PL2159224T3 - Tiazolilohydropirymidyny podstawione bromofenylem - Google Patents

Tiazolilohydropirymidyny podstawione bromofenylem

Info

Publication number
PL2159224T3
PL2159224T3 PL08757463T PL08757463T PL2159224T3 PL 2159224 T3 PL2159224 T3 PL 2159224T3 PL 08757463 T PL08757463 T PL 08757463T PL 08757463 T PL08757463 T PL 08757463T PL 2159224 T3 PL2159224 T3 PL 2159224T3
Authority
PL
Poland
Prior art keywords
bromo
phenyl substituted
substituted thiazolyl
dihydropyrimidines
thiazolyl dihydropyrimidines
Prior art date
Application number
PL08757463T
Other languages
English (en)
Inventor
Goldmann Siegfried
Jing Li
Yisong Liu
Original Assignee
Ruyuan Wei Xiang Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40155886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2159224(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ruyuan Wei Xiang Tech Co Ltd filed Critical Ruyuan Wei Xiang Tech Co Ltd
Publication of PL2159224T3 publication Critical patent/PL2159224T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL08757463T 2007-06-18 2008-06-18 Tiazolilohydropirymidyny podstawione bromofenylem PL2159224T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200710119019 2007-06-18
EP08757463A EP2159224B1 (en) 2007-06-18 2008-06-18 Bromo-phenyl substituted thiazolyl dihydropyrimidines
PCT/CN2008/001187 WO2008154817A1 (en) 2007-06-18 2008-06-18 Bromo-phenyl substituted thiazolyl dihydropyrimidines

Publications (1)

Publication Number Publication Date
PL2159224T3 true PL2159224T3 (pl) 2012-12-31

Family

ID=40155886

Family Applications (2)

Application Number Title Priority Date Filing Date
PL12176861T PL2514750T3 (pl) 2007-06-18 2008-06-18 Tiazolilodihydropirymidyny podstawione bromofenylem
PL08757463T PL2159224T3 (pl) 2007-06-18 2008-06-18 Tiazolilohydropirymidyny podstawione bromofenylem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL12176861T PL2514750T3 (pl) 2007-06-18 2008-06-18 Tiazolilodihydropirymidyny podstawione bromofenylem

Country Status (14)

Country Link
US (4) USRE45004E1 (pl)
EP (2) EP2159224B1 (pl)
JP (2) JP5361879B2 (pl)
KR (1) KR101173892B1 (pl)
CN (2) CN102066369B (pl)
AU (1) AU2008265397C1 (pl)
BR (1) BRPI0813237B8 (pl)
CA (1) CA2691056C (pl)
DK (2) DK2159224T3 (pl)
ES (2) ES2442907T3 (pl)
PL (2) PL2514750T3 (pl)
PT (2) PT2514750E (pl)
RU (1) RU2443703C2 (pl)
WO (1) WO2008154817A1 (pl)

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AU2008265397C1 (en) 2007-06-18 2013-08-29 Sunshine Lake Pharma Co., Ltd. Bromo-phenyl substituted thiazolyl dihydropyrimidines
WO2010069147A1 (zh) * 2008-12-17 2010-06-24 张中能 二氢嘧啶类化合物、其组合物及其应用
CN101744823B (zh) * 2008-12-17 2013-06-19 广东东阳光药业有限公司 一种二氢嘧啶类化合物的固体分散体及其药用制剂
CN101575318B (zh) 2009-06-25 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 二氢嘧啶类化合物及其用于制备治疗和/或预防病毒性疾病的药物的用途
EP2800742B1 (en) * 2012-01-06 2016-04-06 Janssen Sciences Ireland UC 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN104926808B (zh) 2012-08-24 2018-09-14 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN103664897B (zh) * 2012-09-01 2018-04-03 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN103664925B (zh) * 2012-09-07 2018-01-23 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
CA2881322A1 (en) * 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
CN103724339B (zh) * 2012-09-27 2015-10-14 广东东阳光药业有限公司 二氢嘧啶衍生物的晶型
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WO2015074546A1 (en) 2013-11-19 2015-05-28 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
KR102284938B1 (ko) * 2013-11-27 2021-08-02 선샤인 레이크 파르마 컴퍼니 리미티드 다이하이드로피리미딘 유도체 및 이의 중간산물의 제조 방법
CN104945395B (zh) * 2014-03-28 2018-01-23 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
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US10098889B2 (en) 2015-02-07 2018-10-16 Sunshine Lake Pharma Co., Ltd. Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals
JP6668468B2 (ja) 2015-11-03 2020-03-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｈｂｖキャプシドアセンブリ阻害剤とインターフェロンの併用療法
JP2019526562A (ja) 2016-08-24 2019-09-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｈｂｖキャプシドアセンブリ阻害剤とヌクレオシ（チ）ド類似体の併用療法
US11053260B2 (en) 2017-02-23 2021-07-06 Fujian Cosunter Pharmaceutical Co., Ltd. Tri-cycle compound and applications thereof
BR112019020401A2 (pt) * 2017-03-31 2020-04-22 Fujifilm Corp composto 4-piridona ou seu sal, e composição farmacêutica e formulação que inclui o mesmo
AU2018291688B2 (en) 2017-06-27 2022-02-03 Janssen Pharmaceutica Nv Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis B infections
CN107501257B (zh) * 2017-08-17 2020-05-29 山东大学 二氢嘧啶-三氮唑类衍生物及其制备方法与应用
CN113549079A (zh) 2018-05-25 2021-10-26 正大天晴药业集团股份有限公司 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
CA3109746C (en) 2018-08-23 2023-07-11 Fujian Cosunter Pharmaceutical Co., Ltd. Crystal form of tri-cycle compound and application thereof
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
CN114728973B (zh) 2019-11-22 2024-06-28 正大天晴药业集团股份有限公司 一种核蛋白抑制剂的晶型及其应用
EP4289842A4 (en) 2021-02-05 2025-01-08 Hepagene Therapeutics (HK) Limited Phenyldihydropyrimidine compound and use thereof
CN117136187A (zh) * 2021-06-24 2023-11-28 上海齐鲁制药研究中心有限公司 新型抗乙肝化合物

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Also Published As

Publication number Publication date
AU2008265397B9 (en) 2011-08-04
DK2514750T3 (da) 2013-12-02
BRPI0813237B1 (pt) 2020-01-07
EP2514750A1 (en) 2012-10-24
CA2691056C (en) 2014-03-11
JP2010530374A (ja) 2010-09-09
CN102066369B (zh) 2013-05-29
EP2514750B1 (en) 2013-11-20
DK2159224T3 (da) 2012-08-20
JP5970421B2 (ja) 2016-08-17
DK2514750T5 (en) 2014-02-17
EP2159224B1 (en) 2012-08-01
USRE44987E1 (en) 2014-07-01
US8236797B2 (en) 2012-08-07
ES2391597T3 (es) 2012-11-28
AU2008265397B2 (en) 2011-07-21
CN101328171A (zh) 2008-12-24
HK1174035A1 (en) 2013-05-31
KR101173892B1 (ko) 2012-08-16
BRPI0813237A2 (pt) 2014-12-23
KR20100038104A (ko) 2010-04-12
JP2013231036A (ja) 2013-11-14
CA2691056A1 (en) 2008-12-24
CN102066369A (zh) 2011-05-18
RU2443703C2 (ru) 2012-02-27
US8343969B2 (en) 2013-01-01
EP2159224A1 (en) 2010-03-03
US20100240655A1 (en) 2010-09-23
JP5361879B2 (ja) 2013-12-04
PL2514750T3 (pl) 2014-05-30
ES2442907T3 (es) 2014-02-14
WO2008154817A1 (en) 2008-12-24
BRPI0813237B8 (pt) 2021-05-25
EP2159224A4 (en) 2011-08-03
AU2008265397C1 (en) 2013-08-29
RU2010101212A (ru) 2011-07-27
PT2159224E (pt) 2012-10-24
AU2008265397A1 (en) 2008-12-24
USRE45004E1 (en) 2014-07-08
PT2514750E (pt) 2014-01-23
US20120282221A1 (en) 2012-11-08

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