PL2623495T3 - Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę - Google Patents
Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skóręInfo
- Publication number
- PL2623495T3 PL2623495T3 PL13153470T PL13153470T PL2623495T3 PL 2623495 T3 PL2623495 T3 PL 2623495T3 PL 13153470 T PL13153470 T PL 13153470T PL 13153470 T PL13153470 T PL 13153470T PL 2623495 T3 PL2623495 T3 PL 2623495T3
- Authority
- PL
- Poland
- Prior art keywords
- positively charged
- skin penetration
- penetration rate
- charged water
- soluble prodrugs
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 230000035515 penetration Effects 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06795893.4A EP2084132B1 (en) | 2006-09-03 | 2006-09-03 | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
| EP13153470.3A EP2623495B1 (en) | 2006-09-03 | 2006-09-03 | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
| PCT/IB2006/053090 WO2008029199A1 (en) | 2006-09-03 | 2006-09-03 | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2623495T3 true PL2623495T3 (pl) | 2019-11-29 |
Family
ID=39156867
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06795893T PL2084132T3 (pl) | 2006-09-03 | 2006-09-03 | Dodatnio naładowane rozpuszczalne w wodzie proleki z kwasów n-arylantranilowych z bardzo szybką penetracją skóry |
| PL13153470T PL2623495T3 (pl) | 2006-09-03 | 2006-09-03 | Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06795893T PL2084132T3 (pl) | 2006-09-03 | 2006-09-03 | Dodatnio naładowane rozpuszczalne w wodzie proleki z kwasów n-arylantranilowych z bardzo szybką penetracją skóry |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP2084132B1 (pl) |
| CN (1) | CN101506168B (pl) |
| ES (2) | ES2735287T3 (pl) |
| PL (2) | PL2084132T3 (pl) |
| WO (1) | WO2008029199A1 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| WO2008041054A1 (en) | 2006-10-02 | 2008-04-10 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates |
| AU2006350707A1 (en) | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| CA2671938C (en) | 2006-12-10 | 2017-10-17 | Chongxi Yu | Transdermal delivery systems of beta-lactam antibiotics |
| DK2125697T3 (en) | 2007-01-15 | 2016-11-14 | Chongxi Yu | POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF RETINOIDS AND RETINOID SIMILAR COMPOUNDS WITH VERY HIGH SKIN PENETRATION |
| PL2115140T3 (pl) | 2007-01-31 | 2017-03-31 | Yu | Dodatnio naładowane rozpuszczalne w wodzie proleki 1H-imidazo[4,5-c]chinolino-4-amin i powiązane związki o bardzo wysokich wskaźnikach penetracji przez skórę |
| KR20210103586A (ko) * | 2007-06-04 | 2021-08-23 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도 |
| WO2009037705A2 (en) * | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation |
| US8765815B2 (en) | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
| RU2630577C2 (ru) * | 2008-12-04 | 2017-09-11 | Чунси ЮЙ | Композиции интенсивного проникновения и их применение |
| PL2427475T3 (pl) | 2009-05-08 | 2021-07-19 | Techfields Biochem Co., Ltd. | Kompozycje proleku o wysokim przenikaniu peptydów i związków powiązanych z peptydami |
| US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
| US20120022116A1 (en) * | 2010-07-20 | 2012-01-26 | Huayun Deng | Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex |
| CN116898848A (zh) | 2012-01-18 | 2023-10-20 | 苏州泰飞尔医药有限公司 | 治疗肺部疾病的高穿透力前药组合物和医药组合物 |
| CN105143174B (zh) * | 2013-03-15 | 2021-01-12 | 苏州泰飞尔医药有限公司 | 治疗帕金森疾病的新型高穿透力药物及其药物组合物 |
| US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
| US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
| JP7169008B2 (ja) | 2018-04-26 | 2022-11-10 | エーディーティー ファーマシューティカルズ，エルエルシー | 抗がんインデン、インダン、アザインデン、アザインダン、医薬組成物および使用 |
| WO2020070557A1 (en) * | 2018-10-02 | 2020-04-09 | Q Biomed Inc. | Modified therapeutic agent analogs of mefenamic acid |
| WO2021042024A1 (en) * | 2019-08-30 | 2021-03-04 | University Of South Florida | Sting modulators, compositions, and methods of use |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB100208A (en) * | 1915-03-24 | 1917-03-01 | Isidore Swientoslawsk Morrison | Improvements in Watch Movements. |
| US2671805A (en) * | 1952-07-02 | 1954-03-09 | Searle & Co | Basically substituted o-arylamino-benzamides |
| GB984471A (en) * | 1961-01-12 | 1965-02-24 | Parke Davis & Co | Anthranilic acid esters and methods for producing the same |
| BE630053A (pl) * | 1962-03-27 | |||
| US3420871A (en) * | 1964-09-01 | 1969-01-07 | Parke Davis & Co | Anthranilic acid esters |
| DK121236B (da) * | 1967-07-03 | 1971-09-27 | Gea As | Analogifremgangsmåde til fremstilling af terapeutisk aktive, basisk substituerede amider af N-substituerede antranilsyrer, eller syreadditionssalte deraf. |
| GB1187259A (en) * | 1967-10-23 | 1970-04-08 | Hexachimie | New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture |
| US3814811A (en) * | 1972-06-07 | 1974-06-04 | Andreu Sa Dr | Method of eliminating or alleviating local pain with diethylaminoethyl flufenamate |
| JPS57183738A (en) * | 1981-05-06 | 1982-11-12 | Yamanouchi Pharmaceut Co Ltd | Aromatic carboxylic acid derivative |
| AU1508988A (en) * | 1987-04-27 | 1988-10-27 | Syntex Pharmaceuticals International Ltd. | Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs |
| US5654337A (en) | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
| AUPN531195A0 (en) | 1995-09-11 | 1995-10-05 | J.W. Broadbent Nominees Pty. Ltd. | Lipid extract having anti-inflamatory activity |
| KR100213465B1 (ko) | 1996-11-01 | 1999-08-02 | 최좌진 | 케토프로펜 패취 조성물 |
| US5885597A (en) | 1997-10-01 | 1999-03-23 | Medical Research Industries,Inc. | Topical composition for the relief of pain |
| MXPA00012844A (es) | 1998-07-07 | 2004-05-21 | Transdermal Technologies Inc | Composiciones para la liberacion transdermica rapida y sin irritacion de agentes farmaceuticamente activos y metodos para formular tales composiciones y liberar los mismos. |
| US6416772B1 (en) | 2001-01-12 | 2002-07-09 | H. Wayne Van Engelen | Topical dermal anaesthetic |
| US6528040B1 (en) | 2001-01-18 | 2003-03-04 | Maurine Pearson | EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic |
| US7052715B2 (en) | 2003-04-11 | 2006-05-30 | All Natural Fmg, Inc. | Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof |
-
2006
- 2006-09-03 ES ES13153470T patent/ES2735287T3/es active Active
- 2006-09-03 WO PCT/IB2006/053090 patent/WO2008029199A1/en not_active Ceased
- 2006-09-03 CN CN200680055744.7A patent/CN101506168B/zh not_active Expired - Fee Related
- 2006-09-03 EP EP06795893.4A patent/EP2084132B1/en not_active Not-in-force
- 2006-09-03 EP EP13153470.3A patent/EP2623495B1/en active Active
- 2006-09-03 ES ES06795893.4T patent/ES2694685T3/es active Active
- 2006-09-03 PL PL06795893T patent/PL2084132T3/pl unknown
- 2006-09-03 PL PL13153470T patent/PL2623495T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2623495A1 (en) | 2013-08-07 |
| EP2084132B1 (en) | 2018-08-08 |
| PL2084132T3 (pl) | 2019-03-29 |
| CN101506168B (zh) | 2014-12-10 |
| WO2008029199A1 (en) | 2008-03-13 |
| EP2084132A4 (en) | 2010-05-26 |
| CN101506168A (zh) | 2009-08-12 |
| ES2694685T3 (es) | 2018-12-26 |
| EP2084132A1 (en) | 2009-08-05 |
| HK1137426A1 (en) | 2010-07-30 |
| EP2623495B1 (en) | 2019-05-01 |
| ES2735287T3 (es) | 2019-12-17 |
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