inc	Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
ES2357216T3 (es)	2005-06-16	2011-04-20	Mallinckrodt, Inc.	Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
ES2629766T3 (es) *	2006-04-21	2017-08-14	Nektar Therapeutics	Reducción estereoselectiva de una morfinona
TWI489984B (zh)	2006-08-04	2015-07-01	Wyeth Corp	用於非經腸道傳輸化合物之配方及其用途
BRPI0809579B8 (pt)	2007-03-29	2021-05-25	Progenics Pharm Inc	formas cristalinas e seus usos
PL2139890T3 (pl)	2007-03-29	2014-11-28	Wyeth Llc	Antagoniści obwodowych receptorów opioidowych i ich zastosowania
PE20090700A1 (es)	2007-03-29	2009-07-13	Progenics Pharm Inc	Compuestos heterociclicos como antagonistas del receptor opioide periferico
WO2009099411A1 (en)	2008-02-06	2009-08-13	Progenics Pharmaceuticals, Inc.	Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2676881C (en)	2008-09-30	2017-04-25	Wyeth	Peripheral opioid receptor antagonists and uses thereof
US8293906B2 (en)	2008-09-30	2012-10-23	Mallinckrodt Llc	Processes for the alkylation of norbuprenorphine with reduced impurity formation
EP2344509B1 (en)	2008-09-30	2015-11-11	Mallinckrodt LLC	Processes for the production of buprenorphine with reduced impurity formation
US9969746B2 (en)	2013-12-05	2018-05-15	The University Of Bath	Opioid compounds and their uses
CN110330500B (zh) *	2019-07-12	2021-11-23	宜昌人福药业有限责任公司	一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3322771A (en) *		1967-05-30		Intermediates for preparing thebaine derivatives
US3332950A (en) *	1963-03-23	1967-07-25	Endo Lab	14-hydroxydihydronormorphinone derivatives
IL26896A (en) *	1966-01-19	1970-11-30	Endo Lab	14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) *	1971-09-08	1973-03-06	Bristol Myers Co	Procede de preparation de composes analgesiques
US4017497A (en) *	1975-11-18	1977-04-12	Bristol-Myers Company	Process for the preparation of 14-hydroxymorphinan derivatives
US4089855A (en) *	1976-04-23	1978-05-16	Cornell Research Foundation, Inc.	Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby

1977
- 1977-03-23 GB GB12325/77A patent/GB1593191A/en not_active Expired
1978
- 1978-03-14 NZ NZ186692A patent/NZ186692A/xx unknown
- 1978-03-14 IE IE515/78A patent/IE46443B1/en unknown
- 1978-03-15 US US05/886,833 patent/US4241066A/en not_active Expired - Lifetime
- 1978-03-15 ZA ZA00781527A patent/ZA781527B/xx unknown
- 1978-03-21 SU SU782595556A patent/SU921467A3/ru active
- 1978-03-21 AU AU34357/78A patent/AU519643B2/en not_active Expired
- 1978-03-21 FI FI780882A patent/FI68236C/fi not_active IP Right Cessation
- 1978-03-22 CA CA299,532A patent/CA1089456A/en not_active Expired
- 1978-03-22 SE SE7803328A patent/SE436131B/sv not_active IP Right Cessation
- 1978-03-22 IT IT48544/78A patent/IT1105176B/it active
- 1978-03-22 FR FR7808404A patent/FR2384774A1/fr active Granted
- 1978-03-22 DE DE19782812580 patent/DE2812580A1/de not_active Ceased
- 1978-03-22 DD DD78204349A patent/DD133950A5/xx unknown
- 1978-03-22 ES ES468173A patent/ES468173A1/es not_active Expired
- 1978-03-22 LU LU79294A patent/LU79294A1/xx unknown
- 1978-03-22 NL NL7803083A patent/NL7803083A/xx not_active Application Discontinuation
- 1978-03-22 AT AT204278A patent/AT361139B/de not_active IP Right Cessation
- 1978-03-22 JP JP3354678A patent/JPS53119899A/ja active Granted
- 1978-03-22 PL PL1978205498A patent/PL114723B1/pl unknown
- 1978-03-22 DK DK130078A patent/DK149858C/da not_active IP Right Cessation
- 1978-03-22 BE BE186174A patent/BE865183A/xx not_active IP Right Cessation
- 1978-03-22 CH CH316078A patent/CH629809A5/fr not_active IP Right Cessation
- 1978-03-22 CS CS781846A patent/CS200542B2/cs unknown

Also Published As

Publication number	Publication date
CH629809A5 (fr)	1982-05-14
FI68236B (fi)	1985-04-30
NZ186692A (en)	1980-02-21
IT1105176B (it)	1985-10-28
LU79294A1 (fr)	1979-10-29
DE2812580A1 (de)	1978-10-05
ES468173A1 (es)	1979-09-16
AU519643B2 (en)	1981-12-17
FR2384774A1 (fr)	1978-10-20
ZA781527B (en)	1979-04-25
IE780515L (en)	1978-09-23
PL114723B1 (en)	1981-02-28
DK149858B (da)	1986-10-13
JPH0112755B2 (pl)	1989-03-02
CS200542B2 (en)	1980-09-15
BE865183A (fr)	1978-09-22
DK149858C (da)	1987-06-29
IE46443B1 (en)	1983-06-15
DD133950A5 (de)	1979-01-31
SE7803328L (sv)	1978-09-24
US4241066A (en)	1980-12-23
FI780882A7 (fi)	1978-09-24
AT361139B (de)	1981-02-25
AU3435778A (en)	1979-09-27
JPS53119899A (en)	1978-10-19
NL7803083A (nl)	1978-09-26
CA1089456A (en)	1980-11-11
DK130078A (da)	1978-09-24
FI68236C (fi)	1985-08-12
GB1593191A (en)	1981-07-15
FR2384774B1 (pl)	1981-10-16
SU921467A3 (ru)	1982-04-15
SE436131B (sv)	1984-11-12
IT7848544A0 (it)	1978-03-22
ATA204278A (de)	1980-07-15

Legal Events

Date	Code	Title	Description
2010-04-30	LICE	Declarations of willingness to grant licence	Effective date: 20100119

Publication	Publication Date	Title
PL207337A1 (pl)	1979-06-04	Sposob wytwarzania pochodnych ftalazyny
PL205498A1 (pl)	1979-04-09	Sposob wytwarzania pochodnych morfiny
PL205287A1 (pl)	1979-06-04	Sposob wytwarzania nowych 4-acyloaminofenylo-etanoloamin
PL202305A1 (pl)	1979-06-18	Sposob wytwarzania furanokumaryny
PL207887A1 (pl)	1979-05-21	Sposob wytwarzania parabenzochinonu
PL210045A1 (pl)	1979-06-18	Sposob wytwarzania nowych pochodnych czteropeptydow
PL204134A1 (pl)	1979-07-02	Sposob wytwarzania nowych pochodnych aminoalkoksyfenylowych
PL204616A1 (pl)	1979-04-23	Sposob wytwarzania pochodnych 1-oksadetiacefamowych
PL205497A1 (pl)	1979-06-04	Sposob wytwarzania nowych pochodnych morfiny
PL206456A1 (pl)	1979-04-23	Sposob wytwarzania pochodnych pirydazynonu-3
PL208434A1 (pl)	1979-06-04	Sposob wytwarzania nowych pochodnych benzopiranu
PL206833A1 (pl)	1979-04-23	Sposob wytwarzania nowych pochodnych 6-aminopenamu
PL211328A1 (pl)	1979-08-13	Sposob wytwarzania nowych pochodnych fenoksyalkanoloaminy
PL204428A1 (pl)	1979-06-04	Sposob wytwarzania nowych pochodnych erytomycyny
PL215005A1 (pl)	1979-12-17	Sposob wytwarzania nowych pochodnych 1-fenyloetanoloaminy
PL209122A1 (pl)	1979-06-04	Sposob wytwarzania nowych pochodnych 3-amino-17 alfa-aza-d-homo-5 alfa-androstanu
PL209329A1 (pl)	1979-06-04	Sposob wytwarzania 2-chlorosulfinyloazetydynonow-4
PL210932A1 (pl)	1979-07-30	Sposob wytwarzania tiolokarbaminianow
PL198559A1 (pl)	1978-10-09	Sposob wytwarzania dwu-n-propylo-acetonitrylu
PL205590A1 (pl)	1979-03-12	Sposob wytwarzania 2-hydroksybenzotiazoli
PL204964A1 (pl)	1978-11-06	Sposob wytwarzania akantomycyny
PL211668A1 (pl)	1979-07-30	Sposob wytwarzania nowych 3-dwu-n-propyloacetoksybenzodiazepinonow-2
PL208406A1 (pl)	1979-06-04	Sposob wytwarzania pochodnych furokumaryny
PL204882A1 (pl)	1979-03-26	Sposob wytwarzania nowych triazolo-tieno-dwuazepinonow-1
PL196842A1 (pl)	1978-02-13	Sposob wytwarzania nowych zasadowych barwnikow metinowych