PL2623495T3 - Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę - Google Patents

Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę

Info

Publication number
PL2623495T3
PL2623495T3 PL13153470T PL13153470T PL2623495T3 PL 2623495 T3 PL2623495 T3 PL 2623495T3 PL 13153470 T PL13153470 T PL 13153470T PL 13153470 T PL13153470 T PL 13153470T PL 2623495 T3 PL2623495 T3 PL 2623495T3
Authority
PL
Poland
Prior art keywords
positively charged
skin penetration
penetration rate
charged water
soluble prodrugs
Prior art date
Application number
PL13153470T
Other languages
English (en)
Inventor
Chongxi Yu
Lina Xu
Original Assignee
Techfields Biochem Co Ltd
Chongxi Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Techfields Biochem Co Ltd, Chongxi Yu filed Critical Techfields Biochem Co Ltd
Publication of PL2623495T3 publication Critical patent/PL2623495T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL13153470T 2006-09-03 2006-09-03 Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę PL2623495T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06795893.4A EP2084132B1 (en) 2006-09-03 2006-09-03 Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate
PCT/IB2006/053090 WO2008029199A1 (en) 2006-09-03 2006-09-03 Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate
EP13153470.3A EP2623495B1 (en) 2006-09-03 2006-09-03 Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate

Publications (1)

Publication Number Publication Date
PL2623495T3 true PL2623495T3 (pl) 2019-11-29

Family

ID=39156867

Family Applications (2)

Application Number Title Priority Date Filing Date
PL06795893T PL2084132T3 (pl) 2006-09-03 2006-09-03 Dodatnio naładowane rozpuszczalne w wodzie proleki z kwasów n-arylantranilowych z bardzo szybką penetracją skóry
PL13153470T PL2623495T3 (pl) 2006-09-03 2006-09-03 Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL06795893T PL2084132T3 (pl) 2006-09-03 2006-09-03 Dodatnio naładowane rozpuszczalne w wodzie proleki z kwasów n-arylantranilowych z bardzo szybką penetracją skóry

Country Status (5)

Country Link
EP (2) EP2623495B1 (pl)
CN (1) CN101506168B (pl)
ES (2) ES2735287T3 (pl)
PL (2) PL2084132T3 (pl)
WO (1) WO2008029199A1 (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
CA2665081C (en) 2006-10-02 2015-12-01 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates
EP2091914A4 (en) 2006-11-08 2010-12-29 Chongxi Yu TRANSDERMAL ADMINISTRATION SYSTEMS FOR PEPTIDES AND RELATED CONNECTIONS
EP2656879B1 (en) 2006-12-10 2017-06-28 Chongxi Yu Transdermal delivery systems of beta-lactam antibiotics
CN107652212B (zh) 2007-01-15 2019-11-15 于崇曦 维生素a酸类和类维生素a酸化合物的前药
WO2008093173A1 (en) 2007-01-31 2008-08-07 Chongxi Yu Positively charged water-soluble prodrugs of 1h-imidazo[4, 5-c]quinolin-4-amines and related compounds with very high skin penetration rates
JP2010529101A (ja) 2007-06-04 2010-08-26 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
WO2009037707A2 (en) 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
WO2009037705A2 (en) * 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation
CN108191846B (zh) 2008-12-04 2021-08-20 于崇曦 高穿透性组合物及其应用
EP2660247A3 (en) 2009-05-08 2014-09-03 Chongxi Yu High penetration prodrug compositions of peptides and peptide-related compounds
US9969751B2 (en) 2009-06-10 2018-05-15 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
US20120022116A1 (en) * 2010-07-20 2012-01-26 Huayun Deng Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex
HK1207562A1 (en) * 2012-01-18 2016-02-05 苏州泰飞尔医药有限公司 High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
BR112015022896B1 (pt) * 2013-03-15 2022-08-23 Chongxi Yu Composto de fármacos de alta penetração, composição farmacêutica e seus usos para o tratamento de doenças de parkinson
US20160168108A1 (en) 2014-12-16 2016-06-16 Adt Pharmaceuticals, Inc. Method of treating or preventing ras-mediated diseases
US9862698B2 (en) 2014-12-16 2018-01-09 Adt Pharmaceuticals, Inc. Indenyl compounds, pharmaceutical compositions, and medical uses thereof
US11186596B2 (en) 2018-04-26 2021-11-30 Adt Pharmaceuticals, Llc Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses
US20200109117A1 (en) * 2018-10-02 2020-04-09 ACCESS Association Modified Therapeutic Agent Analogs of Mefenamic Acid
US20220267270A1 (en) * 2019-08-30 2022-08-25 University Of South Florida Sting modulators, compositions, and methods of use

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GB984471A (en) * 1961-01-12 1965-02-24 Parke Davis & Co Anthranilic acid esters and methods for producing the same
BE630053A (pl) * 1962-03-27
US3420871A (en) * 1964-09-01 1969-01-07 Parke Davis & Co Anthranilic acid esters
DK121236B (da) * 1967-07-03 1971-09-27 Gea As Analogifremgangsmåde til fremstilling af terapeutisk aktive, basisk substituerede amider af N-substituerede antranilsyrer, eller syreadditionssalte deraf.
GB1187259A (en) * 1967-10-23 1970-04-08 Hexachimie New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture
US3814811A (en) * 1972-06-07 1974-06-04 Andreu Sa Dr Method of eliminating or alleviating local pain with diethylaminoethyl flufenamate
JPS57183738A (en) * 1981-05-06 1982-11-12 Yamanouchi Pharmaceut Co Ltd Aromatic carboxylic acid derivative
JPS6452742A (en) * 1987-04-27 1989-02-28 Syntex Pharma Int Omega-quaternary ammonium alkyl ester and thioester of acidic non-steroidal antiinflammatory
US5654337A (en) 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
AUPN531195A0 (en) 1995-09-11 1995-10-05 J.W. Broadbent Nominees Pty. Ltd. Lipid extract having anti-inflamatory activity
KR100213465B1 (ko) 1996-11-01 1999-08-02 최좌진 케토프로펜 패취 조성물
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US6416772B1 (en) 2001-01-12 2002-07-09 H. Wayne Van Engelen Topical dermal anaesthetic
US6528040B1 (en) 2001-01-18 2003-03-04 Maurine Pearson EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic
US7052715B2 (en) 2003-04-11 2006-05-30 All Natural Fmg, Inc. Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof

Also Published As

Publication number Publication date
EP2623495A1 (en) 2013-08-07
EP2623495B1 (en) 2019-05-01
WO2008029199A1 (en) 2008-03-13
HK1137426A1 (en) 2010-07-30
EP2084132A1 (en) 2009-08-05
EP2084132B1 (en) 2018-08-08
CN101506168B (zh) 2014-12-10
ES2735287T3 (es) 2019-12-17
ES2694685T3 (es) 2018-12-26
CN101506168A (zh) 2009-08-12
EP2084132A4 (en) 2010-05-26
PL2084132T3 (pl) 2019-03-29

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