PL2091919T3 - Pochodne analogów hydrokwinonu geldanamycyny podstawionych 18-amino, o aktywności cytotoksycznej do leczenia raka - Google Patents
Pochodne analogów hydrokwinonu geldanamycyny podstawionych 18-amino, o aktywności cytotoksycznej do leczenia rakaInfo
- Publication number
- PL2091919T3 PL2091919T3 PL07854639T PL07854639T PL2091919T3 PL 2091919 T3 PL2091919 T3 PL 2091919T3 PL 07854639 T PL07854639 T PL 07854639T PL 07854639 T PL07854639 T PL 07854639T PL 2091919 T3 PL2091919 T3 PL 2091919T3
- Authority
- PL
- Poland
- Prior art keywords
- geldamycin
- hydroquinon
- cancer
- derivatives
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
- JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 abstract 1
- QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical compound N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- ATEBXHFBFRCZMA-VXTBVIBXSA-N rifabutin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC(=C2N3)C(=O)C=4C(O)=C5C)C)OC)C5=C1C=4C2=NC13CCN(CC(C)C)CC1 ATEBXHFBFRCZMA-VXTBVIBXSA-N 0.000 abstract 1
- 229960000885 rifabutin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86597706P | 2006-11-15 | 2006-11-15 | |
| EP07854639A EP2091919B1 (en) | 2006-11-15 | 2007-11-14 | Derivatives of 18-amino substituted analogs of the geldamycin hydroquinon with cytotoxic activity for the treatment of cancer |
| PCT/US2007/084662 WO2008061134A1 (en) | 2006-11-15 | 2007-11-14 | Derivatives of 18-amino substituted analogs of the geldamycin hydroquinon with cytotoxic activity for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2091919T3 true PL2091919T3 (pl) | 2011-12-30 |
Family
ID=39106113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07854639T PL2091919T3 (pl) | 2006-11-15 | 2007-11-14 | Pochodne analogów hydrokwinonu geldanamycyny podstawionych 18-amino, o aktywności cytotoksycznej do leczenia raka |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7816346B2 (pl) |
| EP (1) | EP2091919B1 (pl) |
| AT (1) | ATE520666T1 (pl) |
| CA (1) | CA2669820A1 (pl) |
| CY (1) | CY1112755T1 (pl) |
| DK (1) | DK2091919T3 (pl) |
| ES (1) | ES2367876T3 (pl) |
| PL (1) | PL2091919T3 (pl) |
| PT (1) | PT2091919E (pl) |
| SI (1) | SI2091919T1 (pl) |
| WO (1) | WO2008061134A1 (pl) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987035A (en) * | 1974-04-05 | 1976-10-19 | University Of Illinois Foundation | Biologically active compounds |
| EP0664702A1 (en) * | 1992-10-14 | 1995-08-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Tumoricidal activity of benzoquinonoid ansamycins against prostate cancer and primitive neural malignancies |
| US5916596A (en) * | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US6096331A (en) * | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
| US6537579B1 (en) * | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
-
2007
- 2007-11-14 ES ES07854639T patent/ES2367876T3/es active Active
- 2007-11-14 PT PT07854639T patent/PT2091919E/pt unknown
- 2007-11-14 CA CA002669820A patent/CA2669820A1/en not_active Abandoned
- 2007-11-14 WO PCT/US2007/084662 patent/WO2008061134A1/en not_active Ceased
- 2007-11-14 DK DK07854639.7T patent/DK2091919T3/da active
- 2007-11-14 EP EP07854639A patent/EP2091919B1/en active Active
- 2007-11-14 AT AT07854639T patent/ATE520666T1/de active
- 2007-11-14 PL PL07854639T patent/PL2091919T3/pl unknown
- 2007-11-14 SI SI200730759T patent/SI2091919T1/sl unknown
- 2007-11-15 US US11/940,644 patent/US7816346B2/en not_active Expired - Fee Related
-
2011
- 2011-09-20 CY CY20111100907T patent/CY1112755T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE520666T1 (de) | 2011-09-15 |
| SI2091919T1 (sl) | 2011-12-30 |
| US20080234246A1 (en) | 2008-09-25 |
| DK2091919T3 (da) | 2011-12-05 |
| EP2091919A1 (en) | 2009-08-26 |
| ES2367876T3 (es) | 2011-11-10 |
| US7816346B2 (en) | 2010-10-19 |
| CY1112755T1 (el) | 2016-02-10 |
| EP2091919B1 (en) | 2011-08-17 |
| WO2008061134A1 (en) | 2008-05-22 |
| PT2091919E (pt) | 2011-09-05 |
| CA2669820A1 (en) | 2008-05-22 |
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