PL2084132T3 - Dodatnio naładowane rozpuszczalne w wodzie proleki z kwasów n-arylantranilowych z bardzo szybką penetracją skóry - Google Patents
Dodatnio naładowane rozpuszczalne w wodzie proleki z kwasów n-arylantranilowych z bardzo szybką penetracją skóryInfo
- Publication number
- PL2084132T3 PL2084132T3 PL06795893T PL06795893T PL2084132T3 PL 2084132 T3 PL2084132 T3 PL 2084132T3 PL 06795893 T PL06795893 T PL 06795893T PL 06795893 T PL06795893 T PL 06795893T PL 2084132 T3 PL2084132 T3 PL 2084132T3
- Authority
- PL
- Poland
- Prior art keywords
- positively charged
- skin penetration
- penetration rate
- charged water
- soluble prodrugs
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 230000035515 penetration Effects 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2006/053090 WO2008029199A1 (en) | 2006-09-03 | 2006-09-03 | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
| EP06795893.4A EP2084132B1 (en) | 2006-09-03 | 2006-09-03 | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2084132T3 true PL2084132T3 (pl) | 2019-03-29 |
Family
ID=39156867
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13153470T PL2623495T3 (pl) | 2006-09-03 | 2006-09-03 | Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę |
| PL06795893T PL2084132T3 (pl) | 2006-09-03 | 2006-09-03 | Dodatnio naładowane rozpuszczalne w wodzie proleki z kwasów n-arylantranilowych z bardzo szybką penetracją skóry |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13153470T PL2623495T3 (pl) | 2006-09-03 | 2006-09-03 | Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP2084132B1 (pl) |
| CN (1) | CN101506168B (pl) |
| ES (2) | ES2735287T3 (pl) |
| PL (2) | PL2623495T3 (pl) |
| WO (1) | WO2008029199A1 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| PL2084124T3 (pl) | 2006-10-02 | 2014-08-29 | Techfields Biochem Co Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki prostaglandyn i związków pokrewnych o bardzo dużych szybkościach przenikania przez skórę |
| AU2006350707A1 (en) | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| CN101547898B (zh) | 2006-12-10 | 2014-09-24 | 于崇曦 | β-内酰胺类抗生素的透皮给药系统 |
| HUE031712T2 (en) | 2007-01-15 | 2017-08-28 | Chongxi Yu | Retinoids and retinoid-like compounds with positively charged water-soluble prodrugs having very high skin penetration rates |
| WO2008093173A1 (en) | 2007-01-31 | 2008-08-07 | Chongxi Yu | Positively charged water-soluble prodrugs of 1h-imidazo[4, 5-c]quinolin-4-amines and related compounds with very high skin penetration rates |
| KR20150058566A (ko) * | 2007-06-04 | 2015-05-28 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 ｎｓａｉａ 약물전구체 및 이들의 새로운 의약적 용도 |
| WO2009037705A2 (en) * | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation |
| CN101868443A (zh) | 2007-09-20 | 2010-10-20 | 特拉维夫大学拉莫特有限公司 | N-苯基邻氨基苯甲酸衍生物及其用途 |
| BR122021011394B1 (pt) * | 2008-12-04 | 2021-09-28 | Chongxi Yu | Composição de alta penetração de um fármaco principal, e uso de uma hpc |
| PL2427475T3 (pl) | 2009-05-08 | 2021-07-19 | Techfields Biochem Co., Ltd. | Kompozycje proleku o wysokim przenikaniu peptydów i związków powiązanych z peptydami |
| US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
| US20120022116A1 (en) * | 2010-07-20 | 2012-01-26 | Huayun Deng | Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex |
| CN111012914A (zh) * | 2012-01-18 | 2020-04-17 | 苏州泰飞尔医药有限公司 | 治疗肺部疾病的高穿透力前药组合物和医药组合物 |
| CN112521305B (zh) * | 2013-03-15 | 2023-04-25 | 苏州泰飞尔医药有限公司 | 治疗帕金森疾病的新型高穿透力药物及其药物组合物 |
| US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
| US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
| CN112020354A (zh) | 2018-04-26 | 2020-12-01 | Adt制药有限责任公司 | 抗癌茚类、茚满类、氮杂茚类、氮杂茚满类、药物组合物和用途 |
| US20200109117A1 (en) * | 2018-10-02 | 2020-04-09 | ACCESS Association | Modified Therapeutic Agent Analogs of Mefenamic Acid |
| US20220267270A1 (en) * | 2019-08-30 | 2022-08-25 | University Of South Florida | Sting modulators, compositions, and methods of use |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB100208A (en) * | 1915-03-24 | 1917-03-01 | Isidore Swientoslawsk Morrison | Improvements in Watch Movements. |
| US2671805A (en) * | 1952-07-02 | 1954-03-09 | Searle & Co | Basically substituted o-arylamino-benzamides |
| GB984471A (en) * | 1961-01-12 | 1965-02-24 | Parke Davis & Co | Anthranilic acid esters and methods for producing the same |
| BE630053A (pl) * | 1962-03-27 | |||
| US3420871A (en) * | 1964-09-01 | 1969-01-07 | Parke Davis & Co | Anthranilic acid esters |
| DK121236B (da) * | 1967-07-03 | 1971-09-27 | Gea As | Analogifremgangsmåde til fremstilling af terapeutisk aktive, basisk substituerede amider af N-substituerede antranilsyrer, eller syreadditionssalte deraf. |
| GB1187259A (en) * | 1967-10-23 | 1970-04-08 | Hexachimie | New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture |
| US3814811A (en) * | 1972-06-07 | 1974-06-04 | Andreu Sa Dr | Method of eliminating or alleviating local pain with diethylaminoethyl flufenamate |
| JPS57183738A (en) * | 1981-05-06 | 1982-11-12 | Yamanouchi Pharmaceut Co Ltd | Aromatic carboxylic acid derivative |
| JPS6452742A (en) * | 1987-04-27 | 1989-02-28 | Syntex Pharma Int | Omega-quaternary ammonium alkyl ester and thioester of acidic non-steroidal antiinflammatory |
| US5654337A (en) | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
| AUPN531195A0 (en) | 1995-09-11 | 1995-10-05 | J.W. Broadbent Nominees Pty. Ltd. | Lipid extract having anti-inflamatory activity |
| KR100213465B1 (ko) | 1996-11-01 | 1999-08-02 | 최좌진 | 케토프로펜 패취 조성물 |
| US5885597A (en) | 1997-10-01 | 1999-03-23 | Medical Research Industries,Inc. | Topical composition for the relief of pain |
| AU4972599A (en) | 1998-07-07 | 2000-01-24 | Transdermal Technologies, Inc. | Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof |
| US6416772B1 (en) | 2001-01-12 | 2002-07-09 | H. Wayne Van Engelen | Topical dermal anaesthetic |
| US6528040B1 (en) | 2001-01-18 | 2003-03-04 | Maurine Pearson | EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic |
| US7052715B2 (en) | 2003-04-11 | 2006-05-30 | All Natural Fmg, Inc. | Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof |
-
2006
- 2006-09-03 ES ES13153470T patent/ES2735287T3/es active Active
- 2006-09-03 WO PCT/IB2006/053090 patent/WO2008029199A1/en not_active Ceased
- 2006-09-03 PL PL13153470T patent/PL2623495T3/pl unknown
- 2006-09-03 EP EP06795893.4A patent/EP2084132B1/en not_active Not-in-force
- 2006-09-03 EP EP13153470.3A patent/EP2623495B1/en active Active
- 2006-09-03 ES ES06795893.4T patent/ES2694685T3/es active Active
- 2006-09-03 CN CN200680055744.7A patent/CN101506168B/zh not_active Expired - Fee Related
- 2006-09-03 PL PL06795893T patent/PL2084132T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2735287T3 (es) | 2019-12-17 |
| CN101506168B (zh) | 2014-12-10 |
| EP2084132A1 (en) | 2009-08-05 |
| WO2008029199A1 (en) | 2008-03-13 |
| EP2084132B1 (en) | 2018-08-08 |
| ES2694685T3 (es) | 2018-12-26 |
| EP2084132A4 (en) | 2010-05-26 |
| PL2623495T3 (pl) | 2019-11-29 |
| EP2623495B1 (en) | 2019-05-01 |
| HK1137426A1 (en) | 2010-07-30 |
| CN101506168A (zh) | 2009-08-12 |
| EP2623495A1 (en) | 2013-08-07 |
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